Human Cytoplasmic Aconitase (Iron Regulatory Protein 1) Is Converted into Its [3Fe-4S] Form by Hydrogen Peroxide in Vitro but Is Not Activated for Iron-responsive Element Binding

Journal of Biological Chemistry - Tập 274 - Trang 21625-21630 - 1999
Xavier Brazzolotto1, Jacques Gaillard2, Kostas Pantopoulos3, Matthias W. Hentze3, Jean-Marc Moulis1
1Département de Biologie Moléculaire et Structurale, Laboratoire Métalloprotéines and
2Département de Recherche Fondamentale sur la Matière Condensée, Commissariat à l'Energie Atomique, 17 rue des Martyrs, 38054 Grenoble Cedex 9, France and
3European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117 Heidelberg, Germany

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