Salivary cortisol and DHEA: association with measures of cognition and well-being in normal older men, and effects of three months of DHEA supplementation

Altman, 1991 Arlt, 1999, Dehydroepiandrosterone replacement in women with adrenal insufficiency, N. Engl. J. Med., 341, 1013, 10.1056/NEJM199909303411401 Arlt, 1999, Biotransformation of oral dehydroepiandrosterone in elderly men: Significant increase in circulating estrogens, J. Clin. Endocrinol. Metab., 84, 2170, 10.1210/jcem.84.6.5789 Barnhart, 1999, The effects of dehydroepiandrosterone supplementation to symptomatic perimenopausal women on serum endocrine profiles, lipid parameters, and health-related quality of life, J. Clin. Endocrinol. Metab., 84, 3896 Barrett-Connor, 1994, A prospective study of dehydroepiandrosterone sulfate and cognitive function in an older population: The Rancho Bernardo Study, J. Am. Geriatr. Soc., 42, 420, 10.1111/j.1532-5415.1994.tb07491.x Barrett-Connor, 1999, Endogenous levels of dehydroepiandrosterone sulfate, but not other sex hormones, are associated with depressed mood in older women: The Rancho Bernardo Study, J. Am. Geriatr. Soc., 47, 685, 10.1111/j.1532-5415.1999.tb01590.x Barry, 1992, The American Urological Association symptom index for benign prostatic hyperplasia. The Measurement Committee of the American Urological Association, J. Urol., 148, 1549, 10.1016/S0022-5347(17)36966-5 Bastianetto, 1999, Dehydroepiandrosterone (DHEA) protects hippocampal cells from oxidative stress-induced damage, Brain Res. Mol. Brain Res., 66, 35, 10.1016/S0169-328X(99)00002-9 Baulieu, 2000, Dehydroepiandrosterone (DHEA), DHEA sulfate, and aging: Contribution of the DHEAge study to a sociobiomedical issue, Proc. Natl. Acad. Sci. USA, 97, 4279, 10.1073/pnas.97.8.4279 Bergeron, 1996, Potentiation of neuronal NMDA response induced by dehydroepiandrosterone and its suppression by progesterone: an effect mediated via sigma receptors, J. Neurosci., 16, 1193, 10.1523/JNEUROSCI.16-03-01193.1996 Berr, 1996, Relationships of dehydroepiandrosterone sulfate in the elderly with functional, psychological, and mental status, and short-term mortality: a French community-based study, Proc. Natl. Acad. Sci., 93, 13410, 10.1073/pnas.93.23.13410 Blauer, 1991, Dehydroepiandrosterone antagonizes the suppressive effects of dexamethasone on lymphocyte proliferation, Endocrinology, 129, 3174, 10.1210/endo-129-6-3174 Bloch, 1999, Dehydroepiandrosterone treatment of midlife dysthymia, Biol. Psychiatry, 45, 1533, 10.1016/S0006-3223(99)00066-9 Cardounel, 1999, Dehydroepiandrosterone protects hippocampal neurons against neurotoxin-induced cell death: mechanism of action, Proc. Soc. Exp. Biol. Med., 222, 145, 10.1046/j.1525-1373.1999.d01-124.x Carlson, 1999, Relationships among cortisol (CRT), dehydroepiandrosterone–sulfate (DHEAS), and memory in a longitudinal study of healthy elderly men and women, Neurobiol. Aging, 20, 315, 10.1016/S0197-4580(99)00052-4 Cawood, 1996, Steroid hormones, the menopause, sexuality and well-being of women, Psychol. Med., 26, 925, 10.1017/S0033291700035261 Cox, 1993 Curran, 1995, Short form of the Profile of Mood States (POMS-SF): Psychometric information, Psychol. Assessment, 7, 80, 10.1037/1040-3590.7.1.80 Debonnel, 1996, Potentiation by dehydroepiandrosterone of the neuronal response to N-methyl-D-aspartate in the CA3 region of the rat dorsal hippocampus: an effect mediated via sigma receptors, J. Endocrinol., 150, S33 Diener, 1985, The independence of positive and negative affect, J. Pers. Soc. Psychol., 47, 1105, 10.1037/0022-3514.47.5.1105 Flynn, 1999, Dehydroepiandrosterone replacement in aging humans, J. Clin. Endocrinol. Metab., 84, 1527 Goodyer, 1996, Adrenal secretion during major depression in 8- to 16-year olds, I. Altered diurnal rhythms in salivary cortisol and dehydroepiandrosterone (DHEA) at presentation, Psychol. Med., 26, 245, 10.1017/S0033291700034644 Granger, 1999, Assessing dehydroepiandrosterone in saliva: a simple radioimmunoassay for use in studies of children, adolescents and adults, Psychoneuroendocrinology, 24, 567, 10.1016/S0306-4530(99)00013-X Guazzo, 1996, Cortisol, dehydroepiandrosterone (DHEA), and DHEA sulfate in the cerebrospinal fluid of man: relation to blood levels and the effects of age, J. Clin. Endocrinol. Metab., 81, 3951 Herbert, 1997, Stress, the brain, and mental illness, BMJ, 315, 530, 10.1136/bmj.315.7107.530 Hodge, 1994, The epidemiology of obesity, Baillieres Clin. Endocrinol. Metab., 8, 577, 10.1016/S0950-351X(05)80287-3 Hunt, 2000, Improvement in mood and fatigue following DHEA replacement in a randomised double-blind trial in Addison's disease, J. Clin. Endocrinol. Metab., 85, 4650 Huppert, F.A., van Niekerk, J.K., 2000. Dehydroepiandrosterone (DHEA) supplementation for cognitive function (Cochrane Review). In: The Cochrane Library (Issue 2). Oxford: Update Software. Jakubowicz, 1995, Disparate effects of weight reduction by diet on serum dehydroepiandrosterone-sulfate levels in obese men and women, J. Clin. Endocrinol. Metab., 80, 3373 Jenkinson, 1999, Assessment of the SF-36 Version 2 in the United Kingdom, J. Epidemiol. Community Med., 53, 46, 10.1136/jech.53.1.46 Kalmijn, 1998, A prospective study on cortisol, dehydroepiandrosterone sulfate, and cognitive function in the elderly, J. Clin. Endocrinol. Metab., 83, 3487, 10.1210/jcem.83.10.5164 Kimonides, 1998, Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS) protect hippocampal neurons against excitatory amino acid-induced neurotoxicity, Proc. Natl. Acad. Sci. USA, 95, 1852, 10.1073/pnas.95.4.1852 Kimonides, 1999, Dehydroepiandrosterone (DHEA) antagonizes the neurotoxic effects of corticosterone and translocation of stress-activated protein kinase 3 in hippocampal primary cultures, Neuroscience, 89, 429, 10.1016/S0306-4522(98)00347-9 Kronmal, 1993, Spurious correlation and the fallacy of the ratio standard revisited, J. R. Statistical Soc., Series A, 156, 379, 10.2307/2983064 Kudielka, 1998, Sex differences in endocrine and psychological responses to psychosocial stress in healthy elderly subjects and the impact of a 2-week dehydroepiandrosterone treatment, J. Clin. Endocrinol. Metab., 83, 1756 Lupien, 1994, Basal cortisol levels and cognitive deficits in human aging, J. Neurosci., 14, 2893, 10.1523/JNEUROSCI.14-05-02893.1994 Lupien, 1998, Cortisol levels during human aging predict hippocampal atrophy and memory deficits, Nat. Neurosc., 1, 69, 10.1038/271 Majewska, 1995, Neuronal actions of dehydroepiandrosterone, Ann. NY Acad. Sci., 774, 111, 10.1111/j.1749-6632.1995.tb17375.x Maurice, 1997, Neuroprotective and anti-amnesic potentials of sigma receptor ligands, Prog. Neuropsychopharmacol. Biol. Psychiatry, 21, 69, 10.1016/S0278-5846(96)00160-1 May, 1991, Protection from glucocorticoid induced thymic involution by dehydroepiandrosterone, Life. Sci., 46, 1627 McNair, 1992 The Medical Research Council Cognitive Function and Ageing Study (MRC CFAS), 1998. Cognitive function and dementia in six areas of England and Wales: the distribution of MMSE and prevalence of GMS organicity level in the MRC CFA Study. Psychol. Med., 28(2), 319–335. Mohs, 1997, Development of cognitive instruments for use in clinical trials of antidementia drugs: additions to the Alzheimer's Disease Assessment Scale that broaden its scope. The Alzheimer's Disease Cooperative Study, Alzheimer Dis. Assoc. Disord., 11, S13, 10.1097/00002093-199700112-00003 Morales, 1994, Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age, J. Clin. Endocrinol. Metab., 78, 1360 Orentreich, 1992, Long-term longitudinal measurements of plasma dehydroepiandrosterone sulfate in normal men, J. Clin. Endocrinol. Metab., 75, 1002 Park, 2000 Plihal, 1996, Corticosteroid receptor mediated effects on mood in humans, Psychoneuroendocrinology, 21, 515, 10.1016/S0306-4530(96)00011-X Rabkin, 2000, DHEA treatment for HIV+ patients: effects on mood, androgenic and anabolic parameters, Psychoneuroendocrinology, 25, 53, 10.1016/S0306-4530(99)00036-0 Reus, 1997, Antiglucocorticoid treatments in psychiatry, Psychoneuroendocrinology, 22, S121, 10.1016/S0306-4530(97)00016-4 Richards, 1999, Lifetime cognitive function and timing of the natural menopause, Neurology, 52, 308, 10.1212/WNL.53.2.308 Sapolsky, 1996, Why stress is bad for your brain, Science, 273, 749, 10.1126/science.273.5276.749 Seeman, 1997, Increase in urinary cortisol excretion and memory declines: MacArthur studies of successful aging, J. Clin. Endocrinol. Metab., 82, 2458 Shacham, 1983, A shortened version of the Profile of Mood States, J. Pers. Assess., 47, 305, 10.1207/s15327752jpa4703_14 Shafagoj, 1992, Dehydroepiandrosterone prevents dexamethasone-induced hypertension in rats, Am. J. Physiol., 263, E210 Squire, 1992, Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans, Psychol. Rev., 99, 195, 10.1037/0033-295X.99.2.195 Verhey, F.R.J., Huppert, F.A., Stoppe, G., Pena-Casanova, J., Neri, M., De Deyn, P.P., Wallin, A., Gely-Nargeot, M.C., Houx, P., Klinkenberg, E., Commissaris, K., Bohm, P., De Vreese, L., Nordlund, A., Jolles, J. Cross-national validation of the ADAS: The European Harmonization project of instruments for dementia (EURO-HARPID). Paper presented at the 5th International Springfield Conference on the treatment of Alzheimer's Disease and related disorders, Stockholm, Sweden, April 6–8, 2000. Welsh, 1991, Detection of abnormal memory decline in mild cases of Alzheimer's Disease using CERAD neuropsychological measures, Arch. Neurol., 48, 278, 10.1001/archneur.1991.00530150046016 Wolf, 1999, Actions of dehydroepiandrosterone and its sulfate in the central nervous system: effects on cognition and emotion in animals and humans, Brain Res. Rev., 30, 264, 10.1016/S0165-0173(99)00021-1 Wolf, 1998, Opposing effects of DHEA replacement in elderly subjects on declarative memory and attention after exposure to a laboratory stressor, Psychoneuroendocrinology, 23, 617, 10.1016/S0306-4530(98)00032-8 Wolf, 1998, Effects of dehydroepiandrosterone (DHEA) replacement in elderly men on event related potentials (ERPs), memory and well-being, J. Gerontol. A. Biol. Sci. Med. Sci., 53, M385, 10.1093/gerona/53A.5.M385 Wolf, 1997, Effects of a two-week physiological dehydroepiandrosterone substitution on cognitive performance and well-being in healthy elderly women and men, J. Clin. Endocrinol. Metab., 82, 2363 Wolkowitz, 1999, Double-blind treatment of major depression with dehydroepiandrosterone, Am. J. Psychiatry, 156, 646, 10.1176/ajp.156.4.646 Wright, 1992, Antiglucocorticoid action of dehydroepiandrosterone in young obese Zucker rats, Int. J. Obes. Relat. Metab. Disord., 16, 579 Yaffe, 1998, Neuropsychiatric function and dehydroepiandrosterone sulfate in elderly women: a prospective study, Biol. Psychiatry, 43, 694, 10.1016/S0006-3223(97)00303-X Yen, 1995, Replacement of DHEA in aging men and women, Ann. NY Acad. Sci., 774, 128, 10.1111/j.1749-6632.1995.tb17377.x