Advances in gastropod immunity from the study of the interaction between the snail Biomphalaria glabrata and its parasites: A review of research progress over the last decade
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King, 2010, Parasites and poverty: the case of schistosomiasis, Acta Trop, 113, 95, 10.1016/j.actatropica.2009.11.012
King, 2005, Reassessment of the cost of chronic helmintic infection: a meta-analysis of disability-related outcomes in endemic schistosomiasis, Lancet, 365, 1561, 10.1016/S0140-6736(05)66457-4
Doenhoff, 2009, Praziquantel: its use in control of schistosomiasis in sub-Saharan Africa and current research needs, Parasitology, 136, 1825, 10.1017/S0031182009000493
Fallon, 1994, Drug-resistant schistosomiasis: resistance to praziquantel and oxamniquine induced in Schistosoma mansoni in mice is drug specific, Am J Trop Med Hyg, 51, 83, 10.4269/ajtmh.1994.51.83
Melman, 2009, Reduced susceptibility to praziquantel among naturally occurring Kenyan isolates of Schistosoma mansoni, PLoS Negl Trop Dis, 3, e504, 10.1371/journal.pntd.0000504
Adema, 2012, Will all scientists working on snails and the diseases they transmit please stand up?, PLoS Negl Trop Dis, 6, e1835, 10.1371/journal.pntd.0001835
Bayne, 2009, Successful parasitism of vector snail Biomphalaria glabrata by the human blood fluke (trematode) Schistosoma mansoni: a 2009 assessment, Mol Biochem Parasitol, 165, 8, 10.1016/j.molbiopara.2009.01.005
Knight, 2014, Schistosomes and snails: a molecular encounter, Front Genet, 5, 230, 10.3389/fgene.2014.00230
Yoshino, 2011, Immunobiology of biomphalaria–trematode interactions, 159
Mitta, 2005, Gene discovery and expression analysis of immune-relevant genes from Biomphalaria glabrata hemocytes, Dev Comp Immunol, 29, 393, 10.1016/j.dci.2004.10.002
Adema, 2010, Differential transcriptomic responses of Biomphalaria glabrata (Gastropoda, Mollusca) to bacteria and metazoan parasites, Schistosoma mansoni and Echinostoma paraensei (Digenea, Platyhelminthes), Mol Immunol, 47, 849, 10.1016/j.molimm.2009.10.019
Hanington, 2010, Time series analysis of the transcriptional responses of Biomphalaria glabrata throughout the course of intramolluscan development of Schistosoma mansoni and Echinostoma paraensei, Int J Parasitol, 40, 819, 10.1016/j.ijpara.2009.12.005
Lockyer, 2007, Biomphalaria glabrata transcriptome: identification of cell-signalling, transcriptional control and immune-related genes from open reading frame expressed sequence tags (ORESTES), Dev Comp Immunol, 31, 763, 10.1016/j.dci.2006.11.004
Deleury, 2012, Specific versus non-specific immune responses in an invertebrate species evidenced by a comparative de novo sequencing study, PLoS One, 7, e32512, 10.1371/journal.pone.0032512
Hanelt, 2008, Comparative ORESTES-sampling of transcriptomes of immune-challenged Biomphalaria glabrata snails, J Invertebr Pathol, 99, 192, 10.1016/j.jip.2008.06.002
Baeza Garcia, 2010, Involvement of the cytokine MIF in the snail host immune response to the parasite Schistosoma mansoni, PLoS Pathog, 6, e1001115, 10.1371/journal.ppat.1001115
Parisi, 2012, MIF from mussel: coding sequence, phylogeny, polymorphism, 3D model and regulation of expression, Dev Comp Immunol, 36, 688, 10.1016/j.dci.2011.10.014
Zhang, 2007, Characterization of immune genes from the schistosome host snail Biomphalaria glabrata that encode peptidoglycan recognition proteins and gram-negative bacteria binding protein, Immunogenetics, 59, 883, 10.1007/s00251-007-0245-3
Hathaway, 2010, Identification of protein components of egg masses indicates parental investment in immunoprotection of offspring by Biomphalaria glabrata (gastropoda, mollusca), Dev Comp Immunol, 34, 425, 10.1016/j.dci.2009.12.001
Baron, 2013, Parental transfer of the antimicrobial protein LBP/BPI protects Biomphalaria glabrata eggs against oomycete infections, PLoS Pathog, 9, e1003792, 10.1371/journal.ppat.1003792
Anderson, 1979, Prevalence of schistosome infections within molluscan populations: observed patterns and theoretical predictions, Parasitology, 79, 63, 10.1017/S0031182000051982
Sire, 1999, Genetic diversity and recruitment pattern of Schistosoma mansoni in a Biomphalaria glabrata snail population: a field study using random-amplified polymorphic DNA markers, J Parasitol, 85, 436, 10.2307/3285775
Davies, 2001, Trade-offs in the evolution of virulence in an indirectly transmitted macroparasite, Proc Biol Sci, 268, 251, 10.1098/rspb.2000.1367
Richards, 1992, Genetics of Biomphalaria glabrata and its effect on the outcome of Schistosoma mansoni infection, Parasitol Today, 8, 171, 10.1016/0169-4758(92)90015-T
Webster, 2004, Do hosts and parasites coevolve? Empirical support from the Schistosoma system, Am Nat, 164, S33, 10.1086/424607
Langand, 1998, Heritable non-susceptibility in an allopatric host-parasite system: Biomphalaria glabrata (Mollusca)-Echinostoma caproni (platyhelminth Digenea), J Parasitol, 84, 739, 10.2307/3284580
Ataev, 1999, Cellular response to Echinostoma caproni infection in Biomphalaria glabrata strains selected for susceptibility/resistance, Dev Comp Immunol, 23, 187, 10.1016/S0145-305X(99)00023-3
Vergote, 2005, Characterisation of proteins differentially present in the plasma of Biomphalaria glabrata susceptible or resistant to Echinostoma caproni, Int J Parasitol, 35, 215, 10.1016/j.ijpara.2004.11.006
Xu, 2002, Endo-beta-1,4-mannanases from blue mussel, Mytilus edulis: purification, characterization, and mode of action, J Biotechnol, 92, 267, 10.1016/S0168-1656(01)00367-4
Wijdenes, 1983, Effects of two gonadotropic hormones on polysaccharide synthesis in the albumen gland of Lymnaea stagnalis, studied with the organ culture technique, Gen Comp Endocrinol, 51, 263, 10.1016/0016-6480(83)90080-1
Boswell, 1984, Isolation, characterization and functional assessment of a hemagglutinin from the plasma of Biomphalaria glabrata, intermediate host of Schistosoma mansoni, Dev Comp Immunol, 8, 559, 10.1016/0145-305X(84)90088-0
Takamatsu, 1995, Molecular cloning of the defense factor in the albumen gland of the sea hare Aplysia kurodai, FEBS Lett, 377, 373, 10.1016/0014-5793(95)01375-X
Guillou, 2007, Identification and expression of gene transcripts generated during an anti-parasitic response in Biomphalaria glabrata, Dev Comp Immunol, 31, 657, 10.1016/j.dci.2006.10.001
Humbert, 2001, Refractoriness of host haemocytes to parasite immunosuppressive factors as a putative resistance mechanism in the Biomphalaria glabrata-Echinostoma caproni system, Parasitology, 122, 651, 10.1017/S003118200100782X
Bouchut, 2006, Compatibility in the Biomphalaria glabrata/Echinostoma caproni model: potential involvement of adhesion genes, Int J Parasitol, 36, 175, 10.1016/j.ijpara.2005.09.009
Schutze, 2001, Molecular evolution of the metazoan extracellular matrix: cloning and expression of structural proteins from the demosponges Suberites domuncula and Geodia cydonium, J Mol Evol, 53, 402, 10.1007/s002390010230
Fujii, 1992, Isolation, cDNA cloning, and characterization of an 18-kDa hemagglutinin and amebocyte aggregation factor from Limulus polyphemus, J Biol Chem, 267, 22452, 10.1016/S0021-9258(18)41693-6
Bouchut, 2006, Compatibility in the Biomphalaria glabrata/Echinostoma caproni model: potential involvement of proteins from hemocytes revealed by a proteomic approach, Acta Trop, 98, 234, 10.1016/j.actatropica.2006.05.007
Bouchut, 2007, Compatibility in the Biomphalaria glabrata/Echinostoma caproni model: new candidate genes evidenced by a suppressive subtractive hybridization approach, Parasitology, 134, 575, 10.1017/S0031182006001673
Theron, 2005, Are Biomphalaria snails resistant to Schistosoma mansoni?, J Helminthol, 79, 187, 10.1079/JOH2005299
Lewis, 2001, The relationship between Schistosoma mansoni and Biomphalaria glabrata: genetic and molecular approaches, Parasitology, 123, S169, 10.1017/S0031182001007831
Knight, 1999, The identification of markers segregating with resistance to Schistosoma mansoni infection in the snail Biomphalaria glabrata, Proc Natl Acad Sci U S A, 96, 1510, 10.1073/pnas.96.4.1510
Ittiprasert, 2013, Identification and characterisation of functional expressed sequence tags-derived simple sequence repeat (eSSR) markers for genetic linkage mapping of Schistosoma mansoni juvenile resistance and susceptibility loci in Biomphalaria glabrata, Int J Parasitol, 43, 669, 10.1016/j.ijpara.2013.03.007
Blouin, 2013, Three genes involved in the oxidative burst are closely linked in the genome of the snail, Biomphalaria glabrata, Int J Parasitol, 43, 51, 10.1016/j.ijpara.2012.10.020
Bonner, 2012, Effects of Cu/Zn superoxide dismutase (sod1) genotype and genetic background on growth, reproduction and defense in Biomphalaria glabrata, PLoS Negl Trop Dis, 6, e1701, 10.1371/journal.pntd.0001701
Goodall, 2006, Biomphalaria glabrata cytosolic copper/zinc superoxide dismutase (SOD1) gene: association of SOD1 alleles with resistance/susceptibility to Schistosoma mansoni, Mol Biochem Parasitol, 147, 207, 10.1016/j.molbiopara.2006.02.009
Schneider, 2001, Differential display analysis of hemocytes from schistosome-resistant and schistosome-susceptible intermediate hosts, Parasitol Res, 87, 489, 10.1007/s004360100394
Lockyer, 2004, Schistosoma mansoni: resistant specific infection-induced gene expression in Biomphalaria glabrata identified by fluorescent-based differential display, Exp Parasitol, 107, 97, 10.1016/j.exppara.2004.04.004
Lockyer, 2007, Identification of genes involved in interactions between Biomphalaria glabrata and Schistosoma mansoni by suppression subtractive hybridization, Mol Biochem Parasitol, 151, 18, 10.1016/j.molbiopara.2006.09.009
Ittiprasert, 2009, Schistosoma mansoni infection of juvenile Biomphalaria glabrata induces a differential stress response between resistant and susceptible snails, Exp Parasitol, 123, 203, 10.1016/j.exppara.2009.07.015
Ittiprasert, 2012, Reversing the resistance phenotype of the Biomphalaria glabrata snail host Schistosoma mansoni infection by temperature modulation, PLoS Pathog, 8, e1002677, 10.1371/journal.ppat.1002677
Ittiprasert, 2010, Identification of immediate response genes dominantly expressed in juvenile resistant and susceptible Biomphalaria glabrata snails upon exposure to Schistosoma mansoni, Mol Biochem Parasitol, 169, 27, 10.1016/j.molbiopara.2009.09.009
Lockyer, 2013, Early differential gene expression in haemocytes from resistant and susceptible Biomphalaria glabrata strains in response to Schistosoma mansoni, PLoS One, 7, e51102, 10.1371/journal.pone.0051102
Myers, 2008, Differences in cysteine protease activity in Schistosoma mansoni-resistant and -susceptible Biomphalaria glabrata and characterization of the hepatopancreas cathepsin B Full-length cDNA, J Parasitol, 94, 659, 10.1645/GE-1410.1
Hahn, 2001, Killing of Schistosoma mansoni sporocysts by hemocytes from resistant Biomphalaria glabrata: role of reactive oxygen species, J Parasitol, 292, 10.1645/0022-3395(2001)087[0292:KOSMSB]2.0.CO;2
Goodall, 2004, Constitutive differences in Cu/Zn superoxide dismutase mRNA levels and activity in hemocytes of Biomphalaria glabrata (Mollusca) that are either susceptible or resistant to Schistosoma mansoni (Trematoda), Mol Biochem Parasitol, 137, 321, 10.1016/j.molbiopara.2004.06.011
Bender, 2005, Respiratory burst of Biomphalaria glabrata hemocytes: Schistosoma mansoni-resistant snails produce more extracellular H2O2 than susceptible snails, J Parasitol, 91, 275, 10.1645/GE-415R
Bender, 2007, Variation in expression of Biomphalaria glabrata SOD1: a potential controlling factor in susceptibility/resistance to Schistosoma mansoni, Dev Comp Immunol, 31, 874, 10.1016/j.dci.2006.12.005
Larson, 2014, Resistance of Biomphalaria glabrata 13-16-R1 snails to Schistosoma mansoni PR1 is a function of haemocyte abundance and constitutive levels of specific transcripts in haemocytes, Int J Parasitol, 44, 343, 10.1016/j.ijpara.2013.11.004
Wu, 2009, Proteomic analysis of Schistosoma mansoni proteins released during in vitro miracidium-to-sporocyst transformation, Mol Biochem Parasitol, 164, 32, 10.1016/j.molbiopara.2008.11.005
Pan, 1996, Schistosoma mansoni: the ultrastructure of larval morphogenesis in Biomphalaria glabrata and of associated host-parasite interactions, Jpn J Med Sci Biol, 49, 129, 10.7883/yoken1952.49.129
Guillou, 2007, Excretory-secretory proteome of larval Schistosoma mansoni and Echinostoma caproni, two parasites of Biomphalaria glabrata, Mol Biochem Parasitol, 155, 45, 10.1016/j.molbiopara.2007.05.009
Sapp, 2000, Mechanisms underlying digenean-snail specificity: role of miracidial attachment and host plasma factors, J Parasitol, 86, 1012
Daniel, 1992, The in vitro transformation of the miracidium to the mother sporocyst of Schistosoma margrebowiei; changes in the parasite surface and implications for interactions with snail plasma factors, Parasitology, 104, 41, 10.1017/S0031182000060789
Abu-Shakra, 1999, Molecular mimicry between host and pathogen: examples from parasites and implication, Immunol Lett, 67, 147, 10.1016/S0165-2478(99)00004-8
Damian, 1997, Parasite immune evasion and exploitation: reflections and projections, Parasitology, 115, S169, 10.1017/S0031182097002357
Yoshino, 2013, Circulating Biomphalaria glabrata hemocyte subpopulations possess shared schistosome glycans and receptors capable of binding larval glycoconjugates, Exp Parasitol, 133, 28, 10.1016/j.exppara.2012.10.002
Dunn, 1988, Schistosoma mansoni: origin and expression of a tegumental surface antigen on the miracidium and primary sporocyst, Exp Parasitol, 67, 167
Lodes, 1989, Characterization of excretory-secretory proteins synthesized in vitro by Schistosoma mansoni primary sporocysts, J Parasitol, 75, 853, 10.2307/3282863
Martins-Souza, 2011, Participation of N-acetyl-D-glucosamine carbohydrate moieties in the recognition of Schistosoma mansoni sporocysts by haemocytes of Biomphalaria tenagophila, Memorias do Inst Oswaldo Cruz, 106, 884, 10.1590/S0074-02762011000700015
Sullivan, 2014, Fucoidan stimulates cell division in the amebocyte-producing organ of the schistosome-transmitting snail Biomphalaria glabrata, J Invertebr Pathol, 123, 13, 10.1016/j.jip.2014.09.005
Mitta, 2012, Compatibility polymorphism in snail/schistosome interactions: from field to theory to molecular mechanisms, Dev Comp Immunol, 37, 1, 10.1016/j.dci.2011.09.002
Peterson, 2009, Glycotope analysis in miracidia and primary sporocysts of Schistosoma mansoni: differential expression during the miracidium-to-sporocyst transformation, Int J Parasitol, 39, 1331, 10.1016/j.ijpara.2009.06.002
Yoshino, 2012, Glycotope sharing between snail hemolymph and larval schistosomes: larval transformation products alter shared glycan patterns of plasma proteins, PLoS Negl Trop Dis, 6, e1569, 10.1371/journal.pntd.0001569
Roger, 2008, Molecular determinants of compatibility polymorphism in the Biomphalaria glabrata/Schistosoma mansoni model: new candidates identified by a global comparative proteomics approach, Mol Biochem Parasitol, 157, 205, 10.1016/j.molbiopara.2007.11.003
Buscaglia, 2006, Trypanosoma cruzi surface mucins: host-dependent coat diversity, Nat Rev Microbiol, 4, 229, 10.1038/nrmicro1351
Hicks, 2000, The role of mucins in host-parasite interactions. Part I-protozoan parasites, Parasitol Today, 16, 476, 10.1016/S0169-4758(00)01773-7
Rathore, 2005, An immunologically cryptic epitope of Plasmodium falciparum circumsporozoite protein facilitates liver cell recognition and induces protective antibodies that block liver cell invasion, J Biol Chem, 280, 20524, 10.1074/jbc.M414254200
Theodoropoulos, 2001, The role of mucins in host-parasite interactions: part II – helminth parasites, Trends Parasitol, 17, 130, 10.1016/S1471-4922(00)01775-X
Roger, 2008, Expression analysis of highly polymorphic mucin proteins (Sm PoMuc) from the parasite Schistosoma mansoni, Mol Biochem Parasitol, 157, 217, 10.1016/j.molbiopara.2007.11.015
Roger, 2008, Controlled chaos of polymorphic mucins in a metazoan parasite (Schistosoma mansoni) interacting with its invertebrate host (Biomphalaria glabrata), PLoS Negl Trop Dis, 2, e330, 10.1371/journal.pntd.0000330
Perez-Sanchez, 2006, Proteomic analysis of the tegument and excretory-secretory products of adult Schistosoma bovis worms, Proteomics, 6, S226, 10.1002/pmic.200500420
Mone, 2010, A large repertoire of parasite epitopes matched by a large repertoire of host immune receptors in an invertebrate host/parasite model, PLoS Negl Trop Dis, 4, 10.1371/journal.pntd.0000813
Adema, 1997, A family of fibrinogen-related proteins that precipitates parasite-derived molecules is produced by an invertebrate after infection, Proc Natl Acad Sci U S A, 94, 8691, 10.1073/pnas.94.16.8691
Zhang, 2004, Diversification of Ig superfamily genes in an invertebrate, Science, 305, 251, 10.1126/science.1088069
Fraiture, 2009, Two mosquito LRR proteins function as complement control factors in the TEP1-mediated killing of Plasmodium, Cell Host Microbe, 5, 273, 10.1016/j.chom.2009.01.005
Volohonsky, 2010, Focusing on complement in the antiparasitic defense of mosquitoes, Trends Parasitol, 26, 1, 10.1016/j.pt.2009.10.003
Blandin, 2004, Thioester-containing proteins and insect immunity, Mol Immunol, 40, 903, 10.1016/j.molimm.2003.10.010
Blandin, 2007, Phagocytosis in mosquito immune responses, Immunol Rev, 219, 8, 10.1111/j.1600-065X.2007.00553.x
Blandin, 2008, Antimalarial responses in Anopheles gambiae: from a complement-like protein to a complement-like pathway, Cell Host Microbe, 3, 364, 10.1016/j.chom.2008.05.007
Stroschein-Stevenson, 2006, Identification of Drosophila gene products required for phagocytosis of Candida albicans, PLoS Biol, 4, e4, 10.1371/journal.pbio.0040004
van Lookeren Campagne, 2007, Macrophage complement receptors and pathogen clearance, Cell Microbiol, 9, 2095, 10.1111/j.1462-5822.2007.00981.x
Galinier, 2013, Biomphalysin, a new beta pore-forming toxin involved in Biomphalaria glabrata immune defense against Schistosoma mansoni, PLoS Pathog, 9, e1003216, 10.1371/journal.ppat.1003216
Hanington, 2011, Role for a somatically diversified lectin in resistance of an invertebrate to parasite infection, Proc Natl Acad Sci U S A, 107, 21087, 10.1073/pnas.1011242107
Hanington, 2012, A somatically diversified defense factor, FREP3, is a determinant of snail resistance to schistosome infection, PLoS Negl Trop Dis, 6, e1591, 10.1371/journal.pntd.0001591
Perrin, 2012, Schistosoma mansoni mucin gene (SmPoMuc) expression: epigenetic control to shape adaptation to a new host, PLoS Pathog, 9, e1003571, 10.1371/journal.ppat.1003571
Cosseau, 2010, Epigenetic and phenotypic variability in populations of Schistosoma mansoni – a possible kick-off for adaptive host/parasite evolution, Oikos, 119, 669, 10.1111/j.1600-0706.2009.18040.x
Yoshino, 2008, Molecular and functional characterization of a tandem-repeat galectin from the freshwater snail Biomphalaria glabrata, intermediate host of the human blood fluke Schistosoma mansoni, Gene, 411, 46, 10.1016/j.gene.2008.01.003
Portela, 2013, Evidence for specific genotype-dependent immune priming in the lophotrochozoan Biomphalaria glabrata snail, J Innate Immun, 5, 261
Nowak, 2004, Identification of transcripts generated during the response of resistant Biomphalaria glabrata to Schistosoma mansoni infection using suppression subtractive hybridization, J Parasitol, 90, 1034, 10.1645/GE-193R1
Hertel, 2005, Differential expression of FREP genes in two strains of Biomphalaria glabrata following exposure to the digenetic trematodes Schistosoma mansoni and Echinostoma paraensei, Dev Comp Immunol, 29, 295, 10.1016/j.dci.2004.08.003
Raghavan, 2003, Comparative gene analysis of Biomphalaria glabrata hemocytes pre- and post-exposure to miracidia of Schistosoma mansoni, Mol Biochem Parasitol, 126, 181, 10.1016/S0166-6851(02)00272-4
Zelck, 1995, The plasma proteins of Biomphalaria glabrata in the presence and absence of Schistosoma mansoni, Dev Comp Immunol, 19, 181, 10.1016/0145-305X(95)00012-I
Uchikawa, 1992, Echinostoma paraensei and Schistosoma mansoni: adherence of unaltered or modified latex beads to hemocytes of the host snail Biomphalaria glabrata, Exp Parasitol, 75, 223, 10.1016/0014-4894(92)90182-A
Johnston, 2001, Larval Schistosoma mansoni excretory-secretory glycoproteins (ESPs) bind to hemocytes of Biomphalaria glabrata (Gastropoda) via surface carbohydrate binding receptors, J Parasitol, 87, 786
Peterson, 2013, In silico analysis of the fucosylation-associated genome of the human blood fluke Schistosoma mansoni: cloning and characterization of the enzymes involved in GDP-L-fucose synthesis and Golgi import, Parasites Vectors, 6, 201, 10.1186/1756-3305-6-201
Castillo, 2007, Surface membrane proteins of Biomphalaria glabrata embryonic cells bind fucosyl determinants on the tegumental surface of Schistosoma mansoni primary sporocysts, J Parasitol, 93, 832, 10.1645/GE-954R.1
Blankespoor, 1976, Attachment and penetration of miracidia observed by scanning electron microscopy, Science, 191, 291, 10.1126/science.1246613
Yoshino, 1993, Proteinase activity in miracidia, transformation excretory-secretory products, and primary sporocysts of Schistosoma mansoni, J Parasitol, 79, 23, 10.2307/3283272
Yoshino, 2014, Excreted/secreted Schistosoma mansoni venom allergen-like 9 (SmVAL9) modulates host extracellular matrix remodelling gene expression, Int J Parasitol, 44, 551, 10.1016/j.ijpara.2014.04.002
Bayne, 2001, Mechanisms of molluscan host resistance and of parasite strategies for survival, Parasitology, 123, S159, 10.1017/S0031182001008137
Mone, 2011, An example of molecular co-evolution: reactive oxygen species (ROS) and ROS scavenger levels in Schistosoma mansoni/Biomphalaria glabrata interactions, Int J Parasitol, 41, 721, 10.1016/j.ijpara.2011.01.007
Zelck, 2004, Antioxidant enzymes in intramolluscan Schistosoma mansoni and ROS-induced changes in expression, Parasitology, 128, 493, 10.1017/S0031182004004895
Mourao Mde, 2009, Role of the endogenous antioxidant system in the protection of Schistosoma mansoni primary sporocysts against exogenous oxidative stress, PLoS Negl Trop Dis, 3, e550, 10.1371/journal.pntd.0000550
Vermeire, 2006, Schistosoma mansoni: DNA microarray gene expression profiling during the miracidium-to-mother sporocyst transformation, Mol Biochem Parasitol, 147, 39, 10.1016/j.molbiopara.2006.01.006
Vermeire, 2007, Antioxidant gene expression and function in in vitro-developing Schistosoma mansoni mother sporocysts: possible role in self-protection, Parasitology, 134, 1369, 10.1017/S0031182007002697
Hahn, 2000, Production of reactive oxygen species by hemocytes of Biomphalaria glabrata: carbohydrate-specific stimulation, Dev Comp Immunol, 24, 531
Humphries, 2008, Regulation of hydrogen peroxide release in circulating hemocytes of the planorbid snail Biomphalaria glabrata, Dev Comp Immunol, 32, 554, 10.1016/j.dci.2007.09.001