Metastatic duodenal GIST: role of surgery combined with imatinib mesylate
Tóm tắt
The best possible treatment of metastatic high grade large duodenal GIST is controversial. Surgery (with or without segmental organ resection) remains the principal treatment for primary and recurrent GIST. However, patients with advanced duodenal GIST have a high risk of early tumour recurrence and short life expectancy. We present a case of a young man treated with a combined modality of surgery and imatinib for an advanced duodenal GIST. He remains asymptomatic and disease free 42 months following this combined approach. Treatment with imatinib has dramatically improved the outlook for patients with advanced, unresectable and/or metastatic disease.
Tài liệu tham khảo
Sturgeon C, Chejfec G, Espat NJ: Gastrointestinal stromal tumors: a spectrum of disease. Surg Oncol. 2003, 12: 21-26. 10.1016/S0960-7404(02)00074-9.
DeMatteo RP, Lewis JJ, Leung D, Mudan SS, Woodruff JM, Brennan MF: Two hundred gastrointestinal stromal tumors: recurrence patterns and prognostic factors for survival. Ann Surg. 2000, 231: 51-58. 10.1097/00000658-200001000-00008.
Chack A, Canto MI, Rosch T: Endoscopic differentiation of benign and malignant stromal cell tumors. Gastrointestinal Endosc. 1997, 45: 468-473. 10.1016/S0016-5107(97)70175-5.
DeMatteo RP, Heinrich MC, El-Rifai WM, Demetri G: Clinical management of gastrointestinal stromal tumors: Before and after STI-571. Human Pathol. 2002, 33: 466-67. 10.1053/hupa.2002.124122.
Amin MB, Ma CK, Linden MD, Kubus JJ, Zarbo RJ: Prognostic value of proliferating cell nuclear antigen index in gastric stromal tumors. Correlation with mitotic count and clinical outcome. Am J Clin Pathol. 1993, 100: 428-32.
Kindblom LG, Remotti HE, Aldenborg F, Meis-Kindblom JM: Gastrointestinal pacemaker cell tumor (GIPACT): gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal. Am J Pathol. 1998, 152: 1259-1269.
De Saint Aubain Somerhausen N, Fletcher CDM: Gastrointestinal Stromal Tumors. An Update. Sarcoma. 1998, 2: 133-141. 10.1080/13577149877885.
Panizo-Santos A, Sola I, Vega F, de Alava E, Lozano MD, Idoate MA, Pardo-Mindan J: Predicting Metastatic Risk of Gastrointestinal Stromal Tumors: Role of Cell Proliferation and Cell Cycle Regulatory Proteins. Int J Surg Pathol. 2000, 8: 133-44.
Trupiano JK, Stewart RE, Misick C, Appelman HD, Goldblum JR: Gastric stromal tumors: a clinicopathologic study of 77 cases with correlation of features with nonaggressive and aggressive clinical behaviors. Am J Surg Pathol. 2002, 26: 705-14. 10.1097/00000478-200206000-00003.
Miettinen M, El-Rifai W, H L, Sobin L, Lasota J: Evaluation of malignancy and prognosis of gastrointestinal stromal tumors: a review. Hum Pathol. 2002, 33: 478-83. 10.1053/hupa.2002.124123.
Casper ES: Gastrointestinal stromal tumors. Curr Treat Options Oncol. 2000, 1: 267-273.
Roberts PJ, Eisenberg B: Clinical presentation of gastrointestinal stromal tumors and treatment of operable disease. Eur J Cancer. 2002, 38 (suppl 5): S37-38. 10.1016/S0959-8049(02)80601-3.
Singer S, Rubin BP, Lux ML, Chen CJ, Demetri GD, Fletcher CD, Fletcher JA: Prognostic value of KIT mutation type, mitotic activity, and histologic subtype in gastrointestinal stromal tumors. J Clin Oncol. 20: 3898-905. 10.1200/JCO.2002.03.095. 2002 Sep 15
Joensuu H, Roberts PJ, Sarlomo-Rikala M, Andersson LC, Tervahartiala P, Tuveson D, Silberman S, Capdeville R, Dimitrijevic S, Druker B, Demetri GD: Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor. N Engl J Med. 2001, 344: 1052-56. 10.1056/NEJM200104053441404.
Demetri GD, von Mehren M, Blanke CD, Van den Abbeele AD, Eisenberg B, Roberts PJ, Heinrich MC, Tuveson DA, Singer S, Janicek M, Fletcher JA, Silverman SG, Silberman SL, Capdeville R, Kiese B, Peng B, Dimitrijevic S, Druker BJ, Corless C, Fletcher CD, Joensuu H: Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med. 2002, 347: 472-80. 10.1056/NEJMoa020461.
Van Glabbeke M, Verweij J, Casali PG, Simes J, Le Cesne A, Reichardt P, Issels R, Judson IR, van Oosterom AT, Blay JY: Predicting toxicities for patients with advanced gastrointestinal stromal tumours treated with imatinib: a study of the European Organisation for Research and Treatment of Cancer, the Italian Sarcoma Group, and the Australasian Gastro-Intestinal Trials Group (EORTC-ISG-AGITG). Eur J Cancer. 2006, 42: 2277-85. 10.1016/j.ejca.2006.03.029.
Silberman S, Joensuu H: Overview of issues related to imatinib therapy of advanced gastrointestinal stromal tumours: a discussion amongst experts. Eur J Cancer. 2002, 38 (suppl 5): S66-S69. 10.1016/S0959-8049(02)80605-0.
Rankin C, Von Mehren M, Blanke C, Benjamin R, D C, Fletcher M, Bramwell V, Crowley J, Borden E, D G: Demetri. Dose effect of imatinib (IM) in patients (pts) with metastatic GIST – Phase III Sarcoma Group Study S0033. J Clin Oncol. 2004, 22 (14S): 9005-
van Oosterom AT, Judson I, Verweij J, Stroobants S, Donato di Paola E, Dimitrijevic S, Martens M, Webb A, Sciot R, Van Glabbeke M, Silberman S, Nielsen OS, European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group: Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: a phase I study. Lancet. 2001, 358: 1421-1423. 10.1016/S0140-6736(01)06535-7.