Comparison of Three Jet Nebulizer Aerosol Delivery Systems Used to Administer Recombinant Human DNase I to Patients With Cystic Fibrosis

Picot, 1978, Pus deoxyribonucleic acid and sputum viscosity, Thorax, 33, 235, 10.1136/thx.33.2.235 Chernick, 1959, Composition of tracheobronchial secretions in cystic fibrosis of the pancreas and bronchiectasis, Pediatrics, 24, 739, 10.1542/peds.24.5.739 Shak, 1990, Recombinant human DNase 1 reduces the viscosity of cystic fibrosis sputum, Proc Natl Acad Sci USA, 87, 9188, 10.1073/pnas.87.23.9188 Fuchs, 1994, Effect of aerosolized recombinant human DNase on exacerbations of respiratory symptoms and on pulmonary function in patients with cystic fibrosis, N Engl J Med, 331, 637, 10.1056/NEJM199409083311003 Ramsey, 1993, Efficacy and safety of short-term administration of aerosolized recombinant human deoxyribonuclease in patients with cystic fibrosis, Am Rev Respir Dis, 148, 145, 10.1164/ajrccm/148.1.145 Ranasinha, 1993, Efficacy and safety of short-term administration of aerosolized recombinant human DNase I in adults with stable stage cystic fibrosis, Lancet, 342, 199, 10.1016/0140-6736(93)92297-7 Cipolla, 1994, Characterization of aerosols of human recombinant deoxyribonuclease I (rhDNase) generated by jet nebulizers, Pharmaceut Res, 11, 491, 10.1023/A:1018998028490 Cipolla, 1994, Assessment of aerosol delivery systems for recombinant human deoxyribonuclease, S.T.P. Pharma Sci, 4, 50 1987, American Thoracic Society. Standardization of spirometry—1987 update, Am Rev Respir Dis, 136, 1285, 10.1164/ajrccm/136.5.1285 Knudsen, 1983, Changes in the normal maximal expiratory flow-volume curve with growth and aging, Am Rev Respir Dis, 127, 725 1991, American Thoracic Society. Lung function testing: selection of reference values and interpretive strategies, Am Rev Respir Dis, 144, 1202, 10.1164/ajrccm/144.5.1202 Westlake, 1988, Bioavailability and bioequivalence of pharmaceutical formulations, In: Peace KE, ed. Biopharmaceutical statistics for drug development. New York: Marcel Dekker, 341 Phipps, 1990, Droplets produced by medical nebulizers: some factors affecting their size and solute concentration, Chest, 97, 1327, 10.1378/chest.97.6.1327