Checkpoint blockade toxicities: Insights into autoimmunity and treatment
Tài liệu tham khảo
Ribas, 2018, Cancer immunotherapy using checkpoint blockade, Science, 359, 1350, 10.1126/science.aar4060
Baumeister, 2016, Coinhibitory pathways in immunotherapy for cancer, Annu. Rev. Immunol., 34, 539, 10.1146/annurev-immunol-032414-112049
Sade-Feldman, 2018, Defining T cell states associated with response to checkpoint immunotherapy in melanoma, Cell, 175, 998, 10.1016/j.cell.2018.10.038
Wang, 2018, Fatal toxic effects associated with immune checkpoint inhibitors: a systematic review and meta-analysis, JAMA Oncol., 4, 1721, 10.1001/jamaoncol.2018.3923
Dougan, 2017, Checkpoint blockade toxicity and immune homeostasis in the gastrointestinal tract, Front. Immunol., 8, 1547, 10.3389/fimmu.2017.01547
Chang, 2019, Endocrine toxicity of Cancer immunotherapy targeting immune checkpoints, Endocr. Rev., 40, 17, 10.1210/er.2018-00006
Cappelli, 2017, Rheumatic and musculoskeletal immune-related adverse events due to immune checkpoint inhibitors: a systematic review of the literature, Arthritis Care Res. (Hoboken), 69, 1751, 10.1002/acr.23177
Hodi, 2010, Improved survival with ipilimumab in patients with metastatic melanoma, N. Engl. J. Med., 363, 711, 10.1056/NEJMoa1003466
Eggermont, 2016, Prolonged survival in stage III melanoma with ipilimumab adjuvant therapy, N. Engl. J. Med., 375, 1845, 10.1056/NEJMoa1611299
Robert, 2015, Pembrolizumab versus ipilimumab in advanced melanoma, N. Engl. J. Med., 372, 2521, 10.1056/NEJMoa1503093
Larkin, 2015, Combined nivolumab and ipilimumab or monotherapy in untreated melanoma, N. Engl. J. Med., 373, 23, 10.1056/NEJMoa1504030
Paz-Ares, 2018, Pembrolizumab plus chemotherapy for squamous non-small-cell lung cancer, N. Engl. J. Med., 379, 2040, 10.1056/NEJMoa1810865
Rini, 2019, Pembrolizumab plus axitinib versus sunitinib for advanced renal-cell carcinoma, N. Engl. J. Med., 380, 1116, 10.1056/NEJMoa1816714
Schmid, 2018, Atezolizumab and nab-paclitaxel in advanced triple-negative breast Cancer, N. Engl. J. Med., 379, 2108, 10.1056/NEJMoa1809615
Hellmann, 2018, Nivolumab plus ipilimumab in lung cancer with a high tumor mutational burden, N. Engl. J. Med., 378, 2093, 10.1056/NEJMoa1801946
Dougan, 2019, Cancer immunotherapy: beyond checkpoint blockade, Annu. Rev. Cancer Biol., 3, 55, 10.1146/annurev-cancerbio-030518-055552
van der Merwe, 1997, CD80 (B7-1) binds both CD28 and CTLA-4 with a low affinity and very fast kinetics, J. Exp. Med., 185, 393, 10.1084/jem.185.3.393
Schwartz, 2001, Structural basis for co-stimulation by the human CTLA-4/B7-2 complex, Nature, 410, 604, 10.1038/35069112
Qureshi, 2011, Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4, Science, 332, 600, 10.1126/science.1202947
Krummel, 1995, CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation, J. Exp. Med., 182, 459, 10.1084/jem.182.2.459
Tivol, 1995, Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4, Immunity, 3, 541, 10.1016/1074-7613(95)90125-6
Kuehn, 2014, Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4, Science, 345, 1623, 10.1126/science.1255904
Wing, 2008, CTLA-4 control over Foxp3+ regulatory T cell function, Science, 322, 271, 10.1126/science.1160062
Keir, 2008, PD-1 and its ligands in tolerance and immunity, Annu. Rev. Immunol., 26, 677, 10.1146/annurev.immunol.26.021607.090331
Wang, 2017, Molecular dissection of CD8(+) T-Cell dysfunction, Trends Immunol., 38, 567, 10.1016/j.it.2017.05.008
Keir, 2006, Tissue expression of PD-L1 mediates peripheral T cell tolerance, J. Exp. Med., 203, 883, 10.1084/jem.20051776
Latchman, 2001, PD-L2 is a second ligand for PD-1 and inhibits T cell activation, Nat. Immunol., 2, 261, 10.1038/85330
Freeman, 2000, Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation, J. Exp. Med., 192, 1027, 10.1084/jem.192.7.1027
Nishimura, 1999, Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor, Immunity, 11, 141, 10.1016/S1074-7613(00)80089-8
Luoma, 2020, Molecular pathways of Colon inflammation induced by Cancer immunotherapy, Cell, 182, 655, 10.1016/j.cell.2020.06.001
Bluestone, 2020, Tolerance in the age of immunotherapy, N. Engl. J. Med., 383, 1156, 10.1056/NEJMra1911109
Anderson, 2016, Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation, Immunity, 44, 989, 10.1016/j.immuni.2016.05.001
Ingram, 2018, Anti-CTLA-4 therapy requires an Fc domain for efficacy, Proc. Natl. Acad. Sci. U. S. A., 115, 3912, 10.1073/pnas.1801524115
Simpson, 2013, Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma, J. Exp. Med., 210, 1695, 10.1084/jem.20130579
Selby, 2013, Anti-CTLA-4 antibodies of IgG2a isotype enhance antitumor activity through reduction of intratumoral regulatory T cells, Cancer Immunol. Res., 1, 32, 10.1158/2326-6066.CIR-13-0013
Wildin, 2001, X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy, Nat. Genet., 27, 18, 10.1038/83707
Sage, 2013, The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood, Nat. Immunol., 14, 152, 10.1038/ni.2496
Weber, 2009, A randomized, double-blind, placebo-controlled, phase II study comparing the tolerability and efficacy of ipilimumab administered with or without prophylactic budesonide in patients with unresectable stage III or IV melanoma, Clin. Cancer Res., 15, 5591, 10.1158/1078-0432.CCR-09-1024
Hasan Ali, 2019, Human leukocyte antigen variation is associated with adverse events of checkpoint inhibitors, Eur. J. Cancer, 107, 8, 10.1016/j.ejca.2018.11.009
Stamatouli, 2018, Collateral damage: insulin-dependent diabetes induced with checkpoint inhibitors, Diabetes, 67, 1471, 10.2337/dbi18-0002
Abu-Sbeih, 2019, Immune checkpoint inhibitor therapy in patients with preexisting inflammatory bowel disease, J. Clin. Oncol.
Akturk, 2018, PD-1 inhibitor immune-related adverse events in patients with preexisting endocrine autoimmunity, J. Clin. Endocrinol. Metab., 103, 3589, 10.1210/jc.2018-01430
Menzies, 2017, Anti-PD-1 therapy in patients with advanced melanoma and preexisting autoimmune disorders or major toxicity with ipilimumab, Ann. Oncol., 28, 368, 10.1093/annonc/mdw443
Leonardi, 2018, Safety of programmed Death-1 pathway inhibitors among patients with non-small-Cell lung Cancer and preexisting autoimmune disorders, J. Clin. Oncol., 36, 1905, 10.1200/JCO.2017.77.0305
Johnson, 2016, Ipilimumab therapy in patients with advanced melanoma and preexisting autoimmune disorders, JAMA Oncol., 2, 234, 10.1001/jamaoncol.2015.4368
Badran, 2020, Immune checkpoint inhibitor-associated celiac disease, J. Immunother. Cancer, 8, 10.1136/jitc-2020-000958
Safa, 2019, Immune checkpoint inhibitor related myasthenia gravis: single center experience and systematic review of the literature, J. Immunother. Cancer, 7, 319, 10.1186/s40425-019-0774-y
Martins, 2019, Adverse effects of immune-checkpoint inhibitors: epidemiology, management and surveillance, Nat. Rev. Clin. Oncol., 16, 563, 10.1038/s41571-019-0218-0
Dougan, 2020, AGA clinical practice update on diagnosis and management of immune checkpoint inhibitor (ICI) colitis and hepatitis: expert review, Gastroenterology
Seethapathy, 2020, Incidence and clinical features of immune-related acute kidney injury in patients receiving programmed cell death Ligand-1 inhibitors, Kidney Int. Rep., 5, 1700, 10.1016/j.ekir.2020.07.011
Correale, 2006, The risk of relapses in multiple sclerosis during systemic infections, Neurology, 67, 652, 10.1212/01.wnl.0000233834.09743.3b
Brahmer, 2018, Management of immune-related adverse events in patients treated with immune checkpoint inhibitor therapy: american society of clinical oncology clinical practice guideline, J. Clin. Oncol., 10.1200/JCO.2017.77.6385
Haanen, 2017, Management of toxicities from immunotherapy: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up, Ann. Oncol., 28, iv119, 10.1093/annonc/mdx225
Puzanov, 2017, Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group, J. Immunother. Cancer, 5, 95, 10.1186/s40425-017-0300-z
Acharya, 2020, Endogenous glucocorticoid signaling regulates CD8(+) t cell differentiation and development of dysfunction in the tumor microenvironment, Immunity, 53, 658, 10.1016/j.immuni.2020.08.005
Arbour, 2018, Impact of baseline steroids on efficacy of programmed cell Death-1 and programmed death-ligand 1 blockade in patients with non-small-Cell lung Cancer, J. Clin. Oncol., 36, 2872, 10.1200/JCO.2018.79.0006
Faje, 2018, High-dose glucocorticoids for the treatment of ipilimumab-induced hypophysitis is associated with reduced survival in patients with melanoma, Cancer, 10.1002/cncr.31629
Keskin, 2019, Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial, Nature, 565, 234, 10.1038/s41586-018-0792-9
Tawbi, 2018, Nivolumab and ipilimumab in melanoma metastatic to the brain, N. Engl. J. Med., 379, 2178, 10.1056/NEJMoa1805453
Badran, 2019, Concurrent therapy with immune checkpoint inhibitors and TNFalpha blockade in patients with gastrointestinal immune-related adverse events, J. Immunother. Cancer, 7, 226, 10.1186/s40425-019-0711-0
Hughes, 2019, Budesonide treatment for microscopic colitis from immune checkpoint inhibitors, J. Immunother. Cancer, 7, 292, 10.1186/s40425-019-0756-0
Cohen, 2020, Liver biopsy findings in patients on immune checkpoint inhibitors, Mod. Pathol.
Johnson, 2016, Fulminant myocarditis with combination immune checkpoint blockade, N. Engl. J. Med., 375, 1749, 10.1056/NEJMoa1609214
Phillips, 2019, Treatment outcomes of immune-related cutaneous adverse events, J. Clin. Oncol., 37, 2746, 10.1200/JCO.18.02141
Salem, 2019, Abatacept for severe immune checkpoint inhibitor-associated myocarditis, N. Engl. J. Med., 380, 2377, 10.1056/NEJMc1901677
Bishu, 2020, Efficacy and outcome of Tofacitinib in Immune checkpoint inhibitor colitis, Gastroenterology
Spankuch, 2017, Severe hepatitis under combined immunotherapy: resolution under corticosteroids plus anti-thymocyte immunoglobulins, Eur. J. Cancer, 81, 203, 10.1016/j.ejca.2017.05.018
Abu-Sbeih, 2018, Outcomes of vedolizumab therapy in patients with immune checkpoint inhibitor-induced colitis: a multi-center study, J. Immunother. Cancer, 6, 142, 10.1186/s40425-018-0461-4
Teachey, 2016, Identification of predictive biomarkers for cytokine release syndrome after chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia, Cancer Discov., 6, 664, 10.1158/2159-8290.CD-16-0040
Abu-Sbeih, 2019, Early introduction of selective immunosuppressive therapy associated with favorable clinical outcomes in patients with immune checkpoint inhibitor-induced colitis, J. Immunother. Cancer, 7, 93, 10.1186/s40425-019-0577-1
Mooradian, 2020, Mucosal inflammation predicts response to systemic steroids in immune checkpoint inhibitor colitis, J. Immunother. Cancer, 8, 10.1136/jitc-2019-000451
Ridker, 2017, Effect of interleukin-1beta inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial, Lancet, 390, 1833, 10.1016/S0140-6736(17)32247-X
Bertrand, 2017, TNFalpha blockade overcomes resistance to anti-PD-1 in experimental melanoma, Nat. Commun., 8, 2256, 10.1038/s41467-017-02358-7
Perez-Ruiz, 2019, Prophylactic TNF blockade uncouples efficacy and toxicity in dual CTLA-4 and PD-1 immunotherapy, Nature, 569, 428, 10.1038/s41586-019-1162-y
Chen, 2016, Analysis of immune signatures in longitudinal tumor samples yields insight into biomarkers of response and mechanisms of resistance to immune checkpoint blockade, Cancer Discov., 6, 827, 10.1158/2159-8290.CD-15-1545
Gao, 2016, Loss of IFN-gamma pathway genes in tumor cells as a mechanism of resistance to Anti-CTLA-4 therapy, Cell, 167, 397, 10.1016/j.cell.2016.08.069
Gettinger, 2017, Impaired HLA class I antigen processing and presentation as a mechanism of acquired resistance to immune checkpoint inhibitors in lung Cancer, Cancer Discov., 7, 1420, 10.1158/2159-8290.CD-17-0593
Manguso, 2017, In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target, Nature, 547, 413, 10.1038/nature23270
McGranahan, 2017, Allele-specific HLA loss and immune escape in lung cancer evolution, Cell, 171, 1259, 10.1016/j.cell.2017.10.001
Sade-Feldman, 2017, Resistance to checkpoint blockade therapy through inactivation of antigen presentation, Nat. Commun., 8, 1136, 10.1038/s41467-017-01062-w
Shin, 2017, Primary resistance to PD-1 blockade mediated by JAK1/2 mutations, Cancer Discov., 7, 188, 10.1158/2159-8290.CD-16-1223
Zaretsky, 2016, Mutations associated with acquired resistance to PD-1 blockade in melanoma, N. Engl. J. Med., 375, 819, 10.1056/NEJMoa1604958
Verheijden, 2020, Association of Anti-TNF with decreased survival in steroid refractory ipilimumab and Anti-PD1-Treated patients in the dutch melanoma treatment registry, Clin. Cancer Res., 26, 2268, 10.1158/1078-0432.CCR-19-3322