Hippocampal Sirtuin 1 Signaling Mediates Depression-like Behavior

Krishnan, 2008, The molecular neurobiology of depression, Nature, 455, 894, 10.1038/nature07455 Duman, 2012, Synaptic dysfunction in depression: Potential therapeutic targets, Science, 338, 68, 10.1126/science.1222939 Malykhin, 2015, Hippocampal neuroplasticity in major depressive disorder, Neuroscience, 309, 200, 10.1016/j.neuroscience.2015.04.047 McEwen, 2012, Stress and anxiety: Structural plasticity and epigenetic regulation as a consequence of stress, Neuropharmacology, 62, 3, 10.1016/j.neuropharm.2011.07.014 Price, 2010, Neurocircuitry of mood disorders, Neuropsychopharmacology, 35, 192, 10.1038/npp.2009.104 Imai, 2000, Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase, Nature, 403, 795, 10.1038/35001622 Brunet, 2004, Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase, Science, 303, 2011, 10.1126/science.1094637 Kim, 1999, Modulation of life-span by histone deacetylase genes in Saccharomyces cerevisiae, Mol Biol Cell, 10, 3125, 10.1091/mbc.10.10.3125 Landry, 2000, The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases, Proc Natl Acad Sci U S A, 97, 5807, 10.1073/pnas.110148297 Smith, 2000, A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family, Proc Natl Acad Sci U S A, 97, 6658, 10.1073/pnas.97.12.6658 Asher, 2008, SIRT1 regulates circadian clock gene expression through PER2 deacetylation, Cell, 134, 317, 10.1016/j.cell.2008.06.050 Chang, 2013, SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging, Cell, 153, 1448, 10.1016/j.cell.2013.05.027 Nakahata, 2009, Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1, Science, 324, 654, 10.1126/science.1170803 Cohen, 2009, Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction, Genes Dev, 23, 2812, 10.1101/gad.1839209 Ramadori, 2011, SIRT1 deacetylase in SF1 neurons protects against metabolic imbalance, Cell Metab, 14, 301, 10.1016/j.cmet.2011.06.014 Sasaki, 2010, Induction of hypothalamic Sirt1 leads to cessation of feeding via agouti-related peptide, Endocrinology, 151, 2556, 10.1210/en.2009-1319 Satoh, 2010, SIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateral nuclei of the hypothalamus, J Neurosci, 30, 10220, 10.1523/JNEUROSCI.1385-10.2010 Gao, 2010, A novel pathway regulates memory and plasticity via SIRT1 and miR-134, Nature, 466, 1105, 10.1038/nature09271 Michan, 2010, SIRT1 is essential for normal cognitive function and synaptic plasticity, J Neurosci, 30, 9695, 10.1523/JNEUROSCI.0027-10.2010 Ferguson, 2013, Essential role of SIRT1 signaling in the nucleus accumbens in cocaine and morphine action, J Neurosci, 33, 16088, 10.1523/JNEUROSCI.1284-13.2013 Renthal, 2009, Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins, Neuron, 62, 335, 10.1016/j.neuron.2009.03.026 Herskovits, 2014, SIRT1 in neurodevelopment and brain senescence, Neuron, 81, 471, 10.1016/j.neuron.2014.01.028 Kishi, 2010, SIRT1 gene is associated with major depressive disorder in the Japanese population, J Affect Disord, 126, 167, 10.1016/j.jad.2010.04.003 Libert, 2011, SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive, Cell, 147, 1459, 10.1016/j.cell.2011.10.054 2015, Sparse whole-genome sequencing identifies two loci for major depressive disorder, Nature, 523, 588, 10.1038/nature14659 Abe, 2011, Altered sirtuin deacetylase gene expression in patients with a mood disorder, J Psychiatr Res, 45, 1106, 10.1016/j.jpsychires.2011.01.016 Watanabe, 2014, SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system, Mol Brain, 7, 62, 10.1186/s13041-014-0062-1 Ferland, 2013, Sirtuin activity in dentate gyrus contributes to chronic stress-induced behavior and extracellular signal-regulated protein kinases 1 and 2 cascade changes in the hippocampus, Biol Psychiatry, 74, 927, 10.1016/j.biopsych.2013.07.029 Ferland, 2011, Regulation of histone acetylation in the hippocampus of chronically stressed rats: A potential role of sirtuins, Neuroscience, 174, 104, 10.1016/j.neuroscience.2010.10.077 Liu, 2014, Resveratrol reverses the effects of chronic unpredictable mild stress on behavior, serum corticosterone levels and BDNF expression in rats, Behav Brain Res, 264, 9, 10.1016/j.bbr.2014.01.039 Hurley, 2014, Antidepressant effects of resveratrol in an animal model of depression, Behav Brain Res, 268, 1, 10.1016/j.bbr.2014.03.052 Ge, 2013, Antidepressant-like effect of resveratrol: Involvement of antioxidant effect and peripheral regulation on HPA axis, Pharmacol Biochem Behav, 114–115, 64, 10.1016/j.pbb.2013.10.028 Uchida, 2011, Epigenetic status of Gdnf in the ventral striatum determines susceptibility and adaptation to daily stressful events, Neuron, 69, 359, 10.1016/j.neuron.2010.12.023 Uchida, 2010, Early life stress enhances behavioral vulnerability to stress through the activation of REST4-mediated gene transcription in the medial prefrontal cortex of rodents, J Neurosci, 30, 15007, 10.1523/JNEUROSCI.1436-10.2010 David, 2009, Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression, Neuron, 62, 479, 10.1016/j.neuron.2009.04.017 Holick, 2008, Behavioral effects of chronic fluoxetine in BALB/cJ mice do not require adult hippocampal neurogenesis or the serotonin 1A receptor, Neuropsychopharmacology, 33, 406, 10.1038/sj.npp.1301399 Uchida, 2014, Learning-induced and stathmin-dependent changes in microtubule stability are critical for memory and disrupted in ageing, Nat Commun, 5, 4389, 10.1038/ncomms5389 Uchida, 2008, Characterization of the vulnerability to repeated stress in Fischer 344 rats: Possible involvement of microRNA-mediated down-regulation of the glucocorticoid receptor, Eur J Neurosci, 27, 2250, 10.1111/j.1460-9568.2008.06218.x Uchida, 2011, Impaired hippocampal spinogenesis and neurogenesis and altered affective behavior in mice lacking heat shock factor 1, Proc Natl Acad Sci U S A, 108, 1681, 10.1073/pnas.1016424108 Franklin, 2007 Gunduz-Cinar, 2013, Amygdala FAAH and anandamide: Mediating protection and recovery from stress, Trends Pharmacol Sci, 34, 637, 10.1016/j.tips.2013.08.008 Holmes, 2009, Stress-induced prefrontal reorganization and executive dysfunction in rodents, Neurosci Biobehav Rev, 33, 773, 10.1016/j.neubiorev.2008.11.005 Licznerski, 2013, Remodeling of axo-spinous synapses in the pathophysiology and treatment of depression, Neuroscience, 251, 33, 10.1016/j.neuroscience.2012.09.057 McEwen, 2013, The brain on stress: Vulnerability and plasticity of the prefrontal cortex over the life course, Neuron, 79, 16, 10.1016/j.neuron.2013.06.028 Berton, 2006, Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress, Science, 311, 864, 10.1126/science.1120972 File, 2003, A review of 25 years of the social interaction test, Eur J Pharmacol, 463, 35, 10.1016/S0014-2999(03)01273-1 Porsolt, 1977, Behavioral despair in mice: A primary screening test for antidepressants, Arch Int Pharmacodyn Ther, 229, 327 Solomon, 2006, Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage, Mol Cell Biol, 26, 28, 10.1128/MCB.26.1.28-38.2006 Hisahara, 2008, Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation, Proc Natl Acad Sci U S A, 105, 15599, 10.1073/pnas.0800612105 Gray, 2013, Dynamic plasticity: The role of glucocorticoids, brain-derived neurotrophic factor and other trophic factors, Neuroscience, 239, 214, 10.1016/j.neuroscience.2012.08.034 Pittenger, 2008, Stress, depression, and neuroplasticity: A convergence of mechanisms, Neuropsychopharmacology, 33, 88, 10.1038/sj.npp.1301574 Watanabe, 1992, Stress induces atrophy of apical dendrites of hippocampal CA3 pyramidal neurons, Brain Res, 588, 341, 10.1016/0006-8993(92)91597-8 Tsai, 2009, Sigma-1 receptors regulate hippocampal dendritic spine formation via a free radical-sensitive mechanism involving Rac1xGTP pathway, Proc Natl Acad Sci U S A, 106, 22468, 10.1073/pnas.0909089106 Alfonso, 2005, The stress-regulated protein M6a is a key modulator for neurite outgrowth and filopodium/spine formation, Proc Natl Acad Sci U S A, 102, 17196, 10.1073/pnas.0504262102 Dehmelt, 2003, The role of microtubule-associated protein 2c in the reorganization of microtubules and lamellipodia during neurite initiation, J Neurosci, 23, 9479, 10.1523/JNEUROSCI.23-29-09479.2003 Ma׳ayan, 2009, Neuro2A differentiation by Galphai/o pathway, Sci Signal 2:cm1., 10.1126/scisignal.254cm1 Li, 2008, SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons, Cell Metab, 8, 38, 10.1016/j.cmet.2008.05.004 Iniguez, 2010, Extracellular signal-regulated kinase-2 within the ventral tegmental area regulates responses to stress, J Neurosci, 30, 7652, 10.1523/JNEUROSCI.0951-10.2010 Duman, 2007, A role for MAP kinase signaling in behavioral models of depression and antidepressant treatment, Biol Psychiatry, 61, 661, 10.1016/j.biopsych.2006.05.047 Dwivedi, 2001, Reduced activation and expression of ERK1/2 MAP kinase in the post-mortem brain of depressed suicide subjects, J Neurochem, 77, 916, 10.1046/j.1471-4159.2001.00300.x Duric, 2010, A negative regulator of MAP kinase causes depressive behavior, Nat Med, 16, 1328, 10.1038/nm.2219 Alonso, 2004, Mitochondrial extracellular signal-regulated kinases 1/2 (ERK1/2) are modulated during brain development, J Neurochem, 89, 248, 10.1111/j.1471-4159.2004.02323.x Winder, 1999, ERK plays a regulatory role in induction of LTP by theta frequency stimulation and its modulation by beta-adrenergic receptors, Neuron, 24, 715, 10.1016/S0896-6273(00)81124-1 Impey, 1999, Making new connections: Role of ERK/MAP kinase signaling in neuronal plasticity, Neuron, 23, 11, 10.1016/S0896-6273(00)80747-3 Bordone, 2007, SIRT1 transgenic mice show phenotypes resembling calorie restriction, Aging Cell, 6, 759, 10.1111/j.1474-9726.2007.00335.x McBurney, 2003, The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis, Mol Cell Biol, 23, 38, 10.1128/MCB.23.1.38-54.2003 Wolfer, 2002, Knockout mice: Simple solutions to the problems of genetic background and flanking genes, Trends Neurosci, 25, 336, 10.1016/S0166-2236(02)02192-6 Crusio, 2004, Flanking gene and genetic background problems in genetically manipulated mice, Biol Psychiatry, 56, 381, 10.1016/j.biopsych.2003.12.026 Francis, 2003, Epigenetic sources of behavioral differences in mice, Nat Neurosci, 6, 445, 10.1038/nn1038 Hovatta, 2005, Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice, Nature, 438, 662, 10.1038/nature04250 Mozhui, 2010, Strain differences in stress responsivity are associated with divergent amygdala gene expression and glutamate-mediated neuronal excitability, J Neurosci, 30, 5357, 10.1523/JNEUROSCI.5017-09.2010 Fanselow, 2010, Are the dorsal and ventral hippocampus functionally distinct structures?, Neuron, 65, 7, 10.1016/j.neuron.2009.11.031 Bannerman, 2004, Regional dissociations within the hippocampus--memory and anxiety, Neurosci Biobehav Rev, 28, 273, 10.1016/j.neubiorev.2004.03.004 Guo, 2011, Sirt1 overexpression in neurons promotes neurite outgrowth and cell survival through inhibition of the mTOR signaling, J Neurosci Res, 89, 1723, 10.1002/jnr.22725 Codocedo, 2012, SIRT1 regulates dendritic development in hippocampal neurons, PLoS One, 7, e47073, 10.1371/journal.pone.0047073 Sugino, 2010, Protein deacetylase SIRT1 in the cytoplasm promotes nerve growth factor-induced neurite outgrowth in PC12 cells, FEBS Lett, 584, 2821, 10.1016/j.febslet.2010.04.063 Kim, 2009, SIRT1 regulates tyrosine hydroxylase expression and differentiation of neuroblastoma cells via FOXO3a, FEBS Lett, 583, 1183, 10.1016/j.febslet.2009.03.007 Dasgupta, 2007, Resveratrol stimulates AMP kinase activity in neurons, Proc Natl Acad Sci U S A, 104, 7217, 10.1073/pnas.0610068104 Michan, 2007, Sirtuins in mammals: Insights into their biological function, Biochem J, 404, 1, 10.1042/BJ20070140 Westerheide, 2009, Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1, Science, 323, 1063, 10.1126/science.1165946