siRNA Mediated Knockdown of Tissue Factor Expression in Pigs for Xenotransplantation

Dalmasso, 1992, Mechanism of complement activation in the hyperacute rejection of porcine organs transplanted into primate recipients, Am J Pathol, 140, 1157 Cooper, 2014, Progress in pig-to-non-human primate transplantation models (1998-2013): A comprehensive review of the literature, Xenotransplantation, 21, 397, 10.1111/xen.12127 Osterud, 1977, Activation of factor IX by the reaction product of tissue factor and factor VII: Additional pathway for initiating blood coagulation, Proc Natl Acad Sci USA, 74, 5260, 10.1073/pnas.74.12.5260 Mueller, 1992, Expression of tissue factor by melanoma cells promotes efficient hematogenous metastasis, Proc Natl Acad Sci USA, 89, 11832, 10.1073/pnas.89.24.11832 Luther, 1996, Tissue factor expression during human and mouse development, Am J Pathol, 149, 101 Toomey, 1996, Targeted disruption of the murine tissue factor gene results in embryonic lethality, Blood, 88, 1583, 10.1182/blood.V88.5.1583.1583 Parry, 1998, Low levels of tissue factor are compatible with development and hemostasis in mice, J Clin Invest, 101, 560, 10.1172/JCI814 Yamada, 2005, Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue, Nat Med, 11, 32, 10.1038/nm1172 Mohiuddin MM, Singh AK, Corcoran PC, et al. Genetically engineered pigs and target-specific immunomodulation provide significant graft survival and hope for clinical cardiac xenotransplantation. J Thorac Cardiovasc Surg 2014 Jun 6. Lee, 2012, Increased human tumor necrosis factor-alpha levels induce procoagulant change in porcine endothelial cells in vitro, Xenotransplantation, 19, 186, 10.1111/j.1399-3089.2012.00704.x Lin, 2008, Expression of tissue factor and initiation of clotting by human platelets and monocytes after incubation with porcine endothelial cells, Transplantation, 86, 702, 10.1097/TP.0b013e31818410a3 Ma, 2012, Tissue factor knockdown in porcine islets: An effective approach to suppressing the instant blood-mediated inflammatory reaction, Cell Transplant, 21, 61, 10.3727/096368911X580563 Han, 2013, RNA interference of GGTA1 physiological and immune functions in immortalized porcine aortic endothelial cells, J Surg Res, 185, 410, 10.1016/j.jss.2013.05.080 Feng, 2008, Adenovirus-mediated shRNA interference against porcine circovirus type 2 replication both in vitro and in vivo, Antivir Res, 77, 186, 10.1016/j.antiviral.2007.11.005 Jabed, 2012, Targeted microRNA expression in dairy cattle directs production of beta-lactoglobulin-free, high-casein milk, Proc Natl Acad Sci USA, 109, 16811, 10.1073/pnas.1210057109 Hu, 2013, Knockdown of myostatin expression by RNAi enhances muscle growth in transgenic sheep, PloS One, 8, e58521, 10.1371/journal.pone.0058521 Dieckhoff, 2008, Knockdown of porcine endogenous retrovirus (PERV) expression by PERV-specific shRNA in transgenic pigs, Xenotransplantation, 15, 36, 10.1111/j.1399-3089.2008.00442.x Ramsoondar, 2009, Production of transgenic pigs that express porcine endogenous retrovirus small interfering RNAs, Xenotransplantation, 16, 164, 10.1111/j.1399-3089.2009.00525.x Niemann, 2012, Somatic cell nuclear transfer cloning: practical applications and current legislation, Reprod Domest Anim, 47, 2, 10.1111/j.1439-0531.2012.02121.x Carmeliet, 1996, Role of tissue factor in embryonic blood vessel development, Nature, 383, 73, 10.1038/383073a0 Niemann, 2008, Epigenetic reprogramming in embryonic and foetal development upon somatic cell nuclear transfer cloning, Reproduction, 135, 151, 10.1530/REP-07-0397 Banz, 2005, Endothelial cell protection and complement inhibition in xenotransplantation: A novel in vitro model using whole blood, Xenotransplantation, 12, 434, 10.1111/j.1399-3089.2005.00239.x Petersen, 2011, Transgenic expression of human heme oxygenase-1 in pigs confers resistance against xenograft rejection during ex vivo perfusion of porcine kidneys, Xenotransplantation, 18, 355, 10.1111/j.1399-3089.2011.00674.x Wheeler, 2012, Transgenic swine: expression of human CD39 protects against myocardial injury, J Mol Cell Cardiol, 52, 958, 10.1016/j.yjmcc.2012.01.002 Roussel, 2008, Pig thrombomodulin binds human thrombin but is a poor cofactor for activation of human protein C and TAFI, Am J Trans: Off J Am Soc Transpl Am Soc Transpl Surg, 8, 1101, 10.1111/j.1600-6143.2008.02210.x Petersen, 2009, Pigs transgenic for human thrombomodulin have elevated production of activated protein C, Xenotransplantation, 16, 486, 10.1111/j.1399-3089.2009.00537.x Wuensch, 2014, Regulatory sequences of the porcine THBD gene facilitate endothelial-specific expression of bioactive human thrombomodulin in single- and multitransgenic pigs, Transplantation, 97, 138, 10.1097/TP.0b013e3182a95cbc Bottino, 2014, Pig-to-monkey islet xenotransplantation using multi-transgenic pigs, Am J Transplant, 14, 2275, 10.1111/ajt.12868 Le Bas-Bernardet, 2011, Xenotransplantation of galactosyl-transferase knockout, CD55, CD59, CD39, and fucosyl-transferase transgenic pig kidneys into baboons, Transpl Proc, 43, 3426, 10.1016/j.transproceed.2011.09.024