Smart chemistry-based nanosized drug delivery systems for systemic applications: A comprehensive review

Gu, 2016, Biomaterials and emerging anticancer therapeutics: engineering the microenvironment, Nat. Rev. Cancer, 16, 56, 10.1038/nrc.2015.3 Hida, 2016, Heterogeneity of tumor endothelial cells and drug delivery, Adv. Drug Deliv. Rev., 99, 140, 10.1016/j.addr.2015.11.008 Rahoui, 2017, Spatio-temporal control strategy of drug delivery systems based nano structures, J. Control. Release, 255, 176, 10.1016/j.jconrel.2017.04.003 Brannon-Peppas, 2012, Nanoparticle and targeted systems for cancer therapy, Adv. Drug Deliv. Rev., 64, 206, 10.1016/j.addr.2012.09.033 Liu, 2016, The smart drug delivery system and its clinical potential, Theranostics, 6, 1306, 10.7150/thno.14858 Hu, 2016, Recent advances of cocktail chemotherapy by combination drug delivery systems, Adv. Drug Deliv. Rev., 98, 19, 10.1016/j.addr.2015.10.022 Ganta, 2008, A review of stimuli-responsive nanocarriers for drug and gene delivery, J. Control. Release, 126, 187, 10.1016/j.jconrel.2007.12.017 Ramasamy, 2012, Development of solid lipid nanoparticles enriched hydrogels for topical delivery of anti-fungal agent, Macromol. Res., 20, 682, 10.1007/s13233-012-0107-1 Kanamala, 2016, Mechanisms and biomaterials in pH-responsive tumour targeted drug delivery: a review, Biomaterials, 85, 152, 10.1016/j.biomaterials.2016.01.061 Shi, 2017, Cancer nanomedicine: progress, challenges and opportunities, Nat. Rev. Cancer, 17, 20, 10.1038/nrc.2016.108 Gaber, 2017, Protein-lipid nanohybrids as emerging platforms for drug and gene delivery: challenges and outcomes, J. Control. Release, 254, 75, 10.1016/j.jconrel.2017.03.392 Blanco, 2015, Principles of nanoparticle design for overcoming biological barriers to drug delivery, Nat. Biotechnol., 33, 941, 10.1038/nbt.3330 Kim, 2013, Cross-linked polymeric micelles based on block ionomer complexes, Mendeleev Commun., 23, 179, 10.1016/j.mencom.2013.07.001 Ramasamy, 2014, Layer-by-layer assembly of liposomal nanoparticles with PEGylated polyelectrolytes enhances systemic delivery of multiple anticancer drugs, Acta Biomater., 10, 5116, 10.1016/j.actbio.2014.08.021 Choi, 2015, Systemic delivery of axitinib with nanohybrid liposomal nanoparticles inhibits hypoxic tumor growth, J. Mater. Chem. B, 3, 408, 10.1039/C4TB01442A Pérez-Herrero, 2015, Advanced targeted therapies in cancer: drug nanocarriers, the future of chemotherapy, Eur. J. Pharm. Biopharm., 93, 52, 10.1016/j.ejpb.2015.03.018 Yang, 2016, Stimuli responsive drug delivery systems based on nano-graphene for cancer therapy, Adv. Drug Deliv. Rev., 105, 228, 10.1016/j.addr.2016.05.015 Meng, 2009, Reduction-sensitive polymers and bioconjugates for biomedical applications, Biomaterials, 30, 2180, 10.1016/j.biomaterials.2009.01.026 Sheikhpour, 2017, Biomimetics in drug delivery systems: A critical review, J. Control. Release, 253, 97, 10.1016/j.jconrel.2017.03.026 Cheng, 2011, Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery, J. Control. Release, 152, 2, 10.1016/j.jconrel.2011.01.030 Tapeinos, 2016, Physical, chemical, and biological structures based on ROS-sensitive moieties that are able to respond to oxidative microenvironments, Adv. Mater., 28, 5553, 10.1002/adma.201505376 Dissanayake, 2017, Recent developments in anticancer drug delivery using cell penetrating and tumor targetingpeptides, J. Control. Release, 250, 62, 10.1016/j.jconrel.2017.02.006 Arnold, 2017, Engineered polymeric nanoparticles to guide the cellular internalization and trafficking of small interfering ribonucleic acids, J. Control. Release, 10.1016/j.jconrel.2017.02.019 Biswas, 2014, Nanopreparations for organelle-specific delivery in cancer, Adv. Drug Deliv. Rev., 66, 26, 10.1016/j.addr.2013.11.004 Wang, 2016, Stimuli-responsive programmed specific targeting in nanomedicine, ACS Nano, 10, 2991, 10.1021/acsnano.6b00870 Liu, 2016, cRGD-Modified benzimidazole-based pH-responsive nanoparticles for enhanced tumor targeted doxorubicin delivery, ACS Appl. Mater. Interfaces, 8, 10726, 10.1021/acsami.6b01501 Choi, 2016, PEGylated lipid bilayer-supported mesoporous silica nanoparticle composite for synergistic co-delivery of axitinib and celastrol in multi-targeted cancer therapy, Acta Biomater., 39, 94, 10.1016/j.actbio.2016.05.012 Tran, 2016, Combined phototherapy in anti-cancer treatment: therapeutics design and perspectives, J. Pharm. Investig., 46, 505, 10.1007/s40005-016-0272-x Liotta, 1990, The role of cellular proteases and their inhibitors in invasion and metastasis. Introductionary overview, Cancer Metastasis Rev., 9, 285, 10.1007/BF00049519 Chambers, 1997, Changing views of the role of matrix metalloproteinases in metastasis, J. Natl. Cancer Inst., 89, 1260, 10.1093/jnci/89.17.1260 He, 2016, Enzyme-triggered, cell penetrating peptide-mediated delivery of anti-tumor agents, J. Control. Release, 240, 67, 10.1016/j.jconrel.2015.10.040 Ramasamy, 2014, Layer-by-layer coated lipid-polymer hybrid nanoparticles designed for use in anticancer drug delivery, Carbohydr. Polym., 102, 653, 10.1016/j.carbpol.2013.11.009 Kim, 2014, The influence of bile salt on the chemotherapeutic response of decetaxel-loaded thermosensitive nanomicelles, Int. J. Nanomedicine, 9, 3815, 10.2147/IJN.S64794 Perez, 2014, pH and glutathion-responsive hydrogel for localized delivery of paclitaxel, Colloids Surf. B: Biointerfaces, 116, 247, 10.1016/j.colsurfb.2014.01.004 Zhao, 2015, Dual-stimuli responsive hyaluronic acid-conjugated mesoporous silica for targeted delivery to CD44-overexpressing cancer cells, Acta Biomater., 23, 147, 10.1016/j.actbio.2015.05.010 Lee, 2016, A mesoporous nanocontainer gated by a stimuli-responsive peptide for selective triggering of intracellular drug release, Nano, 8, 8070 Aluri, 2009, Environmentally responsive peptides as anticancer drug carriers, Adv. Drug Deliv. Rev., 61, 940, 10.1016/j.addr.2009.07.002 Blum, 2015, Stimuli-responsive nanomaterials for biomedical applications, J. Am. Chem. Soc., 137, 2140, 10.1021/ja510147n Brudno, 2015, On-demand drug delivery from local depots, J. Control. Release, 219, 8, 10.1016/j.jconrel.2015.09.011 Evans, 2016, Biocomputing nanoplatforms as therapeutics and diagnostics, J. Control. Release, 240, 387, 10.1016/j.jconrel.2016.01.045 Bildstein, 2011, Prodrug-based intracellular delivery of anticancer agents, Adv. Drug Deliv. Rev., 63, 3, 10.1016/j.addr.2010.12.005 Meng, 2009, Stimuli-responsive polymersomes for programmed drug delivery, Biomacromolecules, 10, 197, 10.1021/bm801127d Fuks, 2011, Biohybrid block copolymers: towards functional micelles and vesicles, Chem. Soc. Rev., 40, 2475, 10.1039/c0cs00085j Wang, 2010, Core-shell-corona micelle stabilized by reversible cross-linkage for intracellular drug delivery, Macromol. Rapid Commun., 31, 1201, 10.1002/marc.200900863 Han, 2015, Bioreducible shell-cross-linked hyaluronic acid nanoparticles for tumor-targeted drug delivery, Biomacromolecules, 16, 447, 10.1021/bm5017755 Zhang, 2016, Folic acid-targeted disulfide-based cross-linking micelle for enhanced drug encapsulation stability and site-specific drug delivery against tumors, Int. J. Nanomedicine, 11, 1119 Kakizawa, 1999, Environment-sensitive stabilization of core−shell structured polyion complex micelle by reversible cross-linking of the core through disulfide bond, J. Am. Chem. Soc., 121, 11247, 10.1021/ja993057y Matsumoto, 2009, Environment-responsive block copolymer micelles with a disulfide cross-linked core for enhanced siRNA delivery, Biomacromolecules, 10, 119, 10.1021/bm800985e Li, 2009, Reversibly stabilized multifunctional dextran nanoparticles efficiently deliver doxorubicin into the nuclei of cancer cells, Angew. Chem. Int. Ed., 48, 9914, 10.1002/anie.200904260 Zhong, 2013, Ligand-Directed Reduction-Sensitive Shell-Sheddable Biodegradable Micelles Actively Deliver Doxorubicin into the Nuclei of Target Cancer Cells, Biomacromolecules, 14, 3723, 10.1021/bm401098w Sun, 2008, Formation of reversible shell cross-linked micelles from the biodegradable amphiphilic diblock copolymer poly (l-cysteine)-block-poly (l-lactide), Langmuir, 24, 10099, 10.1021/la8013877 Du, 2005, pH-Responsive vesicles based on a hydrolytically self-cross-linkable copolymer, J. Am. Chem. Soc., 127, 12800, 10.1021/ja054755n Jiang, 2009, Degradable thermoresponsive core cross-linked micelles: fabrication, surface functionalization, and biorecognition, Langmuir, 25, 13344, 10.1021/la9034276 Chang, 2009, Temperature and pH double responsive hybrid cross-linked micelles based on P (NIPAAm-co-MPMA)-b-P (DEA): RAFT synthesis and “schizophrenic” micellization, Macromolecules, 42, 4838, 10.1021/ma900492v Dai, 2011, Interlayer-crosslinked micelle with partially hydrated core showing reduction and pH dual sensitivity for pinpointed intracellular drug release, Angew. Chem. Int. Ed., 50, 9404, 10.1002/anie.201103806 Talelli, 2010, Targeted core-crosslinked polymeric micelles with controlled release of covalently entrapped doxorubicin, J. Control. Release, 148, e121, 10.1016/j.jconrel.2010.07.092 Babin, 2008, “Decoration” of shell cross-linked reverse polymer micelles using ATRP: a new route to stimuli-responsive nanoparticles, Macromolecules, 41, 1246, 10.1021/ma702422y Xu, 2011, Reversible imine shell cross-linked micelles from aqueous RAFT-synthesized thermoresponsive triblock copolymers as potential nanocarriers for “pH-triggered” drug release, Macromolecules, 44, 1327, 10.1021/ma102804h Jung, 2007, pH-Sensitive polymer nanospheres for use as a potential drug delivery vehicle, Biomacromolecules, 8, 3401, 10.1021/bm700517z Sethuraman, 2006, pH-Responsive sulfonamide/PEI system for tumor specific gene delivery: an in vitro study, Biomacromolecules, 7, 64, 10.1021/bm0503571 Sagnella, 2013, Dextran-based doxorubicin nanocarriers with improved tumor penetration, Biomacromolecules, 15, 262, 10.1021/bm401526d Shi, 2008, Photo-cross-linking and cleavage induced reversible size change of bio-based nanoparticles, Macromolecules, 41, 8167, 10.1021/ma800648e Fomina, 2010, UV and near-IR triggered release from polymeric nanoparticles, J. Am. Chem. Soc., 132, 9540, 10.1021/ja102595j Boyer, 2009, The stabilization and bio-functionalization of iron oxide nanoparticles using heterotelechelic polymers, J. Mater. Chem., 19, 111, 10.1039/B815202K Lee, 2010, Pluronic/polyethylenimine shell crosslinked nanocapsules with embedded magnetite nanocrystals for magnetically triggered delivery of siRNA, Macromol. Biosci., 10, 239, 10.1002/mabi.200900291 Wen, 2011, Controlled protein delivery based on enzyme-responsive nanocapsules, Adv. Mater., 23, 4549, 10.1002/adma.201101771 Meyer, 2009, Synthesis and biological evaluation of a bioresponsive and endosomolytic siRNA−polymer conjugate, Mol. Pharm., 6, 752, 10.1021/mp9000124 Novoa-Carballal, 2012, Synthesis of polysaccharide-b-PEG block copolymers by oxime click, Chem. Commun., 48, 3781, 10.1039/c2cc30726j Min, 2010, Tumoral acidic pH-responsive MPEG-poly (β-amino ester) polymeric micelles for cancer targeting therapy, J. Control. Release, 144, 259, 10.1016/j.jconrel.2010.02.024 Wang, 2013, Redox-responsive, core-cross-linked micelles capable of on-demand, concurrent drug release and structure disassembly, Biomacromolecules, 14, 3706, 10.1021/bm401086d Desai, 2015, Versatile click alginate hydrogels crosslinked via tetrazine–norbornene chemistry, Biomaterials, 50, 30, 10.1016/j.biomaterials.2015.01.048 Iha, 2009, Applications of orthogonal “click” chemistries in the synthesis of functional soft materials, Chem. Rev., 109, 5620, 10.1021/cr900138t Kolb, 2003, The growing impact of click chemistry on drug discovery, Drug Discov. Today, 8, 1128, 10.1016/S1359-6446(03)02933-7 Srinivasachari, 2008, Polycationic β-cyclodextrin “click clusters”: monodisperse and versatile scaffolds for nucleic acid delivery, J. Am. Chem. Soc., 130, 4618, 10.1021/ja074597v Méndez-Ardoy, 2009, Preorganized macromolecular gene delivery systems: amphiphilic β-cyclodextrin “click clusters”, Org. Biomol. Chem., 7, 2681, 10.1039/b903635k Gou, 2010, Synthesis, self-assembly, and drug-loading capacity of well-defined cyclodextrin-centered drug-conjugated amphiphilic A14B7 miktoarm star copolymers based on poly (ε-caprolactone) and poly (ethylene glycol), Biomacromolecules, 11, 934, 10.1021/bm901371p Cooper, 2009, Polyester-graft-phosphorylcholine prepared by ring-opening polymerization and click chemistry, Chem. Commun., 815, 10.1039/B817600K Parrish, 2005, PEG- and peptide-grafted aliphatic polyesters by click chemistry, J. Am. Chem. Soc., 127, 7404, 10.1021/ja050310n Yu, 2012, Well-defined degradable brush polymer–drug conjugates for sustained delivery of paclitaxel, Mol. Pharm., 10, 867, 10.1021/mp3004868 Denis, 2015, Histone deacetylase inhibitor-polymer conjugate nanoparticles for acid-responsive drug delivery, Eur. J. Med. Chem., 95, 369, 10.1016/j.ejmech.2015.03.037 Zhang, 2014, Dendrimer–doxorubicin conjugate as enzyme-sensitive and polymeric nanoscale drug delivery vehicle for ovarian cancer therapy, Polym. Chem., 5, 5227, 10.1039/C4PY00601A Wang, 2014, A biomimic pH-sensitive polymeric prodrug based on polycarbonate for intracellular drug delivery, Polym. Chem., 5, 854, 10.1039/C3PY00861D Boehnke, 2015, Imine hydrogels with tunable degradability for tissue engineering, Biomacromolecules, 16, 2101, 10.1021/acs.biomac.5b00519 Banerjee, 2010, Chemoselective attachment of small molecule effector functionality to human adenoviruses facilitates gene delivery to cancer cells, J. Am. Chem. Soc., 132, 13615, 10.1021/ja104547x Oh, 2014, Synthetic aptamer-polymer hybrid constructs for programmed drug delivery into specific target cells, J. Am. Chem. Soc., 136, 15010, 10.1021/ja5079464 Kamphuis, 2010, Targeting of cancer cells using click-functionalized polymer capsules, J. Am. Chem. Soc., 132, 15881, 10.1021/ja106405c Wang, 2009, Fast alkene functionalization in vivo by photoclick chemistry: HOMO lifting of nitrile imine dipoles, Angew. Chem., 121, 5434, 10.1002/ange.200901220 Song, 2008, A photoinducible 1, 3-dipolar cycloaddition reaction for rapid, selective modification of tetrazole-containing proteins, Angew. Chem., 120, 2874, 10.1002/ange.200705805 Laughlin, 2008, In vivo imaging of membrane-associated glycans in developing zebrafish, Science, 320, 664, 10.1126/science.1155106 Poloukhtine, 2009, Selective labeling of living cells by a photo-triggered click reaction, J. Am. Chem. Soc., 131, 15769, 10.1021/ja9054096 Shelbourne, 2011, Fast copper-free click DNA ligation by the ring-strain promoted alkyne-azide cycloaddition reaction, Chem. Commun., 47, 6257, 10.1039/c1cc10743g Baskin, 2007, Copper-free click chemistry for dynamic in vivo imaging, Proc. Natl. Acad. Sci., 104, 16793, 10.1073/pnas.0707090104 Dommerholt, 2010, Readily accessible bicyclononynes for bioorthogonal labeling and three-dimensional imaging of living cells, Angew. Chem. Int. Ed., 49, 9422, 10.1002/anie.201003761 Kramer, 2012, Preparation of multifunctional and multireactive polypeptides via methionine alkylation, Biomacromolecules, 13, 1719, 10.1021/bm300807b Schmitz, 2015, Side-chain cysteine-functionalized poly (2-oxazoline) s for multiple peptide conjugation by native chemical ligation, Biomacromolecules, 16, 1088, 10.1021/bm501697t Devaraj, 2009, Fast and sensitive pretargeted labeling of cancer cells through a tetrazine/trans-cyclooctene cycloaddition, Angew. Chem. Int. Ed., 48, 7013, 10.1002/anie.200903233 Devaraj, 2008, Tetrazine-based cycloadditions: application to pretargeted live cell imaging, Bioconjug. Chem., 19, 2297, 10.1021/bc8004446 Devaraj, 2012, Reactive polymer enables efficient in vivo bioorthogonal chemistry, Proc. Natl. Acad. Sci., 109, 4762, 10.1073/pnas.1113466109 Peterson, 2012, Orthogonal amplification of nanoparticles for improved diagnostic sensing, ACS Nano, 6, 3506, 10.1021/nn300536y Rossin, 2010, In vivo chemistry for pretargeted tumor imaging in live mice, Angew. Chem. Int. Ed., 49, 3375, 10.1002/anie.200906294 Pauloehrl, 2012, Adding spatial control to click chemistry: phototriggered Diels–Alder surface (bio) functionalization at ambient temperature, Angew. Chem. Int. Ed., 51, 1071, 10.1002/anie.201107095 Hoyle, 2010, Thiol-click chemistry: a multifaceted toolbox for small molecule and polymer synthesis, Chem. Soc. Rev., 39, 1355, 10.1039/b901979k Stolz, 2013, Experimental and theoretical studies of selective thiol–ene and thiol–yne click reactions involving N-substituted maleimides, J. Org. Chem., 78, 8105, 10.1021/jo4014436 Darling, 2016, Controlling the kinetics of thiol-maleimide Michael-type addition gelation kinetics for the generation of homogenous poly (ethylene glycol) hydrogels, Biomaterials, 101, 199, 10.1016/j.biomaterials.2016.05.053 Kim, 2010, Direct synthesis of polymer nanocapsules: self-assembly of polymer hollow spheres through irreversible covalent bond formation, J. Am. Chem. Soc., 132, 9908, 10.1021/ja1039242 Kakwere, 2009, Orthogonal “relay” reactions for designing functionalized soft nanoparticles, J. Am. Chem. Soc., 131, 1889, 10.1021/ja8075499 Huynh, 2011, Thiol–yne and thiol–ene “click” chemistry as a tool for a variety of platinum drug delivery carriers, from statistical copolymers to crosslinked micelles, Biomacromolecules, 12, 1738, 10.1021/bm200135e Zou, 2014, Poly (ethylene oxide)-block-polyphosphoester-graft-paclitaxel conjugates with acid-labile linkages as a pH-sensitive and functional nanoscopic platform for paclitaxel delivery, Adv. Healthc. Mater, 3, 441, 10.1002/adhm.201300235 Zou, 2011, Clicking well-defined biodegradable nanoparticles and nanocapsules by UV-induced thiol-ene cross-linking in transparent miniemulsions, Adv. Mater., 23, 4274, 10.1002/adma.201101646 Chen, 2014, Biodegradable cationic polymeric nanocapsules for overcoming multidrug resistance and enabling drug–gene co-delivery to cancer cells, Nanoscale, 6, 1567, 10.1039/C3NR04804G Griebenow, 2016, Site-specific conjugation of peptides and proteins via rebridging of disulfide bonds using the thiol–yne coupling reaction, Bioconjug. Chem., 27, 911, 10.1021/acs.bioconjchem.5b00682 Hu, 2016, Surface functionalization of hydrogel by thiol-yne click chemistry for drug delivery, Colloids Surf. A Physicochem. Eng. Asp., 489, 297, 10.1016/j.colsurfa.2015.11.007 Li, 2016, Double-shelled polymer nanocontainers decorated with poly (ethylene glycol) brushes by combined distillation precipitation polymerization and thiol–yne surface chemistry, Macromolecules, 49, 1127, 10.1021/acs.macromol.5b02406 Adzima, 2011, Spatial and temporal control of the alkyne–azide cycloaddition by photoinitiated Cu (II) reduction, Nat. Chem., 3, 256, 10.1038/nchem.980 Zhang, 2012, Facile synthesis of clickable, water-soluble, and degradable polyphosphoesters, ACS Macro Lett., 1, 328, 10.1021/mz200226m Luque-Alcaraz, 2016, Preparation of chitosan nanoparticles by nanoprecipitation and their ability as a drug nanocarrier, RSC Adv., 6, 59250, 10.1039/C6RA06563E Cheng, 2007, Formulation of functionalized PLGA–PEG nanoparticles for in vivo targeted drug delivery, Biomaterials, 28, 869, 10.1016/j.biomaterials.2006.09.047 Tong, 2012, Drug-initiated, controlled ring-opening polymerization for the synthesis of polymer–drug conjugates, Macromolecules, 45, 2225, 10.1021/ma202581d Tong, 2008, Paclitaxel-initiated, controlled polymerization of lactide for the formulation of polymeric nanoparticulate delivery vehicles, Angew. Chem., 120, 4908, 10.1002/ange.200800491 Tong, 2009, Ring-opening polymerization-mediated controlled formulation of polylactide−drug nanoparticles, J. Am. Chem. Soc., 131, 4744, 10.1021/ja8084675 Tong, 2009, Nanopolymeric therapeutics, MRS Bull., 34, 422, 10.1557/mrs2009.118 Tong, 2007, Anticancer polymeric nanomedicines, J. Macromol. Sci. Polym. Rev., 47, 345 Yin, 2013, Drug-initiated ring-opening polymerization of O-carboxyanhydrides for the preparation of anticancer drug–poly (O-carboxyanhydride) nanoconjugates, Biomacromolecules, 14, 920, 10.1021/bm301999c Tran, 2015, Hyaluronic acid-coated solid lipid nanoparticles for targeted delivery of vorinostat to CD44 overexpressing cancer cells, Carbohydr. Polym., 114, 407, 10.1016/j.carbpol.2014.08.026 Ramasamy, 2015, Novel core–shell nanocapsules for the tunable delivery of bioactive rhEGF: formulation, characterization and cytocompatibility studies, J. Biomater. Tissue Eng., 5, 730, 10.1166/jbt.2015.1385 Tran, 2014, Development of vorinostat-loaded solid lipid nanoparticles to enhance pharmacokinetics and efficacy against multidrug-resistant cancer cells, Pharm. Res., 31, 1978, 10.1007/s11095-014-1300-z Tran, 2015, Tumor-targeting, pH-sensitive nanoparticles for docetaxel delivery to drug-resistant cancer cells, Int. J. Nanomedicine, 10, 5249 Ruttala, 2017, Layer-by-layer assembly of hierarchical nanoarchitectures to enhance the systemic performance of nanoparticle albumin-bound paclitaxel, Int. J. Pharm., 519, 11, 10.1016/j.ijpharm.2017.01.011 Ruttala, 2017, Molecularly targeted co-delivery of a histone deacetylase inhibitor and paclitaxel by lipid-protein hybrid nanoparticles for synergistic combinational chemotherapy, Oncotarget, 8, 14925, 10.18632/oncotarget.14742 Gupta, 2017, Development of bioactive PEGylated nanostructured platforms for sequential delivery of doxorubicin and imatinib to overcome drug resistance in metastatic tumors, ACS Appl. Mater. Interfaces, 9, 9280, 10.1021/acsami.6b09163 Ramasamy, 2014, pH sensitive polyelectrolyte complex micelles for highly effective combination chemotherapy, J. Mater. Chem. B, 2, 6324, 10.1039/C4TB00867G Ramasamy, 2015, Engineering of a lipid-polymer nanoarchitectural platform for highly effective combination therapy of doxorubicin and irinotecan, Chem. Commun., 51, 5758, 10.1039/C5CC00482A Shen, 2015, Antibody-drug conjugates: a historical review, 3 Kakinoki, 2008, Synthesis of poly (vinyl alcohol)-doxorubicin conjugates containing cis-aconityl acid-cleavable bond and its isomer dependent doxorubicin release, Biol. Pharm. Bull., 31, 103, 10.1248/bpb.31.103 Ma, 2016, pH-Sensitive polymeric micelles formed by doxorubicin conjugated prodrugs for co-delivery of doxorubicin and paclitaxel, Carbohydr. Polym., 137, 19, 10.1016/j.carbpol.2015.10.050 Li, 2016, A pH-sensitive prodrug micelle self-assembled from multi-doxorubicin-tailed polyethylene glycol for cancer therapy, RSC Adv., 6, 9160, 10.1039/C5RA27293A Xu, 2015, Small, 11, 4321, 10.1002/smll.201501034 Wang, 2016, Redox and pH responsive nano-vesicles of PEGylated hyperbranched poly (amidoamine)-doxorubicin conjugate for the improvement of cancer therapy, J. Nanosci. Nanotechnol., 16, 7530, 10.1166/jnn.2016.12385 Deng, 2015, A strategy for oral chemotherapy via dual pH-sensitive polyelectrolyte complex nanoparticles to achieve gastric survivability, intestinal permeability, hemodynamic stability and intracellular activity, Eur. J. Pharm. Biopharm., 97, 107, 10.1016/j.ejpb.2015.10.010 Battogtokh, 2016, Graphene oxide-incorporated pH-responsive folate-albumin-photosensitizer nanocomplex as image-guided dual therapeutics, J. Control. Release, 234, 10, 10.1016/j.jconrel.2016.05.007 Battogtokh, 2015, Active-targeted pH-responsive albumin–photosensitizer conjugate nanoparticles as theranostic agents, J. Mater. Chem. B, 3, 9349, 10.1039/C5TB01719J Meyer, 2008, Breathing life into polycations: functionalization with pH-responsive endosomolytic peptides and polyethylene glycol enables siRNA delivery, J. Am. Chem. Soc., 130, 3272, 10.1021/ja710344v Du, 2010, A tumor-acidity-activated charge-conversional nanogel as an intelligent vehicle for promoted tumoral-cell uptake and drug delivery, Angew. Chem. Int. Ed., 49, 3621, 10.1002/anie.200907210 Du, 2011, Tailor-made dual pH-sensitive polymer–doxorubicin nanoparticles for efficient anticancer drug delivery, J. Am. Chem. Soc., 133, 17560, 10.1021/ja207150n Siddique, 2015, pH-Sensitive drug-conjugates on water-soluble polymer frameworks, Macromol. Chem. Phys., 216, 265, 10.1002/macp.201400457 Liang, 2015, Preparation of pH sensitive pluronic-docetaxel conjugate micelles to balance the stability and controlled release issues, Materials, 8, 379, 10.3390/ma8020379 Wang, 2015, pH-Sensitive controlled release of doxorubicin from polyelectrolyte multilayers, Colloids Surf. B: Biointerfaces, 125, 127, 10.1016/j.colsurfb.2014.11.017 Zhu, 2015, pH-Sensitive hydroxyethyl starch–doxorubicin conjugates as antitumor prodrugs with enhanced anticancer efficacy, J. Appl. Polym. Sci., 132, 10.1002/app.42778 Ulbrich, 2003, HPMA copolymers with pH-controlled release of doxorubicin: in vitro cytotoxicity and in vivo antitumor activity, J. Control. Release, 87, 33, 10.1016/S0168-3659(02)00348-6 Wei, 2016, Enzyme- and pH-sensitive branched polymer–doxorubicin conjugate-based nanoscale drug delivery system for cancer therapy, ACS Appl. Mater. Interfaces, 8, 11765, 10.1021/acsami.6b02006 Bae, 2003, Design of environment-sensitive supramolecular assemblies for intracellular drug delivery: polymeric micelles that are responsive to intracellular pH change, Angew. Chem., 115, 4788, 10.1002/ange.200250653 Su, 2016, Polymeric complex micelles based on the double-hydrazone linkage and dual drug-loading strategy for pH-sensitive docetaxel delivery, J. Mater. Chem. B, 4, 1122, 10.1039/C5TB02188J Jin, 2015, A peptide-based pH-sensitive drug delivery system for targeted ablation of cancer cells, Chem. Commun., 51, 14454, 10.1039/C5CC05184C Ulbrich, 2004, Polymeric anticancer drugs with pH-controlled activation, Adv. Drug Deliv. Rev., 56, 1023, 10.1016/j.addr.2003.10.040 Aryal, 2009, Polymer−cisplatin conjugate nanoparticles for acid-responsive drug delivery, ACS Nano, 4, 251, 10.1021/nn9014032 Yin, 2016, A pH-sensitive hyaluronic acid prodrug modified with lactoferrin for glioma dual-targeted treatment, Mater. Sci. Eng. C, 67, 159, 10.1016/j.msec.2016.05.012 Li, 2015, A pH-sensitive and biodegradable supramolecular hydrogel constructed from a PEGylated polyphosphoester-doxorubicin prodrug and α-cyclodextrin, Polym. Chem., 6, 5009, 10.1039/C5PY00620A Chen, 2011, Synthesis and properties of star-comb polymers and their doxorubicin conjugates, Bioconjug. Chem., 22, 617, 10.1021/bc100400u Folmer-Andersen, 2011, Thermoresponsive dynamers: thermally induced, reversible chain elongation of amphiphilic poly (acylhydrazones), J. Am. Chem. Soc., 133, 10966, 10.1021/ja2035909 Ding, 2015, An efficient PEGylated liposomal nanocarrier containing cell-penetrating peptide and pH-sensitive hydrazone bond for enhancing tumor-targeted drug delivery, Int. J. Nanomedicine, 10, 6199 Collins, 2016, The emergence of oxime click chemistry and its utility in polymer science, Polym. Chem., 7, 3812, 10.1039/C6PY00635C Jin, 2011, Oxime linkage: a robust tool for the design of pH-sensitive polymeric drug carriers, Biomacromolecules, 12, 3460, 10.1021/bm200956u Hsiao, 2015, Hexanoyl-chitosan-PEG copolymer coated iron oxide nanoparticles for hydrophobic drug delivery, ACS Macro Lett., 4, 403, 10.1021/acsmacrolett.5b00091 Xu, 2015, Versatile preparation of intracellular-acidity-sensitive oxime-linked polysaccharide-doxorubicin conjugate for malignancy therapeutic, Biomaterials, 54, 72, 10.1016/j.biomaterials.2015.03.021 Zhang, 2016, Co-delivery of doxorubicin and curcumin by pH-sensitive prodrug nanoparticle for combination therapy of cancer, Sci. Report., 6 Manchun, 2015, Enhanced anti-tumor effect of pH-responsive dextrin nanogels delivering doxorubicin on colorectal cancer, Carbohydr. Polym., 126, 222, 10.1016/j.carbpol.2015.03.018 Knorr, 2008, Acetal linked oligoethylenimines for use as pH-sensitive gene carriers, Bioconjug. Chem., 19, 1625, 10.1021/bc8001858 Kwon, 2005, In vivo targeting of dendritic cells for activation of cellular immunity using vaccine carriers based on pH-responsive microparticles, Proc. Natl. Acad. Sci. U. S. A., 102, 18264, 10.1073/pnas.0509541102 Heller, 2002, Poly (ortho esters): synthesis, characterization, properties and uses, Adv. Drug Deliv. Rev., 54, 1015, 10.1016/S0169-409X(02)00055-8 Gillies, 2004, Acetals as pH-sensitive linkages for drug delivery, Bioconjug. Chem., 15, 1254, 10.1021/bc049853x Gillies, 2003, A new approach towards acid sensitive copolymer micelles for drug delivery, Chem. Commun., 1640, 10.1039/B304251K Pohlit, 2015, Biodegradable pH-sensitive poly (ethylene glycol) nanocarriers for allergen encapsulation and controlled release, Biomacromolecules, 16, 3103, 10.1021/acs.biomac.5b00458 Lin, 2015, pH-Sensitive polymeric nanoparticles with gold (I) compound payloads synergistically induce cancer cell death through modulation of autophagy, Mol. Pharm., 12, 2869, 10.1021/acs.molpharmaceut.5b00060 Almutairi, 2008, Biodegradable pH-sensing dendritic nanoprobes for near-infrared fluorescence lifetime and intensity imaging, J. Am. Chem. Soc., 130, 444, 10.1021/ja078147e Sy, 2008, Sustained release of a p38 inhibitor from non-inflammatory microspheres inhibits cardiac dysfunction, Nat. Mater., 7, 863, 10.1038/nmat2299 Khaja, 2007, Acid-degradable protein delivery vehicles based on metathesis chemistry, Biomacromolecules, 8, 1391, 10.1021/bm061234z Griset, 2009, Expansile nanoparticles: synthesis, characterization, and in vivo efficacy of an acid-responsive polymeric drug delivery system, J. Am. Chem. Soc., 131, 2469, 10.1021/ja807416t Chan, 2008, Acid-labile core cross-linked micelles for pH-triggered release of antitumor drugs, Biomacromolecules, 9, 1826, 10.1021/bm800043n Yi, 2016, Preparation of pH and redox dual-sensitive core crosslinked micelles for overcoming drug resistance of DOX, Polym. Chem., 7, 1719, 10.1039/C5PY01783A Tang, 2015, Influence of 2-(diisopropylamino) ethyl methacrylate on acid-triggered hydrolysis of cyclic benzylidene acetals and their importance in efficient drug delivery, Polym. Chem., 6, 6671, 10.1039/C5PY00734H Shim, 2010, Acid-transforming polypeptide micelles for targeted nonviral gene delivery, Biomaterials, 31, 3404, 10.1016/j.biomaterials.2010.01.019 Palao-Suay, 2016, Self-assembling polymer systems for advanced treatment of cancer and inflammation, Prog. Polym. Sci., 53, 207, 10.1016/j.progpolymsci.2015.07.005 Liu, 2010, pH-Responsive nanogated ensemble based on gold-capped mesoporous silica through an acid-labile acetal linker, J. Am. Chem. Soc., 132, 1500, 10.1021/ja907838s Chen, 2015, In vitro and in vivo evaluation of PEG-conjugated ketal-based chitosan micelles as pH-sensitive carriers, Polym. Chem., 6, 998, 10.1039/C4PY01639D Chen, 2016, In vivo evaluation of novel ketal-based oligosaccharides of hyaluronan micelles as multifunctional CD44 receptor-targeting and tumor pH-responsive carriers, Artif. Cells Nanomedicine Biotechnol., 44, 898 Li, 2015, A folate modified pH sensitive targeted polymeric micelle alleviated systemic toxicity of doxorubicin (DOX) in multi-drug resistant tumor bearing mice, Eur. J. Pharm. Sci., 76, 95, 10.1016/j.ejps.2015.04.018 Wang, 2016, pH-Sensitive poly (histidine methacrylamide), Langmuir, 32, 6544, 10.1021/acs.langmuir.6b01465 Zhou, 2015, Herceptin conjugated PLGA-PHis-PEG pH sensitive nanoparticles for targeted and controlled drug delivery, Int. J. Pharm., 487, 81, 10.1016/j.ijpharm.2015.03.081 Lee, 2005, Super pH-sensitive multifunctional polymeric micelle, Nano Lett., 5, 325, 10.1021/nl0479987 Li, 2015, pH-Sensitive nanoparticles of poly (l-histidine)–poly (lactide-co-glycolide)–tocopheryl polyethylene glycol succinate for anti-tumor drug delivery, Acta Biomater., 11, 137, 10.1016/j.actbio.2014.09.014 Zhang, 2016, Poly (l-histidine) based copolymers: effect of the chemically substituted l-histidine on the physio-chemical properties of the micelles and in vivo biodistribution, Colloids Surf. B: Biointerfaces, 140, 176, 10.1016/j.colsurfb.2015.12.032 Sun, 2015, Synthesis and characterization of pH-sensitive poly (itaconic acid)–poly (ethylene glycol)–folate–poly (l-histidine) micelles for enhancing tumor therapy and tunable drug release, J. Colloid Interface Sci., 458, 119, 10.1016/j.jcis.2015.07.008 Zhang, 2016, Self-assembly of pH-responsive dextran-g-poly (lactide-co-glycolide)-g-histidine copolymer micelles for intracellular delivery of paclitaxel and its antitumor activity, RSC Adv., 6, 23693, 10.1039/C5RA22463B Bilalis, 2016, pH-Sensitive nanogates based on poly (l-histidine) for controlled drug release from mesoporous silica nanoparticles, Polym. Chem., 7, 1475, 10.1039/C5PY01841B Du, 2009, Controlled-access hollow mechanized silica nanocontainers, J. Am. Chem. Soc., 131, 15136, 10.1021/ja904982j Xue, 2011, pH-Operated mechanized porous silicon nanoparticles, J. Am. Chem. Soc., 133, 8798, 10.1021/ja201252e Wei, 2016, Well-defined labile diselenide-centered poly (ε-caprolactone)-based micelles for activated intracellular drug release, J. Mater. Chem. B, 4, 5059, 10.1039/C6TB01040G Cheng, 2015, Bioresponsive polymeric nanotherapeutics for targeted cancer chemotherapy, Nano Today, 10, 656, 10.1016/j.nantod.2015.09.005 Zheng, 2015, Redox-responsive, reversibly-crosslinked thiolated cationic helical polypeptides for efficient siRNA encapsulation and delivery, J. Control. Release, 205, 231, 10.1016/j.jconrel.2015.02.014 Li, 2015, Biological evaluation of redox-sensitive micelles based on hyaluronic acid-deoxycholic acid conjugates for tumor-specific delivery of paclitaxel, Int. J. Pharm., 483, 38, 10.1016/j.ijpharm.2015.02.002 Zhang, 2016, Disulfide-linked amphiphilic polymer-docetaxel conjugates assembled redox-sensitive micelles for efficient antitumor drug delivery, Biomacromolecules, 17, 1621, 10.1021/acs.biomac.5b01758 Thambi, 2011, Bioreducible block copolymers based on poly (ethylene glycol) and poly (γ-benzyl l-glutamate) for intracellular delivery of camptothecin, Bioconjug. Chem., 22, 1924, 10.1021/bc2000963 Yang, 2014, New amphiphilic glycopolypeptide conjugate capable of self-assembly in water into reduction-sensitive micelles for triggered drug release, Mater. Sci. Eng. C, 41, 36, 10.1016/j.msec.2014.04.015 Ren, 2011, Sheddable micelles based on disulfide-linked hybrid PEG-polypeptide copolymer for intracellular drug delivery, Polymer, 52, 3580, 10.1016/j.polymer.2011.06.013 Ding, 2013, Biocompatible reduction-responsive polypeptide micelles as nanocarriers for enhanced chemotherapy efficacy in vitro, J. Mater. Chem. B, 1, 69, 10.1039/C2TB00063F Zhu, 2016, cRGD-Functionalized reduction-sensitive shell-sheddable biodegradable micelles mediate enhanced doxorubicin delivery to human glioma xenografts in vivo, J. Control. Release, 233, 29, 10.1016/j.jconrel.2016.05.014 Cui, 2015, Reduction-sensitive micelles with sheddable PEG shells self-assembled from a Y-shaped amphiphilic polymer for intracellular doxorubicine release, Colloids Surf. B: Biointerfaces, 129, 137, 10.1016/j.colsurfb.2015.03.040 Sun, 2010, Disassemblable micelles based on reduction-degradable amphiphilic graft copolymers for intracellular delivery of doxorubicin, Biomaterials, 31, 7124, 10.1016/j.biomaterials.2010.06.011 Huo, 2016, Redox-sensitive micelles based on O, N-hydroxyethyl chitosan–octylamine conjugates for triggered intracellular delivery of paclitaxel, Mol. Pharm., 13, 1750, 10.1021/acs.molpharmaceut.5b00696 Yue, 2012, Reduction-responsive shell-crosslinked micelles prepared from Y-shaped amphiphilic block copolymers as a drug carrier, Soft Matter, 8, 7426, 10.1039/c2sm25456e Lv, 2014, Crosslinked triblock copolymeric micelle for redox-responsive drug delivery, Colloids Surf. B: Biointerfaces, 122, 223, 10.1016/j.colsurfb.2014.06.068 Cui, 2013, Cellular uptake, intracellular trafficking, and antitumor efficacy of doxorubicin-loaded reduction-sensitive micelles, Biomaterials, 34, 3858, 10.1016/j.biomaterials.2013.01.101 Moyuan, 2012, A convenient scheme for synthesizing reduction-sensitive chitosan-based amphiphilic copolymers for drug delivery, J. Appl. Polym. Sci., 123, 3137, 10.1002/app.34968 Cui, 2013, Poly (l-aspartamide)-based reduction-sensitive micelles as nanocarriers to improve doxorubicin content in cell nuclei and to enhance antitumor activity, Macromol. Biosci., 13, 1036, 10.1002/mabi.201300031 Khorsand, 2013, Intracellular drug delivery nanocarriers of glutathione-responsive degradable block copolymers having pendant disulfide linkages, Biomacromolecules, 14, 2103, 10.1021/bm4004805 Hu, 2015, Selective redox-responsive drug release in tumor cells mediated by chitosan based glycolipid-like nanocarrier, J. Control. Release, 206, 91, 10.1016/j.jconrel.2015.03.018 Hou, 2016, A novel redox-sensitive system based on single-walled carbon nanotubes for chemo-photothermal therapy and magnetic resonance imaging, Int. J. Nanomedicine, 11, 607 Zhang, 2016, Redox-sensitive micelles assembled from amphiphilic mPEG-PCL-SS-DTX conjugates for the delivery of docetaxel, Colloids Surf. B: Biointerfaces, 142, 89, 10.1016/j.colsurfb.2016.02.045 Yin, 2015, Intracellular delivery and antitumor effects of a redox-responsive polymeric paclitaxel conjugate based on hyaluronic acid, Acta Biomater., 26, 274, 10.1016/j.actbio.2015.08.029 Yin, 2015, Well-defined redox-sensitive polyethene glycol–paclitaxel prodrug conjugate for tumor-specific delivery of paclitaxel using octreotide for tumor targeting, Mol. Pharm., 12, 3020, 10.1021/acs.molpharmaceut.5b00280 Dong, 2015, Disulfide-bridged cleavable PEGylation in polymeric nanomedicine for controlled therapeutic delivery, Nanomedicine, 10, 1941, 10.2217/nnm.15.38 Zhang, 2015, Core-crosslinked polymeric micelles with high doxorubicin loading capacity and intracellular pH- and redox-triggered payload release, Eur. Polym. J., 68, 104, 10.1016/j.eurpolymj.2015.04.033 Xu, 2014, Preparation of a camptothecin prodrug with glutathione-responsive disulfide linker for anticancer drug delivery, Chem. Asian. J., 9, 199, 10.1002/asia.201301030 Cao, 2016, Polymeric prodrugs conjugated with reduction-sensitive dextran–camptothecin and pH-responsive dextran–doxorubicin: an effective combinatorial drug delivery platform for cancer therapy, Polym. Chem., 7, 4198, 10.1039/C6PY00701E Bauhuber, 2009, Delivery of nucleic acids via disulfide-based carrier systems, Adv. Mater., 21, 3286, 10.1002/adma.200802453 Samanta, 2016, 3, 6-Di (pyridin-2-yl)-1, 2, 4, 5-tetrazine (pytz) mediated metal-free mild oxidation of thiols to disulfides in aqueous medium, RSC Adv., 6, 39356, 10.1039/C6RA01509C Zheng, 2011, Lipoic acid modified low molecular weight polyethylenimine mediates nontoxic and highly potent in vitro gene transfection, Mol. Pharm., 8, 2434, 10.1021/mp2003797 Zhang, 2013, Disulfide crosslinked PEGylated starch micelles as efficient intracellular drug delivery platforms, Soft Matter, 9, 2224, 10.1039/c2sm27189c Xu, 2009, Reduction-sensitive reversibly crosslinked biodegradable micelles for triggered release of doxorubicin, Macromol. Biosci., 9, 1254, 10.1002/mabi.200900233 Chen, 2013, Bioreducible polypeptide containing cell-penetrating sequence for efficient gene delivery, Pharm. Res., 30, 1968, 10.1007/s11095-013-1040-5 Lei, 2014, Fabrication of novel reduction-sensitive gene vectors based on three-armed peptides, Macromol. Biosci., 14, 546, 10.1002/mabi.201300422 Wang, 2012, Redox-sensitive shell cross-linked PEG–polypeptide hybrid micelles for controlled drug release, Polym. Chem., 3, 1084, 10.1039/c2py00600f Kim, 2010, Reduction-sensitive self-aggregates as a novel delivery system, Macromol. Chem. Phys., 211, 956, 10.1002/macp.200900671 Cao, 2015, Selenium/tellurium containing polymer materials in nanobiotechnology, Nano Today, 10, 717, 10.1016/j.nantod.2015.11.004 Cai, 2016, Diselenide-labeled cyclic polystyrene with multiple responses: facile synthesis, tunable size, and topology, Macromol. Rapid Commun., 37, 865, 10.1002/marc.201600082 Huo, 2014, Redox-responsive polymers for drug delivery: from molecular design to applications, Polym. Chem., 5, 1519, 10.1039/C3PY01192E Ma, 2009, Dual redox responsive assemblies formed from diselenide block copolymers, J. Am. Chem. Soc., 132, 442, 10.1021/ja908124g Wang, 2014, Dual redox responsive coassemblies of diselenide-containing block copolymers and polymer lipids, Langmuir, 30, 5628, 10.1021/la501054z Chen, 2016, Dual redox-triggered shell-sheddable micelles self-assembled from mPEGylated starch conjugates for rapid drug release, RSC Adv., 6, 9164, 10.1039/C5RA23618E de la Rica, 2012, Enzyme-responsive nanoparticles for drug release and diagnostics, Adv. Drug Deliv. Rev., 64, 967, 10.1016/j.addr.2012.01.002 Kessenbrock, 2010, Matrix metalloproteinases: regulators of the tumor microenvironment, Cell, 141, 52, 10.1016/j.cell.2010.03.015 Mansour, 2003, A new approach for the treatment of malignant melanoma: enhanced antitumor efficacy of an albumin-binding doxorubicin prodrug that is cleaved by matrix metalloproteinase 2, Cancer Res., 63, 4062 Chen, 2015, MMP-2 responsive polymeric micelles for cancer-targeted intracellular drug delivery, Chem. Commun., 51, 465, 10.1039/C4CC07563C Yu, 2015, Enzyme sensitive, surface engineered nanoparticles for enhanced delivery of camptothecin, J. Control. Release, 216, 111, 10.1016/j.jconrel.2015.08.021 Zhang, 2016, Matrix metalloproteinases-2/9-sensitive peptide-conjugated polymer micelles for site-specific release of drugs and enhancing tumor accumulation: preparation and in vitro and in vivo evaluation, Int. J. Nanomedicine, 11, 1643 Liu, 2015, Enzyme responsive mesoporous silica nanoparticles for targeted tumor therapy in vitro and in vivo, Nano, 7, 3614 Hu, 2016, MMP-responsive theranostic nanoplatform based on mesoporous silica nanoparticles for tumor imaging and targeted drug delivery, J. Mater. Chem. B, 4, 1932, 10.1039/C5TB02490K Zhu, 2012, Matrix metalloprotease 2-responsive multifunctional liposomal nanocarrier for enhanced tumor targeting, ACS Nano, 6, 3491, 10.1021/nn300524f Zhu, 2013, Enhanced anticancer activity of nanopreparation containing an MMP2-sensitive PEG-drug conjugate and cell-penetrating moiety, Proc. Natl. Acad. Sci., 110, 17047, 10.1073/pnas.1304987110 Song, 2016, Enzyme-responsive destabilization of stabilized plasmid-lipid nanoparticles as an efficient gene delivery, Eur. J. Pharm. Sci., 91, 20, 10.1016/j.ejps.2016.05.024 Nguyen, 2015, Enzyme-responsive nanoparticles for targeted accumulation and prolonged retention in heart tissue after myocardial infarction, Adv. Mater., 27, 5547, 10.1002/adma.201502003 Tücking, 2015, Dual enzyme-responsive capsules of hyaluronic acid-block-poly (lactic acid) for sensing bacterial enzymes, Macromol. Rapid Commun., 36, 1248, 10.1002/marc.201500076 Hu, 2012, Enzyme-responsive polymeric assemblies, nanoparticles and hydrogels, Chem. Soc. Rev., 41, 5933, 10.1039/c2cs35103j Chau, 2004, Synthesis and characterization of dextran-peptide-methotrexate conjugates for tumor targeting via mediation by matrix metalloproteinase II and matrix metalloproteinase IX, Bioconjug. Chem., 15, 931, 10.1021/bc0499174 Wang, 2010, An enzyme-responsive polymeric superamphiphile, Angew. Chem., 122, 8794, 10.1002/ange.201004253 Callmann, 2015, Therapeutic enzyme-responsive nanoparticles for targeted delivery and accumulation in tumors, Adv. Mater., 27, 4611, 10.1002/adma.201501803 Daniel, 2016, Dual-responsive nanoparticles release cargo upon exposure to matrix metalloproteinase and reactive oxygen species, Chem. Commun., 52, 2126, 10.1039/C5CC09164K Bellat, 2016, Smart nanotransformers with unique enzyme-inducible structural changes and drug release properties, Biomacromolecules, 17, 2040, 10.1021/acs.biomac.6b00227 Rosenbaum, 2015, Encapsulation and covalent binding of molecular payload in enzymatically activated micellar nanocarriers, J. Am. Chem. Soc., 137, 2276, 10.1021/ja510085s Guo, 2012, Cholinesterase-responsive supramolecular vesicle, J. Am. Chem. Soc., 134, 10244, 10.1021/ja303280r Pearson, 2015, Light-responsive azobenzene-based glycopolymer micelles for targeted drug delivery to melanoma cells, Eur. Polym. J., 69, 616, 10.1016/j.eurpolymj.2015.04.001 Yuan, 2016, Light-responsive AIE nanoparticles with cytosolic drug release to overcome drug resistance in cancer cells, Polym. Chem., 7, 3530, 10.1039/C6PY00449K San Miguel, 2011, Wavelength-selective caged surfaces: how many functional levels are possible?, J. Am. Chem. Soc., 133, 5380, 10.1021/ja110572j Fomina, 2012, Photochemical mechanisms of light-triggered release from nanocarriers, Adv. Drug Deliv. Rev., 64, 1005, 10.1016/j.addr.2012.02.006 Gabrielson, 2012, Reactive and bioactive cationic α-helical polypeptide template for nonviral gene delivery, Angew. Chem., 124, 1169, 10.1002/ange.201104262 Xia, 2016, Light-responsive fluids based on reversible wormlike micelle to rodlike micelle transitions, RSC Adv., 6, 45673, 10.1039/C6RA05529J Wang, 2015, Shape transformation of light-responsive pyrene-containing micelles and their influence on cytoviability, Biomacromolecules, 16, 2276, 10.1021/acs.biomac.5b00497 Zhang, 2015, Preparation and photochromic properties of layer-by-layer self-assembly films and light-responsive micelles based on amphiphilic naphthopyran derivative, Spectrochim. Acta A Mol. Biomol. Spectrosc., 151, 525, 10.1016/j.saa.2015.06.082 Johnson, 2010, Core-clickable PEG-branch-azide bivalent-bottle-brush polymers by ROMP: grafting-through and clicking-to, J. Am. Chem. Soc., 133, 559, 10.1021/ja108441d Zhang, 2013, Trigger-responsive chain-shattering polymers, Polym. Chem., 4, 224, 10.1039/C2PY20838E Stricker, 2016, Arylazopyrazoles as light-responsive molecular switches in cyclodextrin-based supramolecular systems, J. Am. Chem. Soc., 138, 4547, 10.1021/jacs.6b00484 Zhao, 2012, Light-responsive block copolymer micelles, Macromolecules, 45, 3647, 10.1021/ma300094t Wang, 2016, pH- and NIR light responsive nanocarriers for combination treatment of chemotherapy and photodynamic therapy, Biomate. Sci., 4, 338, 10.1039/C5BM00328H Jiang, 2006, Toward photocontrolled release using light-dissociable block copolymer micelles, Macromolecules, 39, 4633, 10.1021/ma060142z Liang, 2016, Near infrared light responsive hybrid nanoparticles for synergistic therapy, Biomaterials, 100, 76, 10.1016/j.biomaterials.2016.05.023 Chen, 2016, A light-induced hydrogel based on tumor-targeting mesoporous silica nanoparticles as a theranostic platform for sustained cancer treatment, ACS Appl. Mater. Interfaces, 8, 15857, 10.1021/acsami.6b02562 Liu, 2015, Mesoporous silica coated single-walled carbon nanotubes as a multifunctional light-responsive platform for cancer combination therapy, Adv. Funct. Mater., 25, 384, 10.1002/adfm.201403079 Li, 2016, pH- and NIR light-responsive polymeric prodrug micelles for hyperthermia-assisted site-specific chemotherapy to reverse drug resistance in cancer treatment, Small, 12, 2731, 10.1002/smll.201600365 Liu, 2015, NIR-responsive polypeptide copolymer upconversion composite nanoparticles for triggered drug release and enhanced cytotoxicity, Polym. Chem., 6, 4030, 10.1039/C5PY00479A Jayakumar, 2012, Remote activation of biomolecules in deep tissues using near-infrared-to-UV upconversion nanotransducers, Proc. Natl. Acad. Sci., 109, 8483, 10.1073/pnas.1114551109 Xu, 2016, Mesoporous-silica-coated upconversion nanoparticles loaded with vitamin B 12 for near-infrared-light mediated photodynamic therapy, Mater. Lett., 167, 205, 10.1016/j.matlet.2015.12.105 Jalani, 2016, Photocleavable hydrogel-coated upconverting nanoparticles: a multifunctional theranostic platform for NIR imaging and on-demand macromolecular delivery, J. Am. Chem. Soc., 138, 1078, 10.1021/jacs.5b12357 Cortez-Lemus, 2016, Poly (N-vinylcaprolactam), a comprehensive review on a thermoresponsive polymer becoming popular, Prog. Polym. Sci., 53, 1, 10.1016/j.progpolymsci.2015.08.001 Dabbagh, 2015, Triggering mechanisms of thermosensitive nanoparticles under hyperthermia condition, J. Pharm. Sci., 104, 2414, 10.1002/jps.24536 Kamaly, 2016, Degradable controlled-release polymers and polymeric nanoparticles: mechanisms of controlling drug release, Chem. Rev., 116, 2602, 10.1021/acs.chemrev.5b00346 Grieshaber, 2009, Synthesis and characterization of elastin−mimetic hybrid polymers with multiblock, alternating molecular architecture and elastomeric properties, Macromolecules, 42, 2532, 10.1021/ma802791z Sedlák, 2016, A novel approach to controlled self-assembly of pH-responsive thermosensitive homopolymer polyelectrolytes into stable nanoparticles, Adv. Colloid Interf. Sci., 232, 57, 10.1016/j.cis.2015.12.005 Wright, 2002, Self-assembly of block copolymers derived from elastin-mimetic polypeptide sequences, Adv. Drug Deliv. Rev., 54, 1057, 10.1016/S0169-409X(02)00059-5 MacKay, 2009, Self-assembling chimeric polypeptide–doxorubicin conjugate nanoparticles that abolish tumours after a single injection, Nat. Mater., 8, 993, 10.1038/nmat2569 Huang, 1992, Pharmacokinetics and therapeutics of sterically stabilized liposomes in mice bearing C-26 colon carcinoma, Cancer Res., 52, 6774 Landon, 2011, Nanoscale drug delivery and hyperthermia: the materials design and preclinical and clinical testing of low temperature-sensitive liposomes used in combination with mild hyperthermia in the treatment of local cancer, The Open Nanomed. J., 3, 38, 10.2174/1875933501103010038 Laga, 2015, Thermoresponsive polymer micelles as potential nanosized cancerostatics, Biomacromolecules, 16, 2493, 10.1021/acs.biomac.5b00764 Rahikkala, 2015, Thermoresponsive nanoparticles of self-assembled block copolymers as potential carriers for drug delivery and diagnostics, Biomacromolecules, 16, 2750, 10.1021/acs.biomac.5b00690 Zhao, 2011, PEGylated thermo-sensitive poly (amidoamine) dendritic drug delivery systems, Int. J. Pharm., 409, 229, 10.1016/j.ijpharm.2011.02.005 Sun, 2010, Synthesis and investigation of core−shell dendritic nanoparticles with tunable thermosensitivity, Macromolecules, 43, 9668, 10.1021/ma1017617 Zheng, 2010, Flocculation-resistant multimolecular micelles with thermoresponsive corona from dendritic heteroarm star copolymers, J. Polym. Sci. A Polym. Chem., 48, 4428, 10.1002/pola.24230 Huang, 2016, Magnetic nanoparticle facilitated drug delivery for cancer therapy with targeted and image-guided approaches, Adv. Funct. Mater., 26, 3818, 10.1002/adfm.201504185 Park, 2016, Polymer–iron oxide composite nanoparticles for EPR-independent drug delivery, Biomaterials, 101, 285, 10.1016/j.biomaterials.2016.06.007 Patra, 2015, Dual-responsive polymer coated superparamagnetic nanoparticle for targeted drug delivery and hyperthermia treatment, ACS Appl. Mater. Interfaces, 7, 9235, 10.1021/acsami.5b01786 Yang, 2016, pH-responsive biodegradable polymeric micelles with anchors to interface magnetic nanoparticles for MR imaging in detection of cerebral ischemic area, Nanoscale, 8, 12588, 10.1039/C5NR06542A Hu, 2012, Core-shell nanocapsules stabilized by single-component polymer and nanoparticles for magneto-chemotherapy/hyperthermia with multiple drugs, Adv. Mater., 24, 3627, 10.1002/adma.201201251 Zhao, 2016, Glucose-sensitive polymer nanoparticles for self-regulated drug delivery, Chem. Commun., 52, 7633, 10.1039/C6CC02202B Zhao, 2016, Folate-conjugated dually responsive micelles for targeted anticancer drug delivery, RSC Adv., 6, 35658, 10.1039/C6RA01885H Kitano, 1992, A novel drug delivery system utilizing a glucose responsive polymer complex between poly (vinyl alcohol) and poly (N-vinyl-2-pyrrolidone) with a phenylboronic acid moiety, J. Control. Release, 19, 161, 10.1016/0168-3659(92)90073-Z Kim, 2009, Polymeric monosaccharide receptors responsive at neutral pH, J. Am. Chem. Soc., 131, 13908, 10.1021/ja905652w Kim, 2012, Monosaccharide-responsive release of insulin from polymersomes of polyboroxole block copolymers at neutral pH, J. Am. Chem. Soc., 134, 4030, 10.1021/ja211728x Tan, 2015, Glucose- and pH-responsive nanogated ensemble based on polymeric network capped mesoporous silica, ACS Appl. Mater. Interfaces, 7, 6310, 10.1021/acsami.5b00631 Yang, 2015, Glucose-responsive polymer vesicles templated by α-CD/PEG inclusion complex, Biomacromolecules, 16, 1372, 10.1021/acs.biomac.5b00155 Alouane, 2015, Self-immolative spacers: kinetic aspects, structure–property relationships, and applications, Angew. Chem. Int. Ed., 54, 7492, 10.1002/anie.201500088 Roth, 2015, Dendritic, oligomeric, and polymeric self-immolative molecular amplification, Chem. Rev., 116, 1309, 10.1021/acs.chemrev.5b00372 Weinstain, 2008, Self-Immolative comb-polymers: multiple-release of side-reporters by a single stimulus event, Chem. Eur. J., 14, 6857, 10.1002/chem.200800917 Esser-Kahn, 2010, Programmable microcapsules from self-immolative polymers, J. Am. Chem. Soc., 132, 10266, 10.1021/ja104812p Dewit, 2010, A reduction sensitive cascade biodegradable linear polymer, J. Polym. Sci. A Polym. Chem., 48, 3977, 10.1002/pola.24180 Liu, 2014, Self-immolative polymersomes for high-efficiency triggered release and programmed enzymatic reactions, J. Am. Chem. Soc., 136, 7492, 10.1021/ja5030832 Liu, 2015, Hyperbranched Self-Immolative Polymers (h SIPs) for programmed payload delivery and ultrasensitive detection, J. Am. Chem. Soc., 137, 11645, 10.1021/jacs.5b05060 Tan, 2015, Light-triggered, self-immolative nucleic acid-drug nanostructures, J. Am. Chem. Soc., 137, 6112, 10.1021/jacs.5b00795 Olejniczak, 2015, Light-triggered chemical amplification to accelerate degradation and release from polymeric particles, Chem. Commun., 51, 16980, 10.1039/C5CC06143A Leng, 2016, Molecular level studies on interfacial hydration of zwitterionic and other antifouling polymers in situ, Acta Biomater., 40, 6, 10.1016/j.actbio.2016.02.030 Robinson, 2015, Comparison between polyethylene glycol and zwitterionic polymers as antifouling coatings on wearable devices for selective antigen capture from biological tissue, Biointerphases, 10, 04A305, 10.1116/1.4932055 He, 2016, Zwitterionic materials for antifouling membrane surface construction, Acta Biomater., 40, 142, 10.1016/j.actbio.2016.03.038 Cao, 2012, Super-hydrophilic zwitterionic poly (carboxybetaine) and amphiphilic non-ionic poly (ethylene glycol) for stealth nanoparticles, Nano Today, 7, 404, 10.1016/j.nantod.2012.08.001 Zhang, 2013, Zwitterionic hydrogels implanted in mice resist the foreign-body reaction, Nat. Biotechnol., 31, 553, 10.1038/nbt.2580 Shah, 2016, Transport properties of small molecules in zwitterionic polymers, J. Polym. Sci. B Polym. Phys., 54, 1924, 10.1002/polb.24096 Xiang, 2016, Zwitterionic polymer functionalization of polysulfone membrane with improved antifouling property and blood compatibility by combination of ATRP and click chemistry, Acta Biomater., 40, 162, 10.1016/j.actbio.2016.03.044 Liu, 2016, pH-Responsive zwitterionic polypeptide as a platform for anti-tumor drug delivery, Colloids Surf. B: Biointerfaces, 145, 401, 10.1016/j.colsurfb.2016.05.027 Zhao, 2016, Nano-engineered electro-responsive drug delivery systems, J. Mater. Chem. B, 4, 3019, 10.1039/C6TB00049E Yoshida, 2006, Maskless microfabrication of thermosensitive gels using a microscope and application to a controlled release microchip, Lab Chip, 6, 1384, 10.1039/b606620h Murdan, 2003, Electro-responsive drug delivery from hydrogels, J. Control. Release, 92, 1, 10.1016/S0168-3659(03)00303-1 Mac Kenna, 2015, Electro-stimulated release from a reduced graphene oxide composite hydrogel, J. Mater. Chem. B, 3, 2530, 10.1039/C5TB00050E Wang, 2016, Smart montmorillonite-polypyrrole scaffolds for electro-responsive drug release, Appl. Clay Sci., 134, 50, 10.1016/j.clay.2016.05.004 Seyfoddin, 2015, Electro-responsive macroporous polypyrrole scaffolds for triggered dexamethasone delivery, Eur. J. Pharm. Biopharm., 94, 419, 10.1016/j.ejpb.2015.06.018 Curcio, 2015, On demand delivery of ionic drugs from electro-responsive CNT hybrid films, RSC Adv., 5, 44902, 10.1039/C5RA05484B Yan, 2010, Voltage-responsive vesicles based on orthogonal assembly of two homopolymers, J. Am. Chem. Soc., 132, 9268, 10.1021/ja1027502 Peng, 2016, Star amphiphilic supramolecular copolymer based on host–guest interaction for electrochemical controlled drug delivery, Polymer, 88, 112, 10.1016/j.polymer.2016.02.023 Yoshida, 2016, Ion-responsive drug delivery systems, Curr. Drug Targets, 17, 1, 10.2174/1389450117666160527142138 Yokoyama, 1996, Introduction of cisplatin into polymeric micelle, J. Control. Release, 39, 351, 10.1016/0168-3659(95)00165-4 Ramasamy, 2014, Novel dual drug-loaded block ionomer complex micelles for enhancing the efficacy of chemotherapy treatments, J. Biomed. Nanotechnol., 10, 1304, 10.1166/jbn.2014.1821 Ramasamy, 2015, Polypeptide-based micelles for delivery of irinotecan: physicochemical and in vivo characterization, Pharm. Res., 32, 1947, 10.1007/s11095-014-1588-8 Ramasamy, 2016, Cationic drug-based self-assembled polyelectrolyte complex micelles: Physicochemical, pharmacokinetic, and anticancer activity analysis, Colloids Surf. B: Biointerfaces, 146, 152, 10.1016/j.colsurfb.2016.06.004 Ramasamy, 2010, Solid lipid nanoparticle and nanoparticle lipid carrier for controlled drug delivery – a review of state of art and recent advances, Int. J. Nanoparticles, 3, 32, 10.1504/IJNP.2010.033220 Jiang, 2017, Designing nanomedicine for immuno-oncology, Nat. Biomed. Eng., 1, 0029, 10.1038/s41551-017-0029 Joo, 2011, Nanoncology: a state-of-art update, J. Bionanoscience, 4, 13 Phillips, 2010, Targeted nanodelivery of drugs and diagnostics, Nano Today, 5, 143, 10.1016/j.nantod.2010.03.003 van der Meel, 2013, Ligand-targeted particulate nanomedicines undergoing clinical evaluation: current status, Adv. Drug Deliv. Rev., 65, 1284, 10.1016/j.addr.2013.08.012 Lammers, 2012, Drug targeting to tumors: principles, pitfalls and (pre-) clinical progress, J. Control. Release, 161, 175, 10.1016/j.jconrel.2011.09.063 Danhier, 2010, To exploit the tumor microenvironment: passive and active tumor targeting of nanocarriers for anti-cancer drug delivery, J. Control. Release, 148, 135, 10.1016/j.jconrel.2010.08.027 Talelli, 2013, Intrinsically active nanobody-modified polymeric micelles for tumor-targeted combination therapy, Biomaterials, 34, 1255, 10.1016/j.biomaterials.2012.09.064 Mamot, 2012, Tolerability, safety, pharmacokinetics, and efficacy of doxorubicin-loaded anti-EGFR immunoliposomes in advanced solid tumours: a phase 1 dose-escalation study, Lancet Oncol., 13, 1234, 10.1016/S1470-2045(12)70476-X Patil, 2009, Nanoparticle-mediated simultaneous and targeted delivery of paclitaxel and tariquidar overcomes tumor drug resistance, J. Control. Release, 136, 21, 10.1016/j.jconrel.2009.01.021 Jain, 2010, Delivering nanomedicine to solid tumors, Nat. Rev. Clin. Oncol., 7, 653, 10.1038/nrclinonc.2010.139 Seo, 2013, Development of docetaxel-loaded solid self-nanoemulsifying drug delivery system (SNEDDS) for enhanced chemotherapeutic effect, Int. J. Pharm., 452, 412, 10.1016/j.ijpharm.2013.05.034 Sundaramoorthy, 2016, Engineering of caveolae-specific self-micellizing anticancer lipid nanoparticles to enhance the chemotherapeutic efficacy of oxaliplatin in colorectal cancer cells, Acta Biomater., 42, 220, 10.1016/j.actbio.2016.07.006 Poudel, 2016, Development of polymeric irinotecan nanoparticles using a novel lactone preservation strategy, Int. J. Pharm., 512, 75, 10.1016/j.ijpharm.2016.08.018 Ramasamy, 2017, Engineering of cell microenvironment-responsive polypeptide nanovehicle co-encapsulating a synergistic combination of small molecules for effective chemotherapy in solid tumors, Acta Biomater., 48, 131, 10.1016/j.actbio.2016.10.034 Kim, 2017, PEGylated polypeptide lipid nanocapsules to enhance the anticancer efficacy of erlotinib in non-small cell lung cancer, Colloids Surf. B: Biointerfaces, 150, 393, 10.1016/j.colsurfb.2016.11.002