ApoE Promotes the Proteolytic Degradation of Aβ

Neuron - Tập 58 - Trang 681-693 - 2008
Qingguang Jiang1, C.Y. Daniel Lee1, Shweta Mandrekar1, Brandy Wilkinson1, Paige Cramer1, Noam Zelcer2, Karen Mann3, Bruce Lamb3, Timothy M. Willson4, Jon L. Collins4, Jill C. Richardson5, Jonathan D. Smith6, Thomas A. Comery7, David Riddell7, David M. Holtzman8, Peter Tontonoz2, Gary E. Landreth1
1Alzheimer Research Laboratory, Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
2Howard Hughes Medical Institute, Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
3Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
4GlaxoSmithKline, Discovery Research, Research Triangle Park, NC 27709, USA
5GlaxoSmithKline, New Frontiers Science Park, Harlow, CM19 5AW, UK
6Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
7Discovery Neuroscience, Wyeth Research, Princeton, NJ 08543, USA
8Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8111, St. Louis, MO 63110, USA

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