Way to efficient microbial paclitaxel mass production

Liu, 2023, Current perspectives on paclitaxel: focus on its production, delivery and combination therapy, Mini-Rev Med Chem Shankar Naik, 2018, Developments in taxol production through endophytic fungal biotechnology: a review, Orient, Pharm. Exp. Med., 19, 1 Nazhand, 2020, Rewiring cellular metabolism for heterologous biosynthesis of Taxol, Nat Prod Res, 34, 110, 10.1080/14786419.2019.1630122 Stierle, 1993, Taxol and taxane production by Taxomyces andreanae, an endophytic fungus of Pacific yew, Science, 260, 214, 10.1126/science.8097061 El-Sayed, 2020, Exploiting the biosynthetic potency of taxol from fungal endophytes of conifers plants; genome mining and metabolic manipulation, Molecules, 25, 10.3390/molecules25133000 Kumar, 2019, Hyper-production of taxol from Aspergillus fumigatus, an endophytic fungus isolated from Taxus sp. of the Northern Himalayan region, Biotechnol. Rep., 24 Gu, 2015, Greater taxol yield of fungus Pestalotiopsis hainanensis from dermatitic scurf of the giant panda (Ailuropoda melanoleuca), Appl Biochem Biotechnol, 175, 155, 10.1007/s12010-014-1254-y El-Sayed, 2019, Restoring the Taxol biosynthetic machinery of Aspergillus terreus by Podocarpus gracilior Pilger microbiome, with retrieving the ribosome biogenesis proteins of WD40 superfamily, Sci Rep, 9, 10.1038/s41598-019-47816-y Liu, 2016, Advances in exploring alternative Taxol sources, RSC Adv, 6, 48800, 10.1039/C6RA06640B Sabzehzari, 2020, Alternative sources and metabolic engineering of Taxol: advances and future perspectives, Biotechnol Adv, 43, 10.1016/j.biotechadv.2020.107569 El-Sayed, 2021, Triggering the biosynthetic machinery of Taxol by Aspergillus flavipes via cocultivation with Bacillus subtilis: proteomic analyses emphasize the chromatin remodeling upon fungal-bacterial interaction, Environ Sci Pollut Res, 28, 39866, 10.1007/s11356-021-13533-1 Xiong, 2021, The Taxus genome provides insights into paclitaxel biosynthesis, Nat Plants, 7, 1026, 10.1038/s41477-021-00963-5 Sharma, 2022, An overview on Taxol production technology and its applications as anticancer agent, Biotechnol Bioproc Eng, 27, 706, 10.1007/s12257-022-0063-3 Li, 2019, Chloroplastic metabolic engineering coupled with isoprenoid pool enhancement for committed taxanes biosynthesis in Nicotiana benthamiana, Nat Commun, 10, 4850, 10.1038/s41467-019-12879-y Mutanda, 2021, Recent advances in metabolic engineering, protein engineering, and transcriptome-guided insights toward synthetic production of Taxol, Front Bioeng Biotechnol, 9, 10.3389/fbioe.2021.632269 Xu, 2023, Improving solubility and copy number of taxadiene synthase to enhance the titer of taxadiene in Yarrowia lipolytica, Synth Syst Biotechnol, 8, 331, 10.1016/j.synbio.2023.04.002 Liu, 2009, Isolation and characterization of endophytic taxol-producing fungi from Taxus chinensis, J Ind Microbiol Biotechnol, 36, 1171, 10.1007/s10295-009-0598-8 Deng, 2008, Fusarium solani, Tax-3, a new endophytic taxol-producing fungus from Taxus chinensis, World J Microbiol Biotechnol, 25, 139, 10.1007/s11274-008-9876-2 Yang, 2018, Fermentation engineering for enhanced paclitaxel production by Taxus media endophytic fungus MF-5 (Alternaria sp), J Biobased Mater Bioenergy, 12, 545, 10.1166/jbmb.2018.1806 Christensen, 2022, Drugs that changed society: microtubule-targeting agents belonging to taxanoids, macrolides and non-ribosomal peptides, Molecules, 27, 10.3390/molecules27175648 Mishra, 2021, Exploiting endophytic microbes as micro-factories for plant secondary metabolite production, Appl Microbiol Biotechnol, 105, 6579, 10.1007/s00253-021-11527-0 Das, 2017, An endophytic Basidiomycete, Grammothele lineata, isolated from Corchorus olitorius, produces paclitaxel that shows cytotoxicity, PLoS One, 12, 10.1371/journal.pone.0178612 El-Sayed, 2018, Induction of Taxol biosynthesis by Aspergillus terreus, endophyte of Podocarpus gracilior Pilger, upon intimate interaction with the plant endogenous microbes, Process Biochem, 71, 31, 10.1016/j.procbio.2018.04.020 Gill, 2019, Isolation of taxol producing endophytic fungus Alternaria brassicicola from non-Taxus medicinal plant Terminalia arjuna, World J Microbiol Biotechnol, 35, 74, 10.1007/s11274-019-2651-8 Abdel-Fatah, 2021, Production, bioprocess optimization and gamma-irradiation of Penicillium polonicum, as a new Taxol producing endophyte from Ginko biloba, Biotechnol. Rep., 30 El-Sayed, 2020, Detection, purification and elucidation of chemical structure and antiproliferative activity of taxol produced by Penicillium chrysogenum, Molecules, 25, 10.3390/molecules25204822 Bi, 2013, A new taxol-producing fungus (Pestalotiopsis malicola) and evidence for taxol as a transient product in the culture, Afr J Biotechnol, 10, 6647 Miao, 2018, Transcriptome analysis of a taxol-producing endophytic fungus Cladosporium cladosporioides MD2, Amb Express, 8, 41, 10.1186/s13568-018-0567-6 Qiao, 2017, Enhancing taxol production in a novel endophytic fungus, Aspergillus aculeatinus Tax-6, isolated from Taxus chinensis var. mairei, Fungal Biol, 121, 1037, 10.1016/j.funbio.2017.08.011 Kusari, 2014, Rethinking production of Taxol(R) (paclitaxel) using endophyte biotechnology, Trends Biotechnol, 32, 304, 10.1016/j.tibtech.2014.03.011 Ismaiel, 2017, Production of paclitaxel with anticancer activity by two local fungal endophytes, Aspergillus fumigatus and Alternaria tenuissima, Appl Microbiol Biotechnol, 101, 5831, 10.1007/s00253-017-8354-x Gauchan, 2021, Annulohypoxylon sp. strain MUS1, an endophytic fungus isolated from Taxus wallichiana Zucc., produces taxol and other bioactive metabolites, 3 Biotech, 11, 152, 10.1007/s13205-021-02693-z El-Sayed, 2019, Sterol inhibitor “Fluconazole” enhance the Taxol yield and molecular expression of its encoding genes cluster from Aspergillus flavipes, Process Biochem, 76, 55, 10.1016/j.procbio.2018.10.008 Abdel-Fatah, 2022, Boosting the anticancer activity of Aspergillus flavus "endophyte of jojoba" taxol via conjugation with gold nanoparticles mediated by gamma-irradiation, Appl Biochem Biotechnol, 194, 3558, 10.1007/s12010-022-03906-8 Suresh, 2020, Mycosynthesis of anticancer drug taxol by Aspergillus oryzae, an endophyte of Tarenna asiatica, characterization, and its activity against a human lung cancer cell line, Biocatal Agric Biotechnol, 24, 10.1016/j.bcab.2020.101525 Zhang, 2009, An endophytic taxol-producing fungus from Taxus media, Cladosporium cladosporioides MD2, Curr Microbiol, 59, 227, 10.1007/s00284-008-9270-1 El-Maali, 2018, Novel resources of Taxol from endophytic and entomopathogenic fungi: isolation, characterization and LC-Triple mass spectrometric quantification, Talanta, 190, 466, 10.1016/j.talanta.2018.07.089 El-Sayed, 2020, Production of the anticancer drug taxol by the endophytic fungus Epicoccum nigrum TXB502: enhanced production by gamma irradiation mutagenesis and immobilization technique, Appl Microbiol Biotechnol, 104, 6991, 10.1007/s00253-020-10712-x Garyali, 2014, Enhancement of taxol production from endophytic fungus Fusarium redolens, Biotechnol Bioproc Eng, 19, 908, 10.1007/s12257-014-0160-z Sah, 2017, Cloning and sequence analysis of 10-deacetylbaccatin III-10-O-acetyl transferase gene and WRKY1 transcription factor from taxol-producing endophytic fungus Lasiodiplodia theobromea, FEMS Microbiol Lett, 364, 10.1093/femsle/fnx253 Zhao, 2008, Screening and breeding of high taxol producing fungi by genome shuffling, Sci China Ser C Life Sci, 51, 222, 10.1007/s11427-008-0037-5 Subban, 2019, Salicylic acid as an effective elicitor for improved taxol production in endophytic fungus Pestalotiopsis microspora, PLoS One, 14, 10.1371/journal.pone.0212736 Zaiyou, 2017, An endophytic fungus efficiently producing paclitaxel isolated from Taxus wallichiana var. mairei, Medicine, 96, 10.1097/MD.0000000000007406 El-Sayed, 2019, Bioprocess optimization using response surface methodology for production of the anticancer drug paclitaxel by Aspergillus fumigatus and Alternaria tenuissima: enhanced production by ultraviolet and gamma irradiation, Biocatal Agric Biotechnol, 18, 10.1016/j.bcab.2019.01.034 Somjaipeng, 2016, Environmental stress and elicitors enhance taxol production by endophytic strains of Paraconiothyrium variabile and Epicoccum nigrum, Enzym Microb Technol, 90, 69, 10.1016/j.enzmictec.2016.05.002 Ruiz-Sanchez, 2010, A comparative study of Taxol production in liquid and solid-state fermentation with Nigrospora sp. a fungus isolated from Taxus globosa, J Appl Microbiol, 109, 2144, 10.1111/j.1365-2672.2010.04846.x El-Sayed, 2020, Semi-continuous production of the anticancer drug taxol by Aspergillus fumigatus and Alternaria tenuissima immobilized in calcium alginate beads, Bioproc Biosyst Eng, 43, 997, 10.1007/s00449-020-02295-8 El-Sayed, 2019, Strain improvement and immobilization technique for enhanced production of the anticancer drug paclitaxel by Aspergillus fumigatus and Alternaria tenuissima, Appl Microbiol Biotechnol, 103, 8923, 10.1007/s00253-019-10129-1 Salehi, 2018, Elicitors derived from Hazel (Corylus avellana L.) cell suspension culture enhance growth and paclitaxel production of Epicoccum nigrum, Sci Rep, 8, 10.1038/s41598-018-29762-3 Soliman, 2013, Interactions between Co-Habitating fungi elicit synthesis of Taxol from an endophytic Fungus in host Taxus plants, Front Microbiol, 4, 3, 10.3389/fmicb.2013.00003 Salehi, 2019, New synergistic co-culture of Corylus avellana cells and Epicoccum nigrum for paclitaxel production, J Ind Microbiol Biotechnol, 46, 613, 10.1007/s10295-019-02148-8 Chagas, 2013, A mixed culture of endophytic fungi increases production of antifungal polyketides, J Chem Ecol, 39, 1335, 10.1007/s10886-013-0351-7 Ebrahim, 2016, Metabolites from the fungal endophyte Aspergillus austroafricanus in axenic culture and in fungal–bacterial mixed cultures, J Nat Prod, 79, 914, 10.1021/acs.jnatprod.5b00975 Wang, 2015, Hexacyclopeptides secreted by an endophytic fungus Fusarium solani N06 act as crosstalk molecules in Narcissus tazetta, Appl Microbiol Biotechnol, 99, 7651, 10.1007/s00253-015-6653-7 El-Sayed, 2023, Production and bioprocessing of camptothecin from Aspergillus terreus, an endophyte of Cestrum parqui, restoring their biosynthetic potency by Citrus limonum peel extracts, Microb Cell Factories, 22, 10.1186/s12934-022-02012-y Soliman, 2017, Exogenous and endogenous increase in fungal GGPP increased fungal Taxol production, Appl Microbiol Biotechnol, 101, 7523, 10.1007/s00253-017-8509-9 Wang, 2022, Facile biosynthesis of taxadiene by a newly constructed Escherichia coli strain fusing enzymes taxadiene synthase and geranylgeranyl pyrophosphate synthase, Process Biochem, 122, 129, 10.1016/j.procbio.2022.09.005 Wang, 2016, Optimization of a broth conductivity controlling strategy directed by an online viable biomass sensor for enhancing Taxus cell growth rate and Taxol productivity, RSC Adv, 6, 40631, 10.1039/C5RA26540A El-Sayed, 2020, Conjugation of Aspergillus flavipes Taxol with porphyrin increases the anticancer activity of taxol and ameliorates its cytotoxic effects, Molecules, 25, 10.3390/molecules25020263 Kuang, 2019, Iso-Seq analysis of the Taxus cuspidata transcriptome reveals the complexity of Taxol biosynthesis, BMC Plant Biol, 19, 210, 10.1186/s12870-019-1809-8 Kasaei, 2017, Isolation of taxol-producing endophytic fungi from Iranian Yew through novel molecular approach and their effects on human breast cancer cell line, Curr Microbiol, 74, 702, 10.1007/s00284-017-1231-0 Ajikumar, 2010, Isoprenoid pathway optimization for Taxol precursor overproduction in Escherichia coli, Science, 330, 70, 10.1126/science.1191652 Vogl, 2018, Engineered bidirectional promoters enable rapid multi-gene co-expression optimization, Nat Commun, 9, 3589, 10.1038/s41467-018-05915-w Wu, 2022, Construction of an Escherichia coli cell factory to synthesize taxadien-5α-ol, the key precursor of anti-cancer drug paclitaxel, Bioresour, Bioprocess, 9 Abdallah, 2019, Metabolic engineering of Bacillus subtilis toward Taxadiene biosynthesis as the first committed step for Taxol production, Front Microbiol, 10, 218, 10.3389/fmicb.2019.00218 Nowrouzi, 2020, Enhanced production of taxadiene in Saccharomyces cerevisiae, Microb Cell Factories, 19, 200, 10.1186/s12934-020-01458-2 Edgar, 2016, Mechanistic insights into taxadiene epoxidation by taxadiene-5alpha-hydroxylase, ACS Chem Biol, 11, 460, 10.1021/acschembio.5b00767 Edgar, 2017, Engineering of Taxadiene synthase for improved selectivity and yield of a key Taxol biosynthetic intermediate, ACS Synth Biol, 6, 201, 10.1021/acssynbio.6b00206 Sagwan-Barkdoll, 2018, Taxadiene-5alpha-ol is a minor product of CYP725A4 when expressed in Escherichia coli, Biotechnol Appl Biochem, 65, 294, 10.1002/bab.1606 Biggs, 2016, Overcoming heterologous protein interdependency to optimize P450-mediated Taxol precursor synthesis in Escherichia coli, Proc. Natl. Acad. Sci. U.S.A, 113, 3209, 10.1073/pnas.1515826113 Walls, 2021, Optimizing the biosynthesis of oxygenated and acetylated Taxol precursors in Saccharomyces cerevisiae using advanced bioprocessing strategies, Biotechnol Bioeng, 118, 279, 10.1002/bit.27569 Rouck, 2017, Heterologous expression and characterization of plant Taxadiene-5alpha-Hydroxylase (CYP725A4) in Escherichia coli, Protein Expr Purif, 132, 60, 10.1016/j.pep.2017.01.008 Jiang, 2021, Functional expression of eukaryotic cytochrome P450s in yeast, Biotechnol Bioeng, 118, 1050, 10.1002/bit.27630 Nowrouzi, 2022, Exploring optimal Taxol(R) CYP725A4 activity in Saccharomyces cerevisiae, Microb Cell Factories, 21, 197, 10.1186/s12934-022-01922-1 Dejong, 2006, Genetic engineering of Taxol biosynthetic genes in Saccharomyces cerevisiae, Biotechnol Bioeng, 93, 212, 10.1002/bit.20694 Glasscock, 2021, Dynamic control of gene expression with riboregulated switchable feedback promoters, ACS Synth Biol, 10, 1199, 10.1021/acssynbio.1c00015 Zhou, 2015, Distributing a metabolic pathway among a microbial consortium enhances production of natural products, Nat Biotechnol, 33, 377, 10.1038/nbt.3095 Xu, 2018, Yield enhancement strategies of rare pharmaceutical metabolites from endophytes, Biotechnol Lett, 40, 797, 10.1007/s10529-018-2531-6 Xu, 2006, Strain improvement and optimization of the media of taxol-producing fungus Fusarium maire, Biochem Eng J, 31, 67, 10.1016/j.bej.2006.05.024 El-Sayed, 2020, Agro-industrial wastes for production of paclitaxel by irradiated Aspergillus fumigatus under solid-state fermentation, J Appl Microbiol, 128, 1427, 10.1111/jam.14574 Magocha, 2018, Improvement of industrially important microbial strains by genome shuffling: current status and future prospects, Bioresour Technol, 257, 281, 10.1016/j.biortech.2018.02.118 El-Sayed, 2017, Genome editing approaches: manipulating of lovastatin and taxol synthesis of filamentous fungi by CRISPR/Cas9 system, Appl Microbiol Biotechnol, 101, 3953, 10.1007/s00253-017-8263-z Wei, 2010, An efficient transformation system of taxol-producing endophytic fungus EFY-21 (Ozonium sp), Afr J Biotechnol, 9, 1726, 10.5897/AJB2010.000-3019 Bian, 2017, Production of taxadiene by engineering of mevalonate pathway in Escherichia coli and endophytic fungus Alternaria alternata TPF6, Biotechnol J, 12, 10.1002/biot.201600697 Xu, 2021, An optimized and efficient CRISPR/Cas9 system for the endophytic fungus Pestalotiopsis fici, J Fungi, 7, 10.3390/jof7100809 Yang, 2014, Genome sequencing and analysis of the paclitaxel-producing endophytic fungus Penicillium aurantiogriseum NRRL 62431, BMC Genom, 15, 69, 10.1186/1471-2164-15-69 Qiao, 2020, Comparative transcriptome analysis of a taxol-producing endophytic fungus, Aspergillus aculeatinus Tax-6, and its mutant strain, Sci Rep, 10, 10.1038/s41598-020-67614-1 Mohamed, 2023, Physiological and metabolic traits of Taxol biosynthesis of endophytic fungi inhabiting plants: plant-microbial crosstalk, and epigenetic regulators, Microbiol Res, 272, 10.1016/j.micres.2023.127385