The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction

Immunity - Tập 45 Số 2 - Trang 374-388 - 2016
Nicole E. Scharping1,2, Ashley V. Menk2, Rebecca S. Moreci2, Ryan D. Whetstone1,2, Rebekah Dadey1,2, Simon C. Watkins3,1, Robert L. Ferris1,4,2, Greg M. Delgoffe1,2
1Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA
2Tumor Microenvironment Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15261, USA
3Department of Cell Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA
4Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA 15261, USA

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