Human osteoarthritic synovium impacts chondrogenic differentiation of mesenchymal stem cells via macrophage polarisation state

Murphy, 2003, Stem cell therapy in a caprine model of osteoarthritis, Arthritis Rheum, 48, 3464, 10.1002/art.11365 Yoo, 1998, The chondrogenic potential of human bone-marrow-derived mesenchymal progenitor cells, J Bone Jt Surg Am, 80, 1745, 10.2106/00004623-199812000-00004 Heldens, 2012, Catabolic factors and osteoarthritis-conditioned medium inhibit chondrogenesis of human mesenchymal stem cells, Tissue Eng Part A, 18, 45, 10.1089/ten.tea.2011.0083 Kruger, 2012, Chondrogenic differentiation of human subchondral progenitor cells is affected by synovial fluid from donors with osteoarthritis or rheumatoid arthritis, J Orthop Surg Res, 7, 10, 10.1186/1749-799X-7-10 Pessler, 2008, The synovitis of “non-inflammatory” orthopaedic arthropathies: a quantitative histological and immunohistochemical analysis, Ann Rheum Dis, 67, 1184, 10.1136/ard.2008.087775 Yang, 2006, The effect of synovial fluid from injured knee joints on in vitro chondrogenesis, Tissue Eng, 12, 2957, 10.1089/ten.2006.12.2957 Beekhuizen, 2011, Osteoarthritic synovial tissue inhibition of proteoglycan production in human osteoarthritic knee cartilage: establishment and characterization of a long-term cartilage-synovium coculture, Arthritis Rheum, 63, 1918, 10.1002/art.30364 Stevens, 2008, Nitric oxide enhances aggrecan degradation by aggrecanase in response to TNF-alpha but not IL-1beta treatment at a post-transcriptional level in bovine cartilage explants, Osteoarthritis Cartilage, 16, 489, 10.1016/j.joca.2007.07.015 Legendre, 2003, JAK/STAT but not ERK1/ERK2 pathway mediates interleukin (IL)-6/soluble IL-6R down-regulation of Type II collagen, aggrecan core, and link protein transcription in articular chondrocytes. Association with a down-regulation of SOX9 expression, J Biol Chem, 278, 2903, 10.1074/jbc.M110773200 Benito, 2005, Synovial tissue inflammation in early and late osteoarthritis, Ann Rheum Dis, 64, 1263, 10.1136/ard.2004.025270 Beekhuizen, 2011, Osteoarthritic synovial tissue inhibits proteoglycan production in human osteoarthritic cartilage; establishment and characterisation of a long-term coculture, Arthritis Rheum, 63, 1918, 10.1002/art.30364 Beekhuizen, 2013, Inhibition of oncostatin M in osteoarthritic synovial fluid enhances GAG production in osteoarthritic cartilage repair, Eur Cell Mater, 26, 80, 10.22203/eCM.v026a06 Bondeson, 2010, The role of synovial macrophages and macrophage-produced mediators in driving inflammatory and destructive responses in osteoarthritis, Arthritis Rheum, 62, 647, 10.1002/art.27290 Mosser, 2008, Exploring the full spectrum of macrophage activation, Nat Rev Immunol, 8, 958, 10.1038/nri2448 Hofkens, 2013, Liposomal targeting of prednisolone phosphate to synovial lining macrophages during experimental arthritis inhibits M1 activation but does not favor M2 differentiation, PLoS One, 8, e54016, 10.1371/journal.pone.0054016 Petro, 1995, Effect of CD80 and CD86 on T cell cytokine production, Immunol Invest, 24, 965, 10.3109/08820139509060721 Mantovani, 2004, The chemokine system in diverse forms of macrophage activation and polarization, Trends Immunol, 25, 677, 10.1016/j.it.2004.09.015 Martinez, 2006, Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression, J Immunol, 177, 7303, 10.4049/jimmunol.177.10.7303 Pfander, 2004, Tenascin and aggrecan expression by articular chondrocytes is influenced by interleukin 1beta: a possible explanation for the changes in matrix synthesis during osteoarthritis, Ann Rheum Dis, 63, 240, 10.1136/ard.2002.003749 Malfait, 2009, Intra-articular injection of tumor necrosis factor-alpha in the rat: an acute and reversible in vivo model of cartilage proteoglycan degradation, Osteoarthritis Cartilage, 17, 627, 10.1016/j.joca.2008.10.005 Aida, 2012, IL-6 and soluble IL-6 receptor stimulate the production of MMPs and their inhibitors via JAK-STAT and ERK-MAPK signalling in human chondrocytes, Cell Biol Int, 36, 367, 10.1042/CBI20110150 Shakibaei, 2007, Suppression of NF-kappaB activation by curcumin leads to inhibition of expression of cyclo-oxygenase-2 and matrix metalloproteinase-9 in human articular chondrocytes: Implications for the treatment of osteoarthritis, Biochem Pharmacol, 73, 1434, 10.1016/j.bcp.2007.01.005 Poree, 2008, Interleukin-6 (IL-6) and/or soluble IL-6 receptor down-regulation of human type II collagen gene expression in articular chondrocytes requires a decrease of Sp1.Sp3 ratio and of the binding activity of both factors to the COL2A1 promoter, J Biol Chem, 283, 4850, 10.1074/jbc.M706387200 Koch, 1986, Stimulation of neovascularization by human rheumatoid synovial tissue macrophages, Arthritis Rheum, 29, 471, 10.1002/art.1780290403 Kumagai, 1979, Pretreatment of plastic Petri dishes with fetal calf serum. A simple method for macrophage isolation, J Immunol Methods, 29, 17, 10.1016/0022-1759(79)90121-2 Nazareth, 2007, Characterization of human lung tumor-associated fibroblasts and their ability to modulate the activation of tumor-associated T cells, J Immunol, 178, 5552, 10.4049/jimmunol.178.9.5552 Kelynack, 2000, Human renal fibroblast contraction of collagen I lattices is an integrin-mediated process, Nephrol Dial Transpl, 15, 1766, 10.1093/ndt/15.11.1766 van Osch, 2001, Monoclonal antibody 11-fibrau: a useful marker to characterize chondrocyte differentiation stage, Biochem Biophys Res Commun, 280, 806, 10.1006/bbrc.2000.4168 Van Landuyt, 2010, Flow cytometric characterization of freshly isolated and culture expanded human synovial cell populations in patients with chronic arthritis, Arthritis Res Ther, 12, 10.1186/ar2916 Grotenhuis, 2013, A culture model to analyze the acute biomaterial-dependent reaction of human primary macrophages, Biochem Biophys Res Commun, 433, 115, 10.1016/j.bbrc.2013.02.054 Farndale, 1982, A direct spectrophotometric microassay for sulfated glycosaminoglycans in cartilage cultures, Connect Tissue Res, 9, 247, 10.3109/03008208209160269 Enobakhare, 1996, Quantification of sulfated glycosaminoglycans in chondrocyte/alginate cultures, by use of 1,9-dimethylmethylene blue, Anal Biochem, 243, 189, 10.1006/abio.1996.0502 Cheung, 1990, Contrasting effects of interferon-gamma and interleukin-4 on the interleukin-6 activity of stimulated human monocytes, Immunology, 71, 70 Hart, 1989, Potential antiinflammatory effects of interleukin 4: suppression of human monocyte tumor necrosis factor alpha, interleukin 1, and prostaglandin E2, Proc Natl Acad Sci USA, 86, 3803, 10.1073/pnas.86.10.3803 Martinez-Pomares, 2003, Analysis of mannose receptor regulation by IL-4, IL-10, and proteolytic processing using novel monoclonal antibodies, J Leukoc Biol, 73, 604, 10.1189/jlb.0902450 Farrell, 2009, Chondrogenic priming of human bone marrow stromal cells: a better route to bone repair?, Tissue Eng Part C Methods, 15, 285, 10.1089/ten.tec.2008.0297 Clockaerts, 2011, Peroxisome proliferator activated receptor alpha activation decreases inflammatory and destructive responses in osteoarthritic cartilage, Osteoarthritis Cartilage, 19, 895, 10.1016/j.joca.2011.03.010 Schmittgen, 2008, Analyzing real-time PCR data by the comparative C(T) method, Nat Protoc, 3, 1101, 10.1038/nprot.2008.73 Drutman, 2012, Inflammatory spleen monocytes can upregulate CD11c expression without converting into dendritic cells, J Immunol, 188, 3603, 10.4049/jimmunol.1102741 Barland, 1962, Electron microscopy of the human synovial membrane, J Cell Biol, 14, 207, 10.1083/jcb.14.2.207 Gierman, 2013, Profiling the secretion of soluble mediators by end stage osteoarthritis synovial tissue explants reveals a reduced responsiveness to an inflammatory trigger, PLoS One, 8, e62634, 10.1371/journal.pone.0062634 Tsuneyoshi, 2012, Functional folate receptor beta-expressing macrophages in osteoarthritis synovium and their M1/M2 expression profiles, Scand J Rheumatol, 41, 132, 10.3109/03009742.2011.605391 Freytes, 2013, Macrophages modulate the viability and growth of human mesenchymal stem cells, J Cell Biochem, 114, 220, 10.1002/jcb.24357 Huss, 2010, Synovial tissue-infiltrating natural killer cells in osteoarthritis and periprosthetic inflammation, Arthritis Rheum, 62, 3799, 10.1002/art.27751 Andersson, 2003, Extended-term cultures of human T-lymphocytes and the comet assay: a useful combination when testing for genotoxicity in vitro?, Mutat Res, 540, 43, 10.1016/S1383-5718(03)00169-4 Randau, 2013, The effect of dexamethasone and triiodothyronine on terminal differentiation of primary bovine chondrocytes and chondrogenically differentiated mesenchymal stem cells, PLoS One, 8, e72973, 10.1371/journal.pone.0072973 Heldens, 2012, Catabolic factors and osteoarthritis-conditioned medium inhibit chondrogenesis of human mesenchymal stem cells, Tissue Eng Part A, 18, 45, 10.1089/ten.tea.2011.0083 van Beuningen, 2014, Inhibition of TAK1 and/or JAK can rescue impaired chondrogenic differentiation of human mesenchymal stem cells in osteoarthritis-like conditions, Tissue Eng Part A, 10.1089/ten.tea.2013.0553 de Vries-van Melle, 2014, Chondrogenesis of mesenchymal stem cells in an osteochondral environment is mediated by the subchondral bone, Tissue Eng Part A, 20, 23, 10.1089/ten.tea.2013.0080 Pleumeekers, 2014, The in vitro and in vivo capacity of culture-expanded human cells from several sources encapsulated in alginate to form cartilage, Eur Cell Mater, 27, 264, 10.22203/eCM.v027a19