Synergistic induction of miR-126 by hypoxia and HDAC inhibitors in cardiac myocytes

Gardin, 2004, Left ventricular hypertrophy: the next treatable, silent killer?, JAMA, 292, 2396, 10.1001/jama.292.19.2396 McKinsey, 2012, Therapeutic potential for HDAC inhibitors in the heart, Ann. Rev. Pharmacol. Toxicol., 52, 303, 10.1146/annurev-pharmtox-010611-134712 Antos, 2003, Dose-dependent blockade to cardiomyocyte hypertrophy by histone deacetylase inhibitors, J. Biol. Chem., 278, 28930, 10.1074/jbc.M303113200 Kook, 2003, Cardiac hypertrophy and histone deacetylase-dependent transcriptional repression mediated by the atypical homeodomain protein hop, J. Clin. Invest., 112, 863, 10.1172/JCI19137 Kee, 2006, Inhibition of histone deacetylation blocks cardiac hypertrophy induced by angiotensin II infusion and aortic banding, Circulation, 113, 51, 10.1161/CIRCULATIONAHA.105.559724 Kong, 2006, Suppression of class I and II histone deacetylases blunts pressure-overload cardiac hypertrophy, Circulation, 113, 2579, 10.1161/CIRCULATIONAHA.106.625467 Backs, 2006, CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy, J. Clin. Invest., 116, 1853, 10.1172/JCI27438 Zhang, 2002, Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy, Cell, 110, 479, 10.1016/S0092-8674(02)00861-9 Chang, 2004, Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development, Mol. Cell. Biol., 24, 8467, 10.1128/MCB.24.19.8467-8476.2004 Backs, 2006, CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy, J. Clin. Invest., 116, 1853, 10.1172/JCI27438 Vega, 2004, Protein kinases C and D mediate agonist-dependent cardiac hypertrophy through nuclear export of histone deacetylase 5, Mol. Cell. Biol., 24, 8374, 10.1128/MCB.24.19.8374-8385.2004 Bradner, 2010, Chemical phylogenetics of histone deacetylases, Nat. Chem. Biol., 6, 238, 10.1038/nchembio.313 Heltweg, 2012, Subtype selective substrates for histone deacetylases, J. Med. Chem., 47, 5235, 10.1021/jm0497592 Kee, 2009, Kruppel-like factor 4 mediates histone deacetylase inhibitor-induced prevention of cardiac hypertrophy, J. Mol. Cell. Cardiol., 47, 770, 10.1016/j.yjmcc.2009.08.022 Liao, 2010, Kruppel-like factor 4 regulates pressure-induced cardiac hypertrophy, J. Mol. Cell. Cardiol., 49, 334, 10.1016/j.yjmcc.2010.04.008 Glenn, 2009, Endothelin-stimulated human B-type natriuretic peptide gene expression is mediated by Yin Yang 1 in association with histone deacetylase 2, Hypertension, 53, 549, 10.1161/HYPERTENSIONAHA.108.125088 Chandrasekaran, 2009, Histone deacetylases facilitate sodium/calcium exchanger up-regulation in adult cardiomyocytes, FASEB J., 23, 3851, 10.1096/fj.09-132415 Cao, 2009, Histone deacetylase (HDAC) inhibitors attenuate cardiac hypertrophy by suppressing autophagy, Proc. Natl. Acad. Sci. USA, 108, 4123, 10.1073/pnas.1015081108 Iyer, 2010, Antifibrotic activity of an inhibitor of histone deacetylases in DOCA-salt hypertensive rats, Br. J. Pharmacol., 159, 1408, 10.1111/j.1476-5381.2010.00637.x Lee, 2007, Inhibition of histone deacetylase on ventricular remodeling in infarcted rats, Am. J. Physiol. Heart Circ. Physiol., 293, 968, 10.1152/ajpheart.00891.2006 Granger, 2008, Histone deacetylase inhibition reduces myocardial ischemia-reperfusion injury in mice, FASEB J., 22, 3549, 10.1096/fj.08-108548 Zhao, 2007, Inhibition of histone deacetylases triggers pharmacologic preconditioning effects against myocardial ischemic injury, Cardiovasc. Res., 76, 473, 10.1016/j.cardiores.2007.08.010 Osman, 2012, Micro-RNAs in health and disease-basic science and clinical applications, Clin. Lab., 58, 393 Papageorgiou, 2012, The role of micro-RNAs in cardiovascular disease, Curr. Med. Chem., 19, 2605, 10.2174/092986712800493048 Salloum, 2010, Role of micro-RNAs in cardiac preconditioning, J. Cardiovasc. Pharmacol., 56, 581, 10.1097/FJC.0b013e3181f581ba Fish, 2008, miR-126 regulates angiogenic signaling and vascular integrity, Dev. Cell, 15, 272, 10.1016/j.devcel.2008.07.008 Wang, 2008, The endothelial-specific micro-RNA miR-126 governs vascular integrity and angiogenesis, Dev. Cell, 15, 261, 10.1016/j.devcel.2008.07.002 Kuhnert, 2008, Attribution of vascular phenotypes of the murine Egfl7 locus to the micro-RNA miR-126, Development, 135, 3989, 10.1242/dev.029736 Wakioka, 2001, Spred is a sprouty-related suppressor of ras signalling, Nature, 412, 647, 10.1038/35088082 Ueki, 2003, Positive and negative roles of p85α and p85β regulatory subunits of phosphoinositide 3-kinase in insulin signaling, J. Biol. Chem., 278, 48453, 10.1074/jbc.M305602200 Badiwala, 2010, Epidermal growth factor-like domain 7 suppresses intercellular adhesion molecule 1 expression in response to hypoxia/reoxygenation injury in human coronary artery endothelial cells, Circulation, 122, 156, 10.1161/CIRCULATIONAHA.109.927715 Gustavsson, 2007, Vascular response to hypoxic preconditioning in the immature brain, J. Cereb. Blood Flow Metab., 27, 928, 10.1038/sj.jcbfm.9600408 Webster, 1999, Hypoxia-activated apoptosis of cardiac myocytes requires reoxygenation or a pH shift and is independent of p53, J. Clin. Invest., 104, 239, 10.1172/JCI5871 Kubasiak, 2002, Hypoxia and acidosis activate cardiac myocyte death through the Bcl-2 family protein BNIP3, Proc. Natl. Acad. Sci. USA, 99, 12825, 10.1073/pnas.202474099 Zhao, 2002, Lentiviral vectors for delivery of genes into neonatal and adult ventricular cardiac myocytes in vitro and in vivo, Basic Res. Cardiol., 97, 348, 10.1007/s00395-002-0360-0 Wilson, 2010, Age-related molecular genetic changes of murine bone marrow mesenchymal stem cells, BMC Genom., 11, 229, 10.1186/1471-2164-11-229 Jason, 2009, Fish and Deepak Srivastava microRNAs: opening a new vein in Sci Signal, Sci. Signal., 2, 252 Xiao, 2010, SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice, J. Biol. Chem., 285, 36776, 10.1074/jbc.M110.168039 Zhong, 2010, Raul mostoslavsky the histone deacetylase SIRT6 regulates glucose homeostasis via Hif1α, Cell, 140, 280, 10.1016/j.cell.2009.12.041 Kato, 2004, Histone deacetylase 7 associates with hypoxia-inducible factor 1alpha and increases transcriptional activity, J. Biol. Chem., 279, 41966, 10.1074/jbc.M406320200 Oka, 2008, Molecular mechanisms underlying the transition of cardiac hypertrophy to heart failure, J. Circ., 72 Suppl A, A13, 10.1253/circj.CJ-08-0481 Russell, 2012, Regulated expression of pH sensing G protein-coupled receptor-68 identified through chemical biology defines a new drug target for ischemic heart disease, ACS Chem. Biol., 7, 1077, 10.1021/cb300001m