Pulmonary Alveolar Proteinosis

Rosen, 1958, Pulmonary alveolar proteinosis, N Engl J Med, 258, 1123, 10.1056/NEJM195806052582301 Trapnell, 2003, Pulmonary alveolar proteinosis, N Engl J Med, 349, 2527, 10.1056/NEJMra023226 Seymour, 2002, Pulmonary alveolar proteinosis: progress in the first 44 years, Am J Respir Crit Care Med, 166, 215, 10.1164/rccm.2109105 Trapnell, 2002, GM-CSF regulates pulmonary surfactant homeostasis and alveolar macrophage-mediated innate host defense, Annu Rev Physiol, 64, 775, 10.1146/annurev.physiol.64.090601.113847 Mazzone, 2002, Pulmonary alveolar proteinosis: recent advances, Semin Respir Crit Care Med, 23, 115, 10.1055/s-2002-25375 Gough, 1985, Structure and expression of the mRNA for murine granulocyte-macrophage colony stimulating factor, EMBO J, 4, 645, 10.1002/j.1460-2075.1985.tb03678.x Dranoff, 1994, Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis, Science, 264, 713, 10.1126/science.8171324 Stanley, 1994, Granulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology, Proc Natl Acad Sci U S A, 91, 5592, 10.1073/pnas.91.12.5592 Dranoff, 1994, Activities of granulocyte-macrophage colony-stimulating factor revealed by gene transfer and gene knockout studies [abstract], Stem Cells, 12, 173 Robb, 1995, Hematopoietic and lung abnormalities in mice with a null mutation of the common β subunit of the receptors for granulocyte-macrophage colony-stimulating factor and interleukins 3 and 5, Proc Natl Acad Sci U S A, 92, 9565, 10.1073/pnas.92.21.9565 Yoshida, 2001, GM-CSF regulates protein and lipid catabolism by alveolar macrophages, Am J Physiol Lung Cell Mol Physiol, 280, L379, 10.1152/ajplung.2001.280.3.L379 Ikegami, 1997, Surfactant metabolic consequences of overexpression of GM-CSF in the epithelium of GM-CSF-deficient mice, Am J Physiol, 273, L709 Kitamura, 1999, Idiopathic pulmonary alveolar proteinosis as an autoimmune disease with neutralizing antibody against granulocyte/macrophage colony-stimulating factor, J Exp Med, 190, 875, 10.1084/jem.190.6.875 Uchida, 2004, High-affinity autoanti bodies specifically eliminate granulocyte-macrophage colony-stimulating factor activity in the lungs of patients with idiopathic pulmonary alveolar proteinosis, Blood, 103, 1089, 10.1182/blood-2003-05-1565 Bonfield, 2002, Autoantibodies against granulocyte macrophage colony-stimulating factor are diagnostic for pulmonary alveolar proteinosis, Am J Respir Cell Mol Biol, 27, 481, 10.1165/rcmb.2002-0023OC Suzuki, 2008, Familial pulmonary alveolar proteinosis caused by mutations in CSF2RA, J Exp Med, 205, 2703, 10.1084/jem.20080990 Martinez-Moczygemba, 2008, Pulmonary alveolar proteinosis caused by deletion of the GM-CSFRα gene in the X chromosome pseudoautosomal region 1, J Exp Med, 205, 2711, 10.1084/jem.20080759 Shibata, 2001, GM-CSF regulates alveolar macrophage differentiation and innate immunity in the lung through PU.1, Immunity, 15, 557, 10.1016/S1074-7613(01)00218-7 Nakata, 2006, Why does the autoantibody against granulocyte-macrophage colony-stimulating factor cause lesions only in the lung? [abstract], Respirology, 11, S65, 10.1111/j.1440-1843.2006.00812.x Fleischmann, 1986, Granulocyte-macrophage colony-stimulating factor enhances phagocytosis of bacteria by neutrophils, Blood, 68, 708, 10.1182/blood.V68.3.708.708 Uchida, 2007, GM-CSF autoantibodies and neutrophil dysfunction in pulmonary alveolar proteinosis, N Engl J Med, 356, 567, 10.1056/NEJMoa062505 Bonfield, 2006, Elevated gelatinase activity in pulmonary alveolar proteinosis: role of macrophage-colony stimulating factor, J Leuk Biol, 79, 133, 10.1189/jlb.0805447 Kobayashi, 2008, Differences in the immunolocalization of surfactant protein (SP)-A, SP-D, and KL-6 in pulmonary alveolar proteinosis, Pathol Int, 58, 203, 10.1111/j.1440-1827.2007.02212.x Nara, 2006, Serum antibody against granulocyte-macrophage colony-stimulating factor and KL-6 in idiopathic pulmonary alveolar proteinosis [abstract], Tohoku J Exp Med, 208, 349, 10.1620/tjem.208.349 Bonfield, 2006, Suppression of activin A in autoimmune lung disease associated with anti-GM-CSF, J Autoimmun, 26, 37, 10.1016/j.jaut.2005.10.004 Huffman, 1996, Pulmonary epithelial cell expression of GM-CSF corrects the alveolar proteinosis in GM-CSF-deficient mice, J Clin Invest, 97, 649, 10.1172/JCI118461 Huffman Reed, 1997, GM-CSF enhances lung growth and causes alveolar type II epithelial cell hyperplasia in transgenic mice, Am J Physiol, 273, L715 Zsengeller, 1998, Adenovirus-mediated granulocyte-macrophage colony-stimulating factor improves lung pathology of pulmonary alveolar proteinosis in granulocyte-macrophage colony-stimulating factor-deficient mice, Hum Gene Ther, 9, 2101, 10.1089/hum.1998.9.14-2101 Reed, 1999, Aerosolized GM-CSF ameliorates pulmonary alveolar proteinosis in GM-CSF-deficient mice, Am J Physiol Lung Cell Mol Physiol, 276, 556, 10.1152/ajplung.1999.276.4.L556 Kavuru, 2000, Exogenous granulocyte-macrophage colony-stimulating factor administration for pulmonary alveolar proteinosis, Am J Respir Crit Care Med, 161, 1143, 10.1164/ajrccm.161.4.9906044 Seymour, 2001, Therapeutic efficacy of granulocyte-macrophage colony-stimulating factor in patients with idiopathic acquired alveolar proteinosis, Am J Respir Crit Care Med, 163, 524, 10.1164/ajrccm.163.2.2003146 Venkateshiah, 2006, An open-label trial of granulocyte-macrophage colony-stimulating factor therapy for moderate symptomatic pulmonary alveolar proteinosis, Chest, 130, 227, 10.1378/chest.130.1.227 Bonfield, 2002, Anti-GM-CSF titer predicts response to GM-CSF therapy in pulmonary alveolar proteinosis, Clin Immunol, 105, 342, 10.1006/clim.2002.5301 Price, 2006, Pulmonary alveolar proteinosis associated with anti-GM-CSF antibodies in a child: successful treatment with inhaled GM-CSF, Pediatr Pulmonol, 41, 367, 10.1002/ppul.20347 Robinson, 2009, Quantitative analysis of longitudinal response to aerosolized granulocyte-macrophage colony-stimulating factor in two adolescents with autoimmune pulmonary alveolar proteinosis, Chest, 135, 842, 10.1378/chest.08-1317