Targeted expression of tetanus toxin light chain in Drosophila specifically eliminates synaptic transmission and causes behavioral defects

Archer, 1990, Structures and chromosomal localizations of two human genes encoding synaptobrevins 1 and 2, J. Biol. Chem., 265, 17267, 10.1016/S0021-9258(17)44898-8

Bacon, 1986, The dipteran “giant fibre” pathway: neurons and signals, J. Comp. Physiol. (A), 158, 529, 10.1007/BF00603798

Baumert, 1989, Synaptobrevin: an integral membrane protein of 18,000 daltons present in small synaptic vesicles of rat brain, EMBO J., 8, 379, 10.1002/j.1460-2075.1989.tb03388.x

Bittner, 1989, Isolated light chains of botulinum neurotoxins inhibit exocytosis, J. Biol. Chem., 264, 10354, 10.1016/S0021-9258(18)81627-1

Brand, 1993, Targeted gene expression as a means of altering cell fates and generating dominant phenotypes, Development, 118, 401, 10.1242/dev.118.2.401

Broadie, 1993, Activity-dependent development of the neuromuscular synapse during Drosophila embryogenesis, Neuron, 11, 607, 10.1016/0896-6273(93)90073-Z

Broadie, 1993, Development of the embryonic neuromuscular synapse of Drosophila melanogaster, J. Neurosci, 13, 144, 10.1523/JNEUROSCI.13-01-00144.1993

Broadie, 1994, From growth cone to synapse: the life history of the RP3 motoneuron, Development

Broadie, 1994, Absence of synaptotagmin disrupts excitation-secretion coupling during synaptic transmission, 91

Campos-Ortega, 1985

Chin, 1993, Differential expression of transcripts from syb, a Drosophila melanogaster gene encoding VAMP (synaptobrevin) that is abundant in non-neuronal cells, Gene, 131, 175, 10.1016/0378-1119(93)90291-A

DiAntonio, 1993, Synaptic transmission persists in synaptotagmin mutants of Drosophila, Cell, 73, 1281, 10.1016/0092-8674(93)90356-U

DiAntonio, 1993, Identification and characterization of Drosophila genes for synaptic vesicle proteins, J. Neurosci., 13, 4924, 10.1523/JNEUROSCI.13-11-04924.1993

Eisel, 1993, Tetanus toxin light chain expression in Sertoli cells of transgenic mice causes alterations of the actin cytoskeleton and disrupts spermatogenesis, EMBO J., 12, 3365, 10.1002/j.1460-2075.1993.tb06010.x

Elferink, 1989, Two vesicleassociated membrane protein genes are differentially expressed in the rat central nervous system, J. Biol. Chem., 264, 11061, 10.1016/S0021-9258(18)60426-0

Galli, 1994, Tetanus-toxin-mediated cleavage of cellubrevin impairs exocytosis of transferrin receptor-containing vesicles in CHO cells, J. Cell Biol., 125, 1015, 10.1083/jcb.125.5.1015

Katz, 1969

Harrison, 1994, Mutations in the Drosophila Rop gene suggest a function in general secretion and synaptic transmission, Neuron, 13, 555, 10.1016/0896-6273(94)90025-6

Kurazono, 1992, Minimal essential domains specifying toxicity of the light chains of tetanus toxin and botulinum neurotoxin type A, J. Biol. Chem, 267, 14721, 10.1016/S0021-9258(18)42100-X

Laemmli, 1970, Cleavage of structural proteins during the assembly of the head of bacteriophage T4, Nature, 227, 680, 10.1038/227680a0

Li, 1994, A single mutation in the recombinant light chain of tetanus toxin abolishes its proteolytic activity and removes the toxicity seen after reconstitution with native heavy chain, Biochemistry, 33, 7014, 10.1021/bi00188a034

Link, 1992, Tetanus toxin action: inhibition of neurotransmitter release linked to synaptobrevin proteolysis, Biochem. Biophys. Res. Commun., 189, 1017, 10.1016/0006-291X(92)92305-H

Littleton, 1993, Mutational analysis of Drosophila synaptotagmin demonstrates its essential role in Ca2+-activated neurotransmitter release, Cell, 74, 1125, 10.1016/0092-8674(93)90733-7

Littleton, 1993, Expression of synaptotagmin in Drosophila reveals transport and localization of synaptic vesicles in the synapse, Development, 118, 1077, 10.1242/dev.118.4.1077

Luo, 1994, Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion, Genes Dev., 8, 1787, 10.1101/gad.8.15.1787

McKenna, 1989, A simple chemosensory response in Drosophila and the isolation of ac/ mutants in which it is affected, 86, 8118

McMahon, 1993, Cellubrevin is a ubiquitous tetanus-toxin substrate homologous to a putative synaptic vesicle fusion protein, Nature, 364, 346, 10.1038/364346a0

Misra, 1990, Cytotype control of Drosophila P element transposition: the 66 kd protein is a repressor of transposase activity, Cell, 62, 269, 10.1016/0092-8674(90)90365-L

Mochida, 1990, Exogenous mRNA encoding tetanus or botulinum neurotoxins expressed in Aplysia neurons, 87, 7844

Niemann, 1994, Clostridial neurotoxins: new tools for dissecting exocytosis, Trends Cell Biol., 4, 179, 10.1016/0962-8924(94)90203-8

Nonet, 1993, Synaptic function is impaired but not eliminated in C. elegans mutants lacking synaptotagmin, Cell, 73, 1291, 10.1016/0092-8674(93)90357-V

Osen-Sand, 1993, Inhibition of axonal growth by SNAP-25 antisense oligonucleotides in vitro and in vivo, Nature, 364, 445, 10.1038/364445a0

Poulain, 1988, Neurotransmitter release is blocked intracellularly by botulinum neurotoxin, and this requires uptake of both toxin polypeptides by a process mediated by the larger chain, 85, 4090

Rosahl, 1993, Short-term synaptic plasticity is altered in mice lacking synapsin I, Cell, 75, 661, 10.1016/0092-8674(93)90487-B

Schiavo, 1992, Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin, Nature, 359, 832, 10.1038/359832a0

Shone, 1993, Proteolytic cleavage of synthetic fragments of vesicle-associated membrane protein isoform-2 by botulinum type B neurotoxin, Eur. J. Biochem., 217, 965, 10.1111/j.1432-1033.1993.tb18327.x

Söllner, 1993, SNAP receptors implicated in vesicle targeting and fusion, Nature, 362, 318, 10.1038/362318a0

Spradling, 1986, P element-mediated transformation, 60

Südhof, 1989, A synaptic vesicle membrane protein is conserved from mammals to Drosophila, Neuron, 2, 1475, 10.1016/0896-6273(89)90193-1

Trimble, 1988, VAMP-1: a synaptic vesicle-associated integral membrane protein, 85, 4538

Van Vector, 1993, Genes that control neuromuscular specificity in Drosopholia, Cell, 73, 1137, 10.1016/0092-8674(93)90643-5

Walch-Solimena, 1993, Synaptic vesicle proteins in exocytosis: what do we know?, Curr. Opin. Neurobiol., 3, 329, 10.1016/0959-4388(93)90125-I

Yamasaki, 1994, Cleavage of members of the synaptobrevinNAMP family by types D and F botulinum neurotoxins and tetanus toxin, J. Biol. Chem., 269, 12764, 10.1016/S0021-9258(18)99941-2

Yamasaki, 1994, Synaptobrevin (VAMP) of Aplysia californica: structure and degradation by tetanus toxin, and butulinal neurotoxins type D and F, 91, 4688

Zinsmaier, 1994, Paralysis and early death in cysteirie string protein mutants of Drosophila, Science, 263, 977, 10.1126/science.8310297