Modeling the release of proteins from degrading crosslinked dextran microspheres using kinetic Monte Carlo simulations

van de Wetering, 2005, Poly(ethylene glycol) hydrogels formed by conjugate addition with controllable swelling, degradation, and release of pharmaceutically active proteins, J. Control. Release, 102, 619, 10.1016/j.jconrel.2004.10.029 Kissel, 2002, ABA-triblock copolymers from biodegradable polyester A-blocks and hydrophilic poly(ethylene oxide) B-blocks as a candidate for in situ forming hydrogel delivery systems for proteins, Adv. Drug Deliv. Rev., 54, 99, 10.1016/S0169-409X(01)00244-7 Anseth, 2002, In situ forming degradable networks and their application in tissue engineering and drug delivery, J. Control. Release, 78, 199, 10.1016/S0168-3659(01)00500-4 Bezemer, 1999, A controlled release system for proteins based on poly(ether ester) block-copolymers: polymer network characterization, J. Control. Release, 62, 393, 10.1016/S0168-3659(99)00170-4 Hennink, 1997, Dextran hydrogels for the controlled release of proteins, J. Control. Release, 48, 107, 10.1016/S0168-3659(97)00047-3 Peppas, 2000, Hydrogels in pharmaceutical formulations, Eur. J. Pharm. Biopharm., 50, 27, 10.1016/S0939-6411(00)00090-4 Kofuji, 2003, Retention and release behavior of insulin in chitosan gel beads, J. Biomater. Sci., Polym. Ed., 14, 1243, 10.1163/156856203322553464 Cadée, 2002, Release of recombinant human interleukin-2 from dextran-based hydrogels, J. Control. Release, 17, 1, 10.1016/S0168-3659(01)00483-7 Kuijpers, 2000, In vivo and in vitro release of lysozyme from cross-linked gelatin hydrogels: a model system for the delivery of antibacterial proteins from prosthetic heart valves, J. Control. Release, 67, 323, 10.1016/S0168-3659(00)00221-2 Cadée, 2001, A comparative biocompatibility study of microspheres based on crosslinked dextran or poly(lactic-co-glycolic) acid after subcutaneous injection in rats, J. Biomed. Mater. Res., 56, 600, 10.1002/1097-4636(20010915)56:4<600::AID-JBM1133>3.0.CO;2-I Woo, 2001, Preparation and characterization of a composite PLGA and poly(acryloyl hydroxyethyl starch) microsphere system for protein delivery, Pharm. Res., 18, 1600, 10.1023/A:1013090700443 Martens, 2002, Synthesis and characterization of degradable hydrogels formed from acrylate modified poly(vinyl alcohol) macromers, Polymer, 43, 6093, 10.1016/S0032-3861(02)00561-X Kim, 2001, Albumin release from biodegradable hydrogels composed of dextran and poly(ethylene glycol) macromer, Arch. Pharm. Res., 24, 69, 10.1007/BF02976496 Franssen, 1999, Chemically degrading dextran hydrogels: controlled release of a model protein from cylinders and microspheres, J. Control. Release, 60, 211, 10.1016/S0168-3659(99)00074-7 van Dijk-Wolthuis, 1997, Degradation and release behavior of dextran based hydrogels, Macromolecules, 30, 4639, 10.1021/ma9704018 Stenekes, 1998, The preparation of dextran microspheres in an all-aqueous system: effect of the formulation parameters on particle characteristics, Pharm. Res., 15, 557, 10.1023/A:1011925709873 Stenekes, 2000, Controlled release of liposomes from biodegradable dextran microspheres: a novel delivery concept, Pharm. Res., 17, 690, 10.1023/A:1007526114744 Martens, 2001, A generalized bulk-degradation model for hydrogel networks formed from multivinyl cross-linking molecules, J. Phys. Chem., B, 105, 5131, 10.1021/jp004102n Amsden, 2003, A model for osmotic pressure driven release from cylindrical rubbery polymer matrices, J. Control. Release, 93, 249, 10.1016/j.jconrel.2003.08.007 Peppas, 1985, Analysis of Fickian and non-Fickian drug release from polymers, Pharm. Acta Helv., 60, 110 Huang, 1997, Evaluation of a statistical model for the formation of poly [acryloyl hydroxyethyl starch] microspheres, Pharm. Res., 14, 475, 10.1023/A:1012199500072 Bezemer, 2000, Zero-order release of lysozyme from poly(ethylene glycol)/poly(butylene terephthalate) matrices, J. Control. Release, 64, 179, 10.1016/S0168-3659(99)00127-3 Kanjickal, 2004, Modeling of drug release from polymeric delivery systems — a review, Crit. Rev. Ther. Drug Carr. Syst., 21, 345, 10.1615/CritRevTherDrugCarrierSyst.v21.i5.10 Siepmann, 2001, Mathematical modeling of bioerodible, polymeric drug delivery systems, Adv. Drug Deliv. Rev., 48, 229, 10.1016/S0169-409X(01)00116-8 West, 1995, Photopolymerized hydrogel materials for drug delivery applications, React. Polym., 25, 139, 10.1016/0923-1137(94)00096-N Mason, 2001, Predicting controlled-release behavior of degradable PLA-b-PEG-b-PLA hydrogels, Macromolecules, 34, 4630, 10.1021/ma010025y Zygourakis, 1989, Discrete simulations and bioerodible controlled release systems, Polym. Prep. ACS, 30, 456 Zygourakis, 1990, Development and temporal evolution of erosion fronts in bioerodible controlled release devices, Chem. Eng. Sci., 45, 2359, 10.1016/0009-2509(90)80116-V Göpferich, 1996, Mechanisms of polymer degradation and erosion, Biomaterials, 17, 103, 10.1016/0142-9612(96)85755-3 Göpferich, 1995, Modeling monomer release from bioerodible polymers, J. Control. Release, 33, 55, 10.1016/0168-3659(94)00064-2 Göpferich, 1993, Modeling of polymer erosion, Macromolecules, 26, 4105, 10.1021/ma00068a006 Siepmann, 2002, A new mathematical model quantifying drug release from bioerodible microparticles using Monte Carlo simulations, Pharm. Res., 19, 1885, 10.1023/A:1021457911533 K.D.F. Vlugt-Wensink, Y.J. Meijer, R. Verrijk, W. Jiskoot, D.J.A. Crommelin, W.E. Hennink, Effect of excipients on the release of hGH from dex-HEMA microspheres, Manuscript in preparation. Stenekes, 2000, Pore sizes in hydrated dextran microspheres, Biomacromolecules, 1, 696, 10.1021/bm005574a Philipse, 2003, Caging effects in amorphous hard-spheres solids, Coll. Surf. A, 213, 167, 10.1016/S0927-7757(02)00510-1 Peters, 2001, Caging of a d-dimensional sphere and its relevance for the random dense sphere packing, Phys. Rev., E, 63, 021404, 10.1103/PhysRevE.63.021404 Feller, 1945, The fundamental limit theorems in probability, Bull. Am. Math. Soc., 51, 800, 10.1090/S0002-9904-1945-08448-1 Trotter, 1959, An elementary proof of the central limit theorem, Arch. Math., 10, 226, 10.1007/BF01240790 van Dijk-Wolthuis, 1997, Degradation kinetics of methacrylated dextrans in aqueous solution, J. Pharm. Sci., 86, 413, 10.1021/js9604220 Errington, 1992, Physico-chemical studies on di-iodotyrosine dextran, Carbohydr. Polym., 18, 289, 10.1016/0144-8617(92)90094-7 van Dijk-Wolthuis, 1997, A new class of polymerizable dextrans with hydrolyzable groups: hydroxyethyl methacrylated dextran with and without oligolactate spacer, Polymer, 38, 6235, 10.1016/S0032-3861(97)00189-4 van de Weert, 2002, Semisolid, self-catalyzed poly(ortho ester)s as controlled-release systems: protein release and protein stability issues, J. Pharm. Sci., 91, 1065, 10.1002/jps.10109 Tuinier, 2003, On the long-range attraction between proteins due to nonadsorbing polysaccharide, Biomacromolecules, 4, 28, 10.1021/bm0255544