Genotoxicity of environmental tobacco smoke: a review

U.S. Environmental Protection Agency, Respiratory health effects of passive smoking: lung cancer and other disorders, The Report of the U.S. Environmental Protection Agency, NIH Publication No. 93-3605, 1993. National Cancer Institute, Smoking and Tobacco Control Monograph 10, Health Effects of Exposure to Environmental Tobacco Smoke, National Cancer Institute, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD, 1999 (Californian Environmental Protection Agency, Office of Environmental Health Hazard Assessment, San Francisco, CA, 1997). U.S. Department of Health and Human Services, Report on Carcinogens, tenth ed., U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program, 2002. International Agency for Research on Cancer (IARC), Tobacco smoke and involuntary smoking, IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, vol. 83, International Agency for Research on Cancer, WHO, Lyon, France, 2004. Vineis, 2004, Tobacco and cancer: recent epidemiological evidence, J. Natl. Cancer Inst., 2, 99, 10.1093/jnci/djh014 International Agency for Research on Cancer (IARC), 1986, vol. 38 National Research Council, 1986 International Agency for Research on Cancer (IARC), Overall evaluations of carcinogenicity: an updating of IARC Monographs vols. 1-42, IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, Suppl. 7, International Agency for Research on Cancer, Lyon, 1987. DeMarini, 1983, Genotoxicity of tobacco smoke and tobacco smoke condensate, Mutat. Res., 114, 59, 10.1016/0165-1110(83)90019-2 DeMarini, 2004, Genotoxicity of tobacco smoke and tobacco smoke condensate: a review, Mutat. Res., 567, 447, 10.1016/j.mrrev.2004.02.001 Bermúdez, 1994, Environmental tobacco smoke is just as damaging to DNA as mainstream smoke, Environ. Health Perspect., 102, 870, 10.1289/ehp.94102870 Wolz, 2002, In vitro genotoxicity assay of sidestream smoke using a human bronchial epithelial cell line, Food Chem. Toxicol., 40, 845, 10.1016/S0278-6915(02)00034-0 Chen, 1996, Genotoxicity and DNA adduct formation of incense smoke condensates: comparison with environmental tobacco smoke condensates, Mutat. Res., 367, 105, 10.1016/0165-1218(95)00067-4 Husgafvel-Pursiainen, 1986, Genotoxicity and polynuclear aromatic hydrocarbon analysis of environmental tobacco smoke samples from restaurants, Mutagenesis, 1, 287, 10.1093/mutage/1.4.287 Löfroth, 1986, Environmental tobacco smoke: comparative characterization by mutagenicity assays of sidestream and mainstream cigarette smoke, Environ. Mutagen., 8, 693, 10.1002/em.2860080505 Ling, 1987, Mutagenic determination of passive smoking, Toxicol. Lett., 35, 147, 10.1016/0378-4274(87)90100-7 Morin, 1987, The effect of solvent and extraction methods on the bacterial mutagenicity of sidestream cigarette smoke, Toxicol. Lett., 38, 279, 10.1016/0378-4274(87)90010-5 Löfroth, 1988, Public exposure to environmental tobacco smoke, Mutat. Res., 202, 103, 10.1016/0027-5107(88)90170-4 Claxton, 1989, A genotoxic assessment of environmental tobacco smoke using bacterial assays, Mutat. Res., 222, 81, 10.1016/0165-1218(89)90022-0 Doolittle, 1990, Genetic toxicology studies comparing the activity of sidestream smoke from cigarettes which burn or only heat tobacco, Mutat. Res., 240, 59, 10.1016/0165-1218(90)90008-P Löfroth, 1989, Environmental tobacco smoke: overview of chemical composition and genotoxic components, Mutat. Res., 222, 73, 10.1016/0165-1218(89)90021-9 Lewtas, 1993, Bioassay of complex mixtures of indoor air pollutants, IARC Sci. Publ., 109, 85 Chortyk, 1990, A study on the mutagenicity of tobacco smoke from low-tar cigarettes, Arch. Environ. Health, 45, 237, 10.1080/00039896.1990.9940808 Azuma, 1997, Highly sensitive mutation assay for mutagenicity monitoring of indoor air using Salmonella typhimurium YG1041 and a microsuspension method, Mutagenesis, 12, 373, 10.1093/mutage/12.5.373 Bombick, 1998, Comparative studies of the mutagenicity of environmental tobacco smoke from cigarettes that burn or primarily heat tobacco, Environ. Mol. Mutagen., 31, 169, 10.1002/(SICI)1098-2280(1998)31:2<169::AID-EM9>3.0.CO;2-H Smith, 2000, Urinary mutagenicity in nonsmokers following exposure to fresh diluted sidestream cigarette smoke, Mutat. Res., 470, 53, 10.1016/S1383-5718(00)00097-8 Kado, 1991, Measuring personal exposure to airborne mutagens and nicotine in environmental tobacco smoke, Mutat. Res., 261, 75, 10.1016/0165-1218(91)90100-Z Zhou, 2000, Comparison of environmental tobacco smoke concentrations and mutagenicity for several indoor environments, Mutat. Res., 465, 191, 10.1016/S1383-5718(99)00229-6 Salomaa, 1988, Genotoxicity and PAC analysis of particulate and vapour phases of environmental tobacco smoke, Mutat. Res., 204, 173, 10.1016/0165-1218(88)90087-0 Trivedi, 1990, Assessment of genotoxicity of nicotine employing in vitro mammalian test system, Cancer Lett., 54, 89, 10.1016/0304-3835(90)90096-G Lee, 1992, Fourteen-day inhalation study in rats, using aged and diluted sidestream smoke from a reference cigarette, Fundam. Appl. Toxicol., 19, 141, 10.1016/0272-0590(92)90038-J Lee, 1993, Ninety-day inhalation study in rats, using aged and diluted sidestream smoke from a reference cigarette: DNA adducts and alveolar macrophage cytogenetics, Fundam. Appl. Toxicol., 20, 393, 10.1006/faat.1993.1051 Takenawa, 1994, Urinary excretion of mutagens and covalent DNA damage induced in the bladder and kidney after passive smoking in rats, Urol. Res., 22, 93, 10.1007/BF00310998 Izzotti, 1992, Chemoprevention of smoke-related DNA adduct formation in rat lung and heart, Carcinogenesis, 13, 2187, 10.1093/carcin/13.11.2187 Izzotti, 1999, Formation and persistence of nucleotide alterations in rats exposed whole-body to environmental cigarette smoke, Carcinogenesis, 20, 1499, 10.1093/carcin/20.8.1499 Izzotti, 2001, Modulation of biomarkers by chemopreventive agents in smoke-exposed rats, Cancer Res., 61, 2472 Balansky, 2003, Systemic genotoxic effects produced by light, and synergism with cigarette smoke in the respiratory tract of hairless mice, Carcinogenesis, 24, 1525, 10.1093/carcin/bgg108 Howard, 1998, Oxidative DNA damage in mouse heart, liver, and lung tissue due to acute side-stream tobacco smoke exposure, Arch. Biochem. Biophys., 352, 293, 10.1006/abbi.1998.0605 Arif, 2000, Inhibition of cigarette smoke-related DNA adducts in rat tissues by indole-3-carbinol, Mutat. Res., 452, 11, 10.1016/S0027-5107(00)00010-5 Balansky, 1996, Induction by carcinogens and chemoprevention by N-acetylcysteine of adducts to mitochondrial DNA in rat organs, Cancer Res., 56, 1642 Rithidech, 1989, Cytogenetic effects of cigarette smoke on pulmonary alveolar macrophages of the rat, Environ. Mol. Mutagen., 14, 27, 10.1002/em.2850140106 Mohtashamipur, 1987, Clastogenic effect of passive smoking on bone marrow polychromatic erythrocytes of NMRI mice, Toxicol. Lett., 35, 153, 10.1016/0378-4274(87)90101-9 Mohtashamipur, 1988, Comparative bone marrow clastogenicity of cigarette sidestream, mainstream and recombined smoke condensates in mice, Mutagenesis, 3, 419, 10.1093/mutage/3.5.419 Balansky, 1987, Investigation of the mutagenic activity of tobacco smoke, Mutat. Res., 188, 13, 10.1016/0165-1218(87)90109-1 Balansky, 1988, The mutagenic and clastogenic activity of tobacco smoke, Mutat. Res., 208, 237, 10.1016/0165-7992(88)90067-X Balansky, 1999, Induction, persistence and modulation of cytogenetic alterations in cells of smoke-exposed mice, Carcinogenesis, 20, 1491, 10.1093/carcin/20.8.1491 De Flora, 2003, Molecular alterations and lung tumors in p53 mutant mice exposed to cigarette smoke, Cancer Res., 63, 793 Karube, 1989, Analyses of transplacentally induced sister chromatid exchanges and micronuclei in mouse fetal liver cells following maternal exposure to cigarette smoke, Cancer Res., 49, 3550 Izzotti, 2003, Genomic and transcriptional alterations in mouse fetus liver after transplacental exposure to cigarette smoke, FASEB J., 17, 1127, 10.1096/fj.02-0967fje Hecht, 2002, Human urinary carcinogen metabolites: biomarkers for investigating tobacco and cancer, Carcinogenesis, 23, 907, 10.1093/carcin/23.6.907 Hecht, 2003, Tobacco carcinogens, their biomarkers and tobacco-induced cancer, Nat. Rev. Cancer, 3, 733, 10.1038/nrc1190 Hecht, 1998, Biochemistry, biology and carcinogenicity of tobacco specific N-nitrosamines, Chem. Res. Toxicol., 11, 559, 10.1021/tx980005y Hecht, 1993, A tobacco-specific lung carcinogen in the urine of men exposed to cigarette smoke, N. Engl. J. Med., 329, 1543, 10.1056/NEJM199311183292105 Parsons, 1998, A metabolite of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in the urine of hospital workers exposed to environmental tobacco smoke, Cancer Epidemiol. Biomarkers Prev., 7, 257 Anderson, 2001, Metabolites of a tobacco-specific lung carcinogen in nonsmoking women exposed to environmental tobacco smoke, J. Natl. Cancer Inst., 93, 378, 10.1093/jnci/93.5.378 Carmella, 2003, Analysis of total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in human urine, Cancer Epidemiol. Biomarkers Prev., 12, 1257 Anderson, 2003, Metabolites of a tobacco-specific lung carcinogen in nonsmoking casino patrons, Cancer Epidemiol. Biomarkers Prev., 12, 1544 Hecht, 2001, Metabolites of a tobacco-specific lung carcinogen in the urine of elementary school-aged children, Cancer Epidemiol. Biomarkers Prev., 10, 1109 Tsai, 2003, Exposure to environmental tobacco smoke and urinary 1-hydroxypyrene levels in preschool children, Kaohsiung J. Med. Sci., 19, 97, 10.1016/S1607-551X(09)70456-5 Phillips, 2002, Smoking-related DNA and protein adducts in human tissues, Carcinogenesis, 23, 1979, 10.1093/carcin/23.12.1979 Georgiadis, 2001, Biomarkers of genotoxicity of air pollution (the AULIS project): bulky DNA adducts in subjects with moderate to low exposures to airborne polycyclic aromatic hydrocarbons and their relationship to environmental tobacco smoke and other parameters, Carcinogenesis, 22, 1447, 10.1093/carcin/22.9.1447 Howard, 1998, Oxidative stress induced by environmental tobacco smoke in the workplace is mitigated by antioxidant supplementation, Cancer Epidemiol. Biomarkers Prev., 7, 981 Yildiz, 2002, The changes of superoxide dismutase, catalase and glutathione peroxidase activities in erythrocytes of active and passive smokers, Clin. Chem. Lab. Med., 40, 612, 10.1515/CCLM.2002.106 Dietrich, 2003, Vitamin C supplementation decreases oxidative stress biomarker f2-isoprostanes in plasma of nonsmokers exposed to environmental tobacco smoke, Nutr. Cancer, 45, 176, 10.1207/S15327914NC4502_06 Maclure, 1989, Elevated blood levels of carcinogens in passive smokers, Am. J. Public Health, 79, 1381, 10.2105/AJPH.79.10.1381 Hammond, 1993, Relationship between environmental tobacco smoke exposure and carcinogen–hemoglobin adduct levels in nonsmokers, J. Natl. Cancer Inst., 85, 474, 10.1093/jnci/85.6.474 Crawford, 1994, Biomarkers of environmental tobacco smoke in preschool children and their mothers, J. Natl. Cancer Inst., 86, 1398, 10.1093/jnci/86.18.1398 Tang, 1999, Molecular and genetic damage from environmental tobacco smoke in young children, Cancer Epidemiol. Biomarkers Prev., 8, 427 Baier, 2002, Respiratory diseases and genotoxicity in tobacco smoke exposed children, Laryngo-Rhino-Otologie, 81, 217, 10.1055/s-2002-25038 Holz, 1993, Detection of DNA single-strand breaks in lymphocytes of smokers, Int. Arch. Occup. Environ. Health, 65, 83, 10.1007/BF00405724 Lam, 2002, Lymphocyte DNA damage in elevator manufacturing workers in Guangzhou, China. Mutat. Res., 515, 147, 10.1016/S1383-5718(02)00010-4 Speit, 2003, Investigations on the effect of cigarette smoking in the comet assay, Mutat. Res., 542, 33, 10.1016/j.mrgentox.2003.08.002 Yamasaki, 1977, Concentration of mutagens from urine by absorption with the nonpolar resin XAD-2: cigarette smokers have mutagenic urine, Proc. Natl. Acad. Sci. U.S.A., 74, 3555, 10.1073/pnas.74.8.3555 Sorsa, 1985, Passive and active exposure to cigarette smoke in a smoking experiment, J. Toxicol. Environ. Health, 16, 523, 10.1080/15287398509530760 Husgafvel-Pursiainen, 1987, Passive smoking at work: biochemical and biological measures of exposure to environmental tobacco smoke, Int. Arch. Occup. Environ. Health, 59, 337, 10.1007/BF00405277 Kado, 1988, Use of Salmonella micro pre-incubation procedure for studying personal exposure to mutagens in environmental tobacco smoke: pilot study of urine and airborne mutagenicity for passive smoking, vol. 36 Bartsch, 1990, Carcinogen hemoglobin adducts, urinary mutagenicity, and metabolic phenotype in active and passive cigarette smokers, J. Natl. Cancer Inst., 82, 1826, 10.1093/jnci/82.23.1826 Scherer, 1996, Urinary mutagenicity and thioethers in nonsmokers: role of environmental tobacco smoke (ETS) and diet, Mutat. Res., 368, 195, 10.1016/S0165-1218(96)90061-0 Smith, 2000, Urinary mutagenicity in nonsmokers following exposure to fresh diluted sidestream cigarette smoke, Mutat. Res., 470, 53, 10.1016/S1383-5718(00)00097-8 Vermeulen, 2000, Weekly patterns in smoking habits and influence on urinary cotinine and mutagenicity levels: confounding effect of nonsmoking policies in the workplace, Cancer Epidemiol. Biomarkers Prev., 9, 1205 Scherer, 1989, Biomonitoring after controlled exposure to environmental tobacco smoke (ETS), Exp. Pathol., 37, 158, 10.1016/S0232-1513(89)80039-8 Scherer, 1987, Urinary mutagenicity after controlled exposure to environmental tobacco smoke (ETS), Toxicol. Lett., 35, 135, 10.1016/0378-4274(87)90098-1 Scherer, 1990, Importance of exposure to gaseous and particulate phase components of tobacco smoke in active and passive smokers, Int. Arch. Occup. Environ. Health, 62, 459, 10.1007/BF00379064 Sasson, 1985, Mutagens in human urine: effects of cigarette smoking and diet, Mutat. Res., 158, 149, 10.1016/0165-1218(85)90078-3 Malaveille, 1989, Levels of mutagens in the urine of smokers of black and blond tobacco correlate with their risk of bladder cancer, Carcinogenesis, 10, 577, 10.1093/carcin/10.3.577 Bonassi, 2003, Effect of smoking habit on the frequency of micronuclei in human lymphocytes: results from the human micronucleus project, Mutat. Res., 543, 155, 10.1016/S1383-5742(03)00013-9 Collman, 1986, Effects of alpha-naphthoflavone on levels of sister chromatid exchanges in lymphocytes from active and passive cigarette smokers: dose–response relationships, Cancer Res., 46, 6452 Husgafvel-Pursiainen, 1987, Sister-chromatid exchange and cell proliferation in cultured lymphocytes of passively and actively smoking restaurant personnel, Mutat. Res., 190, 211, 10.1016/0165-7992(87)90031-5 Gorgels, 1992, Passive smoking and sister-chromatid exchanges in lymphocytes, Mutat. Res., 279, 233, 10.1016/0165-1218(92)90238-U Sorsa, 1988, Assessment of passive and transplacental exposure to tobacco smoke, IARC Sci. Publ., 89, 129 Sorsa, 1989, Cytogenetic effects of tobacco smoke exposure among involuntary smokers, Mutat. Res., 222, 111, 10.1016/0165-1218(89)90024-4 Albertini, 2000, IPCS guidelines for the monitoring of genotoxic effects of carcinogens in humans, International Programme on Chemical Safety, Mutat. Res., 463, 111, 10.1016/S1383-5742(00)00049-1 Albertini, 2001, HPRT mutations in humans: biomarkers for mechanistic studies, Mutat. Res., 489, 1, 10.1016/S1383-5742(01)00064-3 Robinson, 1994, An analysis of in vivo hprt mutant frequency in circulating T-lymphocytes in the normal human population: a comparison of four datasets, Mutat. Res., 313, 227, 10.1016/0165-1161(94)90053-1 Burkhart-Schultz, 1996, Spectrum of somatic mutation at the hypoxanthine phosphoribosyltransferase (hprt) gene of healthy people, Carcinogenesis, 17, 1871, 10.1093/carcin/17.9.1871 Ammenheuser, 1997, Frequencies of hprt mutant lymphocytes in smokers, non-smokers, and former smokers, Environ. Mol. Mutagen., 30, 131, 10.1002/(SICI)1098-2280(1997)30:2<131::AID-EM5>3.0.CO;2-Q Vrieling, 1992, Enhanced hprt mutant frequency but no significant difference in mutation spectrum between a smoking and a non-smoking human population, Carcinogenesis, 13, 1625, 10.1093/carcin/13.9.1625 Curry, 1999, Influence of sex, smoking and age on human hprt mutation frequencies and spectra, Genetics, 152, 1065, 10.1093/genetics/152.3.1065 Finette, 1997, The effects of maternal cigarette smoke exposure on somatic mutant frequencies at the hprt locus in healthy newborns, Mutat. Res., 377, 115, 10.1016/S0027-5107(97)00069-9 Finette, 1998, Gene mutations with characteristic deletions in cord blood T lymphocytes associated with passive maternal exposure to tobacco smoke, Nat. Med., 4, 1144, 10.1038/2640 Bigbee, 1999, Impact of maternal lifestyle factors on newborn HPRT mutant frequencies and molecular spectrum—initial results from the prenatal exposures and preeclampsia prevention (PEPP) study, Mutat. Res., 431, 279, 10.1016/S0027-5107(99)00172-4 Hahn, 2002, Modelling the molecular circuitry of cancer, Nat. Rev., 2, 331, 10.1038/nrc795 Lane, 1992, Cancer. p53, guardian of the genome, Nature, 358, 15, 10.1038/358015a0 Hollstein, 1991, p53 Mutations in human cancers, Science, 253, 49, 10.1126/science.1905840 Greenblatt, 1994, Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis, Cancer Res., 54, 4855 Hussain, 1998, Molecular epidemiology of human cancer—contribution of mutation spectra studies of tumor suppressor genes, Cancer Res., 58, 4023 Hainaut, 2000, p53 and human cancer: the first ten thousand mutations, Adv. Cancer Res., 77, 81, 10.1016/S0065-230X(08)60785-X Hernandez-Boussard, 1999, Analysis of somatic mutations of the p53 gene in human cancers: a tool to generate hypotheses about the natural history of cancer, IARC Sci. Publ., 146, 43 Sanchez-Cespedes, 2001, Chromosomal alterations in lung adenocarcinoma from smokers and nonsmokers, Cancer Res., 61, 1309 Suzuki, 1992, p53 Mutations in non-small cell lung cancer in Japan: association between mutations and smoking, Cancer Res., 52, 734 Husgafvel-Pursiainen, 1996, Cigarette smoking and p53 mutations in lung cancer and bladder cancer, Environ. Health Perspect., 104, 553, 10.2307/3432822 Husgafvel-Pursiainen, 2000, p53 Mutations and exposure to environmental tobacco smoke in a multicenter study on lung cancer, Cancer Res., 60, 2906 Ahrendt, 2000, Alcohol consumption and cigarette smoking increase the frequency of p53 mutations in non-small cell lung cancer, Cancer Res., 60, 3155 Vähäkangas, 2001, p53 and K-ras mutations in lung cancers from former and never-smoking women, Cancer Res., 61, 4350 Takeshima, 1993, p53 Mutations in lung cancers from non-smoking atomic-bomb survivors, Lancet, 342, 1520, 10.1016/S0140-6736(05)80087-X Wang, 1995, Mutations in the p53 gene in lung cancer are associated with cigarette smoking and asbestos exposure, Cancer Epidemiol. Biomarkers Prev., 4, 543 Kondo, 1996, A dose–response relationship between the frequency of p53 mutations and tobacco consumption in lung cancer patients, J. Surg. Oncol., 61, 20, 10.1002/(SICI)1096-9098(199601)61:1<20::AID-JSO6>3.0.CO;2-U Husgafvel-Pursiainen, 1999, Lung cancer and past occupational exposure to asbestos, Role of p53 and K-ras mutations, Am. J. Respir. Cell Mol. Biol., 20, 667, 10.1165/ajrcmb.20.4.3404 Hainaut, 2001, Patterns of p53 G->T transversions in lung cancers reflect the primary mutagenic signature of DNA-damage by tobacco smoke, Carcinogenesis, 22, 367, 10.1093/carcin/22.3.367 Denissenko, 1998, Slow repair of bulky DNA adducts along the nontranscribed strand of the human p53 gene may explain the strand bias of transversion mutations in cancers, Oncogene, 16, 1241, 10.1038/sj.onc.1201647 Pfeifer, 2003, On the origin of G->T transversions in lung cancer, Mutat. Res., 526, 39, 10.1016/S0027-5107(03)00013-7 Denissenko, 1996, Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53, Science, 274, 430, 10.1126/science.274.5286.430 Smith, 2000, Targeting of lung cancer mutational hotspots by polycyclic aromatic hydrocarbons, J. Natl. Cancer Inst., 92, 803, 10.1093/jnci/92.10.803 Denissenko, 1997, Cytosine methylation determines hot spots of DNA damage in the human P53 gene, Proc. Natl. Acad. Sci. U.S.A., 94, 3893, 10.1073/pnas.94.8.3893 Chen, 1998, Carcinogens preferentially bind at methylated CpG in the p53 mutational hot spots, Cancer Res., 58, 2070 Yoon, 2001, Methylated CpG dinucleotides are the preferential targets for G-to-T transversion mutations induced by benzo[a]pyrene diol epoxide in mammalian cells: similarities with the p53 mutation spectrum in smoking-associated lung cancers, Cancer Res., 61, 7110 Rodin, 2002, Cancerous hyper-mutagenesis in p53 genes in possibly associated with transcriptional bypass of DNA lesions, Mutat. Res., 510, 153, 10.1016/S0027-5107(02)00260-9 Rodin, 2004, On the excess of G->T transversions in the p53 gene in lung cancer cell lines reply to Pfeifer and Hainaut, Mutat. Res., 545, 141, 10.1016/j.mrfmmm.2003.09.008 Rubin, 2002, Selective clonal expansion and microenvironmental permissiveness in tobacco carcinogenesis, Oncogene, 21, 7392, 10.1038/sj.onc.1205800 Huang, 1998, Mutations in exon 7 and 8 of p53 as poor prognostic factors in patients with non-small cell lung cancer, Oncogene, 16, 2469, 10.1038/sj.onc.1201776 Marchetti, 1998, Genetic analysis of lung tumours of non-smoking subjects: p53 gene mutations are constantly associated with loss of heterozygosity at the FHIT locus, Br. J. Cancer, 78, 73, 10.1038/bjc.1998.445 Takagi, 1998, p53 Mutations in non-small-cell lung cancers occurring in individuals without a past history of active smoking, Br. J. Cancer, 77, 1568, 10.1038/bjc.1998.258 Gealy, 1999, Comparison of mutations in the p53 and K-ras genes in lung carcinomas from smoking and nonsmoking women, Cancer Epidemiol. Biomarkers Prev., 8, 297 DeMarini, 2001, Lung tumor KRAS and TP53 mutations in nonsmokers reflect exposure to PAH-rich coal combustion emissions, Cancer Res., 61, 6679 Granville, 2003, Mutation spectra of smoky coal combustion emissions in Salmonella reflect the TP53 and KRAS mutations in lung tumors from smoky coal-exposed individuals, Mutat. Res., 525, 77, 10.1016/S0027-5107(02)00314-7 Rodenhuis, 1988, Incidence and possible clinical significance of K-ras oncogene activation in adenocarcinoma of the human lung, Cancer Res., 48, 5738 Slebos, 1991, Relationship between K-ras oncogene activation and smoking in adenocarcinoma of the human lung, J. Natl. Cancer Inst., 83, 1024, 10.1093/jnci/83.14.1024 Rodenhuis, 1992, Clinical significance of ras oncogene activation in human lung cancer, Cancer Res., 52, 2665 Husgafvel-Pursiainen, 1993, K-ras mutations in human adenocarcinoma of the lung: association with smoking and occupational exposure to asbestos, Int. J. Cancer, 53, 250, 10.1002/ijc.2910530213 Westra, 1993, Overexpression of the p53 tumor suppressor gene product in primary lung adenocarcinomas is associated with cigarette smoking, Am. J. Surg. Pathol., 17, 213, 10.1097/00000478-199303000-00001 Keohavong, 2003, K-ras mutations in lung carcinomas from nonsmoking women exposed to unvented coal smoke in China, Lung Cancer, 41, 21, 10.1016/S0169-5002(03)00125-9 Nebert, 2002, Clinical importance of the cytochromes P450, Lancet, 360, 1155, 10.1016/S0140-6736(02)11203-7 Perera, 1997, Environment and cancer: who are susceptible?, Science, 278, 1068, 10.1126/science.278.5340.1068 d’Errico, 1999, Review of studies of selected metabolic polymorphisms and cancer, IARC Sci. Publ., 148, 323 Bartsch, 2000, Genetic polymorphisms of CYP genes, alone or in combination, as a risk modifier of tobacco-related cancers, Cancer Epidemiol. Biomarkers Prev., 9, 3 Benhamou, 2002, Meta- and pooled analyses of the effects of glutathione S-transferase M1 polymorphism and smoking on lung cancer risk, Carcinogenesis, 23, 1343, 10.1093/carcin/23.8.1343 Berwick, 2000, Markers of DNA repair and susceptibility to cancer in humans: an epidemiologic review, J. Natl. Cancer Inst., 92, 874, 10.1093/jnci/92.11.874 Vineis, 1994, Genetically based N-acetyltransferase metabolic polymorphism and low-level environmental exposure to carcinogens, Nature, 369, 154, 10.1038/369154a0 Bennett, 1999, Environmental tobacco smoke, genetic susceptibility, and risk of lung cancer in never-smoking women, J. Natl. Cancer Inst., 91, 2009, 10.1093/jnci/91.23.2009 Nyberg, 1998, Glutathione S-transferase mu1 and N-acetyltransferase 2 genetic polymorphisms and exposure to tobacco smoke in nonsmoking and smoking lung cancer patients and population controls, Cancer Epidemiol. Biomarkers Prev., 7, 875 Malats, 2000, Lung cancer risk in nonsmokers and GSTM1 and GSTT1 genetic polymorphism, Cancer Epidemiol. Biomarkers Prev., 9, 827 Hung, 2003, CYP1A1 and GSTM1 genetic polymorphisms and lung cancer risk in Caucasian non-smokers: a pooled analysis, Carcinogenesis, 24, 875, 10.1093/carcin/bgg026 Kiyohara, 2003, Risk modification by CYP1A1 and GSTM1 polymorphisms in the association of environmental tobacco smoke and lung cancer: a case–control study in Japanese nonsmoking women, Int. J. Cancer, 107, 139, 10.1002/ijc.11355 Taioli, 2003, Polymorphisms in CYP1A1, GSTM1, GSTT1 and lung cancer below the age of 45 years, Int. J. Epidemiol., 32, 60, 10.1093/ije/dyg001 Le Marchand, 2003, Pooled analysis of the CYP1A1 exon 7 polymorphism and lung cancer (United States), Cancer Causes Control, 14, 339, 10.1023/A:1023956201228 Miller, 2003, Association between self-reported environmental tobacco smoke exposure and lung cancer: modification by GSTP1 polymorphism, Int. J. Cancer, 104, 758, 10.1002/ijc.10989 Cohet, 2004, Exon 5 polymorphisms in the O6-alkylguanine DNA alkyltranferase gene and lung cancer risk in non-smokers exposed to second-hand smoke, Cancer Epidemiol. Biomarkers Prev., 13, 320, 10.1158/1055-9965.EPI-03-0120 Zhu, 2003, Second hand smoke stimulates tumor angiogenesis and growth, Cancer Cell, 4, 191, 10.1016/S1535-6108(03)00219-8 Heeschen, 2001, Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis, Nat. Med., 7, 833, 10.1038/89961 Jones, 2002, The fundamental role of epigenetic events in cancer, Nat. Rev. Genet., 3, 415, 10.1038/nrg816 Herman, 2003, Gene silencing in cancer in association with promoter hypermethylation, N. Engl. J. Med., 349, 2042, 10.1056/NEJMra023075 Kim, 2001, p16(INK4a) and histology-specific methylation of CpG islands by exposure to tobacco smoke in non-small cell lung cancer, Cancer Res., 61, 3419 Toyooka, 2003, Smoke exposure, histologic type and geography-related differences in the methylation profiles of non-small cell lung cancer, Int. J. Cancer, 103, 153, 10.1002/ijc.10787 Jarmalaite, 2003, Aberrant p16 promoter methylation in smokers and former smokers with non-small cell lung cancer, Int. J. Cancer, 106, 913, 10.1002/ijc.11322 Belinsky, 1998, Aberrant methylation of p16 (INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis, Proc. Natl. Acad. Sci. U.S.A., 95, 11891, 10.1073/pnas.95.20.11891 Zochbauer-Muller, 2001, Aberrant promoter methylation of multiple genes in non-small cell lung cancers, Cancer Res., 61, 249 Belinsky, 2002, Aberrant promoter methylation in bronchial epithelium and sputum from current and former smokers, Cancer Res., 62, 2370 Esteller, 1998, Inactivation of glutathione S-transferase P1 gene by promoter hypermethylation in human neoplasia, Cancer Res., 58, 4515 Anttila, 2003, Methylation of cytochrome P4501A1 promoter in the lung is associated with tobacco smoking, Cancer Res., 63, 8623