Anti-inflammatory and immunosuppressive drugs and reproduction

Arthritis Research & Therapy - Tập 8 - Trang 1-19 - 2006
Monika Østensen1, Munther Khamashta2, Michael Lockshin3, Ann Parke4, Antonio Brucato5, Howard Carp6, Andrea Doria7, Raj Rai8, Pierluigi Meroni9, Irene Cetin10, Ronald Derksen11, Ware Branch12, Mario Motta13, Caroline Gordon14, Guillermo Ruiz-Irastorza15, Arsenio Spinillo16, Deborah Friedman17, Rolando Cimaz18, Andrew Czeizel19, Jean Charles Piette20, Ricard Cervera21, Roger A Levy22, Maurizio Clementi23, Sara De Carolis23, Michelle Petri24, Yehuda Shoenfeld25, David Faden26, Guido Valesini27, Angela Tincani28
1Department of Rheumatology and Clinical Immunology/Allergology, University Hospital of Bern, Switzerland
2Lupus Research Unit, The Rayne Institute, St. Thomas' Hospital, London, UK.
3Barbara Volcker Center for Women and Rheumatic Disease, Hospital for Special Surgery, Joan and Sanford Weill College of Medicine of Cornell University, New York, USA
4Division of Rheumatic Diseases, Department of Medicine, University of Connecticut Health Center, Farmington, USA
5Department of Internal Medicine and Rheumatology, Niguarda Hospital, Milano, Italy
6Department of Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer, Israel, and Tel Aviv University, Israel
7Division of Rheumatology, Department of Clinical and Experimental Medicine, University of Padova, Italy
8Department of Obstetrics and Gynaecology, Imperial College School of Medicine, London, UK
9Cattedra di Medicina Interna, University of Milano, Italy
10Institute of Obstetrics and Gynecology, L Mangiagalli, University of Milano, Italy
11Department of Rheumatology and Clinical Immunology, University Medical Centre Utrecht, The Netherlands
12Department of Obstetrics and Gynecology, The University of Utah Health Sciences Center, Salt Lake City, USA
13Neonatology and Neonatal Intensive Care Unit, Spedali Civili, Brescia, Italy
14Centre for Immune Regulation, Division of Immunity and Infection, The University of Birmingham, Birmingham, UK
15Department of Internal Medicine, Hospital de Cruces, University of The Basque Country, Bizkaia, Spain
16Department of Obstetrics and Gynecology, University of Pavia, Italy
17Health Science Center, University of Texas, Houston, USA
18Pediatrics, Fondazione Policlinico Mangiagalli, Milano, Italy
19Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary
20Service de Médecine Interne, Groupe Hospitalier Pitié-Salpêtrière, Paris, France
21Department of Autoimmune Diseases, Hospital Clínic, Barcelona, Catalonia, Spain
22Discipline of Rheumatology, Faculdades de Ciencias Medicas, Universidade do Estado do Rio de Janeiro, Brazil
23Department of Obstetrics and Gynecology, Catholic University of Sacred Heart, Rome, Italy
24Lupus Center, Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, USA
25Department of Medicine and Center for Autoimmune Diseases, Sheba Medical Center, Tel-Aviv University, Tel-Hashomer, Israel
26Obstetric and Gynecology Department, University and Hospital of Brescia, Italy
27Cattedra di Reumatologia, Università 'La Sapienza', Roma, Italy
28Rheumatology and Clinical Immunology, University and Hospital of Brescia, Italy

Tóm tắt

Rheumatic diseases in women of childbearing years may necessitate drug treatment during a pregnancy, to control maternal disease activity and to ensure a successful pregnancy outcome. This survey is based on a consensus workshop of international experts discussing effects of anti-inflammatory, immunosuppressive and biological drugs during pregnancy and lactation. In addition, effects of these drugs on male and female fertility and possible long-term effects on infants exposed to drugs antenatally are discussed where data were available. Recommendations for drug treatment during pregnancy and lactation are given.

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