Effects of nitrogen dioxide on human health: Systematic review of experimental and epidemiological studies conducted between 2002 and 2006

Ute Latza1, Silke Gerdes1, Xaver Baur1
1Institute for Occupational Medicine and Maritime Medicine (ZfAM), University of Hamburg, Hamburg State Department for Social Affairs, Family, Health, and Consumer Protection, Hamburg, Germany

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AHRQ, Agency for Healthcare Research and Quality (AHRQ), 2002. Systems to rate the strength of scientific evidence. Evidence Report/Technology Assessment No. 47, AHRQ Pub. No. 02-E015, ISSN:1530-440X. Anderson, 1997, Air pollution and daily admissions for chronic obstructive pulmonary disease in 6 European cities: results from the APHEA project, Eur. Respir. J., 10, 1064, 10.1183/09031936.97.10051064 Avissar, 2000, Ozone, but not nitrogen dioxide, exposure decreases gluthathione peroxidases in epithelial lining fluid of human lung, Am. J. Respir. Crit. Care Dis., 162, 1342, 10.1164/ajrccm.162.4.9912041 Bailar, 2001, Environment and health: 9. The science of risk assessment, Can. Med. Assoc. J., 164, 503 Barck, 2002, Ambient level of NO2 augments the inflammatory response to inhaled allergen in asthmatics, Respir. Med., 96, 907, 10.1053/rmed.2002.1374 Barck, 2005, Brief exposures to NO2 augment the allergic inflammation in asthmatics, Environ. Res., 97, 58, 10.1016/j.envres.2004.02.009 Barnett, 2006, The effects of air pollution on hospitalizations for cardiovascular disease in elderly people in Australian and New Zealand cities, Environ. Health Perspect., 114, 1018, 10.1289/ehp.8674 Belanger, 2006, Association of indoor nitrogen dioxide exposure with respiratory symptoms in children with asthma, Am. J. Respir. Crit. Care Med., 173, 297, 10.1164/rccm.200408-1123OC Berger, 2006, Runs of ventricular and supraventricular tachycardia triggered by air pollution in patients with coronary heart disease, J. Occup. Environ. Med., 48, 1149, 10.1097/01.jom.0000245921.15916.03 Biggeri, 2005, Meta-analysis of the Italian studies of short-term effects of air pollution (MISA), 1990–1999, Int. J. Occup. Environ. Health., 11, 107, 10.1179/oeh.2005.11.1.107 Boezen, 2005, Susceptibility to air pollution in elderly males and females, Eur. Respir. J., 25, 1018, 10.1183/09031936.05.00076104 BOHRF, 1999. In: Waddell, G., Burton, G. (Eds.), Occupational Health Guidelines for the Management of Low Back Pain at Work. British Occupational Health Research Foundation, London, UK. Botter, 2002, A longitudinal study of mortality and air pollution for Sao Paulo, Brazil, J. Expo. Anal. Environ. Epidemiol., 12, 335, 10.1038/sj.jea.7500234 Boutin-Forzano, 2004, Visits to the emergency room for asthma attacks and short-term variations in air pollution. A case-crossover study, Respiration, 71, 134, 10.1159/000076673 Brauer, 1997, Nitrogen dioxide in indoor ice skating facilities: an international survey, J. Air Waste Manage. Assoc., 47, 1095, 10.1080/10473289.1997.10464399 Brauer, 2002, Air pollution from traffic and the development of respiratory infections and asthmatic and allergic symptoms in children, Am. J. Respir. Crit. Care Med., 166, 1092, 10.1164/rccm.200108-007OC Brauer, 2006, Traffic-related air pollution and otitis media, Environ. Health Perspect., 114, 1414, 10.1289/ehp.9089 Burnett, 2004, Associations between short-term changes in nitrogen dioxide and mortality in Canadian cities, Arch. Environ. Health, 59, 228, 10.3200/AEOH.59.5.228-236 Cakmak, 2006, Do gender, education, and income modify the effect of air pollution gases on cardiac disease?, J. Occup. Environ. Med., 48, 89, 10.1097/01.jom.0000184878.11956.4b Chan, 2005, Effects of ambient ozone exposure on mail carriers’ peak expiratory flow rates, Environ. Health. Perspect., 113, 735, 10.1289/ehp.7636 Chan, 2005, Association between nitrogen dioxide and heart rate variability in a susceptible population, Eur. J. Cardiovasc. Prev. Rehabil., 12, 580, 10.1097/00149831-200512000-00011 Chauhan, 2003, Personal exposure to nitrogen dioxide (NO2) and the severity of virus-induced asthma in children, Lancet, 361, 1939, 10.1016/S0140-6736(03)13582-9 Chen, 2006, Seasonality in adult asthma admissions, air pollutant levels, and climate: a population-based study, J. Asthma, 43, 287, 10.1080/02770900600622935 Chen, 2005, The association between fatal coronary heart disease and ambient particulate air pollution: are females at greater risk?, Environ. Health Perspect., 113, 1723, 10.1289/ehp.8190 Council Directive, 1999/30/EC of 22 April 1999 relating to limit values for sulphur dioxide, nitro-gen dioxide and oxides of nitrogen, particulate matter and lead in ambient air. Official Journal of the European Communities, 29.6.1999, L 163/41–60. Dales, 2004, Air pollution and sudden infant death syndrome, Pediatrics, 13, e628, 10.1542/peds.113.6.e628 Dales, 2006, Gaseous air pollutants and hospitalization for respiratory disease in the neonatal period, Environ. Health Perspect., 114, 1751, 10.1289/ehp.9044 de Marco, 2002, ISAYA study group. Italian Study on Asthma in Young Adults. The impact of climate and traffic-related NO2 on the prevalence of asthma and allergic rhinitis in Italy, Clin. Exp. Allergy, 32, 1405, 10.1046/j.1365-2745.2002.01466.x Delfino, 2003, Asthma symptoms in Hispanic children and daily ambient exposures to toxic and criteria air pollutants, Environ. Health Perspect., 111, 647, 10.1289/ehp.5992 Delfino, 2004, Association of FEV1 in asthmatic children with personal and microenvironmental exposure to airborne particulate matter, Environ. Health Perspect., 112, 932, 10.1289/ehp.6815 Desqueyroux, 2002, Effects of air pollution on adults with chronic obstructive pulmonary disease, Arch. Environ. Health, 57, 554, 10.1080/00039890209602088 Devalia, 1994, Effect of nitrogen dioxide and sulphur dioxide on airway response of mild asthmatic patients to allergen inhalation, Lancet, 344, 1668, 10.1016/S0140-6736(94)90458-8 D’Ippoliti, 2003, Air pollution and myocardial infarction in Rome: a case-crossover analysis, Epidemiology, 14, 528, 10.1097/01.ede.0000082046.22919.72 Dockery, 2005, Association of air pollution with increased incidence of ventricular tachyarrhythmias recorded by implanted cardioverter defibrillators, Environ. Health Perspect., 113, 670, 10.1289/ehp.7767 Drechsler-Parks, 1995, Cardiac output effects of O3 and NO2 exposure in healthy older adults, Toxicol. Ind. Health, 11, 99, 10.1177/074823379501100109 Emenius, 2003, NO2, as a marker of air pollution, and recurrent wheezing in children: a nested case-control study within the BAMSE birth cohort, Occup. Environ. Med., 60, 876, 10.1136/oem.60.11.876 Emenius, 2004, Building characteristics, indoor air quality and recurrent wheezing in very young children (BAMSE), Indoor Air, 14, 34, 10.1046/j.1600-0668.2003.00207.x Erdei, 2003, Indoor air pollutants and immune biomarkers among Hungarian asthmatic children, Arch. Environ. Health, 58, 337 Farhat, 2005, Effect of air pollution on pediatric respiratory emergency room visits and hospital admissions, Braz. J. Med. Biol. Res., 38, 227, 10.1590/S0100-879X2005000200011 Forastiere, 2005, A case-crossover analysis of out-of-hospital coronary deaths and air pollution in Rome, Italy, Am. J. Respir. Crit. Care Med., 172, 1549, 10.1164/rccm.200412-1726OC Fung, 2006, Association between air pollution and multiple respiratory hospitalizations among the elderly in Vancouver, Canada, Inhal. Toxicol., 18, 10051011, 10.1080/08958370600904538 Galan, 2003, Short-term effects of air pollution on daily asthma emergency room admissions, Eur. Respir. J., 22, 802, 10.1183/09031936.03.00013003 Gauderman, 2002, Association between air pollution and lung function growth in southern California children. Results from a second cohort, Am. J. Respir. Crit. Care Med., 166, 76, 10.1164/rccm.2111021 Gauderman, 2004, The effect of air pollution on lung development from 10 to 18 years of age, N. Engl. J. Med., 351, 1057, 10.1056/NEJMoa040610 Gehring, 2002, Traffic-related air pollution and respiratory health during the first 2yrs of life, Eur. Respir. J., 19, 690, 10.1183/09031936.02.01182001 Gehring, 2006, Long-term exposure to ambient air pollution and cardiopulmonary mortality in women, Epidemiology, 17, 545, 10.1097/01.ede.0000224541.38258.87 Gilboa, 2005, Relation between ambient air quality and selected birth defects, seven county study, Texas, 1997–2000, Am. J. Epidemiol., 162, 238, 10.1093/aje/kwi189 Gong, 2005, Respiratory responses to exposures with fine particulates and nitrogen dioxide in the elderly with and without COPD, Inhal. Toxicol., 17, 123, 10.1080/08958370590904481 Gouveia, 2004, Association between ambient air pollution and birth weight in Sao Paulo, Brazil, J. Epidemiol. Community Health, 58, 11, 10.1136/jech.58.1.11 Grazuleviciene, 2004, Exposure to urban nitrogen dioxide pollution and the risk of myocardial infarction, Scand. J. Work Environ. Health, 30, 293, 10.5271/sjweh.797 Ha, 2003, Infant susceptibility of mortality to air pollution in Seoul, South Korea, Pediatrics, 111, 284, 10.1542/peds.111.2.284 Hansen, 2006, Maternal exposure to low levels of ambient air pollution and preterm birth in Brisbane, Australia, BJOG, 113, 935, 10.1111/j.1471-0528.2006.01010.x Harbour, 2001, A new system for grading recommendations in evidence based guidelines, BMJ, 323, 334, 10.1136/bmj.323.7308.334 Hinwood, 2006, The relationship between changes in daily air pollution and hospitalizations in Perth, Australia 1992–1998: a case-crossover study, Int. J. Environ. Health Res., 16, 27, 10.1080/09603120500397680 Hoek, 2002, Association between mortality and indicators of traffic-related air pollution in the Netherlands: a cohort study, Lancet, 360, 1203, 10.1016/S0140-6736(02)11280-3 Holguín, 2003, Air pollution and heart rate variability among the elderly in Mexico City, Epidemiology, 14, 521, 10.1097/01.ede.0000081999.15060.ae Hong, 2002, Effects of air pollutants on acute stroke mortality, Environ. Health Perspect., 110, 187, 10.1289/ehp.02110187 Horak, 2002, Particulate matter and lung function growth in children: a 3-yr follow-up study in Austrian schoolchildren, Eur. Respir. J., 19, 838, 10.1183/09031936.02.00512001 Jaffe, 2003, Air pollution and emergency department visits for asthma among Ohio Medicaid recipients, 1991–1996, Environ. Res., 91, 21, 10.1016/S0013-9351(02)00004-X Jalaludin, 2004, Acute effects of urban ambient air pollution on respiratory symptoms, asthma medication use, and doctor visits for asthma in a cohort of Australian children, Environ. Res., 95, 32, 10.1016/S0013-9351(03)00038-0 Jang, 2003, Epidemiologic evidence of a relationship between airway hyperresponsiveness and exposure to polluted air, Allergy, 58, 585, 10.1034/j.1398-9995.2003.00205.x Jenkins, 1999, The effect of exposure to ozone and nitrogen dixoide on the airway response of atopic asthmatics to inhaled allergen: dose- and time-dependent effects, Am. J. Respir. Crit. Care Med., 160, 33, 10.1164/ajrccm.160.1.9808119 Jörres, 1991, Effect of 0.25ppm nitrogen dioxide on the airway response to methacholine in asymptomatic asthmatic patients, Lung, 169, 77, 10.1007/BF02714145 Just, 2002, Short-term health effects of particulate and photochemical air pollution in asthmatic children, Eur. Respir. J., 20, 899, 10.1183/09031936.02.00236902 Kan, 2003, A case-crossover analysis of air pollution and daily mortality in Shanghai, J. Occup. Health, 45, 119, 10.1539/joh.45.119 Kan, 2003, Air pollution and daily mortality in Shanghai: a time-series study, Arch. Environ. Health, 58, 360 Kan, 2004, The association of daily diabetes mortality and outdoor air pollution in Shanghai, China, J. Environ. Health, 67, 21 Kan, 2005, Relationship between ambient air pollution and daily mortality of SARS in Beijing, Biomed. Environ. Sci., 18, 1 Karr, 2006, A case-crossover study of wintertime ambient air pollution and infant bronchiolitis, Environ. Health. Perspect., 114, 277, 10.1289/ehp.8313 Kim, 2004, Traffic-related air pollution near busy roads: the East Bay Children's Respiratory Health Study, Am. J. Respir. Crit. Care Med., 170, 520, 10.1164/rccm.200403-281OC Klonoff-Cohen, 2005, Outdoor carbon monoxide, nitrogen dioxide, and sudden infant death syndrome, Arch. Dis. Child., 90, 750, 10.1136/adc.2004.057091 Kraft, 2005, The German view: effects of nitrogen dioxide on human health-derivation of health-related short-term and long-term values, Int. J. Hyg. Environ. Health, 208, 305, 10.1016/j.ijheh.2005.04.002 KRdL, 2003. Bewertung der gesundheitlichen Wirkungen von Stickstoffmonoxid und Stickstoffdioxid. Arbeitsgruppe „Wirkungen von Stickstoffoxiden auf die menschliche Gesundheit” der „Kommission Reinhaltung der Luft” (KRdL) im VDI und DIN im Auftrag des Bundesministeriums für Umwelt, Naturschutz und Reaktorsicherheit (Effects of nitrogen oxides on human health. Study group “Effects of Nitrogen Oxides on Human Health” of the Commission on Air Pollution Prevention (KRdL) in the of VDI and DIN commissioned by the Federal Ministry for Environment, Nature Conservation and Nuclear Safety), May 2003. Lagorio, 2006, Air pollution and lung function among susceptible adult subjects: a panel study, Environ. Health, 5, 5:11, 10.1186/1476-069X-5-11 Latza, U., Baur, X., 2006. Bewertender Vergleich der aktuellen Empfehlungen zu den Luftqualitätsgrenzwerten NO2, Bericht. (Evaluative comparison of the current exposure limits NO2, report). Forschungsvereinigung Automobiltechnik e.V. German Association for Research on Automobile-Technique, Frankfurt/Main, Germany. Latza, U., Gerdes, S., Baur, X., 2007. Evidenz-basierter Vergleich der epidemiologischen Studien 2002–2006 zu Gesundheitseffekten durch NO2, Bericht (Evidence-based comparison of epidemiological studies 2002-2006 on health effects of NO2, report).Forschungsvereinigung Automobiltechnik e.V. German Association for Research on Automobile-Technique, Frankfurt/Main, Germany. Le Tertre, 2002, Short-term effects of air pollution on mortality in nine French cities: a quantitative summary, Arch. Environ. Health, 57, 311, 10.1080/00039890209601414 Lee, 2002, Air pollution and asthma among children in Seoul, Korea, Epidemiology, 13, 481, 10.1097/00001648-200207000-00018 Lee, 2003, Air pollution and hospital admissions for ischemic heart diseases among individuals 64+ years of age residing in Seoul, Korea, Arch. Environ. Health, 58, 617, 10.3200/AEOH.58.10.617-623 Liao, 2004, Association of higher levels of ambient criteria pollutants with impaired cardiac autonomic control: a population-based study, Am. J. Epidemiol., 159, 768, 10.1093/aje/kwh109 Lin, 2003, Effect of short-term exposure to gaseous pollution on asthma hospitalisation in children: a bi-directional case-crossover analysis, J. Epidemiol. Community Health, 57, 50, 10.1136/jech.57.1.50 Lin, 2004, Association between maternal exposure to elevated ambient sulfur dioxide during pregnancy and term low birth weight, Environ. Res., 96, 41, 10.1016/j.envres.2004.03.005 Lipfert, 2006, PM2.5 constituents and related air quality variables as predictors of survival in a cohort of US military veterans, Inhal. Toxicol., 18, 645, 10.1080/08958370600742946 Liu, 2003, Association between gaseous ambient air pollutants and adverse pregnancy outcomes in Vancouver, Canada, Environ. Health Perspect., 111, 1773, 10.1289/ehp.6251 Luginaah, 2005, Association of ambient air pollution with respiratory hospitalization in a government-designated “area of concern”: the case of Windsor, Ontario, Environ. Health Perspect., 113, 290, 10.1289/ehp.7300 Luttmann-Gibson, 2006, Short-term effects of air pollution on heart rate variability in senior adults in Steubenville, Ohio, J. Occup. Environ. Med., 48, 780, 10.1097/01.jom.0000229781.27181.7d Mann, 2002, Air pollution and hospital admissions for ischemic heart disease in persons with congestive heart failure or arrhythmia, Environ. Health Perspect., 110, 1247, 10.1289/ehp.021101247 Martins, 2002, Air pollution and emergency room visits due to chronic lower respiratory diseases in the elderly: an ecological time-series study in Sao Paulo, Brazil, J Occup. Environ. Med., 44, 622, 10.1097/00043764-200207000-00006 McConnell, 2006, Dog ownership enhances symptomatic responses to air pollution in children with asthma, Environ. Health Perspect., 114, 1910, 10.1289/ehp.8548 Metzger, 2004, Ambient air pollution and cardiovascular emergency department visits, Epidemiology, 15, 46, 10.1097/01.EDE.0000101748.28283.97 Migliaretti, 2004, Urban air pollution and asthma in children, Pediatr. Pulmonol., 38, 198, 10.1002/ppul.20057 Migliaretti, 2005, Traffic air pollution and hospital admission for asthma: a case-control approach in a Turin (Italy) population, Int. Arch. Occup. Environ. Health, 78, 164, 10.1007/s00420-004-0569-3 Mills, 2007, Ischemic and thrombotic effects of dilute diesel-exhaust inhalation in men with coronary heart disease, N. Engl. J. Med., 357, 1075, 10.1056/NEJMoa066314 Morgan, 1998, Air pollution and hospital admissions in Sydney, Australia, 1990 through 1994, Am. J. Publ. Health, 188, 1761, 10.2105/AJPH.88.12.1761 Mortimer, 2002, The effect of air pollution on inner-city children with asthma, Eur. Respir. J., 19, 699, 10.1183/09031936.02.00247102 Moshammer, 2006, Low levels of air pollution induce changes of lung function in a panel of schoolchildren, Eur. Respir. J., 27, 1138, 10.1183/09031936.06.00089605 Nitschke, 2006, A cohort study of indoor nitrogen dioxide and house dust mite exposure in asthmatic children, J. Occup. Environ. Med., 48, 462, 10.1097/01.jom.0000215802.43229.62 Oftedal, 2003, Traffic related air pollution and acute hospital admission for respiratory diseases in Drammen, Norway 1995–2000, Eur. J. Epidemiol., 18, 671, 10.1023/A:1024884502114 Orehek, 1976, Effect of short-term low level nitrogen dioxide exposure on bronchial sensitivity of asthmatic patients, J. Clin. Invest., 57, 301, 10.1172/JCI108281 Park, 2002, Association of air pollution with school absenteeism due to illness, Arch. Pediatr. Adolesc. Med., 156, 1235, 10.1001/archpedi.156.12.1235 Park, 2005, Effects of air pollution on heart rate variability: the VA normative aging study, Environ. Health Perspect., 113, 304, 10.1289/ehp.7447 Pattenden, 2006, NO2 and children's respiratory symptoms in the PATY study, Occup. Environ. Med., 63, 828, 10.1136/oem.2006.025213 Peel, 2005, Ambient air pollution and respiratory emergency department visits, Epidemiology, 16, 164, 10.1097/01.ede.0000152905.42113.db Penard-Morand, 2005, Long-term exposure to background air pollution related to respiratory and allergic health in schoolchildren, Clin. Exp. Allergy, 35, 1279, 10.1111/j.1365-2222.2005.02336.x Pershagen, 1995, Air pollution involving nitrogen dioxide exposure and wheezing bronchitis in children, Int. J. Epidemiol., 24, 1147, 10.1093/ije/24.6.1147 Pino, 2004, Fine particulate matter and wheezing illnesses in the first year of life, Epidemiology, 15, 702, 10.1097/01.ede.0000142153.28496.d0 Rich, 2006, Association of ventricular arrhythmias detected by implantable cardioverter defibrillator and ambient air pollutants in the St. Louis, Missouri metropolitan area, Occup. Environ. Med., 63, 591, 10.1136/oem.2005.023457 Ritz, 2006, Air pollution and infant death in southern California, 1989–2000, Pediatrics, 118, 493, 10.1542/peds.2006-0027 Roger, 1990, Pulmonary function, airway responsiveness, and respiratory symptoms in asthmatics following exercise in NO2, Toxicol. Ind. Health, 6, 155, 10.1177/074823379000600110 Rosenlund, 2006, Long-term exposure to urban air pollution and myocardial infarction, Epidemiology, 17, 383, 10.1097/01.ede.0000219722.25569.0f Royal College of General Practitioners, 1995 Rubinstein, 1990, Short-term exposure to 0.3ppm nitrogen dioxide does not potentiate airway responsiveness to sulfur dioxide in asthmatic subjects, Am. Rev. Respir. Dis., 141, 381, 10.1164/ajrccm/141.2.381 Ruidavets, 2005, Increased resting heart rate with pollutants in a population based study, J. Epidemiol. Community Health, 59, 685, 10.1136/jech.2004.026252 Ruidavets, 2005, Ozone air pollution is associated with acute myocardial infarction, Circulation, 111, 563, 10.1161/01.CIR.0000154546.32135.6E Saez, 2002, A combined analysis of the short-term effects of photochemical air pollutants on mortality within the EMECAM project, Environ. Health Perspect., 110, 221, 10.1289/ehp.02110221 Samoli, 2006, Short-term effects of nitrogen dioxide on mortality: an analysis within the APHEA project, Eur. Respir. J., 27, 1129, 10.1183/09031936.06.00143905 Schikowski, 2005, Long-term air pollution exposure and living close to busy roads are associated with COPD in women, Respir. Res., 6, 152, 10.1186/1465-9921-6-152 Schwartz, 2004, Is the association of airborne particles with daily deaths confounded by gaseous air pollutants? An approach to control by matching, Environ. Health Perspect., 112, 557, 10.1289/ehp.6431 Schwartz, 2005, Traffic related pollution and heart rate variability in a panel of elderly subjects, Thorax, 60, 455, 10.1136/thx.2004.024836 Scoggins, 2004, Spatial analysis of annual air pollution exposure and mortality, Sci. Total Environ., 321, 71, 10.1016/j.scitotenv.2003.09.020 Sekine, 2004, Long term effects of exposure to automobile exhaust on the pulmonary function of female adults in Tokyo, Japan, Occup. Environ. Med., 61, 350, 10.1136/oem.2002.005934 Shima, 2002, Effects of air pollution on the prevalence and incidence of asthma in children, Arch. Environ. Health, 57, 529, 10.1080/00039890209602084 Simoni, 2002, The Po River Delta (north Italy) indoor epidemiological study: effects of pollutant exposure on acute respiratory symptoms and respiratory function in adults, Arch. Environ. Health, 57, 130, 10.1080/00039890209602928 Simoni, 2004, Indoor exposures and acute respiratory effects in two general population samples from a rural and an urban area in Italy, J. Expo. Anal. Environ. Epidemiol., 14, S144, 10.1038/sj.jea.7500368 Simpson, 2005, The short-term effects of air pollution on daily mortality in four Australian cities, Aust. N. Z. J. Public Health, 29, 205, 10.1111/j.1467-842X.2005.tb00758.x Stieb, 2002, Meta-analysis of time-series studies of air pollution and mortality: effects of gases and particles and the influence of cause of death, age, and season, J. Air Waste Manage. Assoc., 52, 470, 10.1080/10473289.2002.10470794 Strahlenschutzkommission, 2002. Kriterien zur Bewertung strahlenepidemiologischer Studien. 178. Bericht der Strahlenschutzkommission (Criteria for the appraisal of epidemiological studies on radiation. 178. Report of the National Borad for Atomic Safety and Radiological Protection), Bonn, Germany. 〈http://www.ssk.de/werke/volltext/2002/ssk0207.pdf〉. Strand, 1996, Immediate and delayed effects of nitrogen dioxide exposure at an ambient level on bronchial responsiveness to histamine in subjects with asthma, Eur. Respir. J., 9, 733, 10.1183/09031936.96.09040733 Strand, 1997, Nitrogen dioxide exposure enhances asthmatic reaction to inhaled allergen in subjects with asthma, Am. J. Respir. Crit. Care Med., 155, 881, 10.1164/ajrccm.155.3.9117021 Strand, 1998, Repeated exposure to an ambient level of NO2 enhances asthmatic response to a nonsymptomatic allergen dose, Eur. Respir. J., 12, 6, 10.1183/09031936.98.12010006 Sunyer, 2002, Effect of nitrogen dioxide and ozone on the risk of dying in patients with severe asthma, Thorax, 57, 687, 10.1136/thorax.57.8.687 Sunyer, 2004, Asthma multicentre infants cohort study. Nitrogen dioxide is not associated with respiratory infection during the first year of life, Int. J. Epidemiol., 33, 116, 10.1093/ije/dyh037 Svartengren, 2000, Short-term exposure to air pollution in a road tunnel enhances the asthmatic response to allergen, Eur. Respir. J., 15, 716, 10.1034/j.1399-3003.2000.15d15.x Tager, 2005, Chronic exposure to ambient ozone and lung function in young adults, Epidemiology, 16, 751, 10.1097/01.ede.0000183166.68809.b0 Tenias, 2002, Air pollution and hospital emergency room admissions for chronic obstructive pulmonary disease in Valencia, Spain, Arch. Environ. Health, 57, 41, 10.1080/00039890209602915 Tsai, 2003, Evidence for an association between air pollution and daily stroke admissions in Kaohsiung, Taiwan, Stroke, 34, 2612, 10.1161/01.STR.0000095564.33543.64 Tsai, 2003, Relationship between air pollution and daily mortality in a tropical city: Kaohsiung, Taiwan, J. Toxicol. Environ. Health A, 66, 1341, 10.1080/15287390306389 Tunnicliffe, 1994, Effect of domestic concentrations of nitrogen dioxide on airway responses to inhaled allergen in asthmatic patients, Lancet, 344, 1733, 10.1016/S0140-6736(94)92886-X Venn, 2003, Effects of volatile organic compounds, damp, and other environmental exposures in the home on wheezing illness in children, Thorax, 58, 955, 10.1136/thorax.58.11.955 Von Klot, 2002, Increased asthma medication use in association with fine and ultrafine particles, Eur. Respir. J., 20, 691, 10.1183/09031936.02.01402001 WHO, 2003 WHO, 2005 Wong, 2002, A tale of two cities: effects of air pollution on hospital admissions in Hong Kong and London compared, Environ. Health Perspect., 110, 67, 10.1289/ehp.0211067 Wong, 2002, Associations between daily mortalities from respiratory and cardiovascular diseases and air pollution in Hong Kong, China, Occup. Environ. Med., 59, 30, 10.1136/oem.59.1.30 Yang, 1994, Respiratory function changes from inhalation of polluted air, Arch. Environ. Health, 49, 182, 10.1080/00039896.1994.9940380 Yang, 2002, Respiratory symptoms in primary schoolchildren living near a freeway in Taiwan, J. Toxicol. Environ. Health A, 65, 747, 10.1080/00984100290071036 Yang, 2003, Association between ozone and respiratory admissions among children and the elderly in Vancouver, Canada, Inhal. Toxicol., 15, 1297, 10.1080/08958370390241768 Yang, 2004, Relationship between air pollution and daily mortality in a subtropical city: Taipei, Taiwan, Environ. Int., 30, 519, 10.1016/j.envint.2003.10.006 Yang, 2004, Relationship between ambient air pollution and hospital admissions for cardiovascular diseases in Kaohsiung, Taiwan, J. Toxicol. Environ. Health A, 67, 483, 10.1080/15287390490276502 Yang, 2006, Correlation between air pollution and postneonatal mortality in a subtropical city: Taipei, Taiwan, J. Toxicol. Environ. Health A, 69, 2033, 10.1080/15287390600746181 Zanobetti, 2006, Air pollution and emergency admissions in Boston, MA, J. Epidemiol. Community Health, 60, 890, 10.1136/jech.2005.039834 Zmirou, 2002, Five epidemiological studies on transport and asthma: objectives, design and descriptive results, J. Expo. Anal. Environ. Epidemiol., 12, 186, 10.1038/sj.jea.7500217