Functional expression and characterization of the human ABCG1 and ABCG4 proteins: indications for heterodimerization

Biochemical and Biophysical Research Communications - Tập 320 - Trang 860-867 - 2004
Judit Cserepes1,2, Zsófia Szentpétery1, László Seres2, Csilla Özvegy-Laczka1,2, Thomas Langmann3, Gerd Schmitz3, Hristos Glavinas4, Izabella Klein1, László Homolya2, András Váradi1, Balázs Sarkadi2, N.Barry Elkind2
1Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Hungary
2National Medical Center, Institute of Haematology and Immunology, Membrane Research Group of the Hungarian Academy of Sciences, H-1113 Budapest, Hungary
3Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, Germany
4Solvo Biotechnology, Béke u. 5/a, H-6721 Szeged, Hungary

Tài liệu tham khảo

Klein, 1999, An inventory of the human ABC proteins, Biochim. Biophys. Acta, 1461, 237, 10.1016/S0005-2736(99)00161-3 Ozvegy, 2002, Characterization of drug transport, ATP hydrolysis, and nucleotide trapping by the human ABCG2 multidrug transporter. Modulation of substrate specificity by a point mutation, J. Biol. Chem., 277, 47980, 10.1074/jbc.M207857200 Mitomo, 2003, A functional study on polymorphism of the ATP-binding cassette transporter ABCG2: critical role of arginine-482 in methotrexate transport, Biochem. J., 373, 767, 10.1042/bj20030150 Graf, 2003, ABCG5 and ABCG8 are obligate heterodimers for protein trafficking and biliary cholesterol excretion, J. Biol. Chem., 278, 48275, 10.1074/jbc.M310223200 Haimeur, 2004, The MRP-related and BCRP/ABCG2 multidrug resistance proteins: biology, substrate specificity and regulation, Curr. Drug Metab., 5, 21, 10.2174/1389200043489199 Sarkadi, 2004, ABCG2—a transporter for all seasons, FEBS Lett., 567, 116, 10.1016/j.febslet.2004.03.123 Croop, 1997, Isolation and characterization of a mammalian homolog of the Drosophila white gene, Gene, 185, 77, 10.1016/S0378-1119(96)00633-6 Chen, 1996, Cloning of the cDNA for a human homologue of the Drosophila white gene and mapping to chromosome 21q22.3, Am. J. Hum. Genet., 59, 66 Klucken, 2000, ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport, Proc. Natl. Acad. Sci. USA, 97, 817, 10.1073/pnas.97.2.817 Oldfield, 2002, ABCG4: a novel human white family ABC-transporter expressed in the brain and eye, Biochim. Biophys. Acta, 1591, 175, 10.1016/S0167-4889(02)00269-0 Venkateswaran, 2000, Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols, J. Biol. Chem., 275, 14700, 10.1074/jbc.275.19.14700 Laffitte, 2001, LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes, Proc. Natl. Acad. Sci. USA, 98, 507, 10.1073/pnas.98.2.507 Engel, 2001, The human ABCG4 gene is regulated by oxysterols and retinoids in monocyte-derived macrophages, Biochem. Biophys. Res. Commun., 288, 483, 10.1006/bbrc.2001.5756 Schmitz, 2001, Role of ABCG1 and other ABCG family members in lipid metabolism, J. Lipid Res., 42, 1513, 10.1016/S0022-2275(20)32205-7 Lorkowski, 2001, Expression of the ATP-binding cassette transporter gene ABCG1 (ABC8) in Tangier disease, Biochem. Biophys. Res. Commun., 283, 821, 10.1006/bbrc.2001.4863 Annilo, 2001, Human and mouse orthologs of a new ATP-binding cassette gene, ABCG4, Cytogenet. Cell. Genet., 94, 196, 10.1159/000048816 Ozvegy, 2001, Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells, Biochem. Biophys. Res. Commun., 285, 111, 10.1006/bbrc.2001.5130 Sarkadi, 1992, Expression of the human multidrug resistance cDNA in insect cells generates a high activity drug-stimulated membrane ATPase, J. Biol. Chem., 267, 4854, 10.1016/S0021-9258(18)42909-2 Tusnady, 1998, Principles governing amino acid composition of integral membrane proteins: application to topology prediction, J. Mol. Biol., 283, 489, 10.1006/jmbi.1998.2107 Ilias, 2002, Loss of ATP-dependent transport activity in pseudoxanthoma elasticum- associated mutants of human ABCC6 (MRP6), J. Biol. Chem., 277, 16860, 10.1074/jbc.M110918200 Bodo, 2003, Differential modulation of the human liver conjugate transporters MRP2 and MRP3 by bile acids and organic anions, J. Biol. Chem., 278, 23529, 10.1074/jbc.M303515200 Ewart, 1994, Mutational analysis of the traffic ATPase (ABC) transporters involved in uptake of eye pigment precursors in Drosophila melanogaster. Implications for structure–function relationships, J. Biol. Chem., 269, 10370, 10.1016/S0021-9258(17)34070-X Janvilisri, 2003, Sterol transport by the human breast cancer resistance protein (ABCG2) expressed in Lactococcus lactis, J. Biol. Chem., 278, 20645, 10.1074/jbc.M301358200 Woehlecke, 2003, Enhanced exposure of phosphatidylserine in human gastric carcinoma cells overexpressing the half-size ABC transporter BCRP (ABCG2), Biochem. J., 376, 489, 10.1042/bj20030886 Muller, 1996, Altered drug-stimulated ATPase activity in mutants of the human multidrug resistance protein, J. Biol. Chem., 271, 1877, 10.1074/jbc.271.4.1877 Yoshikawa, 2002, Molecular and cytogenetic characterization of the mouse ATP-binding cassette transporter Abcg4, Gene, 293, 67, 10.1016/S0378-1119(02)00719-9 Mackenzie, 2000, Sub-cellular localisation of the white/scarlet ABC transporter to pigment granule membranes within the compound eye of Drosophila melanogaster, Genetica, 108, 239, 10.1023/A:1004115718597