Naringin mitigates myocardial strain and the inflammatory response in sepsis-induced myocardial dysfunction through regulation of PI3K/AKT/NF-κB pathway

Singer, 2016, The third international consensus definitions for sepsis and septic shock (Sepsis-3), JAMA, 315, 801, 10.1001/jama.2016.0287 Romero-Bermejo, 2011, Sepsis-induced cardiomyopathy, Curr. Cardiol. Rev., 7, 163, 10.2174/157340311798220494 Vieillard-Baron, 2011, Septic cardiomyopathy, Ann. Intensive Care, 1, 6, 10.1186/2110-5820-1-6 Merx, 2007, Sepsis and the heart, Circulation, 116, 793, 10.1161/CIRCULATIONAHA.106.678359 Chen, 2016, Therapeutic potential of naringin: an overview, Pharm. Biol., 54, 3203, 10.1080/13880209.2016.1216131 Peterson, 2012, Associations between flavonoids and cardiovascular disease incidence or mortality in European and US populations, Nutr. Rev., 70, 491, 10.1111/j.1753-4887.2012.00508.x Chen, 2015, Naringin alleviates diabetic kidney disease through inhibiting oxidative stress and inflammatory reaction, PLoS One, 10, 10.1371/journal.pone.0143868 Visnagri, 2015, Effect of naringin on hemodynamic changes and left ventricular function in renal artery occluded renovascular hypertension in rats, J. Pharm. Bioallied Sci., 7, 121, 10.4103/0975-7406.154437 Hsueh TP, Sheen JM, Pang JH, Bi KW, Huang CC, Wu HT, et al. The anti-atherosclerotic effect of naringin is associated with reduced expressions of cell adhesion molecules and chemokines through NF-κB pathway. Molecules. 21 (2) (2016) pii: E195. Rani, 2013, Regulation of heat shock proteins 27 and 70, p-Akt/p-eNOS and MAPKs by naringin dampens myocardial injury and dysfunction in vivo after ischemia/reperfusion, PLoS One, 8, 10.1371/journal.pone.0082577 You, 2016, Naringin protects cardiomyocytes against hyperglycemia-induced injuries in vitro and in vivo, J. Endocrinol., 230, 197, 10.1530/JOE-16-0004 Xianchu, 2016, Naringin protects against lipopolysaccharide-induced cardiac injury in mice, Environ. Toxicol. Pharmacol., 48, 1, 10.1016/j.etap.2016.09.005 Alvarez, 2016, Cardiac dysfunction, mitochondrial architecture, energy production, and inflammatory pathways: interrelated aspects in endotoxemia and sepsis, Int J Biochem Cell Biol. 81(Pt B), 307, 10.1016/j.biocel.2016.07.032 Chen, 2017, Salidroside suppressing LPS-induced myocardial injury by inhibiting ROS-mediated PI3K/Akt/mTOR pathway in vitro and in vivo, J. Cell. Mol. Med., 21, 3178, 10.1111/jcmm.12871 Franceschelli, 2017, Biological effect of licochalcone C on the regulation of PI3K/Akt/eNOS and NF-κB/iNOS/NO signaling pathways in H9c2 cells in response to LPS stimulation, Int. J. Mol. Sci., 18, 10.3390/ijms18040690 Kramann, 2014, Speckle tracking echocardiography detects uremic cardiomyopathy early and predicts cardiovascular mortality in ESRD, J. Am. Soc. Nephrol., 25, 2351, 10.1681/ASN.2013070734 Yamada, 2017, Mechanisms of left ventricular dysfunction assessed by layer-specific strain analysis in patients with repaired tetralogy of Fallot, Circ. J., 81, 846, 10.1253/circj.CJ-16-1162 Cong, 2018, Quantitative evaluation of longitudinal strain in layer-specific myocardium in patients with preeclampsia, Int. J. Card. Imaging, 34, 193, 10.1007/s10554-017-1220-1 Tavener, 2004, Immune cell toll-like receptor 4 is required for cardiac myocyte impairment during endotoxemia, Circ. Res., 95, 700, 10.1161/01.RES.0000144175.70140.8c You, 2009, Cardiac-specific expression of heat shock protein 27 attenuated endotoxin-induced cardiac dysfunction and mortality in mice through a PI3K/Akt-dependent mechanism, Shock, 32, 108, 10.1097/SHK.0b013e318199165d Caglayan, 2018, Naringin protects against cyclophosphamide-induced hepatotoxicity and nephrotoxicity through modulation of oxidative stress, inflammation, apoptosis, autophagy, and DNA damage, Environ. Sci. Pollut. Res. Int., 25, 20968, 10.1007/s11356-018-2242-5 He, 2015, Salidroside mitigates sepsis-induced myocarditis in rats by regulating IGF-1/PI3K/Akt/GSK-3β signaling, Inflammation, 38, 2178, 10.1007/s10753-015-0200-7 Wei, 2016, Correlation between protein 4.1R and the progression of heart failure in vivo, Genet. Mol. Res., 15, 10.4238/gmr.15028648 Zhou, 2018, Boosting mTOR-dependent autophagy via upstream TLR4-MyD88-MAPK signaling and downstream NF-κB pathway quenches intestinal inflammation and oxidative stress injury, EBioMedicine, 35, 345, 10.1016/j.ebiom.2018.08.035 Chen, 2014, Naringin inhibits ROS-activated MAPK pathway in high glucose-induced injuries in H9c2 cardiac cells, Basic Clin. Pharmacol. Toxicol., 114, 293, 10.1111/bcpt.12153 Deng, 2017, Puerarin inhibits expression of tissue factor induced by oxidative low-density lipoprotein through activating the PI3K/Akt/eNOS pathway and inhibiting activation of ERK1/2 and NF-κB, Life Sci., 191, 115, 10.1016/j.lfs.2017.10.018 Kalmár, 2015, Gene-expression analysis of a colorectal cancer-specific discriminatory transcript set on formalin-fixed, paraffin-embedded (FFPE) tissue samples, Diagn. Pathol., 10, 126, 10.1186/s13000-015-0363-4 Wang, 2018, Notch1 inhibits rosiglitazone-induced adipogenic differentiation in primary thymic stromal cells, Front. Pharmacol., 9, 1284, 10.3389/fphar.2018.01284 Luo, 2018, Does masked hypertension cause early left ventricular impairment in youth?, Front. Pediatr., 6, 167, 10.3389/fped.2018.00167 Li, 2014, 2D speckle tracking imaging to assess sepsis induced early systolic myocardial dysfunction and its underlying mechanisms, Eur. Rev. Med. Pharmacol. Sci., 18, 3105 Sarvari, 2013, Layer-specific quantification of myocardial deformation by strain echocardiography may reveal significant CAD in patients with non-ST-segment elevation acute coronary syndrome, JACC Cardiovasc. Imaging, 6, 535, 10.1016/j.jcmg.2013.01.009 Liu, 2019, Evaluation of myocardial viability in patients with acute myocardial infarction: layer-specific analysis of 2-dimensional speckle tracking echocardiography, Medicine (Baltimore), 98, 10.1097/MD.0000000000013959 Drosatos, 2015, Pathophysiology of sepsis-related cardiac dysfunction: driven by inflammation, energy mismanagement, or both?, Curr. Heart Fail. Rep., 12, 130, 10.1007/s11897-014-0247-z Zhao, 2016, Cinnamaldehyde ameliorates LPS-induced cardiac dysfunction via TLR4-NOX4 pathway: the regulation of autophagy and ROS production, J. Mol. Cell. Cardiol., 101, 11, 10.1016/j.yjmcc.2016.10.017 Khodir, 2016, Montelukast attenuates lipopolysaccharide-induced cardiac injury in rats, Hum. Exp. Toxicol., 35, 388, 10.1177/0960327115591372 Abbaszadeh, 2018, Memantine, an NMDA receptor antagonist, attenuates cardiac remodeling, lipid peroxidation and neutrophil recruitment in heart failure: a cardioprotective agent?, Biomed. Pharmacother., 108, 1237, 10.1016/j.biopha.2018.09.153 Lv, 2018, Naringin protects against perfluorooctane sulfonate-induced liver injury by modulating NRF2 and NF-κB in mice, Int. Immunopharmacol., 65, 140, 10.1016/j.intimp.2018.09.019 Kim, 2018, Naringin protects acrolein-induced pulmonary injuries through modulating apoptotic signaling and inflammation signaling pathways in mice, J. Nutr. Biochem., 59, 10, 10.1016/j.jnutbio.2018.05.012 Lee, 2018, 3,4,5-Trihydroxycinnamic acid attenuates lipopolysaccharide (LPS)-induced acute lung injury via downregulating inflammatory molecules and upregulating HO-1/AMPK activation, Int. Immunopharmacol., 64, 123, 10.1016/j.intimp.2018.08.015 Yang, 2013, Gastrodin attenuation of the inflammatory response in H9c2 cardiomyocytes involves inhibition of NF-κB and MAPKs activation via the phos-phatidylinositol 3-kinase signaling, Biochem. Pharmacol., 85, 1124, 10.1016/j.bcp.2013.01.020 Lu, 2019, Protective effect of sophocarpine on lipopolysaccharide-induced acute lung injury in mice, Int. Immunopharmacol., 70, 180, 10.1016/j.intimp.2019.02.020 Chtourou, 2016, Anti-apoptotic and anti-inflammatory effects of naringin on cisplatin-induced renal injury in the rat, Chem. Biol. Interact., 243, 1, 10.1016/j.cbi.2015.11.019 Zhai, 2016, Paeoniflorin attenuates cardiac dysfunction in endotoxemic mice via the inhibition of nuclear factor-κB, Biomed. Pharmacother., 80, 200, 10.1016/j.biopha.2016.03.032 Kulasekaran, 2015, Neuroprotective efficacy of naringin on 3-nitropropionic acid-induced mitochondrial dysfunction through the modulation of Nrf2 signaling pathway in PC12 cells, Mol. Cell. Biochem., 409, 199, 10.1007/s11010-015-2525-9