Resurrection of endogenous retroviruses during aging reinforces senescence
Xiaoqian Liu1,2,3,4, Zunpeng Liu1,2,4, Zeming Wu5,2,4, Jie Ren6,2,4, Yanling Fan6,4, Liang Sun7, Gang Cao8, Yuyu Niu9,10,11, Baohu Zhang1,4, Qianzhao Ji5,4, Xiaoyu Jiang5,4, Cui Wang6,4, Qiaoran Wang6,4, Zhejun Ji1,4, Lanzhu Li5,4, Concepcion Rodriguez Esteban12, Kaowen Yan5,2,4, Wei Li13, Yusheng Cai5,2,4, Si Wang13,2,4,14,15
1State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
2Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China
3Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China
4University of Chinese Academy of Sciences, Beijing, 100049, China
5State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China
6CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China
7NHC Beijing Institute of Geriatrics, NHC Key Laboratory of Geriatrics, Institute of Geriatric Medicine of Chinese Academy of Medical Sciences, National Center of Gerontology/ Beijing Hospital, Beijing 100730, China
8State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China
9State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan 650500, China
10Yunnan Key Laboratory of Primate Biomedical Research, Kunming, Yunnan 650500, China
11Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, 650500, China
12Altos Labs, Inc., San Diego, CA 94022, USA
13Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing, 100053, China
14Aging Translational Medicine Center, International Center for Aging and Cancer, Xuanwu Hospital, Capital Medical University, Beijing Municipal Geriatric Medical Research Center, Beijing 100053, China
15The Fifth People's Hospital of Chongqing, Chongqing, 400062, China