Thiopental combination treatments for cerebral resuscitation after prolonged cardiac arrest in dogs. Exploratory outcome study

Safar, 1997, Resuscitation of the ischemic brain, 557 Safar, 1988, Resuscitation from clinical death: pathophysiologic limits and therapeutic potentials, Crit. Care Med., 16, 923, 10.1097/00003246-198810000-00003 Leonov, 1990, Mild cerebral hypothermia during and after cardiac arrest improves neurologic outcome in dogs, J. Cereb. Blood Flow Metab., 10, 57, 10.1038/jcbfm.1990.8 Sterz, 1991, Mild hypothermic cardiopulmonary resuscitation improves outcome after prolonged cardiac arrest in dogs, Crit. Care Med., 19, 379, 10.1097/00003246-199103000-00017 Weinrauch, 1992, Beneficial effect of mild hypothermia and detrimental effect of deep hypothermia after cardiac arrest in dogs, Stroke, 23, 1454, 10.1161/01.STR.23.10.1454 Kuboyama, 1993, Delay in cooling negates the beneficial effect of mild resuscitative cerebral hypothermia after cardiac arrest in dogs: a prospective, randomized study, Crit. Care Med., 21, 1348, 10.1097/00003246-199309000-00019 Safar, 1996, Improved cerebral resuscitation from cardiac arrest in dogs with mild hypothermia plus blood flow promotion, Stroke, 27, 105, 10.1161/01.STR.27.1.105 Safar, 1976, Amelioration of brain damage after 12 minutes cardiac arrest in dogs, Arch. Neurol., 33/2, 91, 10.1001/archneur.1976.00500020019004 Bleyaert, 1978, Thiopental amelioration of brain damage after global ischemia in monkeys, Anesthesiology, 49, 390, 10.1097/00000542-197812000-00003 Nemoto, 1977, Global brain ischemia: a reproducible monkey model, Stroke, 8, 558, 10.1161/01.STR.8.5.558 Smith, 1974, Barbiturate protection in acute focal cerebral ischemia, Stroke, 5, 1, 10.1161/01.STR.5.1.1 Michenfelder, 1976, Cerebral protection by barbiturate anesthesia. Used after middle cerebral artery occlusion in Java monkeys, Arch. Neurol., 33, 345, 10.1001/archneur.1976.00500050031006 Yatsu, 1972, Experimental brain ischemia: protection from irreversible damage with a rapid-acting barbiturate (methohexital), Stroke, 3, 726, 10.1161/01.STR.3.6.726 Wechsler, 1951, Blood flow and oxygen consumption of the human brain during anesthesia produced by thiopental, Anesthesiology, 12, 308, 10.1097/00000542-195105000-00006 Nemoto, 1996, Supression of cerebral metabolic rate for oxygen (CMRO2) by mild hypothermia compared with thiopental, J. Neurosurg. Anesthesiol., 8, 52, 10.1097/00008506-199601000-00012 Hakim, 1976, Cerebral effects of barbiturate: shift from ‘energy’ to synthesis metabolism for cellular viability, Surg. Forum, 27, 497 Demopoulos, 1980, The free radical pathology and the microcirculation: the major central nervous system disorders, Acta Physiol. Scand., 492, 91 Smith, 1976, Anesthetics and cerebral edema, Anesthesiology, 45, 64, 10.1097/00000542-197607000-00012 Shapiro, 1975, Intracranial hypertension. Therapeutic and anesthetic considerations, Anesthesiology, 43, 445, 10.1097/00000542-197510000-00010 Todd, 1982, The neurologic effects of thiopental therapy following experimental cardiac arrest in cats, Anesthesiology, 57, 76, 10.1097/00000542-198208000-00003 Feustel, 1981, Cerebral oxygen availability and blood flow during middle cerebral artery occlusion: effects of pentobarbital, Stroke, 12, 858, 10.1161/01.STR.12.6.858 Nordstrom, 1977, Effects of phenobarbital anesthesia on post-ischemic cerebral blood flow and oxygen consumption in the rat, Acta Neurol. Scand., 64, 146 Kofke, 1979, Brain blood flow and metabolism after global ischemia and post-insult thiopental therapy in monkeys, Stroke, 10, 554, 10.1161/01.STR.10.5.554 Shiu, 1983, Reassessment of brain free fatty acid liberation during global ischemia and its attenuation by barbiturate anesthesia, J. Neurochem., 40, 880, 10.1111/j.1471-4159.1983.tb08062.x Lin, 1983, Alterations in whole brain cyclic AMP and cerebral cortex inducible cyclic AMP in rats during and after complete global ischemia, 55 MacMurdo, 1981, Brain cyclic-AMP and possible mechanisms cerebrovascular dilatation by anesthetics in rats, Anesthesiology, 55, 435, 10.1097/00000542-198110000-00016 Nemoto, 1983, Free fatty acid accumulation in the pathogenesis and therapy of ischemic-anoxic brain injury, Am. J. Emerg. Med., 1, 175, 10.1016/0735-6757(83)90086-4 Breivik, 1978, Clinical feasibility trials of barbiturate therapy after cardiac arrest, Crit. Care Med., 6, 228, 10.1097/00003246-197807000-00004 Mullie, 1981, Clinical pilot studies of thiopental loading after cardiac arrest, Crit. Care Med. (Abstr.), 9, 184, 10.1097/00003246-198103000-00162 Brain Resuscitation Clinical Trial (BRCT) I Study Group, Abramson NS, Safar P. Randomized clinical study of thiopental loading in comatose survivors of cardiac arrest. N Engl J Med 1986;314:397–403. Gisvold, 1984, Thiopental treatment after global brain ischemia in pigtailed monkeys, Anesthesiology, 60, 88, 10.1097/00000542-198402000-00002 Safar, 1980, Amelioration of postischemic brain damage with barbiturates, Stroke, 11, 565, 10.1161/01.STR.11.5.565 Aldrete, 1979, Effect of pretreatment with thiopental and phenytoin on postischemic brain damage in rabbits, Crit. Care Med., 7, 466, 10.1097/00003246-197910000-00005 Cullen, 1979, Protective action of phenytoin in cerebral ischemia, Anesth. Analg., 58, 165, 10.1213/00000539-197905000-00001 Imaizumi, 1995, Effect of phenytoin on cortical Na+–, K+–ATPase activity in global ischemic rat brain, J. Neurotrauma, 12, 231, 10.1089/neu.1995.12.231 Kinouchi, 1990, Phenytoin affects metabolism of free fatty acids and nucleotides in rat cerebral ischemia, Stroke, 21, 1326, 10.1161/01.STR.21.9.1326 Taft, 1989, Phenytoin protects against ischemia-produced neuronal cell death, Brain Res., 483, 143, 10.1016/0006-8993(89)90045-0 Edmonds, 1996, Anticonvulsant activity of topiramate and phenytoin in a rat model of ischemia-induced epilepsy, Life Sci., 59, PL127, PL131, 10.1016/0024-3205(96)00379-7 Chan, 1998, Fosphenytoin reduces hippocampal neuronal damage in rat following transient global ischemia, Acta Neurochir. (Wien), 140, 175, 10.1007/s007010050080 Boxer, 1990, Comparison of phenytoin with noncompetitive N-methyl-d-asparate antagonists in a model of focal brain ischemia in rat, Stroke, 21, 47 Rataud, 1994, Comparative study of voltage-sensitive sodium channel blockers in focal ischemia and electric convulsions in rodents, Neurosci. Lett., 172, 19, 10.1016/0304-3940(94)90652-1 Vartanian, 1996, Phenytoin pretreatment prevents hypoxic-ischemia brain damage in neonatal rats, Brain Res. Dev. Brain Res., 95, 169, 10.1016/0165-3806(96)00073-9 Hayakawa, 1994, Phenytoin reduces neonatal hypoxic-ischemic brain damage in rats, Life Sci., 54, 387, 10.1016/0024-3205(94)00696-2 Safar, 1980, Steroids in brain insults (a partial review), 164 Bracken, 1984, Efficacy of methylprednisolone in acute spinal cord injury, J. Am. Med. Assoc., 251, 45, 10.1001/jama.251.1.45 Hall, 1992, The neuroprotective pharmacology of methylprednisolone, J. Neurosurg., 76, 13, 10.3171/jns.1992.76.1.0013 Hall, 1992, Antioxidant effects in brain and spinal cord injury, J. Neurotrauma, 9, S165 Daneyemez, 1999, Methylprednisolone and vitamin E therapy in perinatal hypoxic-ischemic brain damage in rats, Neuroscience, 92, 693, 10.1016/S0306-4522(99)00038-X Kalayci, 1992, The effect of bolus methylprednisolone in prevention of brain edema in hypoxic ischemic brain injury: an experimental study in 7-day-old rat pups, Brain Res., 569, 112, 10.1016/0006-8993(92)90376-K de Courten-Meyers, 1994, Efficacious experimental stroke treatment with high-dose methylprednisolone, Stroke, 25, 487, 10.1161/01.STR.25.2.487 Chyatte, 1987, Preliminary report: effects of high dose methylprednisolone on delayed cerebral ischemia in patients at high risk for vasospasm after aneurysmal subarachnoid hemorrhage, Neurosurgery, 21, 157, 10.1227/00006123-198708000-00004 Safar, 1982, Long-term animal models for the study of global brain ischemia, 147 Sterz, 1990, Hypertension with or without hemodilution after cardiac arrest in dogs, Stroke, 21, 1178, 10.1161/01.STR.21.8.1178 Safar, 1993, Cerebral resuscitation after cardiac arrest: research initiatives and future directions. A review, Ann. Emerg. Med., 22, 324, 10.1016/S0196-0644(05)80463-9 Ebmeyer, 1994, Multifaceted cerebral resuscitation in cardiac arrest dog outcome model. Exploratory series II: hypothermia, hypertension, thiopental anesthesia, phenytoin, steroid, hemodilution and normocapnia, Crit. Care Med. (Abstr.), 22, A57, 10.1097/00003246-199401000-00103 Oku, 1993, Mild hypothermia after cardiac arrest in dogs does not affect postarrest multifocal cerebral hypoperfusion, Stroke, 24, 1590, 10.1161/01.STR.24.10.1590 Kuboyama, 1994, Mild hypothermia after cardiac arrest in dogs does not affect postarrest cerebral oxygen uptake/delivery mismatching, Resuscitation, 27, 231, 10.1016/0300-9572(94)90037-X Safar, 1990, Emergency cardiopulmonary bypass for resuscitation from prolonged cardiac arrest, Am. J. Emerg. Med., 8, 55, 10.1016/0735-6757(90)90298-E Leonov, 1992, Hypertension with hemodilution prevents multifocal cerebral hypoperfusion after cardiac arrest in dogs, Stroke, 23, 45, 10.1161/01.STR.23.1.45 Radovsky, 1995, Regional prevalence and distribution of ischemic neurons in dog brains 96 hours after cardiac arrest of 0 to 20 minutes, Stroke, 26, 2127, 10.1161/01.STR.26.11.2127 Xiao, 1998, Mild protective and resuscitative hypothermia for asphyxial cardiac arrest in rats, Am. J. Emerg. Med., 16, 17, 10.1016/S0735-6757(98)90059-6 Dietrich, 1993, Intraischemic but not postischemic brain hypothermia protects chronically following global forebrain ischemia in rats, J. Cereb. Blood Flow Metab., 13, 541, 10.1038/jcbfm.1993.71 Colbourne, 1994, Delayed and prolonged post-ischemic hypothermia is neuroprotective in the gerbil, Brain Res., 654, 265, 10.1016/0006-8993(94)90488-X Colbourne, 1999, Indefatigable CA1 sector neuroprotection with mild hypothermia induced 6 hours after severe forebrain ischemia in rats, J. Cereb. Blood Flow and. Metab., 19, 742, 10.1097/00004647-199907000-00003 Marion, 1997, Treatment of traumatic brain injury with moderate hypothermia, N. Engl. J. Med., 336, 540, 10.1056/NEJM199702203360803 Pomeranz, 1993, The effect of resuscitative moderate hypothermia following epidural brain compression on cerebral damage in a canine outcome model, J. Neurosurg., 79, 241, 10.3171/jns.1993.79.2.0241 Ebmeyer, 1998, Moderate hypothermia for 48 hours after temporary epidural brain compression injury in a canine outcome model, J. Neurotrauma, 15, 323, 10.1089/neu.1998.15.323 Steen, 1979, Detrimental effect of prolonged hypothermia in cats and monkeys with and without regional cerebral ischemia, Stroke, 10, 522, 10.1161/01.STR.10.5.522 Gisvold, 1985, Thiopental after brain ischemia in monkeys. Cardiovascular and electroencephalographic effects, Acta Anaesth. Scand., 29, 339, 10.1111/j.1399-6576.1985.tb02211.x Sterz, 1989, Effect of excitatory amino acid receptor blocker MK-801 on overall, neurologic, and morphologic outcome after prolonged cardiac arrest in dogs, Anesthesiology, 71, 907, 10.1097/00000542-198912000-00014