Probiotic mechanisms of action

Early Human Development - Tập 135 - Trang 58-65 - 2019
Katrina Halloran1, Mark A. Underwood1
1University of California Davis, Department of Pediatrics, Sacramento, CA, USA

Tài liệu tham khảo

Kim, 2017, The interplay between host immune cells and gut microbiota in chronic inflammatory diseases, Exp. Mol. Med., 49, e339, 10.1038/emm.2017.24 Henrick, 2018, Elevated fecal pH indicates a profound change in the breastfed infant gut microbiome due to reduction of Bifidobacterium over the past century, mSphere., 3, 10.1128/mSphere.00041-18 Wassenaar, 2016, Insights from 100 years of research with probiotic E. Coli, European journal of microbiology & immunology., 6, 147, 10.1556/1886.2016.00029 Olson, 2016, Harvesting the benefits of biofilms: a novel probiotic delivery system for the prevention of necrotizing enterocolitis, J. Pediatr. Surg., 51, 936, 10.1016/j.jpedsurg.2016.02.062 Tomaro-Duchesneau, 2012, Probiotic ferulic acid esterase active Lactobacillus fermentum NCIMB 5221 APA microcapsules for Oral delivery: preparation and in vitro characterization, Pharmaceuticals., 5, 236, 10.3390/ph5020236 Underwood, 2015, Bifidobacterium longum subspecies infantis: champion colonizer of the infant gut, Pediatr. Res., 77, 229, 10.1038/pr.2014.156 Frese, 2017, Persistence of supplemented Bifidobacterium longum subsp, infantis EVC001 in Breastfed Infants. mSphere., 3, e00041-18 Amdekar, 2016, Studies on anti-inflammatory and analgesic properties of Lactobacillus rhamnosus in experimental animal models, Journal of complementary & integrative medicine., 13, 145, 10.1515/jcim-2015-0087 La Rosa, 2014, Patterned progression of bacterial populations in the premature infant gut, Proc. Natl. Acad. Sci. U. S. A., 111, 12522, 10.1073/pnas.1409497111 Pammi, 2017, Intestinal dysbiosis in preterm infants preceding necrotizing enterocolitis: a systematic review and meta-analysis, Microbiome., 5, 31, 10.1186/s40168-017-0248-8 Denning, 2018, Neonatal intestinal dysbiosis in necrotizing enterocolitis, Mol. Med., 24, 4, 10.1186/s10020-018-0002-0 Hackam, 2018, Toll-like receptor-mediated intestinal inflammatory imbalance in the pathogenesis of necrotizing enterocolitis, Cellular and molecular gastroenterology and hepatology., 6, 229, 10.1016/j.jcmgh.2018.04.001 Nanthakumar, 2011, The mechanism of excessive intestinal inflammation in necrotizing enterocolitis: an immature innate immune response, PLoS One, 6, 10.1371/journal.pone.0017776 Ganguli, 2013, Probiotics prevent necrotizing enterocolitis by modulating enterocyte genes that regulate innate immune-mediated inflammation, Am. J. Physiol. Gastrointest. Liver Physiol., 304, G132, 10.1152/ajpgi.00142.2012 Meng, 2016, Anti-inflammatory effects of Bifidobacterium longum subsp infantis secretions on fetal human enterocytes are mediated by TLR-4 receptors, Am. J. Physiol. Gastrointest. Liver Physiol., 311, G744, 10.1152/ajpgi.00090.2016 Guo, 2015, Secreted metabolites of Bifidobacterium infantis and Lactobacillus acidophilus protect immature human enterocytes from IL-1beta-induced inflammation: a transcription profiling analysis, PLoS One, 10, 10.1371/journal.pone.0124549 Liu, 2012, Lactobacillus reuteri strains reduce incidence and severity of experimental necrotizing enterocolitis via modulation of TLR4 and NF-kappaB signaling in the intestine, Am. J. Physiol. Gastrointest. Liver Physiol., 302, G608, 10.1152/ajpgi.00266.2011 Lee, 2016, Lactobacillus acidophilus modulates inflammatory activity by regulating the TLR4 and NF-kappaB expression in porcine peripheral blood mononuclear cells after lipopolysaccharide challenge, Br. J. Nutr., 115, 567, 10.1017/S0007114515004857 Wang, 2018, Surface-layer protein from Lactobacillus acidophilus NCFM inhibits lipopolysaccharide-induced inflammation through MAPK and NF-kappaB signaling pathways in RAW264.7 cells, J. Agric. Food Chem., 66, 7655, 10.1021/acs.jafc.8b02012 Sun, 2017, Lactobacillus paracasei modulates LPS-induced inflammatory cytokine release by monocyte-macrophages via the up-regulation of negative regulators of NF-kappaB signaling in a TLR2-dependent manner, Cytokine., 92, 1, 10.1016/j.cyto.2017.01.003 Hoang, 2018, Protective effect of Lactobacillus reuteri DSM 17938 against experimental necrotizing enterocolitis is mediated by toll-like receptor 2, Am. J. Physiol. Gastrointest. Liver Physiol., 315, G231, 10.1152/ajpgi.00084.2017 Rocha-Ramirez LM, Perez-Solano RA, Castanon-Alonso SL, Moreno Guerrero SS, Ramirez Pacheco A, Garcia Garibay M, et al. Probiotic Lactobacillus strains stimulate the inflammatory response and activate human macrophages. J Immunol Res 2017;2017:4607491. Satoh, 2016, Bifidobacterium breve prevents necrotising enterocolitis by suppressing inflammatory responses in a preterm rat model, Benefic. Microbes, 7, 75, 10.3920/BM2015.0035 Manuzak, 2016, Enhancement of microbiota in healthy macaques results in beneficial modulation of mucosal and systemic immune function, J. Immunol., 196, 2401, 10.4049/jimmunol.1502470 Jiang, 2017, The symbiotic bacterial surface factor polysaccharide A on Bacteroides fragilis inhibits IL-1beta-induced inflammation in human fetal enterocytes via toll receptors 2 and 4, PLoS One, 12, 10.1371/journal.pone.0172738 Yang X, Gao XC, Liu J, Ren HY. Effect of EPEC endotoxin and bifidobacteria on intestinal barrier function through modulation of toll-like receptor 2 and toll-like receptor 4 expression in intestinal epithelial cell-18. World journal of gastroenterology: WJG. 2017;23(26):4744–51. Becker, 2014, Probiotic Escherichia coli Nissle 1917 and commensal E. coli K12 differentially affect the inflammasome in intestinal epithelial cells, Digestion., 89, 110, 10.1159/000357521 Kern, 2017, Characterization of inflammasome components in pig intestine and analysis of the influence of probiotic enterococcus faecium during an Escherichia Coli challenge, Immunol. Investig., 46, 742, 10.1080/08820139.2017.1360341 Loss, 2018, Effects of a pathogenic ETEC strain and a probiotic Enterococcus faecium strain on the inflammasome response in porcine dendritic cells, Vet. Immunol. Immunopathol., 203, 78, 10.1016/j.vetimm.2018.08.004 Jeon, 2012, Probiotic Bifidobacterium breve induces IL-10-producing Tr1 cells in the colon, PLoS Pathog., 8, 10.1371/journal.ppat.1002714 Reyes-Diaz, 2018, Milk fermented by specific Lactobacillus strains regulates the serum levels of IL-6, TNF-alpha and IL-10 cytokines in a LPS-stimulated murine model, Nutrients., 10, 10.3390/nu10060691 Ermolenko, 2018, Influence of monostrain and multistrain probiotics on immunity, intestinal ultrastructure and microbiota in experimental dysbiosis, Benefic. Microbes, 1 Stofilova, 2017, Cytokine production in vitro and in rat model of colitis in response to Lactobacillus plantarum LS/07, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie., 94, 1176, 10.1016/j.biopha.2017.07.138 Ottman, 2017, Pili-like proteins of Akkermansia muciniphila modulate host immune responses and gut barrier function, PLoS One, 12, 10.1371/journal.pone.0173004 Wu, 2017, Bifidobacterium adolescentis protects against necrotizing enterocolitis and upregulates TOLLIP and SIGIRR in premature neonatal rats, BMC Pediatr., 17, 1, 10.1186/s12887-016-0759-7 Ekmekciu, 2017, The probiotic compound VSL#3 modulates mucosal, peripheral, and systemic immunity following murine broad-Spectrum antibiotic treatment, Front. Cell. Infect. Microbiol., 7, 167, 10.3389/fcimb.2017.00167 Ekmekciu, 2017, Fecal microbiota transplantation, commensal Escherichia coli and Lactobacillus johnsonii strains differentially restore intestinal and systemic adaptive immune cell populations following broad-spectrum antibiotic treatment, Front. Microbiol., 8, 2430, 10.3389/fmicb.2017.02430 Liu, 2014, Lactobacillus reuteri DSM 17938 differentially modulates effector memory T cells and Foxp3+ regulatory T cells in a mouse model of necrotizing enterocolitis, Am. J. Physiol. Gastrointest. Liver Physiol., 307, G177, 10.1152/ajpgi.00038.2014 Khorasani, 2019, Amelioration of regulatory T cells by Lactobacillus delbrueckii and Lactobacillus rhamnosus in pristane-induced lupus mice model, J. Cell. Physiol., 9778, 10.1002/jcp.27663 Kanmani, 2019, Functional capabilities of probiotic strains on attenuation of intestinal epithelial cell inflammatory response induced by TLR4 stimuli, BioFactors (Oxford, England)., 45, 223, 10.1002/biof.1475 Round, 2011, The toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota, Science., 332, 974, 10.1126/science.1206095 Blackwood, 2017, Probiotic Lactobacillus species strengthen intestinal barrier function and tight junction integrity in experimental necrotizing enterocolitis, Journal of probiotics & health., 5, 10.4172/2329-8901.1000159 Lim, 2016, Lactobacillus sakei OK67 ameliorates high-fat diet-induced blood glucose intolerance and obesity in mice by inhibiting gut microbiota lipopolysaccharide production and inducing colon tight junction protein expression, Nutr. Res., 36, 337, 10.1016/j.nutres.2015.12.001 Trindade, 2018, Oral administration of Simbioflora(R) (synbiotic) attenuates intestinal damage in a mouse model of 5-fluorouracil-induced mucositis, Benefic. Microbes, 9, 477, 10.3920/BM2017.0082 van Beek, 2016, Supplementation with Lactobacillus plantarum WCFS1 prevents decline of mucus barrier in colon of accelerated aging Ercc1(-/Delta7) mice, Front. Immunol., 7, 408, 10.3389/fimmu.2016.00408 Ganesh, 2018, Prebiotics, probiotics, and acetate supplementation prevent hypertension in a model of obstructive sleep apnea, Hypertension., 72, 1141, 10.1161/HYPERTENSIONAHA.118.11695 Everard, 2013, Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity, Proc. Natl. Acad. Sci. U. S. A., 110, 9066, 10.1073/pnas.1219451110 Ottman, 2017, Action and function of Akkermansia muciniphila in microbiome ecology, health and disease, Best Pract. Res. Clin. Gastroenterol., 31, 637, 10.1016/j.bpg.2017.10.001 Da Silva, 2014, Stress disrupts intestinal mucus barrier in rats via mucin O-glycosylation shift: prevention by a probiotic treatment, Am. J. Physiol. Gastrointest. Liver Physiol., 307, G420, 10.1152/ajpgi.00290.2013 Celebioglu, 2017, Mucin- and carbohydrate-stimulated adhesion and subproteome changes of the probiotic bacterium Lactobacillus acidophilus NCFM, J. Proteome, 163, 102, 10.1016/j.jprot.2017.05.015 Ulluwishewa, 2011, Regulation of tight junction permeability by intestinal bacteria and dietary components, J. Nutr., 141, 769, 10.3945/jn.110.135657 Cui, 2017, Lactobacillus reuteri ZJ617 maintains intestinal integrity via regulating tight junction, autophagy and apoptosis in mice challenged with lipopolysaccharide, Oncotarget., 8, 77489, 10.18632/oncotarget.20536 Chen, 2019, Lactobacillus rhamnosus GG treatment improves intestinal permeability and modulates microbiota dysbiosis in an experimental model of sepsis, Int. J. Mol. Med., 43, 1139 Guo, 2017, Secretions of Bifidobacterium infantis and Lactobacillus acidophilus protect intestinal epithelial barrier function, J. Pediatr. Gastroenterol. Nutr., 64, 404, 10.1097/MPG.0000000000001310 Underwood, 2012, Bifidobacterium bifidum in a rat model of necrotizing enterocolitis: antimicrobial peptide and protein responses, Pediatr. Res., 71, 546, 10.1038/pr.2012.11 Underwood, 2014, Bifidobacterium longum subsp. infantis in experimental necrotizing enterocolitis: alterations in inflammation, innate immune response, and the microbiota, Pediatr. Res., 76, 326, 10.1038/pr.2014.102 Strunk, 2017, Probiotics and antimicrobial protein and peptide levels in preterm infants, Acta Paediatr., 106, 1747, 10.1111/apa.13826 Han, 2016, The role of probiotics in lipopolysaccharide-induced autophagy in intestinal epithelial cells, Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry, and pharmacology., 38, 2464, 10.1159/000445597 Wu, 2017, Probiotic bacillus amyloliquefaciens SC06 induces autophagy to protect against pathogens in macrophages, Front. Microbiol., 8, 469, 10.3389/fmicb.2017.00469 Rosenbaum, 2015, The gut microbiota in human energy homeostasis and obesity, Trends Endocrinol Metab, 26, 493, 10.1016/j.tem.2015.07.002 Graham, 2015, Obesity and the gastrointestinal microbiota: a review of associations and mechanisms, Nutr. Rev., 73, 376, 10.1093/nutrit/nuv004 Turnbaugh, 2006, An obesity-associated gut microbiome with increased capacity for energy harvest, Nature., 444, 1027, 10.1038/nature05414 Backhed, 2007, Mechanisms underlying the resistance to diet-induced obesity in germ-free mice, Proc. Natl. Acad. Sci. U. S. A., 104, 979, 10.1073/pnas.0605374104 Rabot, 2010, Germ-free C57BL/6J mice are resistant to high-fat-diet-induced insulin resistance and have altered cholesterol metabolism, FASEB journal: official publication of the Federation of American Societies for Experimental Biology., 24, 4948 Le Roy, 2013, Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice, Gut., 62, 1787, 10.1136/gutjnl-2012-303816 Blanton, 2016, Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children, Science., 351, 10.1126/science.aad3311 Smith, 2013, Gut microbiomes of Malawian twin pairs discordant for kwashiorkor, Science., 339, 548, 10.1126/science.1229000 Wang, 2016, Effects of prebiotics, probiotics, and their combination on growth performance, small intestine morphology, and resident Lactobacillus of male broilers, Poult. Sci., 95, 1332, 10.3382/ps/pew030 de Clercq, 2016, Gut microbiota in obesity and undernutrition, Adv. Nutr., 7, 1080, 10.3945/an.116.012914 Rasmussen, 2018, Antibiotic exposure in early life and childhood overweight and obesity: a systematic review and meta-analysis, Diabetes Obes. Metab., 20, 1508, 10.1111/dom.13230 Brusaferro, 2018, Is it time to use probiotics to prevent or treat obesity?, Nutrients., 10, 10.3390/nu10111613 Davis, 2016, Identification of oligosaccharides in feces of breast-fed infants and their correlation with the gut microbial community, Molecular & cellular proteomics: MCP., 15, 2987, 10.1074/mcp.M116.060665 Underwood, 2017, Digestion of human milk oligosaccharides by Bifidobacterium breve in the premature infant, J. Pediatr. Gastroenterol. Nutr., 65, 449, 10.1097/MPG.0000000000001590 Thomson, 2018, Human milk oligosaccharides and infant gut bifidobacteria: molecular strategies for their utilization, Food Microbiol., 75, 37, 10.1016/j.fm.2017.09.001 Underwood, 2013, A comparison of two probiotic strains of bifidobacteria in premature infants, J. Pediatr., 163, 1585, 10.1016/j.jpeds.2013.07.017 Hamilton, 2017, Prebiotic milk oligosaccharides prevent development of obese phenotype, impairment of gut permeability, and microbial dysbiosis in high fat-fed mice, Am. J. Physiol. Gastrointest. Liver Physiol., 312, G474, 10.1152/ajpgi.00427.2016 Alderete, 2015, Associations between human milk oligosaccharides and infant body composition in the first 6 mo of life, Am. J. Clin. Nutr., 102, 1381, 10.3945/ajcn.115.115451 Sun, 2017, Effects of probiotics on necrotizing enterocolitis, sepsis, intraventricular hemorrhage, mortality, length of hospital stay, and weight gain in very preterm infants: a meta-analysis, Adv. Nutr., 8, 749, 10.3945/an.116.014605 Holscher, 2015, Fiber supplementation influences phylogenetic structure and functional capacity of the human intestinal microbiome: follow-up of a randomized controlled trial, Am. J. Clin. Nutr., 101, 55, 10.3945/ajcn.114.092064 Barczynska, 2016, Effects of dietary fiber preparations made from maize starch on the growth and activity of selected bacteria from the Firmicutes, Bacteroidetes, and Actinobacteria phyla in fecal samples from obese children, Acta Biochim. Pol., 63, 261, 10.18388/abp.2015_1068 Sarma, 2017, Kodo millet whole grain and bran supplementation prevents high-fat diet induced derangements in a lipid profile, inflammatory status and gut bacteria in mice, Food Funct., 8, 1174, 10.1039/C6FO01467D Lambert, 2017, Consuming yellow pea fiber reduces voluntary energy intake and body fat in overweight/obese adults in a 12-week randomized controlled trial, Clinical nutrition (Edinburgh, Scotland)., 36, 126, 10.1016/j.clnu.2015.12.016 Shen, 2018, Increases in phenolic, fatty acid, and phytosterol contents and anticancer activities of sweet potato after fermentation by Lactobacillus acidophilus, J. Agric. Food Chem., 66, 2735, 10.1021/acs.jafc.7b05414 Westfall, 2019, Ferulic acid produced by Lactobacillus fermentum influences developmental growth through a dTOR-mediated mechanism, Mol. Biotechnol., 61, 1, 10.1007/s12033-018-0119-y Rivera-Chavez, 2016, Depletion of butyrate-producing clostridia from the gut microbiota drives an aerobic luminal expansion of salmonella, Cell Host Microbe, 19, 443, 10.1016/j.chom.2016.03.004 Rivera-Chavez, 2017, Oxygen as a driver of gut dysbiosis, Free Radic. Biol. Med., 105, 93, 10.1016/j.freeradbiomed.2016.09.022 Qu, 2018, Antidiabetic effects of Lactobacillus casei fermented yogurt through reshaping gut microbiota structure in type 2 diabetic rats, J. Agric. Food Chem., 66, 12696, 10.1021/acs.jafc.8b04874 Christiansen, 2018, The impact of short-chain fatty acids on GLP-1 and PYY secretion from the isolated perfused rat colon, Am. J. Physiol. Gastrointest. Liver Physiol., 315, G53, 10.1152/ajpgi.00346.2017 Jia, 2017, Butyrate stimulates adipose lipolysis and mitochondrial oxidative phosphorylation through histone hyperacetylation-associated beta3 -adrenergic receptor activation in high-fat diet-induced obese mice, Exp. Physiol., 102, 273, 10.1113/EP086114 Hong, 2016, Butyrate alleviates high fat diet-induced obesity through activation of adiponectin-mediated pathway and stimulation of mitochondrial function in the skeletal muscle of mice, Oncotarget., 7, 56071, 10.18632/oncotarget.11267 Kim, 2018, Probiotics, prebiotics, synbiotics and insulin sensitivity, Nutr. Res. Rev., 31, 35, 10.1017/S095442241700018X Lee, 2018, Microbiota-derived lactate accelerates intestinal stem-cell-mediated epithelial development, Cell Host Microbe, 24, 833, 10.1016/j.chom.2018.11.002 Holecek, 2018, Branched-chain amino acids in health and disease: metabolism, alterations in blood plasma, and as supplements, Nutrition & metabolism., 15, 33, 10.1186/s12986-018-0271-1 He, 2016, Integrated role of Bifidobacterium animalis subsp. lactis supplementation in gut microbiota, immunity, and metabolism of infant rhesus monkeys, mSystems., 1, 10.1128/mSystems.00128-16 Branner, 2006, Influence of pre-, pro-, and synbiotics on the intestinal availability of different B-vitamins, Arch. Anim. Nutr., 60, 191, 10.1080/17450390600678985 LeBlanc, 2017, Beneficial effects on host energy metabolism of short-chain fatty acids and vitamins produced by commensal and probiotic bacteria, Microb. Cell Factories, 16, 79, 10.1186/s12934-017-0691-z Fabian, 2008, Influence of probiotic and conventional yoghurt on the status of vitamins B1, B2 and B6 in young healthy women, Annals of nutrition & metabolism., 52, 29, 10.1159/000114408 Deng, 2018, Effects of products designed to modulate the gut microbiota on hyperlipidaemia, Eur. J. Nutr. Villamor-Martinez, 2017, Probiotic supplementation in preterm infants does not affect the risk of bronchopulmonary dysplasia: a meta-analysis of randomized controlled trials, Nutrients., 9, 10.3390/nu9111197 Dimidi, 2014, The effect of probiotics on functional constipation in adults: a systematic review and meta-analysis of randomized controlled trials, Am. J. Clin. Nutr., 100, 1075, 10.3945/ajcn.114.089151 Jin, 2018, Systematic review and meta-analysis of the effect of probiotic supplementation on functional constipation in children, Medicine., 97, 10.1097/MD.0000000000012174 Rao, 2018, Probiotic supplementation in neonates with major gastrointestinal surgical conditions: a systematic review, J. Matern. Fetal Neonatal Med., 31, 1517, 10.1080/14767058.2017.1317738 Dimidi, 2017, Mechanisms of action of probiotics and the gastrointestinal microbiota on gut motility and constipation, Adv. Nutr., 8, 484, 10.3945/an.116.014407 Guasch-Ferre, 2017, Plasma metabolites from choline pathway and risk of cardiovascular disease in the PREDIMED (prevention with Mediterranean diet) study, J. Am. Heart Assoc., 6, 10.1161/JAHA.117.006524 Troseid, 2015, Microbiota-dependent metabolite trimethylamine-N-oxide is associated with disease severity and survival of patients with chronic heart failure, J. Intern. Med., 277, 717, 10.1111/joim.12328 Li, 2017, Gut microbiota-dependent trimethylamine N-oxide in acute coronary syndromes: a prognostic marker for incident cardiovascular events beyond traditional risk factors, Eur. Heart J., 38, 814 Miao, 2015, Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis, Nat. Commun., 6, 6498, 10.1038/ncomms7498 Shih, 2015, Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis, J. Lipid Res., 56, 22, 10.1194/jlr.M051680 Tripolt, 2015, Effect of Lactobacillus casei Shirota supplementation on trimethylamine-N-oxide levels in patients with metabolic syndrome: an open-label, randomized study, Atherosclerosis., 242, 141, 10.1016/j.atherosclerosis.2015.05.005 Borges, 2018, Effects of probiotic supplementation on trimethylamine-N-oxide plasma levels in hemodialysis patients: a pilot study, Probiotics and antimicrobial proteins. Boutagy, 2015, Probiotic supplementation and trimethylamine-N-oxide production following a high-fat diet, Obesity., 23, 2357, 10.1002/oby.21212 Qiu, 2018, Lactobacillus plantarum ZDY04 exhibits a strain-specific property of lowering TMAO via the modulation of gut microbiota in mice, Food Funct., 9, 4299, 10.1039/C8FO00349A Qiu, 2017, Enterobacter aerogenes ZDY01 attenuates choline-induced trimethylamine N-oxide levels by remodeling gut microbiota in mice, J. Microbiol. Biotechnol., 27, 1491, 10.4014/jmb.1703.03039 Brial, 2018, Implication of gut microbiota metabolites in cardiovascular and metabolic diseases, Cellular and molecular life sciences: CMLS., 75, 3977, 10.1007/s00018-018-2901-1 Chavez-Talavera, 2017, Bile acid control of metabolism and inflammation in obesity, type 2 diabetes, dyslipidemia, and nonalcoholic fatty liver disease, Gastroenterology., 152, 1679, 10.1053/j.gastro.2017.01.055 Kommineni, 2016, Harnessing bacteriocin biology as targeted therapy in the GI tract, Gut Microbes, 7, 512, 10.1080/19490976.2016.1233089 Kommineni, 2015, Bacteriocin production augments niche competition by enterococci in the mammalian gastrointestinal tract, Nature., 526, 719, 10.1038/nature15524 Yang, 2014, Antibacterial activities of bacteriocins: application in foods and pharmaceuticals, Front. Microbiol., 5, 241 van Heel, 2013, BAGEL3: automated identification of genes encoding bacteriocins and (non-)bactericidal posttranslationally modified peptides, Nucleic Acids Res., 41, W448, 10.1093/nar/gkt391 Hammami, 2010, BACTIBASE second release: a database and tool platform for bacteriocin characterization, BMC Microbiol., 10, 22, 10.1186/1471-2180-10-22 Yang, 2018, Antimicrobial peptides produced by Brevibacillus spp.: structure, classification and bioactivity: a mini review, World journal of microbiology & biotechnology., 34, 57, 10.1007/s11274-018-2437-4 Garcia-Gutierrez E, Mayer MJ, Cotter PD, Narbad A. Gut microbiota as a source of novel antimicrobials. Gut Microbes 2018:1–21. Heeney, 2018, Lactobacillus plantarum bacteriocin is associated with intestinal and systemic improvements in diet-induced obese mice and maintains epithelial barrier integrity in vitro, Gut Microbes, 1 Dicks, 2018, The fate of Bacteriocins in the human gastro-intestinal tract: do they cross the gut-blood barrier?, Front. Microbiol., 9, 2297, 10.3389/fmicb.2018.02297