Epsilon toxin from Clostridium perfringens induces toxic effects on skin tissues and HaCaT and human epidermal keratinocytes

Toxicon - Tập 198 - Trang 102-110 - 2021
Zhijun Geng1,2, Lin Kang2, Jing Huang2,3, Shan Gao2, Jing Wang2, Yuan Yuan2, Yanwei Li2, Jinglin Wang2, Wenwen Xin2
1Department of Central Laboratory, First Affiliated Hospital of Bengbu Medical College, Bengbu, 233001, Anhui Province, PR China
2State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, AMMS, Beijing, 100071, PR China
3Life Science Institute of Hebei Normal University, Shijiazhuang, 050011, Hebei Province, PR China

Tài liệu tham khảo

Alonso, 1987, cDNA cloning and sequence of MAL, a hydrophobic protein associated with human T-cell differentiation, Proc. Natl. Acad. Sci. U. S. A., 84, 1997, 10.1073/pnas.84.7.1997 Alves, 2014, Clostridium perfringens epsilon toxin: the third most potent bacterial toxin known, Anaerobe, 30, 102, 10.1016/j.anaerobe.2014.08.016 Blanch, 2018, The cytotoxicity of epsilon toxin from Clostridium perfringens on lymphocytes is mediated by MAL protein expression, Mol. Cell Biol., 38, 10.1128/MCB.00086-18 Chassin, 2007, Pore-forming epsilon toxin causes membrane permeabilization and rapid ATP depletion-mediated cell death in renal collecting duct cells, Am. J. Physiol. Ren. Physiol., 293, F927, 10.1152/ajprenal.00199.2007 Cheong, 1999, VIP17/MAL, a lipid raft-associated protein, is involved in apical transport in MDCK cells, Proc. Natl. Acad. Sci. U. S. A., 96, 6241, 10.1073/pnas.96.11.6241 Dorca-Arévalo, 2018, Epsilon toxin from Clostridium perfringens induces cytotoxicity in FRT thyroid epithelial cells, Anaerobe, 53, 43, 10.1016/j.anaerobe.2018.05.011 Dorca-Arévalo, 2008, Binding of epsilon-toxin from Clostridium perfringens in the nervous system, Vet. Microbiol., 131, 14, 10.1016/j.vetmic.2008.02.015 Gao, 2018, Research articleHemolysis in human erythrocytes by Clostridium perfringens epsilon toxin requires activation of P2 receptors, Virulence, 9, 1601, 10.1080/21505594.2018.1528842 Horie, 2017, Comparative analysis of the intestinal flora in type 2 diabetes and nondiabetic mice, Exp. Anim., 66, 405, 10.1538/expanim.17-0021 Ivie, 2011, Gene-trap mutagenesis identifies mammalian genes contributing to intoxication by Clostridium perfringens epsilon-toxin, PloS One, 6, 10.1371/journal.pone.0017787 Kang, 2017, F199E substitution reduced toxicity of Clostridium perfringens epsilon toxin by depriving the receptor binding capability, Hum. Vaccines Immunother., 13, 1598, 10.1080/21645515.2017.1303022 Khalili, 2017, Structural pierce into molecular mechanism underlying Clostridium perfringens Epsilon toxin function, Toxicon, 127, 90, 10.1016/j.toxicon.2017.01.010 Li, 2013, A low-toxic site-directed mutant of Clostridium perfringens epsilon-toxin as a potential candidate vaccine against enterotoxemia, Hum. Vaccines Immunother., 9, 2386, 10.4161/hv.25649 Linden, 2015, Clostridium perfringens epsilon toxin causes selective death of mature oligodendrocytes and central nervous system demyelination, mBio, 6, 10.1128/mBio.02513-14 Lynch, 2016, The human intestinal microbiome in health and disease, N. Engl. J. Med., 375, 2369, 10.1056/NEJMra1600266 Marazuela, 2004, Expression of MAL and MAL2, two elements of the protein machinery for raft-mediated transport, in normal and neoplastic human tissue, Histol. Histopathol., 19, 925 Miyata, 2002, Clostridium perfringens epsilon-toxin forms a heptameric pore within the detergent-insoluble microdomains of Madin-Darby canine kidney cells and rat synaptosomes, J. Biol. Chem., 277, 39463, 10.1074/jbc.M206731200 Patel, 2017, Aquaporins in the skin, Adv. Exp. Med. Biol., 969, 173, 10.1007/978-94-024-1057-0_11 Payne, 1994, Evaluation of a new cytotoxicity assay for Clostridium perfringens type D epsilon toxin, FEMS Microbiol. Lett., 116, 161, 10.1111/j.1574-6968.1994.tb06695.x Petit, 1997, Clostridium perfringens epsilon-toxin acts on MDCK cells by forming a large membrane complex, J. Bacteriol., 179, 6480, 10.1128/jb.179.20.6480-6487.1997 Rumah, 2013, Isolation of Clostridium perfringens type B in an individual at first clinical presentation of multiple sclerosis provides clues for environmental triggers of the disease, PloS One, 8, 10.1371/journal.pone.0076359 Rumah, 2015, 'The myelin and lymphocyte protein MAL is required for binding and activity of Clostridium perfringens ε-toxin, PLoS Pathog., 11, 10.1371/journal.ppat.1004896 Wioland, 2015, Epsilon toxin from Clostridium perfringens acts on oligodendrocytes without forming pores, and causes demyelination, Cell Microbiol., 17, 369, 10.1111/cmi.12373 Yang, 2016, Abnormalities in the basement membrane structure promote basal keratinocytes in the epidermis of hypertrophic scars to adopt a proliferative phenotype, Int. J. Mol. Med., 37, 1263, 10.3892/ijmm.2016.2519