Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

Cancer Cell - Tập 18 - Trang 553-567 - 2010
Maria E. Figueroa1, Omar Abdel-Wahab2,3, Chao Lu4, Patrick S. Ward4, Jay Patel5, Alan Shih5,3, Yushan Li1, Neha Bhagwat5, Aparna Vasanthakumar6, Hugo F. Fernandez7, Martin S. Tallman3, Zhuoxin Sun8, Kristy Wolniak9, Justine K. Peeters10, Wei Liu11, Sung E. Choe11, Valeria R. Fantin11, Elisabeth Paietta12, Bob Löwenberg10, Jonathan D. Licht9
1Division of Hematology/Oncology, Weill Cornell Medical College, New York, NY 10065, USA
2Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA
3Leukemia Service, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA
4Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA
5Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
6Section of Hematology/Oncology, Department of Medicine, The University of Chicago, Chicago, IL 60637 USA
7Department of Blood and Bone Marrow Transplantation, Moffitt Cancer Center, Tampa, FL 33612, USA
8Dana Farber Cancer Institute, Harvard School of Public Health, Boston, MA 02445, USA
9Division of Hematology/Oncology, Northwestern University, Chicago, IL 60611, USA
10Department of Hematology, Erasmus University Medical Center, 3000 CA Rotterdam, the Netherlands
11Agios Pharmaceuticals, Cambridge, MA 02139, USA
12Cancer Center, Montefiore Medical Center–North Division, Bronx, NY 10466, USA

Tài liệu tham khảo

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