Pioglitazone improves glucose metabolism and modulates skeletal muscle TIMP-3–TACE dyad in type 2 diabetes mellitus: a randomised, double-blind, placebo-controlled, mechanistic study

Devjit Tripathy1, Giuseppe Daniele1,2, Teresa Vanessa Fiorentino1,3, Zandra Perez-Cadena1, Alberto Chavez-Velasquez1, Subhash Kamath1, Paolo Fanti4, Christopher P. Jenkinson1, Francesco Andreozzi1,3, Massimo Federici5, Amalia Gastaldelli1,6, Ralph A. DeFronzo1, Franco Folli1
1Division of Diabetes, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, USA
2Department of Endocrinology and Metabolism, Section of Metabolic Diseases, University of Pisa, Pisa, Italy
3Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy
4Division of Nephrology, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, USA
5Department of Internal Medicine, University ‘Tor Vergata’, Rome, Italy
6Institute of Clinical Physiology, National Research Council (CNR), Pisa, Italy

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