Seasonal variations of potentially toxic elements (PTEs) in drinking water and health risk assessment via Monte Carlo simulation and Sobol sensitivity analysis in southern Iran's largest city
Tóm tắt
The escalating concern over the presence and health implications of potentially toxic elements (PTEs) in drinking water has underscored the need for rigorous risk assessments. Our study aimed to quantify both the non-carcinogenic and carcinogenic health risks associated with exposure to selected PTEs—namely arsenic (As), chromium (Cr), and cadmium (Cd). Also, we evaluated ingestion and skin contact exposures to risks during summer and winter using metrics such as the hazard quotient (HQ), hazard index (HI), and cancer risk (CR) for children, adult males, and adult females. For all demographic groups and exposure pathways, the HQ values remain below the established safety threshold (HQ < 1). Notably, As consistently had the highest average HI value across children, male adults, and female adults. Seasonal variations were statistically significant (p < 0.05) for As and Cr, but not Cd. During the summer, the average total carcinogenic risks (TCR) from drinking water exposure were 7.61 × 10–6, 8.94 × 10–6, and 1.12 × 10–5 for children, male adults, and female adults, respectively. In the winter, these values were 1.18 × 10–5, 1.40 × 10–5, and 1.75 × 10–5, respectively. The fuzzy C-means clustering analysis provided insights into our dataset's Cr, Cd, and As distribution patterns. Results indicate that As, Cr, and Cd mean concentrations were below the World Health Organization health-based guidelines. The CR values for children and adults from drinking water exposure were slightly above or below the US Environmental Protection Agency’s standards. These findings can inform research and policy-making regarding the risk of PTEs in drinking water and highlight the need to monitor Shiraz water regularly.
Tài liệu tham khảo
Abdullah N, Yusof N, Lau WJ et al (2019) Recent trends of heavy metal removal from water/wastewater by membrane technologies. J Ind Eng Chem 76:17–38. https://doi.org/10.1016/j.jiec.2019.03.029
Abeer N, Khan SA, Muhammad S et al (2020) Health risk assessment and provenance of arsenic and heavy metal in drinking water in Islamabad Pakistan. Environ Technol Innov. https://doi.org/10.1016/j.eti.2020.101171
Abolfazli D, Abbasi F, Baghapour MA et al (2023) Hazardous exposure of children with heavy metal in a southwestern city of Iran. Int J Environ Anal Chem 103:3264–3276. https://doi.org/10.1080/03067319.2021.1906423
Ajloon FH, Dong X, Ayejoto DA et al (2022) Seasonal assessment of water quality and water quality index (WQI) variations, in Jiangsu Kunshan Tianfu National Wetland Park, China. Int J Environ Anal Chem. https://doi.org/10.1080/03067319.2022.2125309
Alao JO, Fahad A, Abdo HG et al (2023) Effects of dumpsite leachate plumes on surface and groundwater and the possible public health risks. Sci Total Environ 897:165469. https://doi.org/10.1016/j.scitotenv.2023.165469
Ameri Z, Hoodaji M, Rajaie M, Ataabadi M (2021) Optimizing modified rice bran for treating aqueous solutions polluted by Cr (VI) ions Isotherm and kinetics analyses. Qual Assur Saf Crop Foods 13:1–11. https://doi.org/10.15586/QAS.V13ISP1.942
Amin S, Farjoud MR, Shabani A (2011) Groundwater Contamination by Heavy Metals in Water Resources of Shiraz Area
Awual MR, Hasan MM, Asiri AM, Rahman MM (2019) Cleaning the arsenic(V)contaminated water for safe-guarding the public health using novel composite material. Compos Part B Eng 171:294–301. https://doi.org/10.1016/j.compositesb.2019.05.078
Ayejoto DA, Agbasi JC, Egbueri JC, Abba SI (2023a) Evaluation of oral and dermal health risk exposures of contaminants in groundwater resources for nine age groups in two densely populated districts. Nigeria Heliyon 9:e15483. https://doi.org/10.1016/j.heliyon.2023.e15483
Ayejoto DA, Agbasi JC, Egbueri JC, Echefu KI (2022) Assessment of oral and dermal health risk exposures associated with contaminated water resources: an update in Ojoto area, southeast Nigeria. Int J Environ Anal Chem. https://doi.org/10.1080/03067319.2021.2023515
Ayejoto DA, Egbueri JC, Agbasi JC, et al (2023b) Influence of seasonal changes on the quality of water resources in southwestern Nigeria: A Review. In: Springer climate. Springer, pp 423–447
Azhdari A, Soltani A, Alidadi M (2018) Urban morphology and landscape structure effect on land surface temperature: evidence from Shiraz, a semi-arid city. Sustain Cities Soc 41:853–864. https://doi.org/10.1016/j.scs.2018.06.034
Aşkan E, Topcu Y, Şahin AN (2021) Determining consumption preferences of consumers considering quality attributes of drinking water: case of Iğdır. Ital J Food Sci 33:156–165. https://doi.org/10.15586/IJFS.V33I2.2040
Badeenezhad A, Darabi K, Heydari M et al (2021) Temporal distribution and zoning of nitrate and fluoride concentrations in Behbahan drinking water distribution network and health risk assessment by using sensitivity analysis and Monte Carlo simulation. Int J Environ Anal Chem. https://doi.org/10.1080/03067319.2021.1903455
Badeenezhad A, Tabatabaee HR, Nikbakht HA et al (2020) Estimation of the groundwater quality index and investigation of the affecting factors their changes in Shiraz drinking groundwater Iran. Groundw Sustain Dev. https://doi.org/10.1016/j.gsd.2020.100435
Bahita TA, Swain S, Pandey P, Pandey A (2021) Assessment of heavy metal contamination in livestock drinking water of Upper Ganga Canal (Roorkee City, India). Arab J Geosci. https://doi.org/10.1007/s12517-021-08874-7
Barbhuiya SN, Warisa R, Barhoi D, et al (2023) Consequences of arsenic exposure in plant-health status: an overview. https://doi.org/10.1007/s12517-021-08874-7
Basu A, Saha D, Saha R et al (2014) A review on sources, toxicity and remediation technologies for removing arsenic from drinking water. Res Chem Intermed 40:447–485
Bera T, Kumar V, Sarkar DJ et al (2022) Pollution assessment and mapping of potentially toxic elements (PTE) distribution in urban wastewater fed natural wetland, Kolkata, India. Environ Sci Pollut Res 29:67801–67820. https://doi.org/10.1007/s11356-022-20573-8
Cai S, Zeng B, Li C (2023) Potential health risk assessment of metals in the muscle of seven wild fish species from the Wujiangdu reservoir China. Qual Assur Saf Crop Foods 15:73–83. https://doi.org/10.15586/qas.v15i1.1121
Chauhan S, Dahiya D, Sharma V et al (2022) Advances from conventional to real time detection of heavy metal(loid)s for water monitoring: an overview of biosensing applications. Chemosphere 307:136124. https://doi.org/10.1016/j.chemosphere.2022.136124
Du B, Zhou J, Lu B et al (2020) Environmental and human health risks from cadmium exposure near an active lead-zinc mine and a copper smelter China. Sci Total Environ. https://doi.org/10.1016/j.scitotenv.2020.137585
Egbueri JC, Agbasi JC, Ayejoto DA et al (2023a) Extent of anthropogenic influence on groundwater quality and human health-related risks an integrated assessment based on selected physicochemical characteristics. Geocarto Int. https://doi.org/10.1080/10106049.2023.2210100
Egbueri JC, Ayejoto DA, Agbasi JC (2023b) Pollution assessment and estimation of the percentages of toxic elements to be removed to make polluted drinking water safe: a case from Nigeria. Toxin Rev 42:146–160. https://doi.org/10.1080/15569543.2021.2025401
Egbueri JC, Enyigwe MT (2020) Pollution and ecological risk assessment of potentially toxic elements in natural waters from the Ameka Metallogenic District in Southeastern Nigeria. Anal Lett 53:2812–2839. https://doi.org/10.1080/00032719.2020.1759616
Ezugwu CK, Onwuka OS, Egbueri JC et al (2019) Multi-criteria approach to water quality and health risk assessments in a rural agricultural province, southeast Nigeria. HydroResearch 2:40–48. https://doi.org/10.1016/j.hydres.2019.11.005
Fallahzadeh RA, Ghaneian MT, Miri M, Dashti MM (2017) Spatial analysis and health risk assessment of heavy metals concentration in drinking water resources. Environ Sci Pollut Res 24:24790–24802. https://doi.org/10.1007/s11356-017-0102-3
Fattahzadeh M, Hoshyari E, Parang S et al (2021) Assessment of Heavy metal concentration and their source in the groundwater near the landfill site: case study (Shiraz landfill). J Matter Environ Sci 12:1430–1443
Gao Y, Qian H, Zhou Y et al (2022b) Cumulative health risk assessment of multiple chemicals in groundwater based on deterministic and Monte Carlo models in a large semiarid basin. J Clean Prod. https://doi.org/10.1016/j.jclepro.2022.131567
Gao L, Huang X, Wang P, et al (2022a) Concentrations and health risk assessment of 24 residual heavy metals in Chinese mitten crab (Eriocheir sinensis). Qual Assur Saf Crop Foods 14:82–91. https://doi.org/10.15586/QAS.V14I1.1034
Genchi G, Lauria G, Catalano A et al (2022) Arsenic: a review on a great health issue worldwide. Appl Sci 12:6184
Genchi G, Sinicropi MS, Lauria G, et al (2020) The effects of cadmium toxicity. Int J Environ Res Publ Health 17
Heshmati A, Khorshidi M, Khaneghah AM (2021) The prevalence and risk assessment of aflatoxin in sesame-based products. Ital J Food Sci 33:92–102. https://doi.org/10.15586/ijfs.v33iSP1.2065
Hu G, Bakhtavar E, Hewage K et al (2019) Heavy metals risk assessment in drinking water: an integrated probabilistic-fuzzy approach. J Environ Manage. https://doi.org/10.1016/j.jenvman.2019.109514
Hu L, Wang X, Zou Y et al (2022) Effects of inorganic and organic selenium intervention on resistance of radish to arsenic stress. Ital J Food Sci 34:44–58. https://doi.org/10.15586/ijfs.v34i1.2105
Hughes J, Cowper-Heays K, Olesson E et al (2021) Impacts and implications of climate change on wastewater systems: a New Zealand perspective. Clim Risk Manag 31:100262
Hui XM, Yuan J, Li C, et al (2023) Analysis of hydrochemical characteristics and genesis of water-deficient rivers in China: a case study of the Ciyao River Basin in Shanxi Province. Qual Assur Saf Crop Foods 15:32–43. https://doi.org/10.15586/qas.v15i1.1213
Jafari K, Fathabad AE, Fakhri Y, et al (2021) Aflatoxin M1 in traditional and industrial pasteurized milk samples from Tiran County, Isfahan Province: a probabilistic health risk assessment. Ital J Food Sci 33:103–116. https://doi.org/10.15586/ijfs.v33iSP1.2054
Jahandari A, Abbasnejad A, Jamasb R (2020) Concentration, likely sources, and ecological risk assessment of potentially toxic elements in urban soils of Shiraz City, SW Iran: a preliminary assessment. Arab J Geosci. https://doi.org/10.1007/s12517-020-05959-7
Jean J, Sirot V, Hulin M et al (2018) Dietary exposure to cadmium and health risk assessment in children: results of the French infant total diet study. Food Chem Toxicol 115:358–364. https://doi.org/10.1016/j.fct.2018.03.031
Jiménez-Oyola S, Chavez E, García-Martínez MJ et al (2021) Probabilistic multi-pathway human health risk assessment due to heavy metal(loid)s in a traditional gold mining area in Ecuador. Ecotoxicol Environ Saf 224:112629. https://doi.org/10.1016/j.ecoenv.2021.112629
Karunanidhi D, Aravinthasamy P, Subramani T et al (2021) Chromium contamination in groundwater and Sobol sensitivity model based human health risk evaluation from leather tanning industrial region of South India. Environ Res. https://doi.org/10.1016/j.envres.2021.111238
Kashki A, Karami M, Zandi R, Roki Z (2021) Evaluation of the effect of geographical parameters on the formation of the land surface temperature by applying OLS and GWR, a case study Shiraz City, Iran. Urban Clim 37:100832. https://doi.org/10.1016/j.uclim.2021.100832
Kazemi A, Esmaeilbeigi M, Sahebi Z, Ansari A (2022) Health risk assessment of total chromium in the qanat as historical drinking water supplying system. Sci Total Environ. https://doi.org/10.1016/j.scitotenv.2021.150795
Khan A, Naeem M, Bilal M et al (2021) Assessing the physico-chemical parameters and some metals of underground water and associated soil in the arid and semiarid regions of Tank District, Khyber Pakhtunkhwa, Pakistan. Environ Monit Assess. https://doi.org/10.1007/s10661-021-09370-x
Kubier A, Wilkin RT, Pichler T (2019) Cadmium in soils and groundwater: a review. Appl Geochem 108:1
Kumar R, Patel M, Singh P et al (2019) Emerging technologies for arsenic removal from drinking water in rural and peri-urban areas: methods, experience from, and options for Latin America. Sci Total Environ 694:133427. https://doi.org/10.1016/j.scitotenv.2019.07.233
Li P, Li X, Meng X et al (2016) Appraising groundwater quality and health risks from contamination in a semiarid region of Northwest China. Expo Heal 8:361–379. https://doi.org/10.1007/s12403-016-0205-y
Lian G, Wang B, Lee X et al (2019) Enhanced removal of hexavalent chromium by engineered biochar composite fabricated from phosphogypsum and distillers grains. Sci Total Environ 697:134119. https://doi.org/10.1016/j.scitotenv.2019.134119
Luo Q, Bei E, Liu C et al (2020) Spatial, temporal variability and carcinogenic health risk assessment of nitrosamines in a drinking water system in China. Sci Total Environ 736:139695. https://doi.org/10.1016/j.scitotenv.2020.139695
Luo C, Sun J, Tan Y, et al (2022) Comparison of the health risks associated with exposure to toxic metals and metalloids following consumption of freshwater catches in China. Qual Assur Saf Crop Foods 14:1–12. https://doi.org/10.15586/qas.v14i4.1117
Mahlknecht J, Aguilar-Barajas I, Farias P et al (2023) Hydrochemical controls on arsenic contamination and its health risks in the Comarca Lagunera region (Mexico): implications of the scientific evidence for public health policy. Sci Total Environ 857:159347. https://doi.org/10.1016/j.scitotenv.2022.159347
Maleki A, Jari H (2021) Evaluation of drinking water quality and non-carcinogenic and carcinogenic risk assessment of heavy metals in rural areas of Kurdistan, Iran. Environ Technol Innov. https://doi.org/10.1016/j.eti.2021.101668
Marufi N, Oliveri Conti G, Ahmadinejad P, et al (2022) Carcinogenic and non-carcinogenic human health risk assessments of heavy metals contamination in drinking water supplies in Iran: a systematic review. Rev Environ Health
Mirzabeygi M, Abbasnia A, Yunesian M et al (2017) Heavy metal contamination and health risk assessment in drinking water of Sistan and Baluchistan, Southeastern Iran. Hum Ecol Risk Assess 23:1893–1905. https://doi.org/10.1080/10807039.2017.1322895
Mishra S, Bharagava RN, More N, et al (2019) Heavy metal contamination: an alarming threat to environment and human health. In: Environmental biotechnology: for sustainable future. Springer Singapore, pp 103–125
Mohammadi AA, Zarei A, Majidi S et al (2019) Carcinogenic and non-carcinogenic health risk assessment of heavy metals in drinking water of Khorramabad. Iran Methodsx 6:1642–1651. https://doi.org/10.1016/j.mex.2019.07.017
Mondal D, Rahman MM, Suman S et al (2021) Arsenic exposure from food exceeds that from drinking water in endemic area of Bihar, India. Sci Total Environ 754:142082. https://doi.org/10.1016/j.scitotenv.2020.142082
Mukherjee I, Singh UK (2021) Characterization of groundwater nitrate exposure using Monte Carlo and Sobol sensitivity approaches in the diverse aquifer systems of an agricultural semiarid region of Lower Ganga Basin, India. Sci Total Environ. https://doi.org/10.1016/j.scitotenv.2021.147657
Mukherjee I, Singh UK (2022) Environmental fate and health exposures of the geogenic and anthropogenic contaminants in potable groundwater of Lower Ganga Basin, India. Geosci Front. https://doi.org/10.1016/j.gsf.2022.101365
Nie G, Tu T, Hu L, et al (2023) Accumulation characteristics and evaluation of heavy metals in soils and vegetables of plastic-covered sheds in typical red soil areas of China. Benef Microbes; 15:22–35. https://doi.org/10.15586/qas.v15i3.1222
Nordberg GF, Åkesson A, Nogawa K, Nordberg M (2021) Cadmium. Handbook on the toxicology of metals, 5th edn. Elsevier, Amsterdam, pp 141–196
Onyeaka H, Anumudu CK, Okolo CA et al (2022) A review of the top 100 most cited papers on food safety. Qual Assur Saf Crop Foods 14:91–104
Prasad S, Yadav KK, Kumar S et al (2021) Chromium contamination and effect on environmental health and its remediation: a sustainable approaches. J Environ Manage 285:112174
Pérez-Ortega J, Roblero-Aguilar SS, Almanza-Ortega NN et al (2022) Hybrid fuzzy c-means clustering algorithm oriented to big data realms. Axioms 11:377. https://doi.org/10.3390/axioms11080377
Qiao J, Zhu Y, Jia X et al (2020) Distributions of arsenic and other heavy metals, and health risk assessments for groundwater in the Guanzhong Plain region of China. Environ Res. https://doi.org/10.1016/j.envres.2019.108957
Rajabi S, Zarei MR, Karamoozian A et al (2022) Sobol sensitivity analysis for non-carcinogenic health risk assessment and water quality index for Kohgiluyeh and Boyer-Ahmad Province. Western Iran Arab J Chem 15:104342. https://doi.org/10.1016/j.arabjc.2022.104342
Rajaei Q, Pourkhabbaz A, Hesari Motlagh S (2012) Assessment of heavy metals health risk of groundwater in ali abad katoul plian. J North Khorasan Univ Med Sci; 4:155–162. https://doi.org/10.29252/jnkums.4.2.155
Saleh HN, Panahande M, Yousefi M et al (2019) Carcinogenic and non-carcinogenic risk assessment of heavy metals in groundwater wells in neyshabur plain. Iran Biol Trace Elem Res 190:251–261. https://doi.org/10.1007/s12011-018-1516-6
Sarkar S, Greenleaf JE, Gupta A et al (2012) Sustainable engineered processes to mitigate the global arsenic crisis in drinking water: Challenges and progress. Annu Rev Chem Biomol Eng 3:497–517
Schaefer HR, Dennis S, Fitzpatrick S (2020) Cadmium: mitigation strategies to reduce dietary exposure. J Food Sci 85:260–267
Sharma P, Singh SP, Parakh SK, Tong YW (2022) Health hazards of hexavalent chromium (Cr (VI)) and its microbial reduction. Bioengineered 13:4923–4938
Shiraz S, Shakeri A, Moore F et al (2009) Heavy metal contamination in the Shiraz Industrial Complex zone groundwater. World Appl Sci J 7:522–530
Sobol IM (2001) Global sensitivity indices for nonlinear mathematical models and their Monte Carlo estimates
Sun HF, Li YH, Ji YF et al (2010) Environmental contamination and health hazard of lead and cadmium around Chatian mercury mining deposit in western Hunan Province, China. Trans Nonferrous Met Soc China (english Ed) 20:308–314. https://doi.org/10.1016/S1003-6326(09)60139-4
Talema A (2023) Causes, negative effects, and preventive methods of water pollution in Ethiopia. Qual Assur Saf Crop Foods; 15:129–139. https://doi.org/10.15586/qas.v15i2.1271
Tzanes G, Zafirakis D, Makropoulos C et al (2023) Energy vulnerability and the exercise of a data-driven analysis protocol: a comparative assessment on power generation aspects for the non-interconnected islands of Greece. Energy Policy 177:113515. https://doi.org/10.1016/j.enpol.2023.113515
Ustaoğlu F, Aydın H (2020) Health risk assessment of dissolved heavy metals in surface water in a subtropical rivers basin system of Giresun (North-eastern Turkey). Desalin Water Treat 194:222–234. https://doi.org/10.5004/dwt.2020.25900
WHO (2017) Guidelines for drinking-water quality addendum. WHO, Geneva
Yuan X, Wang J, Shang Y, Sun B (2014) Health risk assessment of cadmium via dietary intake by adults in China. J Sci Food Agric 94:373–380. https://doi.org/10.1002/jsfa.6394
Zare K, Sheykhi V, Zare M (2020) Investigating the heavy metals’ removal capacity of some native plant species from the wetland groundwater of Maharlu Lake in Fars province. Iran Int J Phytoremediation 22:781–788. https://doi.org/10.1080/15226514.2019.1710815
Zarei MR, Fallahizadeh S, Rajabi S et al (2022) Non-carcinogenic health risk assessment and Monte Carlo simulation of nitrite, nitrate, and fluoride in drinking water of Yasuj, Iran. Int J Environ Anal Chem. https://doi.org/10.1080/03067319.2022.2144269
Zhang M, Zhang W, Sicotte H, Yang P (2009) A new validity measure for a correlation-based fuzzy C-means clustering algorithm. In: Proceedings of the 31st annual international conference of the IEEE engineering in medicine and biology society: engineering the future of biomedicine, EMBC 2009. IEEE computer society, pp 3865–3868
Zhao L, Gong D, Zhao W et al (2020) Spatial-temporal distribution characteristics and health risk assessment of heavy metals in surface water of the Three Gorges Reservoir, China. Sci Total Environ. https://doi.org/10.1016/j.scitotenv.2019.134883
Zheng L, Kuo CC, Fadrowski J et al (2014) Arsenic and chronic kidney disease: a systematic review. Curr Environ Heal Rep 1:192–207
Zoghi A, Salimi M, Mirmahdi RS, et al (2022) Effect of Pretreatments on bioremoval of metals and subsequent exposure to simulated gastrointestinal conditions. Qual Assur Saf Crop Foods; 14:145–155. https://doi.org/10.15586/qas.v14i3.1012