On-chip single nanoparticle detection and sizing by mode splitting in an ultrahigh-Q microresonator

Nature Photonics - Tập 4 Số 1 - Trang 46-49 - 2010
Jian‐Gang Zhu1, Şahin Kaya Özdemir1, Yun‐Feng Xiao1,2, Lin Li3, Lina He1, Da‐Ren Chen3, Lan Yang1
1Department of Electrical and Systems Engineering, Washington University, St. Louis, USA
2Present address: State Key Laboratory for Artificial Microstructure, Institute of Modern Optics, Peking University, Beijing, China,
3Department of Energy, Environmental & Chemical Engineering, Washington University, St. Louis, USA

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O'Regan, B. & Grätzel, M. A low-cost, high-efficiency solar cell based on dye-sensitized colloidal TiO2 films. Nature 353, 737–740 (1991).

Alivisatos, P. The use of nanocrystals in biological detection. Nature Biotechnol. 22, 47–52 (2004).

Colvin, V. L. The potential environmental impact of engineered nanomaterials. Nature Biotechnol. 21, 1166–1170 (2003).

Hoet, P. H., Brüske-Hohlfeld, I. & Salata, O. V. Nanoparticles—known and unknown health risks. J. Nanobiotechnol. 2, 2–12 (2004).

Betzig, E., Trautmann, J. K., Harris, T. D., Weiner, J. S. & Kostelak, R. L. Breaking the diffraction barrier: optical microscopy on a nanometric scale. Science 251, 1468–1470 (1991).

Nie, S. M. & Emery, S. R. Probing single molecules and single nanoparticles by surface-enhanced Raman scattering. Science 275, 1102–1106 (1997).

Knollenberg, R. G. Measurement of latex particle sizes using scattering ratios in the Rayleigh scattering region. J. Aerosol Sci. 3, 331–345 (1989).

Szymanski, W. W., Nagy, A., Czitrovszky, A. & Jani, P. A new method for the simultaneous measurement of aerosol particle size, complex refractive index and particle density. Meas. Sci. Technol. 13, 303–307 (2002).

Vahala, K. J. Optical microcavities. Nature 424, 839–846 (2003).

Armani, D. K., Kippenberg, T. J., Spillane, S. M. & Vahala, K. J., Ultrahigh-Q toroid microcavity on a chip. Nature 421, 925–928 (2003).

Vollmer, F. & Arnold, S. Whispering-gallery-mode biosensing: label-free detection down to single molecules. Nature Meth. 5, 591–596 (2008).

Armani, A. M., Kulkarni, R. P., Fraser, S. E., Flagan, R. C. & Vahala, K. J. Label-free, single-molecule detection with optical microcavities. Science 317, 783–787 (2007).

Vollmer, F., Arnold, S. & Keng, D. Single virus detection from the reactive shift of a whispering-gallery mode. Proc. Natl Acad. Sci. USA 105, 20701–20704 (2008).

White, I. M., Oveys, H. & Fan, X. Liquid-core optical ring-resonator sensors. Opt. Lett. 31, 1319–1321 (2006).

Weiss, D. S. et al. Splitting of high-Q Mie modes induced by light backscattering in silica microspheres. Opt. Lett. 20, 1835–1837 (1995).

Gorodetsky, M. L., Pryamikov, A. D. & Ilchenko, V. S. Rayleigh scattering in high-Q microspheres. J. Opt. Soc. Am. B 17, 1051–1057 (2000).

Kippenberg, T. J., Spillane, S. M. & Vahala, K. J. Modal coupling in travelling-wave resonators. Opt. Lett. 27, 1669–1671 (2002).

Mazzei, A. et al. Controlled coupling of counterpropagating whispering-gallery modes by a single Rayleigh scatterer: a classical problem in a quantum optical light. Phys. Rev. Lett. 99, 173603 (2007).

Kippenberg, T. J., Tchebotareva, A. L., Kalkman, J., Polman, A. & Vahala, K. J. Purcell-factor-enhanced scattering from Si nanocrystals in an optical microcavity. Phys. Rev. Lett. 103, 027406 (2009).

Chantada, L., Nikolaev, N. I., Ivanov, A. L., Borri, P. & Langbein, W. Optical resonances in microcylinders: response to perturbations for biosensing. J. Opt. Soc. Am. B 25, 1312–1321 (2008).

Arnold, S. et al. Whispering-gallery-mode carousel—a photonic mechanism for enhanced nanoparticle detection in biosensing. Opt. Express 17, 6230–6238 (2009).

Russell, L. M. & Ming, L. Deliquescence of small particles. J. Chem. Phys. 116, 311–321 (2002).

Friedlander, S. K. Smoke, Dust and Haze: Fundamentals of Aerosol Dynamics (Oxford Univ. Press, 2000).

Burg, T. P. et al. Weighing of biomolecules, single cells and single nanoparticles in fluid. Nature 446, 1066–1069 (2007).