Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells
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Kolonel,L.N., Hankin,J.H., Whittemore,A.S. et al . ( 2000 ) Vegetables, fruits, legumes and prostate cancer: a multiethnic case-control study. Cancer Epidemiol. Biomarkers Prev. , 9 , 795 –804.
Cohen,J.H., Kristal,A.R. and Stanford,J.L. ( 2000 ) Fruit and vegetable intakes and prostate cancer risk. J. Natl Cancer Inst. , 92 , 61 –68.
Kristal,A.R. and Lampe,J.W. ( 2002 ) Brassica vegetables and prostate cancer risk: a review of the epidemiological evidence. Nutr. Cancer , 42 , 1 –9.
Giovannucci,E., Rimm,E.B., Liu,Y., Stampfer,M.J. and Willett,W.C. ( 2003 ) A prospective study of cruciferous vegetables and prostate cancer. Cancer Epidemiol. Biomarkers Prev. , 12 , 1403 –1409.
Zhang,Y., Talalay,P., Cho,C.G. and Posner,G.H. ( 1992 ) A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Proc. Natl Acad. Sci. USA , 89 , 2399 –2403.
Chung,F.L., Conaway,C.C., Rao,C.V. and Reddy,B.S. ( 2000 ) Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate. Carcinogenesis , 21 , 2287 –2291.
Fahey,J.W., Zhang,Y. and Talalay,P. ( 1997 ) Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proc. Natl Acad. Sci. USA , 94 , 10367 –10372.
Zhang,Y., Kensler,T.W., Cho,C.G., Posner,G.H. and Talalay,P. ( 1994 ) Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates. Proc. Natl Acad. Sci. USA , 91 , 3147 –3150.
Singh,A.V., Xiao,D., Lew,K.L., Dhir,R. and Singh,S.V. ( 2004 ) Sulforaphane induces caspase-mediated apoptosis in cultured PC-3 human prostate cancer cells and retards growth of PC-3 xenografts in vivo . Carcinogenesis , 25 , 83 –90.
Chiao,J.W., Chung,F.L., Kancherla,R., Ahmed,T., Mittelman,A. and Conaway,C.C. ( 2002 ) Sulforaphane and its metabolite mediate growth arrest and apoptosis in human prostate cancer cells. Int. J. Oncol. , 20 , 631 –636.
Gingras,D., Gendron,M., Boivin,D., Moghrabi,A., Theoret,Y. and Beliveau,R. ( 2004 ) Induction of medulloblastoma cell apoptosis by sulforaphane, a dietary anticarcinogen from Brassica vegetables. Cancer Lett. , 203 , 35 –43.
Bonnesen,C., Eggleston,I.M. and Hayes,J.D. ( 2001 ) Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines. Cancer Res. , 61 , 6120 –6130.
Gamet-Payrastre,L., Li,P., Lumeau,S., Cassar,G., Dupont,M.A., Chevolleau,S., Gasc,N., Tulliez,J. and Terce,F. ( 2000 ) Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells. Cancer Res. , 60 , 1426 –1433.
Fimognari,C., Nusse,M., Cesari,R., Iori,R., Cantelli-Forti,G. and Hrelia,P. ( 2002 ) Growth inhibition, cell-cycle arrest and apoptosis in human T-cell leukemia by the isothiocyanate sulforaphane. Carcinogenesis , 23 , 581 –586.
Fimognari,C., Nusse,M., Berti,F., Iori,R., Cantelli-Forti,G. and Hrelia,P. ( 2002 ) Cyclin D3 and p53 mediate sulforaphane-induced cell cycle delay and apoptosis in non-transformed human T lymphocytes. Cell. Mol. Life Sci. , 59 , 2004 –2012.
Jackson,S.J. and Singletary,K.W. ( 2004 ) Sulforaphane: a naturally occurring mammary carcinoma mitotic inhibitor which disrupts tubulin polymerization. Carcinogenesis , 25 , 219 –227.
Gamet-Payrastre,L., Lumeau,S., Gasc,N., Cassar,G., Rollin,P. and Tulliez,J. ( 1998 ) Selective cytostatic and cytotoxic effects of glucosinolates hydrolysis products on human colon cancer cells in vitro . Anticancer Drugs , 9 , 141 –148.
Wang,L., Liu,D., Ahmed,T., Chung,F.L., Conaway,C. and Chiao,J.W. ( 2004 ) Targeting cell cycle machinery as a molecular mechanism of sulforaphane in prostate cancer prevention. Int. J. Oncol. , 24 , 187 –192.
Myzak,M.C., Karplus,P.A., Chung,F.-L. and Dashwood,R.H. ( 2004 ) A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase. Cancer Res. , 64 , 5767 –5774.
Rosato,R.R. and Grant,S. ( 2003 ) Histone deacetylase inhibitors in cancer therapy. Cancer Biol. Ther. , 2 , 30 –37.
Marks,P., Rifkind,R.A., Richon,V.M., Breslow,R., Miller,T. and Kelly,W.K. ( 2001 ) Histone deacetylases and cancer: causes and therapies. Nat. Rev. Cancer , 1 , 194 –202.
Marks,P.A., Richon,V.M. and Rifkind,R.A. ( 2000 ) Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells. J. Natl Cancer Inst. , 92 , 1210 –1216.
Oh,H.J., CHung,E.J., Lee,S., Loaiza-Perez,A., Sausville,E.A. and Trepel,J.B. ( 2004 ) Targeting histone deacetylase as a strategy for cancer prevention. In Kelloff,G.J., Hawk,E.T. and Sigman,C.C. (eds), Cancer Prevention: Promising Cancer Chemopreventive Agents . Human Press, Inc, Totowa, NJ, vol. 1 , pp. 659–678.
Kopelovich,L., Crowell,J.A. and Fay,J.R. ( 2003 ) The epigenome as a target for cancer chemoprevention. J. Natl Cancer Inst. , 95 , 1747 –1757.
Patra,S.K., Patra,A. and Dahiya,R. ( 2001 ) Histone deacetylase and DNA methyltransferase in human prostate cancer. Biochem. Biophy. Res. Commun. , 287 , 705 –713.
Halkidou,K., Gaughan,L., Cook,S., Leung,H.Y., Neal,D.E. and Robson,C.N. ( 2004 ) Upregulation and nuclear recruitment of HDAC1 in hormone refractory prostate cancer. Prostate , 59 , 177 –189.
Fronsdal,K. and Saatcioglu,F. ( 2005 ) Histone deacetylase inhibitors differentially mediate apoptosis in prostate cancer cells. Prostate , 62 , 299 –306.
Thelen,P., Schweyer,S., Hemmerlein,B., Wuttke,W., Seseke,F. and Ringert,R.H. ( 2004 ) Expressional changes after histone deacetylase inhibition by valproic acid in LNCaP human prostate cancer cells. Int. J. Oncol. , 24 , 25 –31.
Butler,L.M., Agus,D.B., Scher,H.I., Higgins,B., Rose,A., Cordon-Cardo,C., Thaler,H.T., Rifkind,R.A., Marks,P.A. and Richon,V.M. ( 2000 ) Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses the growth of prostate cancer cells in vitro and in vivo . Cancer Res. , 60 , 5165 –5170.
Billin,A.N., Thirlwell,H. and Ayer,D.E. ( 2000 ) Beta -catenin-histone deacetylase interactions regulate the transition of LEF1 from a transcriptional repressor to an activator. Mol. Cell. Biol. , 20 , 6882 –6890.
Hu,R., Hebbar,V., Kim,B.R., Chen,C., Winnik,B., Buckley,B., Soteropoulos,P., Tolias,P., Hart,R.P. and Kong,A.N. ( 2004 ) In vivo pharmacokinetics and regulation of gene expression profiles by isothiocyanate sulforaphane in the rat. J. Pharmacol. Exp. Ther. , 310 , 263 –271.
Druesne,N., Pagniez,A., Mayeur,C., Thomas,M., Cherbuy,C., Duee,P.H., Martel,P. and Chaumontet,C. ( 2004 ) Diallyl disulfide (DADS) increases histone acetylation and p21(waf1/cyp1) expression in human colon tumor cell lines. Carcinogenesis , 25 , 1227 –1236.
Hinnebusch,B.F., Meng,S., Wu,J.T., Archer,S.Y. and Hodin,R.A. ( 2002 ) The effects of short-chain fatty acids on human colon cancer cell phenotype are associated with histone hyperacetylation. J. Nutr. , 132 , 1012 –1027.
Remiszewski,S.W., Sambucetti,L.C., Atadja,P. et al . ( 2002 ) Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J. Med. Chem. , 45 , 753 –757.
Woo,S.H., Frechette,S., Abou Khalil,E. et al . ( 2002 ) Structurally simple trichostatin A-like straight chain hydroxamates as potent histone deacetylase inhibitors. J. Med. Chem. , 45 , 2877 –2885.
Della Ragione,F., Criniti,V., Della Pietra,V., Borriello,A., Oliva,A., Indaco,S., Yamamoto,T. and Zappia,V. ( 2001 ) Genes modulated by histone acetylation as new effectors of butyrate activity. FEBS Lett. , 499 , 199 –204.
Richon,V.M., Sandhoff,T.W., Rifkind,R.A. and Marks,P.A. ( 2000 ) Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation. Proc. Natl Acad. Sci. USA , 97 , 10014 –10019.
Lavelle,D., Chen,Y.H., Hankewych,M. and DeSimone,J. ( 2001 ) Histone deacetylase inhibitors increase p21(WAF1) and induce apoptosis of human myeloma cell lines independent of decreased IL-6 receptor expression. Am. J. Hematol. , 68 , 170 –178.
Eickhoff,B., Ruller,S., Laue,T., Kohler,G., Stahl,C., Schlaak,M. and van der Bosch,J. ( 2000 ) Trichostatin A modulates expression of p21waf1/cip1, Bcl-xL, ID1, ID2, ID3, CRAB2, GATA-2, hsp86 and TFIID/TAFII31 mRNA in human lung adenocarcinoma cells. Biol. Chem. , 381 , 107 –112.
Finzer,P., Kuntzen,C., Soto,U., zur Hausen,H. and Rosl,F. ( 2001 ) Inhibitors of histone deacetylase arrest cell cycle and induce apoptosis in cervical carcinoma cells circumventing human papillomavirus oncogene expression. Oncogene , 20 , 4768 –4776.
Kobayashi,H., Tan,E.M. and Fleming,S.E. ( 2004 ) Acetylation of histones associated with the p21WAF1/CIP1 gene by butyrate is not sufficient for p21WAF1/CIP1 gene transcription in human colorectal adenocarcinoma cells. Int. J. Cancer , 109 , 207 –213.
Diaz,G.D., Li,Q. and Dashwood,R.H. ( 2003 ) Caspase-8 and apoptosis-inducing factor mediate a cytochrome c-independent pathway of apoptosis in human colon cancer cells induced by the dietary phytochemical chlorophyllin. Cancer Res. , 63 , 1254 –1261.
Dinkova-Kostova,A.T., Holtzclaw,W.D., Cole,R.N., Itoh,K., Wakabayashi,N., Katoh,Y., Yamamoto,M. and Talalay,P. ( 2002 ) Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. Proc. Natl Acad. Sci. USA , 99 , 11908 –11913.
Thimmulappa,R.K., Mai,K.H., Srisuma,S., Kensler,T.W., Yamamoto,M. and Biswal,S. ( 2002 ) Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. Cancer Res. , 62 , 5196 –5203.
Kwak,M.K., Egner,P.A., Dolan,P.M., Ramos-Gomez,M., Groopman,J.D., Itoh,K., Yamamoto,M. and Kensler,T.W. ( 2001 ) Role of phase 2 enzyme induction in chemoprotection by dithiolethiones. Mutat. Res. , 480-481 , 305 –315.
Ye,L., Dinkova-Kostova,A.T., Wade,K.L., Zhang,Y., Shapiro,T.A. and Talalay,P. ( 2002 ) Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: pharmacokinetics of broccoli sprout isothiocyanates in humans [Erratum (2002) Clin. Chim. Acta , 321 , 127–129.]. Clin. Chim. Acta , 316 , 43–53 .
Zhang,Y. ( 2000 ) Role of glutathione in the accumulation of anticarcinogenic isothiocyanates and their glutathione conjugates by murine hepatoma cells. Carcinogenesis , 21 , 1175 –1182.
Myzak,M.C., Dashwood,W.M., Orner,G.A., Dashwood,R.H. and Ho,E. ( 2005 ) Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apcmin mice. FASEB J ., in press.
Zhang,Y., Kolm,R.H., Mannervik,B. and Talalay,P. ( 1995 ) Reversible conjugation of isothiocyanates with glutathione catalyzed by human glutathione transferases. Biochem. Biophys. Res. Commun. , 206 , 748 –755.
Kassahun,K., Davis,M., Hu,P., Martin,B. and Baillie,T. ( 1997 ) Biotransformation of the naturally occurring isothiocyanate sulforaphane in the rat: identification of phase I metabolites and glutathione conjugates. Chem. Res. Toxicol. , 10 , 1228 –1233.
Conaway,C.C., Krzeminski,J., Amin,S. and Chung,F.L. ( 2001 ) Decomposition rates of isothiocyanate conjugates determine their activity as inhibitors of cytochrome p450 enzymes. Chem. Res. Toxicol. , 14 , 1170 –1176.
Conaway,C.C., Yang,Y.M. and Chung,F.L. ( 2002 ) Isothiocyanates as cancer chemopreventive agents: their biological activities and metabolism in rodents and humans. Curr. Drug Metab. , 3 , 233 –255.
Yegnasubramanian,S., Kowalski,J., Gonzalgo,M.L., Zahurak,M., Piantadosi,S., Walsh,P.C., Bova,G.S., De Marzo,A.M., Isaacs,W.B. and Nelson,W.G. ( 2004 ) Hypermethylation of CpG islands in primary and metastatic human prostate cancer. Cancer Res. , 64 , 1975 –1986.
Millar,D.S., Ow,K.K., Paul,C.L., Russell,P.J., Molloy,P.L. and Clark,S.J. ( 1999 ) Detailed methylation analysis of the glutathione S-transferase pi (GSTP1) gene in prostate cancer. Oncogene , 18 , 1313 –1324.
Myzak,M.C. and Dashwood,R.H. ( 2005 ) Chemoprevention by sulforaphane: Keep one eye beyone Keap1. Cancer Lett. , in press.
Myzak,M.C. and Dashwood,R.H. ( 2005 ) Histone deacetylases as targets for dietary cancer preventive agents: Lessons learned with butyrate, diallyl disulfide, and sulforaphane. Current Drug Targets , in press.
Singh,S.V., Herman-Antosiewicz,A., Singh,A.V., Lew,K.L., Srivastava,S.K., Kamath,R., Brown,K.D., Zhang,L. and Baskaran,R. ( 2004 ) Sulforaphane-induced G2/M phase cell cycle arrest involves checkpoint kinase 2-mediated phosphorylation of cell division cycle 25C. J. Biol. Chem. , 279 , 25813 –25822.