A Systematic Review of miR-29 in Cancer
Tài liệu tham khảo
Lee, 1993, The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14, Cell, 75, 843, 10.1016/0092-8674(93)90529-Y
Calin, 2002, Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia, Proc. Natl. Acad. Sci. USA, 99, 15524, 10.1073/pnas.242606799
Sassi, 2017, Cardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling, Nat. Commun., 8, 1614, 10.1038/s41467-017-01737-4
Zhang, 2017, miR-29a regulates the proliferation and differentiation of retinal progenitors by targeting Rbm8a, Oncotarget, 8, 31993, 10.18632/oncotarget.16669
Pereira, 2016, Recombinant pre-miR-29b for Alzheimer's disease therapeutics, Sci. Rep., 6, 19946, 10.1038/srep19946
van Rooij, 2008, Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis, Proc. Natl. Acad. Sci. USA, 105, 13027, 10.1073/pnas.0805038105
Cushing, 2015, The role of miR-29 in pulmonary fibrosis, Biochem. Cell Biol., 93, 109, 10.1139/bcb-2014-0095
Cushing, 2011, miR-29 is a major regulator of genes associated with pulmonary fibrosis, Am. J. Respir. Cell Mol. Biol., 45, 287, 10.1165/rcmb.2010-0323OC
Roderburg, 2011, Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis, Hepatology, 53, 209, 10.1002/hep.23922
Xiao, 2012, miR-29 inhibits bleomycin-induced pulmonary fibrosis in mice, Mol. Ther., 20, 1251, 10.1038/mt.2012.36
Qin, 2011, TGF-β/Smad3 signaling promotes renal fibrosis by inhibiting miR-29, J. Am. Soc. Nephrol., 22, 1462, 10.1681/ASN.2010121308
Chung, 2015, MicroRNAs in renal fibrosis, Front. Physiol., 6, 50, 10.3389/fphys.2015.00050
Sekiya, 2011, Suppression of hepatic stellate cell activation by microRNA-29b, Biochem. Biophys. Res. Commun., 412, 74, 10.1016/j.bbrc.2011.07.041
Guo, 2017, Role of miR-29 as marker of risk of acute rejection after heart transplant, Br. J. Biomed. Sci., 74, 187, 10.1080/09674845.2017.1333265
Dawson, 2013, MicroRNA29: a mechanistic contributor and potential biomarker in atrial fibrillation, Circulation, 127, 1466, 10.1161/CIRCULATIONAHA.112.001207
Kogure, 2012, Hepatic miR-29ab1 expression modulates chronic hepatic injury, J. Cell. Mol. Med., 16, 2647, 10.1111/j.1582-4934.2012.01578.x
Roy, 2015, The role of miRNAs in the regulation of inflammatory processes during hepatofibrogenesis, Hepatobiliary Surg. Nutr., 4, 24
Wei, 2013, The regulation and function of microRNAs in kidney diseases, IUBMB Life, 65, 602, 10.1002/iub.1174
Yang, 2014, Induction of miR-29a by saturated fatty acids impairs insulin signaling and glucose uptake through translational repression of IRS-1 in myocytes, FEBS Lett., 588, 2170, 10.1016/j.febslet.2014.05.011
Massart, 2017, Altered miR-29 Expression in Type 2 Diabetes Influences Glucose and Lipid Metabolism in Skeletal Muscle, Diabetes, 66, 1807, 10.2337/db17-0141
Qiu, 2015, microRNAs and Neurodegenerative Diseases, Adv. Exp. Med. Biol., 888, 85, 10.1007/978-3-319-22671-2_6
Hébert, 2008, Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer’s disease correlates with increased BACE1/beta-secretase expression, Proc. Natl. Acad. Sci. USA, 105, 6415, 10.1073/pnas.0710263105
Lee, 2004, MicroRNA genes are transcribed by RNA polymerase II, EMBO J., 23, 4051, 10.1038/sj.emboj.7600385
Lee, 2003, The nuclear RNase III Drosha initiates microRNA processing, Nature, 425, 415, 10.1038/nature01957
Bråte, 2018, Unicellular Origin of the Animal MicroRNA Machinery, Curr. Biol., 28, 3288, 10.1016/j.cub.2018.08.018
Lund, 2004, Nuclear export of microRNA precursors, Science, 303, 95, 10.1126/science.1090599
Michlewski, 2019, Post-transcriptional control of miRNA biogenesis, RNA, 25, 1, 10.1261/rna.068692.118
Grishok, 2001, Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing, Cell, 106, 23, 10.1016/S0092-8674(01)00431-7
Ha, 2014, Regulation of microRNA biogenesis, Nat. Rev. Mol. Cell Biol., 15, 509, 10.1038/nrm3838
Pratt, 2009, The RNA-induced silencing complex: a versatile gene-silencing machine, J. Biol. Chem., 284, 17897, 10.1074/jbc.R900012200
O’Brien, 2018, Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation, Front. Endocrinol. (Lausanne), 9, 402, 10.3389/fendo.2018.00402
Landgraf, 2007, A mammalian microRNA expression atlas based on small RNA library sequencing, Cell, 129, 1401, 10.1016/j.cell.2007.04.040
Koh, 2010, Analysis of deep sequencing microRNA expression profile from human embryonic stem cells derived mesenchymal stem cells reveals possible role of let-7 microRNA family in downstream targeting of hepatic nuclear factor 4 alpha, BMC Genomics, 11, S6, 10.1186/1471-2164-11-S1-S6
Agarwal, 2015, Predicting effective microRNA target sites in mammalian mRNAs, eLife, 4, e05005, 10.7554/eLife.05005
Hwang, 2007, A hexanucleotide element directs microRNA nuclear import, Science, 315, 97, 10.1126/science.1136235
Jagannathan, 2015, MiR-29b replacement inhibits proteasomes and disrupts aggresome+autophagosome formation to enhance the antimyeloma benefit of bortezomib, Leukemia, 29, 727, 10.1038/leu.2014.279
Jeffries, 2011, Nuclear and cytoplasmic localization of neural stem cell microRNAs, RNA, 17, 675, 10.1261/rna.2006511
Khudayberdiev, 2013, A comprehensive characterization of the nuclear microRNA repertoire of post-mitotic neurons, Front. Mol. Neurosci., 6, 43, 10.3389/fnmol.2013.00043
Roberts, 2014, The MicroRNA Biology of the Mammalian Nucleus, Mol. Ther. Nucleic Acids, 3, e188, 10.1038/mtna.2014.40
Liang, 2013, Nuclear microRNAs and their unconventional role in regulating non-coding RNAs, Protein Cell, 4, 325, 10.1007/s13238-013-3001-5
Zhang, 2011, Uracils at nucleotide position 9-11 are required for the rapid turnover of miR-29 family, Nucleic Acids Res., 39, 4387, 10.1093/nar/gkr020
Tumaneng, 2012, YAP mediates crosstalk between the Hippo and PI(3)K–TOR pathways by suppressing PTEN via miR-29, Nat. Cell Biol., 14, 1322, 10.1038/ncb2615
Liu, 2010, Renal medullary microRNAs in Dahl salt-sensitive rats: miR-29b regulates several collagens and related genes, Hypertension, 55, 974, 10.1161/HYPERTENSIONAHA.109.144428
Dooley, 2016, The microRNA-29 Family Dictates the Balance Between Homeostatic and Pathological Glucose Handling in Diabetes and Obesity, Diabetes, 65, 53, 10.2337/db15-0770
Kwon, 2015, Pathophysiological role of microRNA-29 in pancreatic cancer stroma, Sci. Rep., 5, 11450, 10.1038/srep11450
Friedman, 2009, Most mammalian mRNAs are conserved targets of microRNAs, Genome Res., 19, 92, 10.1101/gr.082701.108
Papadopoulou, 2011, The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor, Nat. Immunol., 13, 181, 10.1038/ni.2193
Cushing, 2015, Disruption of miR-29 Leads to Aberrant Differentiation of Smooth Muscle Cells Selectively Associated with Distal Lung Vasculature, PLoS Genet., 11, e1005238, 10.1371/journal.pgen.1005238
Smith, 2012, miR-29ab1 deficiency identifies a negative feedback loop controlling Th1 bias that is dysregulated in multiple sclerosis, J. Immunol., 189, 1567, 10.4049/jimmunol.1103171
Waddington, 2012, The epigenotype. 1942, Int. J. Epidemiol., 41, 10, 10.1093/ije/dyr184
Lin, 2007, Alteration of DNA methyltransferases contributes to 5'CpG methylation and poor prognosis in lung cancer, Lung Cancer, 55, 205, 10.1016/j.lungcan.2006.10.022
Girault, 2003, Expression analysis of DNA methyltransferases 1, 3A, and 3B in sporadic breast carcinomas, Clin. Cancer Res., 9, 4415
Saito, 2003, Increased protein expression of DNA methyltransferase (DNMT) 1 is significantly correlated with the malignant potential and poor prognosis of human hepatocellular carcinomas, Int. J. Cancer, 105, 527, 10.1002/ijc.11127
Patra, 2002, DNA methyltransferase and demethylase in human prostate cancer, Mol. Carcinog., 33, 163, 10.1002/mc.10033
Fabbri, 2007, MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B, Proc. Natl. Acad. Sci. USA, 104, 15805, 10.1073/pnas.0707628104
Allis, 2016, The molecular hallmarks of epigenetic control, Nat. Rev. Genet., 17, 487, 10.1038/nrg.2016.59
Hideshima, 2015, Rational combination treatment with histone deacetylase inhibitors and immunomodulatory drugs in multiple myeloma, Blood Cancer J., 5, e312, 10.1038/bcj.2015.38
Lane, 2009, Histone deacetylase inhibitors in cancer therapy, J. Clin. Oncol., 27, 5459, 10.1200/JCO.2009.22.1291
Amodio, 2016, Therapeutic Targeting of miR-29b/HDAC4 Epigenetic Loop in Multiple Myeloma, Mol. Cancer Ther., 15, 1364, 10.1158/1535-7163.MCT-15-0985
Ito, 2011, Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine, Science, 333, 1300, 10.1126/science.1210597
Tahiliani, 2009, Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1, Science, 324, 930, 10.1126/science.1170116
He, 2011, Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA, Science, 333, 1303, 10.1126/science.1210944
Morita, 2013, miR-29 represses the activities of DNA methyltransferases and DNA demethylases, Int. J. Mol. Sci., 14, 14647, 10.3390/ijms140714647
Jacobsen, 2013, Analysis of microRNA-target interactions across diverse cancer types, Nat. Struct. Mol. Biol., 20, 1325, 10.1038/nsmb.2678
Tsai, 2014, TET1 regulates hypoxia-induced epithelial-mesenchymal transition by acting as a co-activator, Genome Biol., 15, 513, 10.1186/s13059-014-0513-0
Wu, 2014, Suppression of TET1-dependent DNA demethylation is essential for KRAS-mediated transformation, Cell Rep., 9, 1827, 10.1016/j.celrep.2014.10.063
Wang, 2017, MiR-29b/TET1/ZEB2 signaling axis regulates metastatic properties and epithelial-mesenchymal transition in breast cancer cells, Oncotarget, 8, 102119, 10.18632/oncotarget.22183
Tu, 2015, MicroRNA-29b/Tet1 regulatory axis epigenetically modulates mesendoderm differentiation in mouse embryonic stem cells, Nucleic Acids Res., 43, 7805, 10.1093/nar/gkv653
Cui, 2016, miR-29 regulates Tet1 expression and contributes to early differentiation of mouse ESCs, Oncotarget, 7, 64932, 10.18632/oncotarget.10751
Oakes, 2017, Endoplasmic reticulum proteostasis: a key checkpoint in cancer, Am. J. Physiol. Cell Physiol., 312, C93, 10.1152/ajpcell.00266.2016
Cohen-Kaplan, 2016, The ubiquitin-proteasome system and autophagy: Coordinated and independent activities, Int. J. Biochem. Cell Biol., 79, 403, 10.1016/j.biocel.2016.07.019
Crawford, 2011, Proteasome inhibitors in cancer therapy, J. Cell Commun. Signal., 5, 101, 10.1007/s12079-011-0121-7
Van Drie, 2011, Protein folding, protein homeostasis, and cancer, Chin. J. Cancer, 30, 124, 10.5732/cjc.010.10162
Kaur, 2015, Autophagy at the crossroads of catabolism and anabolism, Nat. Rev. Mol. Cell Biol., 16, 461, 10.1038/nrm4024
He, 2009, Regulation mechanisms and signaling pathways of autophagy, Annu. Rev. Genet., 43, 67, 10.1146/annurev-genet-102808-114910
Apel, 2008, Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy, Cancer Res., 68, 1485, 10.1158/0008-5472.CAN-07-0562
Li, 2013, Autophagy promotes hepatocellular carcinoma cell invasion through activation of epithelial-mesenchymal transition, Carcinogenesis, 34, 1343, 10.1093/carcin/bgt063
Fels, 2008, Preferential cytotoxicity of bortezomib toward hypoxic tumor cells via overactivation of endoplasmic reticulum stress pathways, Cancer Res., 68, 9323, 10.1158/0008-5472.CAN-08-2873
Claerhout, 2010, Concomitant inhibition of AKT and autophagy is required for efficient cisplatin-induced apoptosis of metastatic skin carcinoma, Int. J. Cancer, 127, 2790, 10.1002/ijc.25300
Akalay, 2013, Epithelial-to-mesenchymal transition and autophagy induction in breast carcinoma promote escape from T-cell-mediated lysis, Cancer Res., 73, 2418, 10.1158/0008-5472.CAN-12-2432
Kanzawa, 2004, Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells, Cell Death Differ., 11, 448, 10.1038/sj.cdd.4401359
Li, 2008, Autophagy protects LNCaP cells under androgen deprivation conditions, Autophagy, 4, 54, 10.4161/auto.5209
Hashimoto, 2014, Autophagy is needed for the growth of pancreatic adenocarcinoma and has a cytoprotective effect against anticancer drugs, Eur. J. Cancer, 50, 1382, 10.1016/j.ejca.2014.01.011
Donadelli, 2011, Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism, Cell Death Dis., 2, e152, 10.1038/cddis.2011.36
Yang, 2015, Blockade of autophagy reduces pancreatic cancer stem cell activity and potentiates the tumoricidal effect of gemcitabine, Mol. Cancer, 14, 179, 10.1186/s12943-015-0449-3
Yang, 2014, Autophagy is critical for pancreatic tumor growth and progression in tumors with p53 alterations, Cancer Discov., 4, 905, 10.1158/2159-8290.CD-14-0362
Yang, 2011, Pancreatic cancers require autophagy for tumor growth, Genes Dev., 25, 717, 10.1101/gad.2016111
Wang, 2017, Lovastatin upregulates microRNA-29b to reduce oxidative stress in rats with multiple cardiovascular risk factors, Oncotarget, 8, 9021, 10.18632/oncotarget.14462
Fu, 2015, Lentivirus-mediated Bos taurus bta-miR-29b overexpression interferes with bovine viral diarrhoea virus replication and viral infection-related autophagy by directly targeting ATG14 and ATG9A in Madin-Darby bovine kidney cells, J. Gen. Virol., 96, 85, 10.1099/vir.0.067140-0
Song, 2018, MiR-29 family members interact with SPARC to regulate glucose metabolism, Biochem. Biophys. Res. Commun., 497, 667, 10.1016/j.bbrc.2018.02.129
Pullen, 2011, miR-29a and miR-29b contribute to pancreatic beta-cell-specific silencing of monocarboxylate transporter 1 (Mct1), Mol. Cell. Biol., 31, 3182, 10.1128/MCB.01433-10
Mersey, 2005, Human microRNA (miR29b) expression controls the amount of branched chain alpha-ketoacid dehydrogenase complex in a cell, Hum. Mol. Genet., 14, 3371, 10.1093/hmg/ddi368
Teng, 2015, MicroRNA-29B (mir-29b) regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3, Oncotarget, 6, 40799, 10.18632/oncotarget.5695
Vander Heiden, 2009, Understanding the Warburg effect: the metabolic requirements of cell proliferation, Science, 324, 1029, 10.1126/science.1160809
Young, 2008, Activated Akt1 accelerates MMTV-c-ErbB2 mammary tumourigenesis in mice without activation of ErbB3, Breast Cancer Res., 10, R70, 10.1186/bcr2132
Ru, 2016, Feedback Loop Regulation of SCAP/SREBP-1 by miR-29 Modulates EGFR Signaling-Driven Glioblastoma Growth, Cell Rep., 16, 1527, 10.1016/j.celrep.2016.07.017
Eberlé, 2004, SREBP transcription factors: master regulators of lipid homeostasis, Biochimie, 86, 839, 10.1016/j.biochi.2004.09.018
Cheng, 2015, Glucose-Mediated N-glycosylation of SCAP Is Essential for SREBP-1 Activation and Tumor Growth, Cancer Cell, 28, 569, 10.1016/j.ccell.2015.09.021
Muluhngwi, 2017, The miR-29 transcriptome in endocrine-sensitive and resistant breast cancer cells, Sci. Rep., 7, 5205, 10.1038/s41598-017-05727-w
Golias, 2004, Cell proliferation and cell cycle control: a mini review, Int. J. Clin. Pract., 58, 1134, 10.1111/j.1742-1241.2004.00284.x
McDonald, 2001, Checkpoint genes in cancer, Ann. Med., 33, 113, 10.3109/07853890109002066
Cole, 2010, Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss, Cancer Res., 70, 8149, 10.1158/0008-5472.CAN-10-0315
Rivadeneira, 2010, Proliferative suppression by CDK4/6 inhibition: complex function of the retinoblastoma pathway in liver tissue and hepatoma cells, Gastroenterology, 138, 1920, 10.1053/j.gastro.2010.01.007
Sherr, 2016, Targeting CDK4 and CDK6: From Discovery to Therapy, Cancer Discov., 6, 353, 10.1158/2159-8290.CD-15-0894
Zhao, 2010, microRNA expression profile and identification of miR-29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma, Blood, 115, 2630, 10.1182/blood-2009-09-243147
Garzon, 2009, MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1, Blood, 113, 6411, 10.1182/blood-2008-07-170589
Ma, 2011, The microRNA miR-29 controls innate and adaptive immune responses to intracellular bacterial infection by targeting interferon-γ, Nat. Immunol., 12, 861, 10.1038/ni.2073
Kortylewski, 2004, Interferon-gamma-mediated growth regulation of melanoma cells: involvement of STAT1-dependent and STAT1-independent signals, J. Invest. Dermatol., 122, 414, 10.1046/j.0022-202X.2004.22237.x
Schmitt, 2012, Interferon-γ-induced activation of Signal Transducer and Activator of Transcription 1 (STAT1) up-regulates the tumor suppressing microRNA-29 family in melanoma cells, Cell Commun. Signal., 10, 41, 10.1186/1478-811X-10-41
Mazzoccoli, 2018, MiR-29 silencing modulates the expression of target genes related to proliferation, apoptosis and methylation in Burkitt lymphoma cells, J. Cancer Res. Clin. Oncol., 144, 483, 10.1007/s00432-017-2575-3
Baldwin, 2008, Kinase requirements in human cells: II. Genetic interaction screens identify kinase requirements following HPV16 E7 expression in cancer cells, Proc. Natl. Acad. Sci. USA, 105, 16478, 10.1073/pnas.0806195105
Li, 2011, Progressive miRNA expression profiles in cervical carcinogenesis and identification of HPV-related target genes for miR-29, J. Pathol., 224, 484, 10.1002/path.2873
Ma, 2018, MicroRNA-29a inhibits proliferation and motility of schwannoma cells by targeting CDK6, J. Cell. Biochem., 119, 2617, 10.1002/jcb.26426
Chen, 2017, circRNA_100290 plays a role in oral cancer by functioning as a sponge of the miR-29 family, Oncogene, 36, 4551, 10.1038/onc.2017.89
Arias-Romero, 2013, Targeting Cdc42 in cancer, Expert Opin. Ther. Targets, 17, 1263, 10.1517/14728222.2013.828037
Cerione, 2004, Cdc42: new roads to travel, Trends Cell Biol., 14, 127, 10.1016/j.tcb.2004.01.008
Nishikawa, 2015, Tumour-suppressive microRNA-29s directly regulate LOXL2 expression and inhibit cancer cell migration and invasion in renal cell carcinoma, FEBS Lett., 589, 2136, 10.1016/j.febslet.2015.06.005
Cristiano, 2006, A specific role for AKT3 in the genesis of ovarian cancer through modulation of G(2)-M phase transition, Cancer Res., 66, 11718, 10.1158/0008-5472.CAN-06-1968
Wei, 2013, miR-29 targets Akt3 to reduce proliferation and facilitate differentiation of myoblasts in skeletal muscle development, Cell Death Dis., 4, e668, 10.1038/cddis.2013.184
Francy, 2007, Sphingosine kinase 1 expression is regulated by signaling through PI3K, AKT2, and mTOR in human coronary artery smooth muscle cells, Biochim. Biophys. Acta, 1769, 253, 10.1016/j.bbaexp.2007.03.005
Li, 2004, Akt2, phosphatidylinositol 3-kinase, and PTEN are in lipid rafts of intestinal cells: role in absorption and differentiation, Gastroenterology, 126, 122, 10.1053/j.gastro.2003.10.061
Liu, 1998, AKT2, a member of the protein kinase B family, is activated by growth factors, v-Ha-ras, and v-src through phosphatidylinositol 3-kinase in human ovarian epithelial cancer cells, Cancer Res., 58, 2973
Wang, 2007, Pharmacologic inhibition of CDK4/6: mechanistic evidence for selective activity or acquired resistance in acute myeloid leukemia, Blood, 110, 2075, 10.1182/blood-2007-02-071266
Decker, 2002, Cell cycle progression of chronic lymphocytic leukemia cells is controlled by cyclin D2, cyclin D3, cyclin-dependent kinase (cdk) 4 and the cdk inhibitor p27, Leukemia, 16, 327, 10.1038/sj.leu.2402389
Gong, 2014, The role, mechanism and potentially therapeutic application of microRNA-29 family in acute myeloid leukemia, Cell Death Differ., 21, 100, 10.1038/cdd.2013.133
Logan, 2005, E2F-8: an E2F family member with a similar organization of DNA-binding domains to E2F-7, Oncogene, 24, 5000, 10.1038/sj.onc.1208703
Di Stefano, 2003, E2F7, a novel E2F featuring DP-independent repression of a subset of E2F-regulated genes, EMBO J., 22, 6289, 10.1093/emboj/cdg613
Li, 2012, Downregulation of microRNAs miR-1, -206 and -29 stabilizes PAX3 and CCND2 expression in rhabdomyosarcoma, Lab. Invest., 92, 571, 10.1038/labinvest.2012.10
Liu, 2015, FOXM1 overexpression is associated with cisplatin resistance in non-small cell lung cancer and mediates sensitivity to cisplatin in A549 cells via the JNK/mitochondrial pathway, Neoplasma, 62, 61, 10.4149/neo_2015_008
Lima, 2011, MicroRNA regulation of core apoptosis pathways in cancer, Eur. J. Cancer, 47, 163, 10.1016/j.ejca.2010.11.005
Wong, 2011, Apoptosis in cancer: from pathogenesis to treatment, J. Exp. Clin. Cancer Res., 30, 87, 10.1186/1756-9966-30-87
Indran, 2011, Recent advances in apoptosis, mitochondria and drug resistance in cancer cells, Biochim. Biophys. Acta, 1807, 735, 10.1016/j.bbabio.2011.03.010
Pileczki, 2016, MicroRNAs as regulators of apoptosis mechanisms in cancer, Clujul Med., 89, 50
Calin, 2008, MiR-15a and miR-16-1 cluster functions in human leukemia, Proc. Natl. Acad. Sci. USA, 105, 5166, 10.1073/pnas.0800121105
Warr, 2008, Unique biology of Mcl-1: therapeutic opportunities in cancer, Curr. Mol. Med., 8, 138, 10.2174/156652408783769580
Yagi, 2003, Identification of a gene expression signature associated with pediatric AML prognosis, Blood, 102, 1849, 10.1182/blood-2003-02-0578
Kaufmann, 1998, Elevated expression of the apoptotic regulator Mcl-1 at the time of leukemic relapse, Blood, 91, 991, 10.1182/blood.V91.3.991
Garzon, 2009, MicroRNA 29b functions in acute myeloid leukemia, Blood, 114, 5331, 10.1182/blood-2009-03-211938
Muniyappa, 2009, MiRNA-29a regulates the expression of numerous proteins and reduces the invasiveness and proliferation of human carcinoma cell lines, Eur. J. Cancer, 45, 3104, 10.1016/j.ejca.2009.09.014
Yu, 2003, PUMA mediates the apoptotic response to p53 in colorectal cancer cells, Proc. Natl. Acad. Sci. USA, 100, 1931, 10.1073/pnas.2627984100
Ouyang, 2013, Astrocyte-enriched miR-29a targets PUMA and reduces neuronal vulnerability to forebrain ischemia, Glia, 61, 1784, 10.1002/glia.22556
Kim, 2009, Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis, Mol. Cell, 36, 487, 10.1016/j.molcel.2009.09.030
Spender, 2013, Transforming growth factor-β directly induces p53-up-regulated modulator of apoptosis (PUMA) during the rapid induction of apoptosis in myc-driven B-cell lymphomas, J. Biol. Chem., 288, 5198, 10.1074/jbc.M112.410274
Wang, 2016, Targeting miR-29 induces apoptosis of osteosarcoma MG-63 cells via regulation of TGF-β1/PUMA signal, Eur. Rev. Med. Pharmacol. Sci., 20, 3552
Wong, 2016, Up-regulation of histone methyltransferase SETDB1 by multiple mechanisms in hepatocellular carcinoma promotes cancer metastasis, Hepatology, 63, 474, 10.1002/hep.28304
Heerboth, 2015, EMT and tumor metastasis, Clin. Transl. Med., 4, 6, 10.1186/s40169-015-0048-3
Chaffer, 2011, A perspective on cancer cell metastasis, Science, 331, 1559, 10.1126/science.1203543
Gong, 2014, Characterization of microRNA-29 family expression and investigation of their mechanistic roles in gastric cancer, Carcinogenesis, 35, 497, 10.1093/carcin/bgt337
Gravdal, 2007, A switch from E-cadherin to N-cadherin expression indicates epithelial to mesenchymal transition and is of strong and independent importance for the progress of prostate cancer, Clin. Cancer Res., 13, 7003, 10.1158/1078-0432.CCR-07-1263
Anastasiadis, 2007, p120-ctn: A nexus for contextual signaling via Rho GTPases, Biochim. Biophys. Acta, 1773, 34, 10.1016/j.bbamcr.2006.08.040
Wang, 2015, Chemotherapy-Induced miRNA-29c/Catenin-δ Signaling Suppresses Metastasis in Gastric Cancer, Cancer Res., 75, 1332, 10.1158/0008-5472.CAN-14-0787
Luo, 2017, [Effects of recombinant adenovirus Ad-miR-29b2c on HGC-27 cell proliferation and migration], Sheng Wu Gong Cheng Xue Bao, 33, 1136
Tan, 2013, Suppression of Wnt signaling by the miR-29 family is mediated by demethylation of WIF-1 in non-small-cell lung cancer, Biochem. Biophys. Res. Commun., 438, 673, 10.1016/j.bbrc.2013.07.123
Drago-Ferrante, 2017, Suppressive role exerted by microRNA-29b-1-5p in triple negative breast cancer through SPIN1 regulation, Oncotarget, 8, 28939, 10.18632/oncotarget.15960
To, 2017, β-catenin downregulates Dicer to promote ovarian cancer metastasis, Oncogene, 36, 5927, 10.1038/onc.2017.185
Bähr, 2005, The IGF-1 receptor and its contributions to metastatic tumor growth-novel approaches to the inhibition of IGF-1R function, Growth Factors, 23, 1, 10.1080/08977190400020229
Wang, 2017, miR-29a-3p suppresses cell proliferation and migration by downregulating IGF1R in hepatocellular carcinoma, Oncotarget, 8, 86592, 10.18632/oncotarget.21246
Lu, 2015, MiR-29c inhibits cell growth, invasion, and migration of pancreatic cancer by targeting ITGB1, OncoTargets Ther., 9, 99
Blandin, 2015, β1 Integrins as Therapeutic Targets to Disrupt Hallmarks of Cancer, Front. Pharmacol., 6, 279, 10.3389/fphar.2015.00279
Schwartz, 1995, Integrins: emerging paradigms of signal transduction, Annu. Rev. Cell Dev. Biol., 11, 549, 10.1146/annurev.cb.11.110195.003001
Wong, 2014, Lysyl oxidase-like 2 is critical to tumor microenvironment and metastatic niche formation in hepatocellular carcinoma, Hepatology, 60, 1645, 10.1002/hep.27320
Zhong, 2018, Recent opportunities in matrix metalloproteinase inhibitor drug design for cancer, Expert Opin. Drug Discov., 13, 75, 10.1080/17460441.2018.1398732
Zou, 2015, miR-29c suppresses pancreatic cancer liver metastasis in an orthotopic implantation model in nude mice and affects survival in pancreatic cancer patients, Carcinogenesis, 36, 676, 10.1093/carcin/bgv027
Fang, 2011, MicroRNA-29b suppresses tumor angiogenesis, invasion, and metastasis by regulating matrix metalloproteinase 2 expression, Hepatology, 54, 1729, 10.1002/hep.24577
Kwon, 2016, Novel role of miR-29a in pancreatic cancer autophagy and its therapeutic potential, Oncotarget, 7, 71635, 10.18632/oncotarget.11928
Tréhoux, 2015, Micro-RNAs miR-29a and miR-330-5p function as tumor suppressors by targeting the MUC1 mucin in pancreatic cancer cells, Biochim. Biophys. Acta, 1853, 2392, 10.1016/j.bbamcr.2015.05.033
Hollingsworth, 2004, Mucins in cancer: protection and control of the cell surface, Nat. Rev. Cancer, 4, 45, 10.1038/nrc1251
Jonckheere, 2008, The membrane-bound mucins: how large O-glycoproteins play key roles in epithelial cancers and hold promise as biological tools for gene-based and immunotherapies, Crit. Rev. Oncog., 14, 177, 10.1615/CritRevOncog.v14.i2-3.30
Roy, 2011, MUC1 enhances invasiveness of pancreatic cancer cells by inducing epithelial to mesenchymal transition, Oncogene, 30, 1449, 10.1038/onc.2010.526
Takaku, 2016, GATA3-dependent cellular reprogramming requires activation-domain dependent recruitment of a chromatin remodeler, Genome Biol., 17, 36, 10.1186/s13059-016-0897-0
Chou, 2013, GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression, Nat. Cell Biol., 15, 201, 10.1038/ncb2672
Sun, 2015, MicroRNA-29a Promotes Pancreatic Cancer Growth by Inhibiting Tristetraprolin, Cell. Physiol. Biochem., 37, 707, 10.1159/000430389
Rostas, 2014, microRNA-29 negatively regulates EMT regulator N-myc interactor in breast cancer, Mol. Cancer, 13, 200, 10.1186/1476-4598-13-200
Cochrane, 2012, Progestin regulated miRNAs that mediate progesterone receptor action in breast cancer, Mol. Cell. Endocrinol., 355, 15, 10.1016/j.mce.2011.12.020
Bussard, 2016, Tumor-associated stromal cells as key contributors to the tumor microenvironment, Breast Cancer Res., 18, 84, 10.1186/s13058-016-0740-2
Rhim, 2014, Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma, Cancer Cell, 25, 735, 10.1016/j.ccr.2014.04.021
Özdemir, 2014, Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival, Cancer Cell, 25, 719, 10.1016/j.ccr.2014.04.005
Levental, 2009, Matrix crosslinking forces tumor progression by enhancing integrin signaling, Cell, 139, 891, 10.1016/j.cell.2009.10.027
He, 2012, The potential of microRNAs in liver fibrosis, Cell. Signal., 24, 2268, 10.1016/j.cellsig.2012.07.023
Wang, 2012, Suppression of microRNA-29 expression by TGF-β1 promotes collagen expression and renal fibrosis, J. Am. Soc. Nephrol., 23, 252, 10.1681/ASN.2011010055
Harmanci, 2017, Role of the microRNA-29 family in fibrotic skin diseases, Biomed. Rep., 6, 599, 10.3892/br.2017.900
Bonnans, 2014, Remodelling the extracellular matrix in development and disease, Nat. Rev. Mol. Cell Biol., 15, 786, 10.1038/nrm3904
Zhu, 2015, Chaperone Hsp47 Drives Malignant Growth and Invasion by Modulating an ECM Gene Network, Cancer Res., 75, 1580, 10.1158/0008-5472.CAN-14-1027
Yano, 2018, Regulation of type I collagen expression by microRNA-29 following ionizing radiation, Radiat. Environ. Biophys., 57, 41, 10.1007/s00411-017-0723-4
Lourdusamy, 2015, microRNA network analysis identifies miR-29 cluster as key regulator of LAMA2 in ependymoma, Acta Neuropathol. Commun., 3, 26, 10.1186/s40478-015-0206-2
Zhu, 2015, Integrated miRNA-mRNA analysis of Epstein-Barr virus-positive nasopharyngeal carcinoma, Genet. Mol. Res., 14, 6028, 10.4238/2015.June.1.20
Wang, 2015, Integrated regulatory mechanisms of miRNAs and targeted genes involved in colorectal cancer, Int. J. Clin. Exp. Pathol., 8, 517
Yu, 2014, Downregulation of miR-29 contributes to cisplatin resistance of ovarian cancer cells, Int. J. Cancer, 134, 542, 10.1002/ijc.28399
Heid, 2017, Age-dependent increase of oxidative stress regulates microRNA-29 family preserving cardiac health, Sci. Rep., 7, 16839, 10.1038/s41598-017-16829-w
Kota, 2017, Pancreatic cancer: Stroma and its current and emerging targeted therapies, Cancer Lett., 391, 38, 10.1016/j.canlet.2016.12.035
Apte, 2012, Dangerous liaisons: pancreatic stellate cells and pancreatic cancer cells, J. Gastroenterol. Hepatol., 27, 69, 10.1111/j.1440-1746.2011.07000.x
Xuan, 2017, MiR-29a and miR-652 Attenuate Liver Fibrosis by Inhibiting the Differentiation of CD4+ T Cells, Cell Struct. Funct., 42, 95, 10.1247/csf.17005
Parangi, 1996, Antiangiogenic therapy of transgenic mice impairs de novo tumor growth, Proc. Natl. Acad. Sci. USA, 93, 2002, 10.1073/pnas.93.5.2002
Holmgren, 1995, Dormancy of micrometastases: balanced proliferation and apoptosis in the presence of angiogenesis suppression, Nat. Med., 1, 149, 10.1038/nm0295-149
Folkman, 1971, Tumor angiogenesis: therapeutic implications, N. Engl. J. Med., 285, 1182, 10.1056/NEJM197111182852108
Rajabi, 2017, The Role of Angiogenesis in Cancer Treatment, Biomedicines, 5, E34, 10.3390/biomedicines5020034
Yang, 2013, MiR-29a modulates the angiogenic properties of human endothelial cells, Biochem. Biophys. Res. Commun., 434, 143, 10.1016/j.bbrc.2013.03.054
Shepard, 1989, A tripartite interaction among alleles of Notch, Delta, and Enhancer of split during imaginal development of Drosophila melanogaster, Genetics, 122, 429, 10.1093/genetics/122.2.429
Simons, 2016, Mechanisms and regulation of endothelial VEGF receptor signalling, Nat. Rev. Mol. Cell Biol., 17, 611, 10.1038/nrm.2016.87
Carmeliet, 2005, VEGF as a key mediator of angiogenesis in cancer, Oncology, 69, 4, 10.1159/000088478
Li, 2017, MiRNA-29b suppresses tumor growth through simultaneously inhibiting angiogenesis and tumorigenesis by targeting Akt3, Cancer Lett., 397, 111, 10.1016/j.canlet.2017.03.032
Chen, 2017, MicroRNA-29b Inhibits Angiogenesis by Targeting VEGFA through the MAPK/ERK and PI3K/Akt Signaling Pathways in Endometrial Carcinoma, Cell. Physiol. Biochem., 41, 933, 10.1159/000460510
Xu, 2017, Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression, Nat. Commun., 8, 14399, 10.1038/ncomms14399
Zhang, 2016, TNFSF15 suppresses VEGF production in endothelial cells by stimulating miR-29b expression via activation of JNK-GATA3 signals, Oncotarget, 7, 69436, 10.18632/oncotarget.11683
Chen, 2014, miR-29a suppresses growth and invasion of gastric cancer cells in vitro by targeting VEGF-A, BMB Rep., 47, 39, 10.5483/BMBRep.2014.47.1.079
Szczyrba, 2013, Identification of ZNF217, hnRNP-K, VEGF-A and IPO7 as targets for microRNAs that are downregulated in prostate carcinoma, Int. J. Cancer, 132, 775, 10.1002/ijc.27731
Gao, 2016, IGF1 3'UTR functions as a ceRNA in promoting angiogenesis by sponging miR-29 family in osteosarcoma, J. Mol. Histol., 47, 135, 10.1007/s10735-016-9659-2
Hiroki, 2010, Changes in microRNA expression levels correlate with clinicopathological features and prognoses in endometrial serous adenocarcinomas, Cancer Sci., 101, 241, 10.1111/j.1349-7006.2009.01385.x
Frattari, 2017, The role of miR-29a in HIV-1 replication and latency, J. Virus Erad., 3, 185, 10.1016/S2055-6640(20)30322-8
Picarda, 2016, Molecular Pathways: Targeting B7-H3 (CD276) for Human Cancer Immunotherapy, Clin. Cancer Res., 22, 3425, 10.1158/1078-0432.CCR-15-2428
Xu, 2009, MicroRNA miR-29 modulates expression of immunoinhibitory molecule B7-H3: potential implications for immune based therapy of human solid tumors, Cancer Res., 69, 6275, 10.1158/0008-5472.CAN-08-4517
Amicarella, 2017, Dual role of tumour-infiltrating T helper 17 cells in human colorectal cancer, Gut, 66, 692, 10.1136/gutjnl-2015-310016
Lund, 2004, Recognition of single-stranded RNA viruses by Toll-like receptor 7, Proc. Natl. Acad. Sci. USA, 101, 5598, 10.1073/pnas.0400937101
Heil, 2004, Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8, Science, 303, 1526, 10.1126/science.1093620
Fabbri, 2012, MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response, Proc. Natl. Acad. Sci. USA, 109, E2110, 10.1073/pnas.1209414109
Steiner, 2011, MicroRNA-29 regulates T-box transcription factors and interferon-γ production in helper T cells, Immunity, 35, 169, 10.1016/j.immuni.2011.07.009
van der Woude, 2017, Migrating into the Tumor: a Roadmap for T Cells, Trends Cancer, 3, 797, 10.1016/j.trecan.2017.09.006
Yanaihara, 2006, Unique microRNA molecular profiles in lung cancer diagnosis and prognosis, Cancer Cell, 9, 189, 10.1016/j.ccr.2006.01.025
Landi, 2010, MicroRNA expression differentiates histology and predicts survival of lung cancer, Clin. Cancer Res., 16, 430, 10.1158/1078-0432.CCR-09-1736
Wu, 2015, c-Myc suppresses microRNA-29b to promote tumor aggressiveness and poor outcomes in non-small cell lung cancer by targeting FHIT, Oncogene, 34, 2072, 10.1038/onc.2014.152
Zhang, 2017, MicroRNA-related genetic variants in iron regulatory genes, dietary iron intake, microRNAs and lung cancer risk, Ann. Oncol., 28, 1124, 10.1093/annonc/mdx046
Joerger, 2014, Circulating microRNA profiling in patients with advanced non-squamous NSCLC receiving bevacizumab/erlotinib followed by platinum-based chemotherapy at progression (SAKK 19/05), Lung Cancer, 85, 306, 10.1016/j.lungcan.2014.04.014
Butrym, 2016, Clinical response to azacitidine therapy depends on microRNA-29c (miR-29c) expression in older acute myeloid leukemia (AML) patients, Oncotarget, 7, 30250, 10.18632/oncotarget.7172
Zhu, 2013, Prognostic value of miR-29a expression in pediatric acute myeloid leukemia, Clin. Biochem., 46, 49, 10.1016/j.clinbiochem.2012.09.002
Xu, 2014, Altered expression pattern of miR-29a, miR-29b and the target genes in myeloid leukemia, Exp. Hematol. Oncol., 3, 17, 10.1186/2162-3619-3-17
Wang, 2015, Hsa-miR-21 and Hsa-miR-29 in Tissue as Potential Diagnostic and Prognostic Biomarkers for Gastric Cancer, Cell. Physiol. Biochem., 37, 1454, 10.1159/000438514
Nguyen, 2011, Downregulation of microRNA-29c is associated with hypermethylation of tumor-related genes and disease outcome in cutaneous melanoma, Epigenetics, 6, 388, 10.4161/epi.6.3.14056
Wu, 2015, Identification and Evaluation of Serum MicroRNA-29 Family for Glioma Screening, Mol. Neurobiol., 52, 1540, 10.1007/s12035-014-8937-9
van Rooij, 2012, Developing microRNA therapeutics, Circ. Res., 110, 496, 10.1161/CIRCRESAHA.111.247916
Chakraborty, 2017, Therapeutic miRNA and siRNA: Moving from Bench to Clinic as Next Generation Medicine, Mol. Ther. Nucleic Acids, 8, 132, 10.1016/j.omtn.2017.06.005
Slabáková, 2017, Alternative mechanisms of miR-34a regulation in cancer, Cell Death Dis., 8, e3100, 10.1038/cddis.2017.495
Robbins, 2008, Misinterpreting the therapeutic effects of small interfering RNA caused by immune stimulation, Hum. Gene Ther., 19, 991, 10.1089/hum.2008.131
Adams, 2018, Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis, N. Engl. J. Med., 379, 11, 10.1056/NEJMoa1716153
Wang, 2015, Recent progress in microRNA delivery for cancer therapy by non-viral synthetic vectors, Adv. Drug Deliv. Rev., 81, 142, 10.1016/j.addr.2014.10.031
Riley, 2017, Recent Advances in Nanomaterials for Gene Delivery-A Review, Nanomaterials (Basel), 7, E94, 10.3390/nano7050094
Herrera-Carrillo, 2017, Improving miRNA Delivery by Optimizing miRNA Expression Cassettes in Diverse Virus Vectors, Hum. Gene Ther. Methods, 28, 177, 10.1089/hgtb.2017.036
Duhachek-Muggy, 2015, ADAM12-L is a direct target of the miR-29 and miR-200 families in breast cancer, BMC Cancer, 15, 93, 10.1186/s12885-015-1108-1
Cittelly, 2013, Progestin suppression of miR-29 potentiates dedifferentiation of breast cancer cells via KLF4, Oncogene, 32, 2555, 10.1038/onc.2012.275
Ben-David, 2018, Genetic and transcriptional evolution alters cancer cell line drug response, Nature, 560, 325, 10.1038/s41586-018-0409-3
Dagogo-Jack, 2018, Tumour heterogeneity and resistance to cancer therapies, Nat. Rev. Clin. Oncol., 15, 81, 10.1038/nrclinonc.2017.166
Flynt, 2008, Biological principles of microRNA-mediated regulation: shared themes amid diversity, Nat. Rev. Genet., 9, 831, 10.1038/nrg2455
Bartel, 2004, Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs, Nat. Rev. Genet., 5, 396, 10.1038/nrg1328
Brenner, 2010, Loss of individual microRNAs causes mutant phenotypes in sensitized genetic backgrounds in C. elegans, Curr. Biol., 20, 1321, 10.1016/j.cub.2010.05.062
Erhard, 2014, Widespread context dependency of microRNA-mediated regulation, Genome Res., 24, 906, 10.1101/gr.166702.113
Zhang, 2012, Coordinated silencing of MYC-mediated miR-29 by HDAC3 and EZH2 as a therapeutic target of histone modification in aggressive B-Cell lymphomas, Cancer Cell, 22, 506, 10.1016/j.ccr.2012.09.003
Mott, 2010, Transcriptional suppression of mir-29b-1/mir-29a promoter by c-Myc, hedgehog, and NF-kappaB, J. Cell. Biochem., 110, 1155, 10.1002/jcb.22630
Teng, 2014, Id-1, a protein repressed by miR-29b, facilitates the TGFβ1-induced epithelial-mesenchymal transition in human ovarian cancer cells, Cell. Physiol. Biochem., 33, 717, 10.1159/000358647
Bakkar, 2008, IKK/NF-kappaB regulates skeletal myogenesis via a signaling switch to inhibit differentiation and promote mitochondrial biogenesis, J. Cell Biol., 180, 787, 10.1083/jcb.200707179
Caretti, 2004, The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation, Genes Dev., 18, 2627, 10.1101/gad.1241904
Wang, 2008, NF-kappaB-YY1-miR-29 regulatory circuitry in skeletal myogenesis and rhabdomyosarcoma, Cancer Cell, 14, 369, 10.1016/j.ccr.2008.10.006
Kouros-Mehr, 2006, GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland, Cell, 127, 1041, 10.1016/j.cell.2006.09.048
Kouros-Mehr, 2008, GATA-3 links tumor differentiation and dissemination in a luminal breast cancer model, Cancer Cell, 13, 141, 10.1016/j.ccr.2008.01.011
Jacquemier, 2009, Association of GATA3, P53, Ki67 status and vascular peritumoral invasion are strongly prognostic in luminal breast cancer, Breast Cancer Res., 11, R23, 10.1186/bcr2249
Usary, 2004, Mutation of GATA3 in human breast tumors, Oncogene, 23, 7669, 10.1038/sj.onc.1207966
Plaisier, 2012, A miRNA-regulatory network explains how dysregulated miRNAs perturb oncogenic processes across diverse cancers, Genome Res., 22, 2302, 10.1101/gr.133991.111
Park, 2009, miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42, Nat. Struct. Mol. Biol., 16, 23, 10.1038/nsmb.1533