CRISPR Interference-Based Platform for Multimodal Genetic Screens in Human iPSC-Derived Neurons

Neuron - Tập 104 Số 2 - Trang 239-255.e12 - 2019
Ruilin Tian1,2,3, Mariam A. Gachechiladze4, Connor Ludwig2,3, Matthew T. Laurie3, Jason Hong2,3, Diane Nathaniel2,3, Anika V. Prabhu5, Michael S. Fernandopulle4, Rajan Patel4, Mehrnoosh Abshari6, Michael E. Ward4, Martin Kampmann2,3
1Biophysics Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA
2Chan-Zuckerberg Biohub, San Francisco, CA 94158, USA
3Institute for Neurodegenerative Diseases, Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA
4National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, 20892, USA
5National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA
6National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD 20892, USA

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