How Ras works: structure of a Rap–Raf complex

Structure - Tập 3 - Trang 641-643 - 1995
Stephen R Sprang1
1Stephen R Sprang, Howard Hughes Medical Institute and Department of Biochemistry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235-9050, USA

Tài liệu tham khảo

Nassar, 1995, The 2.2 å crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf-1 in complex with Rap1 and a GTP analogue, Nature, 375, 554, 10.1038/375554a0 Burgering, 1995, Regulation of Ras-mediated signalling: more than one way to skin a cat, Trends Biochem. Sci, 20, 18, 10.1016/S0968-0004(00)88944-6 Leevers, 1994, Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane, Nature, 369, 411, 10.1038/369411a0 Vojtek, 1993, Mammalian Ras interacts directly with the serine/threonine kinase Raf, Cell, 74, 205, 10.1016/0092-8674(93)90307-C Kitayama, 1989, A ras-related gene with transformational suppressor activity, Cell, 56, 77, 10.1016/0092-8674(89)90985-9 Zhang, 1993, Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1, Nature, 364, 308, 10.1038/364308a0 Emerson, 1994, Chemical shift assignments and folding topology of the Ras-binding domain of human Raf-1 as determined by heteronuclear three-dimensional NMR spectroscopy, Biochemistry, 33, 7745, 10.1021/bi00191a001 Orengo, 1994, Protein superfamilies and domain superfolds, Nature, 372, 631, 10.1038/372631a0 Pai, 1990, Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 å resolution: implications for the mechanism of GTP hydrolysis, EMBO J, 9, 2351, 10.1002/j.1460-2075.1990.tb07409.x Milburn, 1990, Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins, Nature, 247, 939 Noel, 1993, The 2.2 å crystal structure of transducin-α complexed with GTPγS, Nature, 366, 654, 10.1038/366654a0 Coleman, 1994, Structures of active conformations of Giα1 and the mechanism of GTP hydrolysis, Science, 265, 1405, 10.1126/science.8073283 Hermann, 1995, Quantitative analysis of the complex between p21ras and the Ras-binding domain of the human Raf-1 protein kinase, J. Biol. Chem, 270, 2901, 10.1074/jbc.270.7.2901 Janin, 1990, The structure of protein–protein recognition sites, J. Biol. Chem, 265, 16027, 10.1016/S0021-9258(17)46181-3 Polakis, 1993, Structural requirements for the interaction of p21ras with GAP, exchange factors, and its biological effector target, J. Biol. Chem, 268, 9157, 10.1016/S0021-9258(18)98325-0 Conklin, 1993, Structural elements of Gα subunits that interact with Gβγ, receptors and effectors, Cell, 73, 631, 10.1016/0092-8674(93)90245-L Kraulis, 1991, MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures, J. Appl. Crystallogr, 24, 946, 10.1107/S0021889891004399