Lack of CD47 on nonhematopoietic cells induces split macrophage tolerance to CD47nullcells

Proceedings of the National Academy of Sciences of the United States of America - Tập 104 Số 34 - Trang 13744-13749 - 2007
Hui Wang1, Maria Lucia L. Madariaga2, Shumei Wang2, Nico van Rooijen3, Per‐Arne Oldenborg4, Yong‐Guang Yang2
1Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
2*Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129;
3Department of Molecular Cell Biology, Faculty of Medicine, Vrije Universiteit, VUMC, Van der Boechorstraat 7, 1081 BT, Amsterdam, The Netherlands; and
4Department of Integrative Medical Biology, Section for Histology and Cell Biology, Umeå University, SE-901 87 Umeå, Sweden

Tóm tắt

Macrophages recognize CD47 as a marker of “self” and phagocytose CD47nullhematopoietic cells. Using CD47 chimera models, here, we show that the phagocytic activity of macrophages against CD47nullhematopoietic cells is conferred by CD47 expression on nonhematopoietic cells, and this “education” process is hematopoietic cell-independent. Macrophages in the chimeras where nonhematopoietic cells express CD47 phagocytose CD47nullcells, whereas those in the chimeras lacking CD47 on nonhematopoietic cells are tolerant to CD47nullcells. However, macrophages in the latter chimeras retain phagocytic activity against CD47nullRBCs, demonstrating a split macrophage tolerance to CD47nullhematopoietic cells. The findings highlight the potential importance of nonhematopoietic cells in the regulation of macrophage function, and suggest a previously uncharacterized mechanism of macrophage tolerance.

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Proceedings of the National Academy of Sciences of the United States of America

Tập 104 Số 34

13744-13749

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