Evidence for Extensive Transmission Distortion in the Human Genome

Abecasis, 2002, Merlin—rapid analysis of dense genetic maps using sparse gene flow trees, Nat Genet, 30, 97, 10.1038/ng786 Broman, 1998, Comprehensive human genetic maps: individual and sex-specific variation in recombination, Am J Hum Genet, 63, 861, 10.1086/302011 Chakraborty, 1996, Segregation distortion of the CTG repeats at the myotonic dystrophy locus, Am J Hum Genet, 59, 109 Crow, 1991, Why is Mendelian segregation so exact?, Bioessays, 13, 305, 10.1002/bies.950130609 Daw, 2000, Bias in multipoint linkage analysis arising from map misspecification, Genet Epidemiol, 19, 366, 10.1002/1098-2272(200012)19:4<366::AID-GEPI8>3.0.CO;2-F Eaves, 1999, Transmission ratio distortion at the INS-IGF2 VNTR, Nat Genet, 22, 324, 10.1038/11890 Edmonds, 1982, Early embryonic mortality in women, Fertil Steril, 38, 447, 10.1016/S0015-0282(16)46579-9 Edwards, 2003, Sib-pairs in multifactorial disorders: the sib-similarity problem, Clin Genet, 63, 1, 10.1034/j.1399-0004.2003.630101.x Evans, 1994, Genetic linkage of cone-rod retinal dystrophy to chromosome 19q and evidence for segregation distortion, Nat Genet, 6, 210, 10.1038/ng0294-210 Girardet, 2000, Meiotic segregation analysis of RB1 alleles in retinoblastoma pedigrees by use of single-sperm typing, Am J Hum Genet, 66, 167, 10.1086/302715 Greenwood, 2000, The impact of transmission-ratio distortion on allele sharing in affected sibling pairs, Am J Hum Genet, 66, 2001, 10.1086/302918 Kong, 2002, A high-resolution recombination map of the human genome, Nat Genet, 31, 241, 10.1038/ng917 Kruglyak, 1996, Parametric and nonparametric linkage analysis: a unified multipoint approach, Am J Hum Genet, 58, 1347 LeMaire-Adkins, 2000, Nonrandom segregation of the mouse univalent X chromosome: evidence of spindle-mediated meiotic drive, Genetics, 156, 775, 10.1093/genetics/156.2.775 Lyttle, 1993, Cheaters sometimes prosper: distortion of Mendelian segregation by meiotic drive, Trends Genet, 9, 205, 10.1016/0168-9525(93)90120-7 Macklon, 2002, Conception to ongoing pregnancy: the “black box” of early pregnancy loss, Hum Reprod Update, 8, 333, 10.1093/humupd/8.4.333 Naumova, 2001, Imprinting and deviation from Mendelian transmission ratios, Genome, 44, 311, 10.1139/g01-013 Naumova, 1998, Parental origin–dependent, male offspring–specific transmission-ratio distortion at loci on the human X chromosome, Am J Hum Genet, 62, 1493, 10.1086/301860 Newman, 2003, Major loci influencing serum triglyceride levels on 2q14 and 9p21 localized by homozygosity-by-descent mapping in a large Hutterite pedigree, Hum Mol Genet, 12, 137, 10.1093/hmg/ddg012 Ober, 1998, HLA and pregnancy: the paradox of the fetal allograft, Am J Hum Genet, 62, 1, 10.1086/301692 Ober, 1999, Inbreeding effects on fertility in humans: evidence for reproductive compensation, Am J Hum Genet, 64, 225, 10.1086/302198 Ober, 2000, A second-generation genomewide screen for asthma-susceptibility alleles in a founder population, Am J Hum Genet, 67, 1154 O’Connell, 1998, PedCheck: a program for identification of genotype incompatibilities in linkage analysis, Am J Hum Genet, 63, 259, 10.1086/301904 Pardo-Manuel de Villena, 2000, Natural selection and the function of genome imprinting: beyond the silenced minority, Trends Genet, 16, 573, 10.1016/S0168-9525(00)02134-X Pardo-Manuel de Villena, 2001, Nonrandom segregation during meiosis: the unfairness of females, Mamm Genome, 12, 331, 10.1007/s003350040003 Polanski, 1998, Dynamic balance of segregation distortion and selection maintains normal allele sizes at the myotonic dystrophy locus, Math Biosci, 147, 93, 10.1016/S0025-5564(97)00082-5 Regan, 2000, Epidemiology and the medical causes of miscarriage, Baillieres Best Pract Res Clin Obstet Gynaecol, 14, 839, 10.1053/beog.2000.0123 Risch, 1995, Genetic analysis of idiopathic torsion dystonia in Ashkenazi Jews and their recent descent from a small founder population, Nat Genet, 9, 152, 10.1038/ng0295-152 Risch, 1999, A genomic screen of autism: evidence for a multilocus etiology, Am J Hum Genet, 65, 493, 10.1086/302497 Roberts, 1975, Where have all the conceptions gone?, Lancet, 7907, 498, 10.1016/S0140-6736(75)92837-8 Spielman, 1993, Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM), Am J Hum Genet, 52, 506 Weber, 2001, Genotyping for human whole-genome scans: past, present, and future, volume 42, 77 Westendorp, 2001, Optimizing human fertility and survival, Nat Med, 7, 873, 10.1038/90868