The LIFE child study: a life course approach to disease and health

BMC Public Health - Tập 12 Số 1 - 2012
Mirja Quante1, Mara Hesse1, Mirko Döhnert1, Michael Fuchs2, Christian R Hirsch1, Elena Sergeyev3, Nora Casprzig1, Mandy Geserick1, Stephanie Naumann1, Christiane Koch1, Matthew A. Sabin4,5, Andreas Hiemisch1, Antje Körner1, Wieland Kieß1
1LIFE Leipzig Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany
2Section of Phoniatrics and Audiology of the Department of Otorhinolaryngology, University of Leipzig, Leipzig, Germany
3LIFE - Leipzig Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany
4Murdoch Children’s Research Institute and Royal Children’s Hospital, Melbourne, Australia
5University of Melbourne, Melbourne, Melbourne, Australia

Tóm tắt

Abstract Background Profound knowledge about child growth, development, health, and disease in contemporary children and adolescents is still rare. Epidemiological studies together with new powerful research technologies present exciting opportunities to the elucidation of risk factor-outcome associations with potentially major consequences for prevention, diagnosis and treatment. Aim To conduct a unique prospective longitudinal cohort study in order to assess how environmental, metabolic and genetic factors affect growth, development and health from fetal life to adulthood. Methods The ‘Leipzig Research Centre for Civilization Diseases (LIFE) Child Study’ focuses on two main research objectives: (1) monitoring of normal growth, development and health; (2) non-communicable diseases such as childhood obesity and its co-morbidities, atopy and mental health problems. Detailed assessments will be conducted alongside long-term storage of biological samples in 2,000 pregnant women and more than 10,000 children and their families. Results Close coordination and engagement of a multidisciplinary team in the LIFE Child study successfully established procedures and systems for balancing many competing study and ethical needs. Full participant recruitment and complete data collection started in July 2011. Early data indicate a high acceptance rate of the study program, successful recruitment strategies and the establishment of a representative cohort for the population of Leipzig. A series of subprojects are ongoing, and analyses and publications are on their way. Discussion This paper addresses key elements in the design and implementation of the new prospective longitudinal cohort study LIFE Child. Given the recognized need for long-term data on adverse effects on health and protective factors, our study data collection should provide magnificent opportunities to examine complex interactions that govern the emergence of non-communicable diseases.

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Tập 12 Số 1

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