The hyh mutation uncovers roles for αSnap in apical protein localization and control of neural cell fate

Bronson, R.T. & Lane, P.W. Hydrocephalus with hop gait (hyh): a new mutation on chromosome 7 in the mouse. Brain Res. Dev. Brain Res. 54, 131–136 (1990).

Chae, T.H., Allen, K.M., Davisson, M.T., Sweet, H.O. & Walsh, C.A. Mapping of the mouse hyh gene to a YAC/BAC contig on proximal Chromosome 7. Mamm Genome 13, 239–244 (2002).

Marz, K.E., Lauer, J.M. & Hanson, P.I. Defining the SNARE complex binding surface of alpha-SNAP: implications for SNARE complex disassembly. J. Biol. Chem. 278, 27000–27008 (2003).

Piano, F., Schetter, A.J., Mangone, M., Stein, L. & Kemphues, K.J. RNAi analysis of genes expressed in the ovary of Caenorhabditis elegans. Curr. Biol. 10, 1619–1622 (2000).

D'Arcangelo, G. et al. Reelin is a secreted glycoprotein recognized by the CR-50 monoclonal antibody. J. Neurosci. 17, 23–31 (1997).

Ferland, R.J., Cherry, T.J., Preware, P.O., Morrisey, E.E. & Walsh, C.A. Characterization of Foxp2 and Foxp1 mRNA and protein in the developing and mature brain. J. Comp. Neurol. 460, 266–279 (2003).

McEvilly, R.J., de Diaz, M.O., Schonemann, M.D., Hooshmand, F. & Rosenfeld, M.G. Transcriptional regulation of cortical neuron migration by POU domain factors. Science 295, 1528–1532 (2002).

Pearlman, A.L. & Sheppard, A.M. Extracellular matrix in early cortical development. Prog. Brain Res. 108, 117–134 (1996).

Gleeson, J.G., Lin, P.T., Flanagan, L.A. & Walsh, C.A. Doublecortin is a microtubule-associated protein and is expressed widely by migrating neurons. Neuron 23, 257–271 (1999).

Takahashi, T., Nowakowski, R.S. & Caviness, V.S., Jr. Mode of cell proliferation in the developing mouse neocortex. Proc. Natl. Acad. Sci. USA 91, 375–379 (1994).

Caviness, V.S. Jr. & Takahashi, T. Proliferative events in the cerebral ventricular zone. Brain Dev. 17, 159–163 (1995).

Caviness, V.S. Jr., Takahashi, T. & Nowakowski, R.S. Numbers, time and neocortical neuronogenesis: a general developmental and evolutionary model. Trends Neurosci. 18, 379–383 (1995).

Takahashi, T., Nowakowski, R.S. & Caviness, V.S. Jr. The cell cycle of the pseudostratified ventricular epithelium of the embryonic murine cerebral wall. J. Neurosci. 15, 6046–6057 (1995).

Clary, D.O., Griff, I.C. & Rothman, J.E. SNAPs, a family of NSF attachment proteins involved in intracellular membrane fusion in animals and yeast. Cell 61, 709–721 (1990).

Puschel, A.W., O'Connor, V. & Betz, H. The N-ethylmaleimide-sensitive fusion protein (NSF) is preferentially expressed in the nervous system. FEBS Lett. 347, 55–58 (1994).

Le Borgne, R., Bellaiche, Y. & Schweisguth, F. Drosophila E-cadherin regulates the orientation of asymmetric cell division in the sensory organ lineage. Curr. Biol. 12, 95–104 (2002).

Hurd, T.W., Gao, L., Roh, M.H., Macara, I.G. & Margolis, B. Direct interaction of two polarity complexes implicated in epithelial tight junction assembly. Nat. Cell Biol. 5, 137–142 (2003).

Jimenez, A.J. et al. A programmed ependymal denudation precedes congenital hydrocephalus in the hyh mutant mouse. J. Neuropathol. Exp. Neurol. 60, 1105–1119 (2001).

Cai, Y., Yu, F., Lin, S., Chia, W. & Yang, X. Apical complex genes control mitotic spindle geometry and relative size of daughter cells in Drosophila neuroblast and pI asymmetric divisions. Cell 112, 51–62 (2003).

Yu, F., Cai, Y., Kaushik, R., Yang, X. & Chia, W. Distinct roles of Galphai and Gbeta13F subunits of the heterotrimeric G protein complex in the mediation of Drosophila neuroblast asymmetric divisions. J. Cell Biol. 162, 623–633 (2003).

Zhong, W., Feder, J.N., Jiang, M.M., Jan, L.Y. & Jan, Y.N. Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis. Neuron 17, 43–53 (1996).

Bogdanovic, A. et al. Syntaxin 7, syntaxin 8, Vti1 and VAMP7 (vesicle-associated membrane protein 7) form an active SNARE complex for early macropinocytic compartment fusion in Dictyostelium discoideum. Biochem. J. 368, 29–39 (2002).

Lafont, F. et al. Raft association of SNAP receptors acting in apical trafficking in Madin-Darby canine kidney cells. Proc. Natl. Acad. Sci. USA 96, 3734–3738 (1999).

Coco, S. et al. Subcellular localization of tetanus neurotoxin-insensitive vesicle-associated membrane protein (VAMP)/VAMP7 in neuronal cells: evidence for a novel membrane compartment. J. Neurosci. 19, 9803–9812 (1999).

Martinez-Arca, S., Alberts, P., Zahraoui, A., Louvard, D. & Galli, T. Role of tetanus neurotoxin insensitive vesicle-associated membrane protein (TI-VAMP) in vesicular transport mediating neurite outgrowth. J. Cell Biol. 149, 889–900 (2000).

Reh, T.A. & Kljavin, I.J. Age of differentiation determines rat retinal germinal cell phenotype: induction of differentiation by dissociation. J. Neurosci. 9, 4179–4189 (1989).

Sheen, V.L. et al. Mutations in ARFGEF2 implicate vesicle trafficking in neural progenitor proliferation and migration in the human cerebral cortex. Nat. Genet. 36, 69–76 (2004).

Kolehmainen, J. et al. Cohen Syndrome is caused by mutations in a novel gene, COH1, encoding a transmembrane protein with a presumed role in vesicle-mediated sorting and intracellular protein transport. Am. J. Hum. Genet. 72, 1359–1369 (2003).

Low, S.H. et al. The SNARE machinery is involved in apical plasma membrane trafficking in MDCK cells. J. Cell Biol. 141, 1503–1513 (1998).

Ogawa, M. et al. The reeler gene-associated antigen on Cajal-Retzius neurons is a crucial molecule for laminar organization of cortical neurons. Neuron 14, 899–912 (1995).