AS Anderson Z An WR Strohl (2000) Polyketide antibiotics. Lederberg (Eds) Encyclopedia for Microbiology, vol. 3 Academic Press San Diego 241–254
AS Anderson D Clark P Gibbons J Sigmund (2002) ArticleTitleThe detection of diverse aminoglycoside phosphotransferases within natural populations of actinomycetes. J Ind Microbiol Biotechnol 29 60–69 Occurrence Handle1:CAS:528:DC%2BD38XlslymtLY%3D Occurrence Handle12161772
JF Aparicio I Molnar T Schwecke A König SF Haydock LE Khaw J Staunton PF Leadlay (1996) ArticleTitleOrganization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of the enzymatic domains in the modular polyketide synthase. Gene 169 9–16 Occurrence Handle1:CAS:528:DyaK28XhsVaktr0%3D Occurrence Handle8635756
JF Aparicio R Fouces VM Mendes N Oliver JF Martín (2000) ArticleTitleA complex multienzyme system encoded by five polyketide synthase genes is involved in the biosynthesis of the 26-membered polyene macrolide pimaricin in Streptomyces natalensis. Chem Biol 7 895–905 Occurrence Handle1:CAS:528:DC%2BD3cXosVWitLo%3D Occurrence Handle11094342
RL Arslanian L Tang S Blough W Ma RG Qiu L Katz JR Carney (2002) ArticleTitleA new cytotoxic epothilone from modified polyketide synthases heterologously expressed in Myxococcus xanthus. J Nat Prod 65 1061–1064 Occurrence Handle1:CAS:528:DC%2BD38Xkt1Clu7k%3D Occurrence Handle12141877
SD Bentley KF Chater AM Cerdeño-Tárraga GL Challis NR Thomson KD James DE Harris MA Quail H Kieser D Harper A Bateman S Brown G Chandra CW Chen M Collins A Cronin A Fraser A Goble J Hidalgo T Hornsby S Howarth CH Huang T Kieser L Larke L Murphy K Oliver S O’Neil E Rabbinowitsch MA Rajandream K Rutherford S Rutter K Seeger D Saunders S Sharp R Squares S Squares K Taylor T Warren A Wietzorrek J Woodward BG Barrell J Parkhill DA Hopwood (2002) ArticleTitleComplete genome sequence of the model actinomycete Streptomyces coelicolor A3(2). Nature 417 141–147 Occurrence Handle12000953
S Beyer B Kunze B Silakowski R Müller (1999) ArticleTitleMetabolic diversity in myxobacteria: identification of the myxalamid and the stigmatellin biosynthetic gene cluster of Stigmatella aurantiaca Sg a15 and a combined polyketide–(poly)peptide gene cluster from the epothilone producing strain Sorangium cellulosum So ce90. Biochim Biophys Acta 1445 185–195 Occurrence Handle1:CAS:528:DyaK1MXjs1ehtr4%3D Occurrence Handle10320771
LE Bingle CM Lazarus (1999) ArticleTitleKetosynthase domain probes identify two subclasses of fungal polyketide synthase genes. Fungal Genet Biol 26 209–223 Occurrence Handle1:CAS:528:DyaK1MXjsFKnsLo%3D Occurrence Handle10361035
T Brautaset ON Sekurova H Sletta TE Ellingsen AR Stronm S Valla S Zotchev (2000) ArticleTitleBiosynthesis of the polyene antifungal antibiotic nystatin in Streptomyces noursei ATCC 11455: analysis of the gene cluster and deduction of biosynthetic pathway. Chem Biol 7 395–403 Occurrence Handle1:CAS:528:DC%2BD3cXktl2nsLk%3D Occurrence Handle10873841
GL Challis J Ravel CA Townsend (2000) ArticleTitlePredictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains. Chem Biol 7 211–224 Occurrence Handle1:CAS:528:DC%2BD3cXitVOkt7k%3D Occurrence Handle10712928
YQ Cheng GL Tang B Shen (2003) ArticleTitleType I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesis. Proc Natl Acad Sci USA 100 3149–3154 Occurrence Handle1:CAS:528:DC%2BD3sXisVCnsbk%3D Occurrence Handle12598647
G Christiansen E Dittmann LV Ordorika R Rippka M Herdman T Börner (2001) ArticleTitleNonribosomal peptide synthase genes occur in most cyanobacterial genera as evidenced by their distribution in axenic strains of the PCC. Arch Microbiol 176 452–458 Occurrence Handle1:CAS:528:DC%2BD38XhtFyitQ%3D%3D Occurrence Handle11734889
JJ Coque JF Martin JG Calzada P Liras (1991) ArticleTitleThe cephamycin biosynthetic genes pcbAB, encoding a large multidomain peptide synthetase, and pcbC of Nocardia lactamdurans are clustered together in an organization different from the same genes in Acremonium chrysogenum and Penicillium chrysogenum. Mol Microbiol 5 1125–1133 Occurrence Handle1:CAS:528:DyaK3MXksVaqsLc%3D Occurrence Handle1956290
V de Crecy-Lagard W Saurin D Thibaut P Gil L Naudin J Crouzet V Blanc (1997) ArticleTitleStreptogramin B biosynthesis in Streptomyces pristinaespiralis and Streptomyces virginiae: molecular characterization of the last structural peptide synthetase gene. Antimicrob Agents Chemother 41 1904–1909 Occurrence Handle1:CAS:528:DyaK2sXlvFOgtLY%3D Occurrence Handle9303382
S Donadio L Katz (1992) ArticleTitleOrganization of the enzymatic domains in the multifunctional polyketide synthase involved in erythromycin formation in Saccharopolyspora erythraea. Gene 111 51–60 Occurrence Handle1:CAS:528:DyaK38XltVOitLw%3D Occurrence Handle1547954
SF Haydock JF Aparicio I Molnar T Schwecke LE Khaw A König AF Marsden IS Galloway J Staunton PF Leadlay (1995) ArticleTitleDivergent sequence motifs correlated with the substrate specificity of (methyl)malonyl-CoA:acyl carrier protein transacylase domains in modular polyketide synthases. FEBS Lett 374 246–248 Occurrence Handle1:CAS:528:DyaK2MXptlCmtrk%3D Occurrence Handle7589545
MP Heaton FC Neuhaus (1992) ArticleTitleBiosynthesis of D-alanyl-lipoteichoic acid: cloning, nucleotide sequence, and expression of the Lactobacillus casei gene for D-alanine-activating enzyme. J Bacteriol 174 4707–4717 Occurrence Handle1:CAS:528:DyaK3sXkt1emsL8%3D Occurrence Handle1385594
GL Igloi (1998) ArticleTitleVariability in the stability of DNA-peptide nucleic acid (PNA) single-base mismatched duplexes: real-time hybridization during affinity electrophoresis in PNA-containing gels. Proc Natl Acad Sci USA 95 8562–8567 Occurrence Handle1:CAS:528:DyaK1cXkvFamu7Y%3D Occurrence Handle9671717
H Ikeda T Nonomiya M Usami T Ohta S Omura (1999) ArticleTitleOrganization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis. Proc Natl Acad Sci USA 96 9509–9514 Occurrence Handle1:CAS:528:DyaK1MXlsVyms74%3D Occurrence Handle10449723
MA Innis DH Gelfand JJ Sninsky TJ White (1990) PCR Protocols. A Guide to Methods and Applications Academic Press San Diego
SJ Kakavas L Katz D Stassi (1997) ArticleTitleIdentification and characterization of the niddamycin polyketide synthase genes from Streptomyces caelestis. J Bacteriol 179 7515–7522 Occurrence Handle1:CAS:528:DyaK2sXnvFeksbw%3D Occurrence Handle9393718
C Khosla RS Gokhale JR Jacobsen DE Cane (1999) ArticleTitleTolerance and specificity of polyketide synthases. Annu Rev Biochem 68 219–253 Occurrence Handle1:CAS:528:DyaK1MXlvFajsL0%3D Occurrence Handle10872449
D Konz MA Marahiel (1999) ArticleTitleHow do peptide synthases generate structural diversity? Chem Biol 6 39–48
SY Lee SK Rhee CH Kim JW Suh (1998) ArticleTitleRapid and efficient isolation of genes for biosynthesis of peptide antibiotics from gram-positive bacterial strain. J Microbiol Biotechnol 8 310–317 Occurrence Handle1:CAS:528:DyaK1cXmsVeksr8%3D
MA Marahiel (1997) ArticleTitleProtein templates for the biosynthesis of antibiotics. Chem Biol 4 561–567 Occurrence Handle1:CAS:528:DyaK2sXmt1ansrk%3D Occurrence Handle9281530
HD Mootz D Schwarzer A Marahiel (2002) ArticleTitleBiosynthetic strategies of nonribosomal peptide synthetases. Chem Bio Chem 3 490–504 Occurrence Handle1:CAS:528:DC%2BD38XksFemsr8%3D Occurrence Handle12325005
H Motamedi A Shafiee (1998) ArticleTitleThe biosynthetic gene cluster for the macrolactone ring of the immunosuppressant FK506. Eur J Biochem 256 528–534 Occurrence Handle1:CAS:528:DyaK1cXmtlCgtbg%3D Occurrence Handle9780228
TP Nicholson M Dawson CM Lazarus TJ Simpson RJ Cox (2001) ArticleTitleDesign and utility of oligonucleotide gene probes for fungal polyketide synthases. Chem Biol 8 157–178 Occurrence Handle1:CAS:528:DC%2BD3MXjtV2kurk%3D Occurrence Handle11251290
S Omura H Ikeda J Ishikawa A Hanamato C Takahashi M Shinose et al. (2001) ArticleTitleGenome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites. Proc Natl Acad Sci USA 98 12215–12220 Occurrence Handle1:CAS:528:DC%2BD3MXns1Cjtrk%3D Occurrence Handle11572948
S Pelzer W Reichert M Huppert D Heckmann W Wohlleben (1997) ArticleTitleCloning and analysis of a peptide synthetase gene of the balhimycin producer Amycolatopsis mediterranei DSM 5908 and development of a gene disruption/replacement system. J Biotechnol 56 115–128 Occurrence Handle1:CAS:528:DyaK2sXltl2ktLk%3D Occurrence Handle9304873
M Perego P Glaser A Minutello MA Strauch K Leopold W Fisher (1995) ArticleTitleIncorporation of D-alanine into lipoteichoic acid and wall teichoic acid in Bacillus subtilis. J Biol Chem 26 15598–15606
J Piel (2002) ArticleTitleA polyketide synthase–peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetles. Proc Natl Acad Sci USA 99 14002–14007 Occurrence Handle1:CAS:528:DC%2BD38XosF2isbw%3D Occurrence Handle12381784
N Rajendran (1999) ArticleTitleIdentification and cloning of a gene locus encoding peptide synthase of Pseudomonas fluorescens by two sets of PCR primers. Z Naturforsch 54 105–109 Occurrence Handle1:CAS:528:DyaK1MXhsFOgtLo%3D
J Recktenwald R Shawky O Puk F Pfennig U Keller W Wohlleben S Pelzer (2002) ArticleTitleNonribosomal biosynthesis of vancomycin-type antibiotics: a heptapeptide backbone and eight peptide synthetase modules. Microbiology 148 1105–1118 Occurrence Handle1:CAS:528:DC%2BD38Xjt1ems7Y%3D Occurrence Handle11932455
X Ruan D Stassi SA Lax L Katz (1997) ArticleTitleA second type-I PKS gene cluster isolated from Streptomyces hygroscopicus ATCC 29253, a rapamycin-producing strain. Gene 203 1–9 Occurrence Handle1:CAS:528:DyaK2sXotFSqtrc%3D Occurrence Handle9426000
J Sambrook DW Russel (2001) Molecular Cloning: A Laboratory Manual, 3rd ed. Cold Spring Harbor Laboratory Press Cold Spring Harbor, NY
M Sauser P Lu R Sangari S Kennedy J Polishook G Bills Z An (2002) ArticleTitleEstimating polyketide metabolic potential among nonsporulating fungal endophytes of Vaccinium macrocarpon. Mycol Res 106 460–470
F Schauwecker F Pfennig W Schroder U Keller (1998) ArticleTitleMolecular cloning of the actinomycin synthetase gene cluster from Streptomyces chrysomallus and functional heterologous expression of the gene encoding actinomycin synthetase II. J Bacteriol 180 2468–2474 Occurrence Handle1:CAS:528:DyaK1cXivFOlsL4%3D Occurrence Handle9573200
T Schupp C Toupet E Nathalie S Goff (1998) ArticleTitleCloning and sequence analysis of the putative rifamycin polyketide synthase gene cluster from Amycolatopsis mediterranei. FEMS Microbiol Lett 159 201–207 Occurrence Handle1:CAS:528:DyaK1cXht1Wgt7c%3D Occurrence Handle9503613
L Serre EC Verbree A Dauter AR Stuitje ZS Derewenda (1995) ArticleTitleThe Escherichia coli malonyl-CoA:acyl carrier protein transacylase at 1.5 Å resolution. J Biol Chem 270 12961–12964 Occurrence Handle1:CAS:528:DyaK2MXmtV2itrs%3D Occurrence Handle7768883
S Shah Q Xue L Tang JR Carney M Betlach R McDaniel (2000) ArticleTitleCloning, characterization and heterologous expression of a polyketide synthase and P-450 oxidase involved in the biosynthesis of the antibiotic oleandomycin. J Antibiot 53 502–508 Occurrence Handle1:CAS:528:DC%2BD3cXjslejurg%3D Occurrence Handle10908114
JM Sigmund DJ Clark FA Rainey AS Anderson (2003) ArticleTitleDetection of eubacterial 3-hydroxy-3-methylglutaryl coenzyme A reductases from natural populations of actinomycetes. Microb Ecol 46 106–112 Occurrence Handle1:CAS:528:DC%2BD3sXnt1Git78%3D Occurrence Handle12754661
M Sosio M Bossi A Bianchi S Donadio (2000) ArticleTitleMultiple peptide synthase gene clusters in actinomycetes. Mol Gen Genet 264 213–221 Occurrence Handle1:CAS:528:DC%2BD3cXot1Gkt7g%3D Occurrence Handle11085259
T Stachelhaus MA Marahiel (1995) ArticleTitleModular structure of genes encoding multifunctional peptide synthetases required for non-ribosomal peptide synthesis. FEMS Microbiol Lett 125 3–14 Occurrence Handle1:CAS:528:DyaK2MXivVKlsbo%3D Occurrence Handle7867917
DA Stahl R Amann (1991) Development and application of nucleic acid probes. E Stackebrandt M Goodfellow (Eds) Nucleic Acid Techniques in Bacterial Systematics Wiley Chichester, UK 205–248
JD Thompson DG Higgins TJ Gibson (1994) ArticleTitleCLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res 22 4673–4680 Occurrence Handle1:CAS:528:DyaK2MXitlSgu74%3D Occurrence Handle7984417
JW Trauger CT Walsh (2000) ArticleTitleHeterologous expression in Escherichia coli of the first module of the nonribosomal peptide synthetase for chloroeremomycin, a vancomycin-type glycopeptide antibiotic. Prac Natl Acad Sci USA 97 3112–3117 Occurrence Handle1:CAS:528:DC%2BD3cXitlWru7Y%3D
K Turgay MA Marahiel (1994) ArticleTitleA general approach for identifying and cloning peptide synthetase genes. Pept Res 7 238–241 Occurrence Handle1:CAS:528:DyaK2MXht1aksr8%3D Occurrence Handle7849417
KJ Weissman M Bycroft J Staunton F Leadlay (1998) ArticleTitleOrigin of starter units for erythromycin biosynthesis. Biochemistry 37 11012–11017 Occurrence Handle1:CAS:528:DyaK1cXkvVylsL4%3D Occurrence Handle9692995
K Wu L Chung WP Revill L Katz CD Reeves (2000) ArticleTitleThe FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units. Gene 251 81–90 Occurrence Handle1:CAS:528:DC%2BD3cXktV2itLk%3D Occurrence Handle10863099
Y Xue D Wilson DH Sherman (2000) ArticleTitleGenetic architecture of the polyketide synthases for methylmycin and pikromycin series macrolides. Gene 245 203–211 Occurrence Handle1:CAS:528:DC%2BD3cXhsFanurs%3D Occurrence Handle10713461
G Zhu MJ LaGier F Stejskal JJ Millership X Cai JS Keithly (2002) ArticleTitleCryptosporidium parvum: the first protist known to encode a putative polyketide synthase. Gene 298 79–89 Occurrence Handle1:CAS:528:DC%2BD38XotFOmur8%3D Occurrence Handle12406578