Comparative, double-blind, controlled study of intra-articular hyaluronic acid (Hyalubrix®) injections versus local anesthetic in osteoarthritis of the hip

Arthritis Research & Therapy - Tập 11 - Trang 1-8 - 2009
Alberto Migliore1, Umberto Massafra1, Emanuele Bizzi1, Francesca Vacca1, Severino Martin-Martin2, Mauro Granata3, Andrea Alimonti1, Sandro Tormenta4
1Operative Unit of Rheumatology, San Pietro Fatebenefratelli Hospital, Rome, Italy
2Department of Internal Medicine, Regina Apostolorum Hospital, Albano Laziale, Italy
3Operative Unit of Rheumatology, San Filippo Neri Hospital, Rome, Italy
4Department of Radiology, San Pietro Fatebenefratelli Hospital, Rome, Italy

Tóm tắt

Comparison of intra-articular bacterial-derived hyaluronic acid (Hyalubrix®) (HA) with local analgesia (mepivacaine) for osteoarthritis (OA) of the hip. A pilot prospective, double-blind, 6-month randomized trial of 42 patients with hip OA. HA or mepivacaine was administered twice (once a month) under ultrasound guidance. Efficacy measurements included the Lequesne's algofunctional index, a visual analog scale for pain, concomitant use of analgesia, patient and physician global measurement, and safety. Patients in the HA group exhibited a significantly reduced Lequesne's algofunctional index 3 and 6 months after treatment (P < 0.001) and significantly reduced visual analog scale pain scores 3 and 6 months after treatment (P < 0.05) compared with the local anesthetic group. All primary and secondary measures were significantly improved versus baseline, but other than the above were not different from each other at 3 or 6 months. Adverse effects were minimal. This comparative study suggests a beneficial effect and safety of intra-articular HA in the management of hip OA. ISRCTN39397064.

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