Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion

Cancer Cell - Tập 38 - Trang 79-96.e11 - 2020
Rui Su1, Lei Dong1, Yangchan Li1,2, Min Gao1,3, Li Han1,4, Mark Wunderlich5, Xiaolan Deng1, Hongzhi Li6, Yue Huang7, Lei Gao1,8, Chenying Li1,9, Zhicong Zhao1,10, Sean Robinson1, Brandon Tan1, Ying Qing1, Xi Qin1, Emily Prince1, Jun Xie6, Hanjun Qin11, Wei Li1
1Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA
2Department of Radiation Oncology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, China
3School of Pharmaceutical Science and Technology, Tianjin Key Laboratory for Modern Drug Delivery and High Efficiency, and Collaborative Innovation Center of Chemical Science and Engineer (Tianjin), Tianjin University, Tianjin 300072, China
4School of Pharmacy, China Medical University, Shenyang, Liaoning 110001, China
5Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA
6Department of Molecular Medicine, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA
7State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
8Department of Pathology and Genomic Medicine, Houston Methodist, Houston, TX 77030, USA
9Department of Hematology, The First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang 31003, China
10Department of Liver Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
11The Integrative Genomics Core, Beckman Research Institute, City of Hope Medical Center, Duarte, CA 91010, USA

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