Role of γ-glutamyl cysteine synthetase (γ-GCS) gene expression as marker of drug sensitivity in acute myeloid leukemias

Shen, 1997, Importance of glutathione and associated enzymes in drug response, Oncol Res, 9, 295 Sagara, 1998, Cellular mechanisms of resistance to chronic oxidative stress, Free Radic Biol Med, 24, 1375, 10.1016/S0891-5849(97)00457-7 O'Brien, 2000, The influence of coordinate overexpression of glutathione phase II detoxification gene products on drug resistance, J Pharmacol Exp Ther, 294, 480 Iida, 2001, Hammerhead ribozyme against gamma-glutamylcysteine synthetase sensitizes human colonic cancer cells to cisplatin by down-regulating both the glutathione synthesis and the expression of multidrug resistance proteins, Cancer Gene Ther, 8, 803, 10.1038/sj.cgt.7700371 Dai, 1999, Malignant cells can be sensitized to undergo growth inhibition and apoptosis by arsenic trioxide through modulation of the glutathione redox system, Blood, 93, 268, 10.1182/blood.V93.1.268 Davison, 2003, Glutathione depletion overcomes resistance to arsenic trioxide in arsenic-resistant cell lines, Leukemia, 17, 931, 10.1038/sj.leu.2402876 Hayes, 1995, Potential contribution of the glutathione S-transferase supergene family to resistance to oxidative stress, Free Radic Res, 22, 193, 10.3109/10715769509147539 Vignetti, 2004, Cytoreduction rate after hydroxyurea pre-treatment is an independent prognostic factor for complete remission in adult acute myeloid leukemia, Hematol J, S37 Mandelli, 1997, Molecular remission in PML/RAR-positive acute promyelocytic leucemia by combined all-trans retinoic acid and idarubicin (AIDA) therapy, Blood, 90, 1014 Bennet, 1985, Proposed revised criteria for the acute myeloid leukemias: a report of the French–American–British Cooperative Group, Ann Intern Med, 103, 620, 10.7326/0003-4819-103-4-620 Livak KJ. Comparative Ct method. ABI Prism 7700 sequence detection system. User Bulletin no. 2. PE Applied Biosystems; 1997. Mantymaa, 2000, Cellular redox state and its relationship to the inhibition of clonal cell growth and the induction of apoptosis during all-trans retinoic acid exposure in acute myeloblastic leukemia cells, Haematologica, 85, 238 Wild, 2000, Regulation of γ-glutamylcysteine synthetase subunit gene expression: insight into trascriptional control of antioxidant defenses, Free Radic Res, 32, 281, 10.1080/10715760000300291 Sekhar, 1997, Expression of glutathione and γ-glutamylcysteine synthetase mRNA is Jun dependent, Biochem Biophys Res Commun, 234, 588, 10.1006/bbrc.1997.6697 Wild, 1998, Overlapping antioxidant responsive element and PMA response element sequences mediate basal and g-naphthoflavone-induced expression of the human γ-glutamylcysteine synthetase catalytic subunit gene, Biochem J, 332, 373, 10.1042/bj3320373