Persisting autoimmune heparin-induced thrombocytopenia after elective abdominal aortic aneurysm repair: a case report

Journal of Thrombosis and Thrombolysis - Tập 50 - Trang 674-677 - 2020
Guillaume Roberge1,2, Tobias Tritschler1,3, Caleb MacGillivray4, Laurence Dufresne5, Sudhir Kumar Nagpal5, Dimitrios Scarvelis1
1Department of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada
2Department of General Internal Medicine, Centre Hospitalier Universitaire de Québec, Hôpital St-François d’Assise, Université Laval, Québec, Canada
3Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
4Clinical Epidemiology Program, Thrombosis Research Group, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada
5Division of Vascular Surgery, The Ottawa Hospital, University of Ottawa, Ottawa, Canada

Tóm tắt

Persisting heparin-induced thrombocytopenia (HIT) is characterized by ongoing thrombocytopenia more than 7 days after stopping heparin. It is part of cases referred to as autoimmune HIT (aHIT). In contrast to typical HIT cases, aHIT involves heparin-independent platelet activation mechanism highlighted by a strongly positive functional assay done without heparin. We report the first case of persisting HIT after an elective abdominal aortic aneurysm repair presenting with arterial and venous thrombosis, and describe the potential role of intravenous immunoglobulin in such patients.

Tài liệu tham khảo

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