HFE genotypes and dietary heme iron: No evidence of strong gene–nutrient interaction on serum ferritin concentrations in middle-aged women

Daphne L. van der A1,2, Petra H.M. Peeters1, Diederick E. Grobbee1, Mark Roest3, Hieronymus A.M. Voorbij3, Yvonne T. van der Schouw1
1Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
2Center for Nutrition and Health, National Institute for Public Health and the Environment, Bilthoven, the Netherlands
3Department of Clinical Chemistry, University Medical Center Utrecht, The Netherlands

Tài liệu tham khảo

Feder, 1996, A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis, Nat Genet, 13, 399, 10.1038/ng0896-399 Hanson, 2001, HFE gene and hereditary hemochromatosis: a HuGE review. Human Genome Epidemiology, Am J Epidemiol, 154, 193, 10.1093/aje/154.3.193 Njajou, 2003, A population-based study of the effect of the HFE C282Y and H63D mutations on iron metabolism, Eur J Hum Genet, 11, 225, 10.1038/sj.ejhg.5200955 Asberg, 2001, Screening for hemochromatosis: high prevalence and low morbidity in an unselected population of 65,238 persons, Scand J Gastroenterol, 36, 1108, 10.1080/003655201750422747 Waalen, 2002, Penetrance of hemochromatosis, Blood Cells Mol Dis, 29, 418, 10.1006/bcmd.2002.0596 Jackson, 2001, HFE mutations, iron deficiency and overload in 10,500 blood donors, Br J Haematol, 114, 474, 10.1046/j.1365-2141.2001.02949.x Beutler, 2002, Penetrance of 845G→A (C282Y) HFE hereditary haemochromatosis mutation in the USA, Lancet, 359, 211, 10.1016/S0140-6736(02)07447-0 Beutler, 2003, The HFE Cys282Tyr mutation as a necessary but not sufficient cause of clinical hereditary hemochromatosis, Blood, 101, 3347, 10.1182/blood-2002-06-1747 Levy, 2000, Genes that modify the hemochromatosis phenotype in mice, J Clin Invest, 105, 1209, 10.1172/JCI9635 Lee, 2001, A study of genes that may modulate the expression of hereditary hemochromatosis: transferrin receptor-1, ferroportin, ceruloplasmin, ferritin light and heavy chains, iron regulatory proteins (IRP)-1 and -2, and hepcidin, Blood Cells Mol Dis, 27, 783, 10.1006/bcmd.2001.0445 Baynes, 1996, Assessment of iron status, Clin Biochem, 29, 209, 10.1016/0009-9120(96)00010-K Beutler, 2003, Haematological effects of the C282Y HFE mutation in homozygous and heterozygous states among subjects of northern and southern European ancestry, Br J Haematol, 120, 887, 10.1046/j.1365-2141.2003.04215.x de Valk, 2000, Biochemical expression of heterozygous hereditary hemochromatosis, Eur J Intern Med, 11, 317, 10.1016/S0953-6205(00)00111-4 Boker, 2001, Prospect-EPIC Utrecht: study design and characteristics of the cohort population. European Prospective Investigation into Cancer and Nutrition, Eur J Epidemiol, 17, 1047, 10.1023/A:1020009325797 van der, 2003, Heterozygosity for the Cys282Tyr mutation in the HFE gene and the risk of colorectal cancer (Netherlands), Cancer Causes Control, 14, 541, 10.1023/A:1024839528684 Roest, 1999, Heterozygosity for a hereditary hemochromatosis gene is associated with cardiovascular death in women, Circulation, 100, 1268, 10.1161/01.CIR.100.12.1268 Stichting Nederlandse Voedingsstoffenbestand, 1996 Ocke, 1997, The Dutch EPIC food frequency questionnaire. I. Description of the questionnaire, and relative validity and reproducibility for food groups, Int J Epidemiol, 26, S37, 10.1093/ije/26.suppl_1.S37 Ocke, 1997, The Dutch EPIC food frequency questionnaire. II. Relative validity and reproducibility for nutrients, Int J Epidemiol, 26, S49, 10.1093/ije/26.suppl_1.S49 Willett, 1986, Total energy intake: implications for epidemiologic analyses, Am J Epidemiol, 124, 17, 10.1093/oxfordjournals.aje.a114366 Hardy, 1908, Mendelian proportions in a mixed population, Science, 28, 41, 10.1126/science.28.706.49 Weinberg, 1963, On the demonstration of heredity in man Soustre, 1986, Dietary determinants of the iron status in menstruating women, Int J Vitam Nutr Res, 56, 281 Whitfield, 2003, Relative importance of female-specific and non-female-specific effects on variation in iron stores between women, Br J Haematol, 120, 860, 10.1046/j.1365-2141.2003.04224.x Milman, 1999, Relationship between serum ferritin and risk factors for ischaemic heart disease in 2235 Danes aged 30–60 years, J Intern Med, 245, 423, 10.1046/j.1365-2796.1999.00465.x Fleming, 1998, Dietary determinants of iron stores in a free-living elderly population: The Framingham Heart Study, Am J Clin Nutr, 67, 722, 10.1093/ajcn/67.4.722 Fleming, 2001, Aspirin intake and the use of serum ferritin as a measure of iron status, Am J Clin Nutr, 74, 219, 10.1093/ajcn/74.2.219 Kato, 2000, Risk of iron overload among middle-aged women, Int J Vitam Nutr Res, 70, 119, 10.1024/0300-9831.70.3.119 Leggett, 1990, Factors affecting the concentrations of ferritin in serum in a healthy Australian population, Clin Chem, 36, 1350, 10.1093/clinchem/36.7.1350 Penckofer, 2000, Improved iron status parameters may be a benefit of hormone replacement therapy, J Womens Health Gend Based Med, 9, 141, 10.1089/152460900318632 Liu, 2003, Body iron stores and their determinants in healthy postmenopausal US women, Am J Clin Nutr, 78, 1160, 10.1093/ajcn/78.6.1160 Garry, 1991, A prospective study of blood donations in healthy elderly persons, Transfusion, 31, 686, 10.1046/j.1537-2995.1991.31892023491.x Torti, 2002, Regulation of ferritin genes and protein, Blood, 99, 3505, 10.1182/blood.V99.10.3505 Heath, 2002, Clinical implications of changes in the modern diet: iron intake, absorption and status, Best Pract Res Clin Haematol, 15, 225, 10.1053/beha.2002.0208 Yokoi, 1994, Iron and zinc nutriture of premenopausal women: associations of diet with serum ferritin and plasma zinc disappearance and of serum ferritin with plasma zinc and plasma zinc disappearance, J Lab Clin Med, 124, 852 Preziosi, 1994, Iron status of a healthy French population: factors determining biochemical markers, Ann Nutr Metab, 38, 192, 10.1159/000177811 Galan, 1998, Determining factors in the iron status of adult women in the SU.VI.MAX study. SUpplementation en VItamines et Mineraux AntioXydants, Eur J Clin Nutr, 52, 383, 10.1038/sj.ejcn.1600561 Payette, 1991, Dietary intake and biochemical indices of nutritional status in an elderly population, with estimates of the precision of the 7-d food record, Am J Clin Nutr, 54, 478, 10.1093/ajcn/54.3.478 Garry, 2000, Effects of iron intake on iron stores in elderly men and women: longitudinal and cross-sectional results, J Am Coll Nutr, 19, 262, 10.1080/07315724.2000.10718925 Waheed, 2002, Regulation of transferrin-mediated iron uptake by HFE, the protein defective in hereditary hemochromatosis, Proc Natl Acad Sci U S A, 99, 3117, 10.1073/pnas.042701499 Miret, 2003, Physiology and molecular biology of dietary iron absorption, Annu Rev Nutr, 23, 283, 10.1146/annurev.nutr.23.011702.073139 Hallberg, 1997, Iron absorption from the whole diet in men: how effective is the regulation of iron absorption?, Am J Clin Nutr, 66, 347, 10.1093/ajcn/66.2.347 Hunt, 2004, Iron absorption by heterozygous carriers of the HFE C282Y mutation associated with hemochromatosis, Am J Clin Nutr, 80, 924, 10.1093/ajcn/80.4.924 Salonen, 1992, High stored iron levels are associated with excess risk of myocardial infarction in eastern Finnish men, Circulation, 86, 803, 10.1161/01.CIR.86.3.803 Kiechl, 1997, Body iron stores and the risk of carotid atherosclerosis: prospective results from the Bruneck study, Circulation, 96, 3300, 10.1161/01.CIR.96.10.3300 Klipstein-Grobusch, 1999, Serum ferritin and risk of myocardial infarction in the elderly: the Rotterdam Study, Am J Clin Nutr, 69, 1231, 10.1093/ajcn/69.6.1231 Stevens, 1994, Moderate elevation of body iron level and increased risk of cancer occurrence and death, Int J Cancer, 56, 364, 10.1002/ijc.2910560312 Nelson, 2001, Iron and colorectal cancer risk: human studies, Nutr Rev, 59, 140, 10.1111/j.1753-4887.2001.tb07002.x Salonen, 1998, Relation between iron stores and non-insulin dependent diabetes in men: case-control study, Br Med J, 317, 727, 10.1136/bmj.317.7160.727 Ford, 1999, Diabetes and serum ferritin concentration among U.S. adults, Diabetes Care, 22, 1978, 10.2337/diacare.22.12.1978