Unraveling the active hypoglycemic agent trigonelline in Balanites aegyptiaca date fruit using metabolite fingerprinting by NMR

Farag, 2012, Metabolome classification of commercial Hypericum perforatum (St. John’s Wort) preparations via UPLC-qTOF-MS and chemometrics, Planta Med., 78, 488, 10.1055/s-0031-1298170 van der Kooy, 2009, Quality control of herbal material and phytopharmaceuticals with MS and NMR based metabolic fingerprinting, Planta Med., 75, 763, 10.1055/s-0029-1185450 Kim, 2010, NMR-based metabolomic analysis of plants, Nat. Prot., 5, 536, 10.1038/nprot.2009.237 Farag, 2014, Classification of commercial cultivars of Humulus lupulus L. (hop) by chemometric pixel analysis of two dimensional nuclear magnetic resonance spectra, Metabolomics, 10, 21, 10.1007/s11306-013-0547-4 Schroeder, 2007, Differential analysis of 2D NMR spectra: new natural products from a pilot-scale fungal extract library, Angew. Chem. Int. Ed., 46, 901, 10.1002/anie.200603821 Liang, 2006, Identification of phenylpropanoids in methyl jasmonate treated Brassica rapa leaves using two-dimensional nuclear magnetic resonance spectroscopy, J. Chromatogr. A, 1112, 148, 10.1016/j.chroma.2005.11.114 Mohamed, 1999, Some pharmacological and toxicological studies on Balanites aegyptiaca bark, Phytother. Res., 13, 439, 10.1002/(SICI)1099-1573(199908/09)13:5<439::AID-PTR460>3.0.CO;2-6 Kamel, 1991, Studies on Balanites-aegyptiaca fruits, an antidiabetic Egyptian folk medicine, Chem. Pharm. Bull., 39, 1229, 10.1248/cpb.39.1229 Farid, 2002, New steroidal glycosides from Balanites aegyptiaca, Helv. Chim. Acta, 85, 1019, 10.1002/1522-2675(200204)85:4<1019::AID-HLCA1019>3.0.CO;2-S El Tahir, 1998, The potential antileishmanial activity of some Sudanese medicinal plants, Phytother. Res., 12, 576, 10.1002/(SICI)1099-1573(199812)12:8<576::AID-PTR354>3.0.CO;2-# Gad, 2006, Biochemical study of the anti-diabetic action of the Egyptian plants Fenugreek and Balanites, Mol. Cell. Biochem., 281, 173, 10.1007/s11010-006-0996-4 Abdel Motaal, 2015, Phytomedicine, 22, 829, 10.1016/j.phymed.2015.05.059 Meda, 2011, Identification and quantification of phenolic compounds from Balanites aegyptiaca (L.) Del (Balanitaceae) galls and leaves by HPLC–MS, Nat. Prod. Res., 25, 93, 10.1080/14786419.2010.482933 Sarker, 2000, Alkaloids from Balanites aegyptiaca, Fitoterapia, 71, 328, 10.1016/S0367-326X(99)00149-5 AlMourabit, 1997, Pyraxinine, a novel nitrogenous compound from the marine sponge Cymbastela cantharella, J. Nat. Prod., 60, 290, 10.1021/np960562p Yoshinari, 2009, Anti-diabetic effects of pumpkin and its components, trigonelline and nicotinic acid, on Goto-Kakizaki rats, Biosci. Biotechnol. Biochem., 73, 1033, 10.1271/bbb.80805 Yoshinari, 2013, Trigonelline ameliorates oxidative stress in type 2 diabetic Goto-Kakizaki rats, J. Med. Food, 16, 34, 10.1089/jmf.2012.2311 Amaro, 2014, Hypoglycemic and hypotensive activity of a root extract of smilax aristolochiifolia, standardized on N-trans-feruloyl-tyramine, Molecules, 19, 11366, 10.3390/molecules190811366 del Campo, 2010, Quantitative determination of caffeine, formic acid, trigonelline and 5-(hydroxymethyl) furfural in soluble coffees by H-1 NMR spectrometry, Talanta, 81, 367, 10.1016/j.talanta.2009.12.010 Satheeshkumar, 2010, Acetylcholinesterase enzyme inhibitory potential of standardized extract of Trigonella foenum graecum L. and its constituents, Phytomedicine, 17, 292, 10.1016/j.phymed.2009.06.006