Quiescent Tissue Stem Cells Evade Immune Surveillance

Agudo, 2015, GFP-specific CD8 T cells enable targeted cell depletion and visualization of T-cell interactions, Nat. Biotechnol., 33, 1287, 10.1038/nbt.3386 Ali, 2017, Regulatory T cells in skin facilitate epithelial stem cell differentiation, Cell, 169, 1119, 10.1016/j.cell.2017.05.002 Ankrum, 2014, Mesenchymal stem cells: immune evasive, not immune privileged, Nat. Biotechnol., 32, 252, 10.1038/nbt.2816 Barker, 2014, Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration, Nat. Rev. Mol. Cell Biol., 15, 19, 10.1038/nrm3721 Barker, 2007, Identification of stem cells in small intestine and colon by marker gene Lgr5, Nature, 449, 1003, 10.1038/nature06196 Barker, 2009, Crypt stem cells as the cells-of-origin of intestinal cancer, Nature, 457, 608, 10.1038/nature07602 Beerman, 2014, Quiescent hematopoietic stem cells accumulate DNA damage during aging that is repaired upon entry into cell cycle, Cell Stem Cell, 15, 37, 10.1016/j.stem.2014.04.016 Blanpain, 2014, Stem cell plasticity. Plasticity of epithelial stem cells in tissue regeneration, Science, 344, 10.1126/science.1242281 Blokzijl, 2016, Tissue-specific mutation accumulation in human adult stem cells during life, Nature, 538, 260, 10.1038/nature19768 Brack, 2012, Tissue-specific stem cells: lessons from the skeletal muscle satellite cell, Cell Stem Cell, 10, 504, 10.1016/j.stem.2012.04.001 Busch, 2016, Unperturbed vs. post-transplantation hematopoiesis: both in vivo but different, Curr. Opin. Hematol., 23, 295, 10.1097/MOH.0000000000000250 Chen, 2013, Oncology meets immunology: the cancer-immunity cycle, Immunity, 39, 1, 10.1016/j.immuni.2013.07.012 Chidgey, 2008, Immune privilege for stem cells: not as simple as it looked, Cell Stem Cell, 3, 357, 10.1016/j.stem.2008.09.011 Clevers, 2015, STEM CELLS. What is an adult stem cell?, Science, 350, 1319, 10.1126/science.aad7016 Codega, 2014, Prospective identification and purification of quiescent adult neural stem cells from their in vivo niche, Neuron, 82, 545, 10.1016/j.neuron.2014.02.039 Cui, 2010, NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways, Cell, 141, 483, 10.1016/j.cell.2010.03.040 Drukker, 2002, Characterization of the expression of MHC proteins in human embryonic stem cells, Proc. Natl. Acad. Sci. USA, 99, 9864, 10.1073/pnas.142298299 Flesken-Nikitin, 2013, Ovarian surface epithelium at the junction area contains a cancer-prone stem cell niche, Nature, 495, 241, 10.1038/nature11979 Jaks, 2008, Lgr5 marks cycling, yet long-lived, hair follicle stem cells, Nat. Genet., 40, 1291, 10.1038/ng.239 Jan, 2012, Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia, Sci. Transl. Med., 4, 149ra118, 10.1126/scitranslmed.3004315 Kissenpfennig, 2005, Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells, Immunity, 22, 643, 10.1016/j.immuni.2005.04.004 Lay, 2016, FOXC1 maintains the hair follicle stem cell niche and governs stem cell quiescence to preserve long-term tissue-regenerating potential, Proc. Natl. Acad. Sci. USA, 113, E1506, 10.1073/pnas.1601569113 Li, 2016, Mouse label-retaining cells are molecularly and functionally distinct from reserve intestinal stem cells, Gastroenterology, 151, 298, 10.1053/j.gastro.2016.04.049 Malladi, 2016, Metastatic latency and immune evasion through autocrine inhibition of WNT, Cell, 165, 45, 10.1016/j.cell.2016.02.025 Mandal, 2011, DNA damage response in adult stem cells: pathways and consequences, Nat. Rev. Mol. Cell Biol., 12, 198, 10.1038/nrm3060 Martincorena, 2015, Tumor evolution. High burden and pervasive positive selection of somatic mutations in normal human skin, Science, 348, 880, 10.1126/science.aaa6806 Mathew, 2011, Connective tissue fibroblasts and Tcf4 regulate myogenesis, Development, 138, 371, 10.1242/dev.057463 Meissner, 2010, NLR family member NLRC5 is a transcriptional regulator of MHC class I genes, Proc. Natl. Acad. Sci. USA, 107, 13794, 10.1073/pnas.1008684107 Meissner, 2012, NLRC5 cooperates with the RFX transcription factor complex to induce MHC class I gene expression, J. Immunol., 188, 4951, 10.4049/jimmunol.1103160 Méndez-Ferrer, 2010, Mesenchymal and haematopoietic stem cells form a unique bone marrow niche, Nature, 466, 829, 10.1038/nature09262 Metcalfe, 2014, Lgr5+ stem cells are indispensable for radiation-induced intestinal regeneration, Cell Stem Cell, 14, 149, 10.1016/j.stem.2013.11.008 Morris, 2004, Capturing and profiling adult hair follicle stem cells, Nat. Biotechnol., 22, 411, 10.1038/nbt950 Ng, 2014, Lgr5 marks stem/progenitor cells in ovary and tubal epithelia, Nat. Cell Biol., 16, 745, 10.1038/ncb3000 Orr, 2010, Natural killer cell education and tolerance, Cell, 142, 847, 10.1016/j.cell.2010.08.031 Page, 2013, The epidermis comprises autonomous compartments maintained by distinct stem cell populations, Cell Stem Cell, 13, 471, 10.1016/j.stem.2013.07.010 Pamer, 1998, Mechanisms of MHC class I--restricted antigen processing, Annu. Rev. Immunol., 16, 323, 10.1146/annurev.immunol.16.1.323 Paus, 2005, A ‘hairy’ privilege, Trends Immunol., 26, 32, 10.1016/j.it.2004.09.014 Piontek, 1985, YAC-1 MHC class I variants reveal an association between decreased NK sensitivity and increased H-2 expression after interferon treatment or in vivo passage, J. Immunol., 135, 4281, 10.4049/jimmunol.135.6.4281 Plaks, 2013, Lgr5-expressing cells are sufficient and necessary for postnatal mammary gland organogenesis, Cell Rep., 3, 70, 10.1016/j.celrep.2012.12.017 Purbhoo, 2004, T cell killing does not require the formation of a stable mature immunological synapse, Nat. Immunol., 5, 524, 10.1038/ni1058 Quarta, 2016, An artificial niche preserves the quiescence of muscle stem cells and enhances their therapeutic efficacy, Nat. Biotechnol., 34, 752, 10.1038/nbt.3576 Rosenberg, 2015, Adoptive cell transfer as personalized immunotherapy for human cancer, Science, 348, 62, 10.1126/science.aaa4967 Sakaue-Sawano, 2008, Visualizing spatiotemporal dynamics of multicellular cell-cycle progression, Cell, 132, 487, 10.1016/j.cell.2007.12.033 Setiady, 2010, In vivo depletion of CD4+FOXP3+ Treg cells by the PC61 anti-CD25 monoclonal antibody is mediated by FcgammaRIII+ phagocytes, Eur. J. Immunol., 40, 780, 10.1002/eji.200939613 Staehli, 2012, NLRC5 deficiency selectively impairs MHC class I- dependent lymphocyte killing by cytotoxic T cells, J. Immunol., 188, 3820, 10.4049/jimmunol.1102671 Stucci, 2017, Immune-related adverse events during anticancer immunotherapy: Pathogenesis and management, Oncol. Lett., 14, 5671 Swijnenburg, 2008, Immunosuppressive therapy mitigates immunological rejection of human embryonic stem cell xenografts, Proc. Natl. Acad. Sci. USA, 105, 12991, 10.1073/pnas.0805802105 Tang, 2013, Immunogenicity of in vitro maintained and matured populations: potential barriers to engraftment of human pluripotent stem cell derivatives, Methods Mol. Biol., 1029, 17, 10.1007/978-1-62703-478-4_2 Tian, 2011, A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable, Nature, 478, 255, 10.1038/nature10408 Tran, 2015, Immunogenicity of somatic mutations in human gastrointestinal cancers, Science, 350, 1387, 10.1126/science.aad1253 Turner, 2009, Intestinal mucosal barrier function in health and disease, Nat. Rev. Immunol., 9, 799, 10.1038/nri2653 van der Flier, 2009, Stem cells, self-renewal, and differentiation in the intestinal epithelium, Annu. Rev. Physiol., 71, 241, 10.1146/annurev.physiol.010908.163145 Vasioukhin, 1999, The magical touch: genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin, Proc. Natl. Acad. Sci. USA, 96, 8551, 10.1073/pnas.96.15.8551 Wang, 2016, Foxc1 reinforces quiescence in self-renewing hair follicle stem cells, Science, 351, 613, 10.1126/science.aad5440 Westgate, 1991, Immune privilege in hair growth, J. Invest. Dermatol., 97, 417, 10.1111/1523-1747.ep12481002 Wilson, 2008, Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair, Cell, 135, 1118, 10.1016/j.cell.2008.10.048 Wood, 2016, Understanding stem cell immunogenicity in therapeutic applications, Trends Immunol., 37, 5, 10.1016/j.it.2015.11.005 Wu, 2008, Embryonic stem cells and their differentiated derivatives have a fragile immune privilege but still represent novel targets of immune attack, Stem Cells, 26, 1939, 10.1634/stemcells.2008-0078 Yan, 2012, The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations, Proc. Natl. Acad. Sci. USA, 109, 466, 10.1073/pnas.1118857109