Oligomerization of Cry9Aa in solution without receptor binding, is not related with insecticidal activity

Schnepf, 1998, Bacillus thuringiensis and its pesticidal crystal proteins, Microbiol Mol Biol Rev, 62, 775, 10.1128/MMBR.62.3.775-806.1998 Bravo, 2007, Mode of action of Bacillus thuringiensis Cry and Cyt toxins and their potential for insect control, Toxicon, 49, 423, 10.1016/j.toxicon.2006.11.022 Van Frankenhuyzen, 2009, Insecticidal activity of Bacillus thuringiensis crystal proteins, J Invertebr Pathol, 101, 1, 10.1016/j.jip.2009.02.009 Christou, 2006, Recent developments and future prospects in insect pest control in transgenic crops, Trends Plant Sci, 11, 302, 10.1016/j.tplants.2006.04.001 Crickmore, 2006, Beyond the spore-past and future developments of Bacillus thuringiensis as a biopesticide, J Appl Microbiol, 101, 616, 10.1111/j.1365-2672.2006.02936.x Gatehouse, 2008, Biotechnological prospects for engineering insect-resistant plants, Plant Physiol, 146, 881, 10.1104/pp.107.111096 Alberghini, 2005, Construction of a Pseudomonas sp. derivative carrying the cry9Aa gene from Bacillus thuringiensis and a proposal for new standard criteria to assess entomocidal properties of bacteria, Res Microbiol, 156, 690, 10.1016/j.resmic.2005.02.003 Su, 2010, Cloning, expression and insecticidal activity of two cry9Aa genes from Bacillus thuringiensis strains, Plant Prot, 37, 541 Kuvshinov, 2001, Transgenic crop plants expressing synthetic cry9Aa gene are protected against insect damage, Plant Sci, 160, 341, 10.1016/S0168-9452(00)00398-8 Marchetti, 2009, Effects of conventional and transgenic Bacillus thuringiensis galleriae toxin on Exorista larvarum (Diptera: Tachinidae), a parasitoid of forest defoliating Lepidoptera, Biocontrol Sci Tech, 19, 463, 10.1080/09583150902807535 Naimov, 2014, A novel Cry9Aa with increased toxicity for Spodoptera exigua (Hübner), J Invertebr Pathol, 115, 99, 10.1016/j.jip.2013.11.003 Shu, 2013, Characterization of cry9Da4, cry9Eb2, and cry9Ee1 genes from Bacillus thuringiensis strain T03B001, Appl Microbiol Biotechnol, 97, 9705, 10.1007/s00253-013-4781-5 Li, 2014, Evaluation of the synergistic activities of Bacillus thuringiensis Cry proteins against Helicoverpa armigera (Lepidoptera: Noctuidae), J Invertebr Pathol, 121, 7, 10.1016/j.jip.2014.06.005 Fang, 2015, The minimal active fragment of the Cry9Aa3 toxin against Plutella xylostella and Ostrinia Furnacalis, Plant Prot, 41, 85 Gómez, 2002, Cadherin-like receptor binding facilitates proteolytic cleavage of helix α-1 in domain I and oligomer pre-pore formation of Bacillus thuringiensis Cry1Ab toxin, FEBS Lett, 513, 242, 10.1016/S0014-5793(02)02321-9 Gómez, 2014, Bacillus thuringiensis Cry1A toxins are versatile-proteins with multiple modes of action: Two distinct pre-pores are involved in toxicity, Biochem J, 459, 383, 10.1042/BJ20131408 Jiménez-Juárez, 2007, Bacillus thuringiensis Cry1Ab mutants affecting oligomer formation are non-toxic to Manduca sexta larvae, J Biol Chem, 282, 21222, 10.1074/jbc.M701314200 Güereca, 1999, The oligomeric state of Bacillus thuringiensis Cry toxins in solution, Biochim Biophys Acta Protein Struct Mol Enzymol, 1429, 342, 10.1016/S0167-4838(98)00241-6 Walters, 1994, A stable oligomer of Bacillus thuringiensis delta-endotoxin, CryIIIA, Insect Biochem Mol Biol, 24, 963, 10.1016/0965-1748(94)90133-3 Guo, 2009, Protease-resistant core form of Bacillus thuringiensis Cry1Ie: Monomeric and oligomeric forms in solution, Biotechnol Lett, 31, 1769, 10.1007/s10529-009-0078-2 Zhou, 2011, Toxicity analysis of activated Cry1Ah of monomeric and oligomeric forms in the solution, Plant Prot, 37, 48 Zhang, 2009, Cloning, expression and insecticidal activity of cry2A gene from Bacillus thuringiensis, Biotechnol Bull, 10, 145 Tabashnik, 1993, Increasing efficiency of bioassays: Evaluation resistance to Bacillus thuringiensis in diamondback moth (Lepidoptera: Plutellidae), J Econ Entomol, 86, 635, 10.1093/jee/86.3.635 Bravo, 2004, Oligomerization triggers binding of a Bacillus thuringiensis Cry1Ab pore-forming toxin to aminopeptidase N receptor leading to insertion into membrane microdomains, Biochim Biophys Acta Biomembr, 1667, 38, 10.1016/j.bbamem.2004.08.013 Welker, 2002, Intramolecular versus intermolecular disulfide bonds in prion proteins, J Biol Chem, 277, 33477, 10.1074/jbc.M204273200 Lindsay, 1998, Examination of the structure of the glutenin macropolymer in wheat flour and doughs by stepwise reduction, J Agric Food Chem, 46, 3447, 10.1021/jf980315m Mou, 2003, Inducers of plant systemic acquired resistance regulate NPR1 function through redox changes, Cell, 113, 935, 10.1016/S0092-8674(03)00429-X