Genetics of onset of asthma

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Saglani, 2007, Early detection of airway wall remodeling and eosinophilic inflammation in preschool wheezers., Am J Respir Crit Care Med, 176, 858, 10.1164/rccm.200702-212OC

Pohunek, 2005, Markers of eosinophilic inflammation and tissue re-modelling in children before clinically diagnosed bronchial asthma., Pediatr Allergy Immunol, 16, 43, 10.1111/j.1399-3038.2005.00239.x

Stern, 2008, Wheezing and bronchial hyper-responsiveness in early childhood as predictors of newly diagnosed asthma in early adulthood: a longitudinal birth-cohort study., Lancet, 372, 1058, 10.1016/S0140-6736(08)61447-6

Mitchell, 2012, The association between tobacco and the risk of asthma, rhinoconjunctivitis and eczema in children and adolescents: analyses from Phase Three of the ISAAC programme., Thorax, 67, 941, 10.1136/thoraxjnl-2011-200901

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Porsbjerg, 2006, Risk factors for onset of asthma: a 12-year prospective follow-up study., Chest, 129, 309, 10.1378/chest.129.2.309

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Shaaban, 2008, Rhinitis and onset of asthma: a longitudinal population-based study., Lancet, 372, 1049, 10.1016/S0140-6736(08)61446-4

Gergen, 2009, Total IgE levels and asthma prevalence in the US population: results from the National Health and Nutrition Examination Survey 2005-2006., J Allergy Clin Immunol, 124, 447, 10.1016/j.jaci.2009.06.011

Arbes, 2007, Asthma cases attributable to atopy: results from the Third National Health and Nutrition Examination Survey., J Allergy Clin Immunol, 120, 1139, 10.1016/j.jaci.2007.07.056

Gelfand, 2008, Is asthma in childhood different from asthma in adults Why do we need special approaches to asthma in children Allergy Asthma P, roc, 29, 99

Miranda, 2004, Distinguishing severe asthma phenotypes: role of age at onset and eosinophilic inflammation., J Allergy Clin Immunol, 113, 101, 10.1016/j.jaci.2003.10.041

Bossley, 2012, Pediatric severe asthma is characterized by eosinophilia and remodeling without T(H)2 cytokines., J Allergy Clin Immunol, 129, 974, 10.1016/j.jaci.2012.01.059

Paull, 2005, Do NHLBI lung function criteria apply to children A cross-sectional evaluation of childhood asthma at National Jewish Medical and Research Center, 1999-2002., Pediatr Pulmonol, 39, 311, 10.1002/ppul.20161

Hogg, 1968, Site and nature of airway obstruction in chronic obstructive lung disease., N Engl J Med, 278, 1355, 10.1056/NEJM196806202782501

Thomsen, 2010, Genetic influence on the age at onset of asthma: a twin study., J Allergy Clin Immunol, 126, 626, 10.1016/j.jaci.2010.06.017

Bottema, 2005, Phenotype definition, age, and gender in the genetics of asthma and atopy., Immunol Allergy Clin North Am, 25, 621, 10.1016/j.iac.2005.07.002

Moffatt, 2007, Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma., Nature, 448, 470, 10.1038/nature06014

Himes, 2009, Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene., Am J Hum Genet, 84, 581, 10.1016/j.ajhg.2009.04.006

Sleiman, 2010, Variants of DENND1B associated with asthma in children., N Engl J Med, 362, 36, 10.1056/NEJMoa0901867

Noguchi, 2011, Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations., PLoS Genet, 7, e1002170, 10.1371/journal.pgen.1002170

Schauberger, 2011, Identification of ATPAF1 as a novel candidate gene for asthma in children., J Allergy Clin Immunol, 128, 753, 10.1016/j.jaci.2011.04.058

Forno, 2012, Genome-wide association study of the age of onset of childhood asthma., J Allergy Clin Immunol, 130, 83, 10.1016/j.jaci.2012.03.020

Spycher, 2012, Genome-wide prediction of childhood asthma and related phenotypes in a longitudinal birth cohort., J Allergy Clin Immunol, 130, 503, 10.1016/j.jaci.2012.06.002

Moffatt, 2010, A large-scale, consortium-based genomewide association study of asthma., N Engl J Med, 363, 1211, 10.1056/NEJMoa0906312

Torgerson, 2011, Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations., Nat Genet, 43, 887, 10.1038/ng.888

Hirota, 2011, Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population., Nat Genet, 43, 893, 10.1038/ng.887

Ferreira, 2011, Identification of IL6R and chromosome 11q13.5 as risk loci for asthma., Lancet, 378, 1006, 10.1016/S0140-6736(11)60874-X

Wan, 2012, Genome-wide association study to identify genetic determinants of severe asthma., Thorax, 67, 762, 10.1136/thoraxjnl-2011-201262

Ramasamy, 2012, Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA., PLoS One, 7, e44008, 10.1371/journal.pone.0044008

Myers, 2012, Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans., J Allergy Clin Immunol, 130, 1294, 10.1016/j.jaci.2012.07.054

Bouzigon, 2008, Effect of 17q21 variants and smoking exposure in early-onset asthma., N Engl J Med, 359, 1985, 10.1056/NEJMoa0806604

Bisgaard, 2009, Chromosome 17q21 gene variants are associated with asthma and exacerbations but not atopy in early childhood., Am J Respir Crit Care Med, 179, 179, 10.1164/rccm.200809-1436OC

Sleiman, 2008, ORMDL3 variants associated with asthma susceptibility in North Americans of European ancestry., J Allergy Clin Immunol, 122, 1225, 10.1016/j.jaci.2008.06.041

Ferreira, 2011, Association between ORMDL3, IL1RL1 and a deletion on chromosome 17q21 with asthma risk in Australia., Eur J Hum Genet, 19, 458, 10.1038/ejhg.2010.191

Hirota, 2008, Genetic polymorphism regulating ORM1-like 3 (Saccharomyces cerevisiae) expression is associated with childhood atopic asthma in a Japanese population., J Allergy Clin Immunol, 121, 769, 10.1016/j.jaci.2007.09.038

Yang, 2012, Single nucleotide polymorphisms in the ORM1-like 3 gene associated with childhood asthma in a Chinese population., Genet Mol Res, 11, 4646, 10.4238/2012.October.19.1

Mathias, 2010, A genome-wide association study on African-ancestry populations for asthma., J Allergy Clin Immunol, 125, 336, 10.1016/j.jaci.2009.08.031

Halapi, 2010, A sequence variant on 17q21 is associated with age at onset and severity of asthma., Eur J Hum Genet, 18, 902, 10.1038/ejhg.2010.38

Binia, 2011, Chromosome 17q21 SNP and severe asthma., J Hum Genet, 56, 97, 10.1038/jhg.2010.134

van der Valk, 2012, Interaction of a 17q12 variant with both fetal and infant smoke exposure in the development of childhood asthma-like symptoms., Allergy, 67, 767, 10.1111/j.1398-9995.2012.02819.x

Smit, 2010, 17q21 variants modify the association between early respiratory infections and asthma., Eur Respir J, 36, 57, 10.1183/09031936.00154509

Flory, 2009, 17q12-21 variants interact with smoke exposure as a risk factor for pediatric asthma but are equally associated with early-onset versus late-onset asthma in North Americans of European ancestry., J Allergy Clin Immunol, 124, 605, 10.1016/j.jaci.2009.05.047

Verlaan, 2009, Allele-specific chromatin remodeling in the ZPBP2GSDMBORMDL3 locus associated with the risk of asthma and autoimmune disease., Am J Hum Genet, 85, 377, 10.1016/j.ajhg.2009.08.007

Berlivet, 2012, Interaction between genetic and epigenetic variation defines gene expression patterns at the asthma-associated locus 17q12-q21 in lymphoblastoid cell lines., Hum Genet, 131, 1161, 10.1007/s00439-012-1142-x

Cantero-Recasens, 2010, The asthma-associated ORMDL3 gene product regulates endoplasmic reticulum-mediated calcium signaling and cellular stress., Hum Mol Genet, 19, 111, 10.1093/hmg/ddp471

Akhabir, 2011, Genome-wide association studies for discovery of genes involved in asthma., Respirology, 16, 396, 10.1111/j.1440-1843.2011.01939.x

Carreras-Sureda, 2013, ORMDL3 modulates store-operated calcium entry and lymphocyte activation., Hum Mol Genet, 22, 519, 10.1093/hmg/dds450

Miller, 2012, ORMDL3 is an inducible lung epithelial gene regulating metalloproteases, chemokines, OAS, and ATF6., Proc Natl Acad Sci U S A, 109, 16648, 10.1073/pnas.1204151109

Breslow, 2010, Orm family proteins mediate sphingolipid homeostasis., Nature, 463, 1048, 10.1038/nature08787

Komiyama, 2010, Alu-derived cis-element regulates tumorigenesis-dependent gastric expression of GASDERMIN B (GSDMB)., Genes Genet Syst, 85, 75, 10.1266/ggs.85.75

Hansen, 2000, Absence of muscarinic cholinergic airway responses in mice deficient in the cyclic nucleotide phosphodiesterase PDE4D., Proc Natl Acad Sci U S A, 97, 6751, 10.1073/pnas.97.12.6751

Varney, 2010, HLA DPA1, DPB1 alleles and haplotypes contribute to the risk associated with type 1 diabetes: analysis of the type 1 diabetes genetics consortium families., Diabetes, 59, 2055, 10.2337/db09-0680

Plenge, 2007, TRAF1-C5 as a risk locus for rheumatoid arthritis: a genomewide study., N Engl J Med, 357, 1199, 10.1056/NEJMoa073491

Sladek, 2007, A genome-wide association study identifies novel risk loci for type 2 diabetes., Nature, 445, 881, 10.1038/nature05616

Burgess, 2006, Who remembers whether they had asthma as children J A, sthma, 43, 727

Ober, 2008, Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function., N Engl J Med, 358, 1682, 10.1056/NEJMoa0708801

Weidinger, 2008, Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus., PLoS Genet, 4, e1000166, 10.1371/journal.pgen.1000166

Gudbjartsson, 2009, Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction., Nat Genet, 41, 342, 10.1038/ng.323

Esparza-Gordillo, 2009, A common variant on chromosome 11q13 is associated with atopic dermatitis., Nat Genet, 41, 596, 10.1038/ng.347

Rothenberg, 2010, Common variants at 5q22 associate with pediatric eosinophilic esophagitis., Nat Genet, 42, 289, 10.1038/ng.547

Ramasamy, 2011, A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order., J Allergy Clin Immunol, 128, 996, 10.1016/j.jaci.2011.08.030

Paternoster, 2011, Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis., Nat Genet, 44, 187, 10.1038/ng.1017

Granada, 2012, A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study., J Allergy Clin Immunol, 129, 840, 10.1016/j.jaci.2011.09.029

Hirota, 2012, Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population., Nat Genet, 44, 1222, 10.1038/ng.2438

Lau, 2000, Early exposure to house-dust mite and cat allergens and development of childhood asthma: a cohort study. Multicentre Allergy Study Group., Lancet, 356, 1392, 10.1016/S0140-6736(00)02842-7

Lodrup Carlsen, 2012, Does pet ownership in infancy lead to asthma or allergy at school age Pooled analysis of individual participant data from 11 European birth cohorts., PLoS One, 7, e43214, 10.1371/journal.pone.0043214

Gehring, 2012, The 8-year follow-up of the PIAMA intervention study assessing the effect of mite-impermeable mattress covers., Allergy, 67, 248, 10.1111/j.1398-9995.2011.02739.x

Guerra, 2011, Is allergy an asthmatic disease Arch B, ronconeumol, 47, 479

Hao, 2012, Lung eQTLs to help reveal the molecular underpinnings of asthma., PLoS Genet, 8, e1003029, 10.1371/journal.pgen.1003029