Dissecting the Unique Role of the Retinoblastoma Tumor Suppressor during Cellular Senescence

Balciunaite, 2005, Pocket protein complexes are recruited to distinct targets in quiescent and proliferating cells, Mol. Cell. Biol., 25, 8166, 10.1128/MCB.25.18.8166-8178.2005 Burkhart, 2008, Cellular mechanisms of tumour suppression by the retinoblastoma gene, Nat. Rev. Cancer, 8, 671, 10.1038/nrc2399 Butt, 2008, Cell cycle machinery: Links with genesis and treatment of breast cancer, Adv. Exp. Med. Biol., 630, 189, 10.1007/978-0-387-78818-0_12 Cam, 2004, A common set of gene regulatory networks links metabolism and growth inhibition, Mol. Cell, 16, 399, 10.1016/j.molcel.2004.09.037 Campisi, 2007, Cellular senescence: When bad things happen to good cells, Nat. Rev. Mol. Cell Biol., 8, 729, 10.1038/nrm2233 Classon, 2002, The retinoblastoma tumour suppressor in development and cancer, Nat. Rev. Cancer, 2, 910, 10.1038/nrc950 Coppe, 2008, Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor, PLoS Biol., 6, 2853, 10.1371/journal.pbio.0060301 Courtois-Cox, 2008, Many roads lead to oncogene-induced senescence, Oncogene, 27, 2801, 10.1038/sj.onc.1210950 Dennis, 2003, DAVID: Database for annotation, visualization, and integrated discovery, Genome Biol., 4, R60, 10.1186/gb-2003-4-9-r60 Eisen, 1998, Cluster analysis and display of genome-wide expression patterns, Proc. Natl. Acad. Sci. USA, 95, 14863, 10.1073/pnas.95.25.14863 Geng, 2007, Kinase-independent function of cyclin E, Mol. Cell, 25, 127, 10.1016/j.molcel.2006.11.029 Geng, 2003, Cyclin E ablation in the mouse, Cell, 114, 431, 10.1016/S0092-8674(03)00645-7 Guo, 2009, Retinoblastoma protein (pRb), but not p107 or p130, is required for maintenance of enterocyte quiescence and differentiation in small intestine, J. Biol. Chem., 284, 134, 10.1074/jbc.M806133200 Halazonetis, 2008, An oncogene-induced DNA damage model for cancer development, Science, 319, 1352, 10.1126/science.1140735 Hurford, 1997, pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes, Genes Dev., 11, 1447, 10.1101/gad.11.11.1447 Markey, 2007, Loss of the retinoblastoma tumor suppressor: differential action on transcriptional programs related to cell cycle control and immune function, Oncogene, 26, 6307, 10.1038/sj.onc.1210450 Marusyk, 2007, Replicational stress selects for p53 mutation, Cell Cycle, 6, 2148, 10.4161/cc.6.17.4732 Massie, 2007, New androgen receptor genomic targets show an interaction with the ETS1 transcription factor, EMBO Rep., 8, 871, 10.1038/sj.embor.7401046 Mendez, 2000, Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: Assembly of prereplication complexes in late mitosis, Mol. Cell. Biol., 20, 8602, 10.1128/MCB.20.22.8602-8612.2000 Mulligan, 1998, The retinoblastoma gene family: Cousins with overlapping interests, Trends Genet., 14, 223, 10.1016/S0168-9525(98)01470-X Narita, 2006, A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation, Cell, 126, 503, 10.1016/j.cell.2006.05.052 Narita, 2005, Senescence comes of age, Nat. Med., 11, 920, 10.1038/nm0905-920 Narita, 2003, Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence, Cell, 113, 703, 10.1016/S0092-8674(03)00401-X Orlando, 1997, Analysis of chromatin structure by in vivo formaldehyde cross-linking, Methods, 11, 205, 10.1006/meth.1996.0407 Park, 2009, ChIP-seq: Advantages and challenges of a maturing technology, Nat. Rev. Genet., 10, 669, 10.1038/nrg2641 Prieur, 2008, Cellular senescence in vivo: A barrier to tumorigenesis, Curr. Opin. Cell Biol., 20, 150, 10.1016/j.ceb.2008.01.007 Rayman, 2002, E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex, Genes Dev., 16, 933, 10.1101/gad.969202 Robertson, 2007, Genome-wide profiles of STAT1 DNA association using chromatin immunoprecipitation and massively parallel sequencing, Nat. Methods, 4, 651, 10.1038/nmeth1068 Romanov, 2001, Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes, Nature, 409, 633, 10.1038/35054579 Rowland, 2006, Re-evaluating cell-cycle regulation by E2Fs, Cell, 127, 871, 10.1016/j.cell.2006.11.019 Sage, 2003, Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry, Nature, 424, 223, 10.1038/nature01764 Sage, 2000, Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization, Genes Dev., 14, 3037, 10.1101/gad.843200 Sang, 2008, Control of the reversibility of cellular quiescence by the transcriptional repressor HES1, Science, 321, 1095, 10.1126/science.1155998 Santegoets, 2007, HPV related VIN: highly proliferative and diminished responsiveness to extracellular signals, Int. J. Cancer, 121, 759, 10.1002/ijc.22769 Serrano, 1997, Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a, Cell, 88, 593, 10.1016/S0092-8674(00)81902-9 Shay, 1991, A role for both RB and p53 in the regulation of human cellular senescence, Exp. Cell Res., 196, 33, 10.1016/0014-4827(91)90453-2 Sheaff, 1997, Cyclin E-CDK2 is a regulator of p27Kip1, Genes Dev., 11, 1464, 10.1101/gad.11.11.1464 Sherr, 2004, Living with or without cyclins and cyclin-dependent kinases, Genes Dev., 18, 2699, 10.1101/gad.1256504 Silva, 2005, Second-generation shRNA libraries covering the mouse and human genomes, Nat. Genet., 37, 1281, 10.1038/ng1650 Smith, 2006, DNA motifs in human and mouse proximal promoters predict tissue-specific expression, Proc. Natl. Acad. Sci. USA, 103, 6275, 10.1073/pnas.0508169103 Srinivasan, 2007, RB loss promotes aberrant ploidy by deregulating levels and activity of DNA replication factors, J. Biol. Chem., 282, 23867, 10.1074/jbc.M700542200 Stillman, 1996, Cell cycle control of DNA replication, Science, 274, 1659, 10.1126/science.274.5293.1659 Talluri, 2010, A G1 checkpoint mediated by the retinoblastoma protein that is dispensable in terminal differentiation but essential for senescence, Mol. Cell. Biol., 30, 948, 10.1128/MCB.01168-09 Voorhoeve, 2003, The tumor-suppressive functions of the human INK4A locus, Cancer Cell, 4, 311, 10.1016/S1535-6108(03)00223-X Wells, 2000, Target gene specificity of E2F and pocket protein family members in living cells, Mol. Cell. Biol., 20, 5797, 10.1128/MCB.20.16.5797-5807.2000 Zhang, 2007, Life without kinase: cyclin E promotes DNA replication licensing and beyond, Mol. Cell, 25, 175, 10.1016/j.molcel.2007.01.008 Zhang, 2005, Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA, Dev. Cell, 8, 19, 10.1016/j.devcel.2004.10.019 Zhang, 2008, Model-based analysis of ChIP-Seq (MACS), Genome Biol., 9, R137, 10.1186/gb-2008-9-9-r137