A signature of immune-related gene pairs predicts oncologic outcomes and response to immunotherapy in lung adenocarcinoma

Genomics - Tập 112 - Trang 4675-4683 - 2020
Feng Xu1, Xueqin Zhan2, Xiaohe Zheng1, Huan Xu3, Yangyi Li1, Xiaoling Huang1, Ling Lin3, Yongsong Chen4
1Department of Respiratory Medicine, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China
2Department of Pulmonology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
3Department of Rheumatology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China
4Department of Endocrinology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China

Tài liệu tham khảo

Luo, 2018, Characteristics of genomic alterations of lung adenocarcinoma in young never-smokers, Int. J. Cancer, 143, 1696, 10.1002/ijc.31542 Xu, 2020, Analysis of lung adenocarcinoma subtypes based on immune signatures identifies clinical implications for cancer therapy, Mol. Ther. Oncolytics, 17, 241, 10.1016/j.omto.2020.03.021 Pitt, 2016, Targeting the tumor microenvironment: removing obstruction to anticancer immune responses and immunotherapy, Ann. Oncol., 27, 1482, 10.1093/annonc/mdw168 Quail, 2013, Microenvironmental regulation of tumor progression and metastasis, Nat. Med., 19, 1423, 10.1038/nm.3394 Li, 2020, A signature of tumor immune microenvironment genes associated with the prognosis of nonsmall cell lung cancer, Oncol. Rep., 43, 795 Alsaab, 2017, PD-1 and PD-L1 checkpoint signaling inhibition for cancer immunotherapy: mechanism, combinations, and clinical outcome, Front. Pharmacol., 8, 561, 10.3389/fphar.2017.00561 Akinleye, 2019, Immune checkpoint inhibitors of PD-L1 as cancer therapeutics, J. Hematol. Oncol., 12, 92, 10.1186/s13045-019-0779-5 Zhang, 2019, Development of cancer immunotherapy based on PD-1/PD-L1 pathway blockade, RSC Adv., 9, 33903, 10.1039/C9RA04590B Wang, 2019, A novel 4-gene signature for overall survival prediction in lung adenocarcinoma patients with lymph node metastasis, Cancer Cell Int., 19 Xie, 2019, A six-gene signature predicts survival of adenocarcinoma type of non-small-cell lung cancer patients: a comprehensive study based on integrated analysis and weighted gene coexpression network, Biomed. Res. Int., 2019, 10.1155/2019/4250613 Krzystanek, 2016, A robust prognostic gene expression signature for early stage lung adenocarcinoma, Biomark. Res., 4, 10.1186/s40364-016-0058-3 Ma, 2020, Identification of a sixteen-gene prognostic biomarker for lung adenocarcinoma using a machine learning method, J. Cancer, 11, 1288, 10.7150/jca.34585 Xu, 2020, A TP53-associated gene signature for prediction of prognosis and therapeutic responses in lung squamous cell carcinoma, Oncoimmunology, 9, 10.1080/2162402X.2020.1731943 Xu, 2020, Immune signature of T follicular helper cells predicts clinical prognostic and therapeutic impact in lung squamous cell carcinoma, Int. Immunopharmacol., 81, 10.1016/j.intimp.2019.105932 Wilkerson, 2010, ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking, Bioinformatics, 26, 1572, 10.1093/bioinformatics/btq170 Yang, 2019, Molecular subtypes based on DNA methylation predict prognosis in colon adenocarcinoma patients, Aging, 11, 11880, 10.18632/aging.102492 Daily, 2017, Molecular, phenotypic, and sample-associated data to describe pluripotent stem cell lines and derivatives, Sci. Data, 4, 10.1038/sdata.2017.30 Yoshihara, 2013, Inferring tumour purity and stromal and immune cell admixture from expression data, Nat. Commun., 4, 10.1038/ncomms3612 Zhou, 2019, Immune cell infiltration as a biomarker for the diagnosis and prognosis of stage I-III colon cancer, Cancer Immunol. Immunother., 68, 433, 10.1007/s00262-018-2289-7 Yu, 2012, clusterProfiler: an R package for comparing biological themes among gene clusters, Omics, 16, 284, 10.1089/omi.2011.0118 Malta, 2018, Machine learning identifies stemness features associated with oncogenic dedifferentiation, Cell, 173, 338, 10.1016/j.cell.2018.03.034 Postow, 2015, Immune checkpoint blockade in cancer therapy, J. Clin. Oncol., 33, 1974, 10.1200/JCO.2014.59.4358 Lu, 2019, Immune signature-based subtypes of cervical squamous cell carcinoma tightly associated with human papillomavirus type 16 expression, molecular features, and clinical outcome, Neoplasia, 21, 591, 10.1016/j.neo.2019.04.003 Miranda, 2019, Cancer stemness, intratumoral heterogeneity, and immune response across cancers, Proc. Natl. Acad. Sci., 116, 9020, 10.1073/pnas.1818210116 Perez-Ramirez, 2016, Liquid biopsy in early stage lung cancer, J. Thorac. Dis., 5, 517 Mony, 2018, Prognostic implications of heterogeneity in intra-tumoral immune composition for recurrence in early stage lung cancer, Front. Immunol., 9, 2298, 10.3389/fimmu.2018.02298 Liu, 2017, The prognostic landscape of tumor-infiltrating immune cell and immunomodulators in lung cancer, Biomed. Pharmacother., 95, 55, 10.1016/j.biopha.2017.08.003 Pagès, 2005, Effector memory T cells, early metastasis, and survival in colorectal cancer, N. Engl. J. Med., 353, 2654, 10.1056/NEJMoa051424 Liu, 2020, Development of an immune gene prognostic classifier for survival prediction and respond to immunocheckpoint inhibitor therapy/chemotherapy in endometrial cancer, Int. Immunopharmacol., 86, 10.1016/j.intimp.2020.106735 Shukuya, 2016, Predictive markers for the efficacy of anti-PD-1/PD-L1 antibodies in lung cancer, J. Thorac. Oncol., 11, 976, 10.1016/j.jtho.2016.02.015 Chen, 2015, Anti-PD-1/PD-L1 therapy of human cancer: past, present, and future, J. Clin. Invest., 125, 3384, 10.1172/JCI80011 Long, 2019, Development and validation of a TP53-associated immune prognostic model for hepatocellular carcinoma, EBioMedicine, 42, 363, 10.1016/j.ebiom.2019.03.022 Jiang, 2018, Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response, Nat. Med., 24, 1550, 10.1038/s41591-018-0136-1 Wang, 2020, Analysis of immune-related signatures of lung adenocarcinoma identified two distinct subtypes: implications for immune checkpoint blockade therapy, Aging, 12, 3312, 10.18632/aging.102814 Zheng, 2020, Interaction between CAF and CD8+ T cells in non-small cell lung cancer affects prognosis and efficacy of immunotherapy, J. Clin. Oncol., 38, 10.1200/JCO.2020.38.15_suppl.9536 Chen, 2020, Analysis of immune-related signatures of colorectal cancer identifying two different immune phenotypes: evidence for immune checkpoint inhibitor therapy, Oncol. Lett., 20, 517, 10.3892/ol.2020.11605 Pérez-Guijarro, 2019, Multi-model preclinical platform predicts clinical response of melanoma to immunotherapy, bioRxiv, 26, 781